Title: Hotels by Wyndham Hotels in Medical Center from CA $115 | Expedia.ca [Medical Center Travel Guide](https://expedia.ca/Detroit-Medical-Center.dx802472874695356416)[Vacation Rentals in Detroit](https://expedia.ca/Detroit-Vacation-Rentals.d178255.Travel-Guide-VacationRentals)[Flights to Detroit](https://expedia.ca/Cheap-Flights-To-Detroit.d178255.Travel-Guide-Flights)[Things to do in Detroit](https://expedia.ca/Things-To-Do-In-Detroit.d178255.Travel-Guide-Activities)[Medical Center Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center.d802472874695356416.Car-Rental-Guide)[Medical Center Vacations](https://expedia.ca/Medical-Center.d802472874695356416.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Wyndham Hotels in Medical Center from CA $115 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 18 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=802472874695356416&startDate=2025-10-18&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=802472874695356416&startDate=2025-10-19&endDate=2025-10-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=802472874695356416&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=802472874695356416&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Medical Center Wyndham Hotels Hotels ![Suite, 1 Bedroom, Non Smoking (Master,Riverfront)](https://images.trvl-media.com/lodging/1000000/10000/3700/3653/a02adac5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/10000/3700/3653/6b7fccfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/10000/3700/3653/7fe50033.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3700/3653/c80bd5aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fort Pontchartrain Detroit, a Wyndham Hotel Downtown Detroit 8.4/10 Very good (2259) "Great location to stay downtown!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Natalie CA $189 CA $220 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Detroit-Hotels-Hotel-Pontchartrain-Detroit-By-Bel-Air-Collection.h3653.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/3900/3860/c39373a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3900/3860/0e111dda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/3900/3860/aad1d7e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business Room, 1 King Bed, Non Smoking, Balcony](https://images.trvl-media.com/lodging/1000000/10000/3900/3860/7d8fd1d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Garden Romulus Detroit Metro Airport Romulus 6.2/10 (1020) "Very good breakfast and courteous, professional staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Max CA $100 CA $115 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Detroit-Hotels-Wyndham-Garden-Romulus-Detroit-Metro-Airport.h3860.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-01&endDate=2025-11-02®ionId=802472874695356416&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMedical-Center-Detroit-Hotels-Wyndham-Hotels.0-n802472874695356416-0--bWyndhamHotels.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMedical-Center-Detroit-Hotels-Wyndham-Hotels.0-n802472874695356416-0--bWyndhamHotels.Travel-Guide-Filter-Hotels) ## Top Medical Center Hotel Reviews ![The Siren Hotel, an Ash Hotel](//images.trvl-media.com/lodging/20000000/19370000/19365900/19365870/6959df23_y.jpg) ### The Siren Hotel, an Ash Hotel 10/10 Excellent "." [](https://expedia.ca/Detroit-Hotels-The-Siren-Hotel.h19365870.Hotel-Information) ![Hotel Indigo Detroit Downtown by IHG](//images.trvl-media.com/lodging/1000000/550000/543800/543746/ce917fe8_y.jpg) ### Hotel Indigo Detroit Downtown by IHG 10/10 Excellent "Well appointed & spacious rooms located close to transport links. Walking distance to downtown. Reception staff helpful in providing information on places to visit. " [](https://expedia.ca/Detroit-Hotels-Hotel-Indigo-Detroit-Downtown.h543746.Hotel-Information) ![Hollywood Casino at Greektown](//images.trvl-media.com/lodging/3000000/2420000/2413900/2413847/fcac1d7f_y.jpg) ### Hollywood Casino at Greektown 10/10 Excellent "The hotel was nice and convenient for our event. " [](https://expedia.ca/Detroit-Hotels-Greektown-Casino-Hotel.h2413847.Hotel-Information) ![MotorCity Casino Hotel](//images.trvl-media.com/lodging/2000000/1770000/1764800/1764738/f5b46796_y.jpg) ### MotorCity Casino Hotel 10/10 Excellent "Loved the casino and food options" [](https://expedia.ca/Detroit-Hotels-MotorCity-Casino-Hotel.h1764738.Hotel-Information) ![ROOST Detroit](//images.trvl-media.com/lodging/94000000/93110000/93108000/93107990/64662fc3_y.jpg) ### ROOST Detroit 10/10 Excellent "Great spot in Detroit with friendly, courteous staff. " [](https://expedia.ca/Detroit-Hotels-ROOST-Detroit.h93107990.Hotel-Information) ![Skyline Hotel Detroit Airport, SureStay Collection by BW](//images.trvl-media.com/lodging/1000000/20000/15700/15682/bc464996_y.jpg) ### Skyline Hotel Detroit Airport, SureStay Collection by BW 10/10 Excellent "Nice staff, close to airport with free shuttle" [](https://expedia.ca/Detroit-Hotels-Skyline-Hotel-Detroit-Airport.h15682.Hotel-Information) ![Cambria Hotel Detroit Downtown](//images.trvl-media.com/lodging/62000000/61640000/61631200/61631167/a0753ec5_y.jpg) ### Cambria Hotel Detroit Downtown 10/10 Excellent "Very nice, clean, " [](https://expedia.ca/Detroit-Hotels-Cambria-Hotel-Detroit-Downtown.h61631167.Hotel-Information) ![Trumbull and Porter Hotel](//images.trvl-media.com/lodging/2000000/1470000/1461200/1461189/975c9340_y.jpg) ### Trumbull and Porter Hotel 10/10 Excellent "clean room, good value" [](https://expedia.ca/Detroit-Hotels-Trumbull-And-Porter-Hotel.h1461189.Hotel-Information) ![Fort Pontchartrain Detroit, a Wyndham Hotel](//images.trvl-media.com/lodging/1000000/10000/3700/3653/a02adac5_y.jpg) ### Fort Pontchartrain Detroit, a Wyndham Hotel 10/10 Excellent "Wonderful" [](https://expedia.ca/Detroit-Hotels-Hotel-Pontchartrain-Detroit-By-Bel-Air-Collection.h3653.Hotel-Information) ## Find out more about Medical Center ## Medical Center Hotels Guide Expedia.ca offers a selection of 1781 hotels in Medical Center. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Medical Center. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Medical Center neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Medical Center, Detroit now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Other - More ways to book - [La Quinta Inn & Suites Hotels in Belle Isle](https://www.expedia.ca/Belle-Isle-Hotels-La-Quinta-Inn-Suites.0-0-d507224--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Wyndham Hotels in Belle Isle](https://www.expedia.ca/Belle-Isle-Hotels-Wyndham-Hotels.0-0-d507224--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Brush Park](https://www.expedia.ca/Brush-Park-Detroit-Hotels-Adults-Only-Resorts.0-n553248635976482504-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Brush Park](https://www.expedia.ca/Brush-Park-Detroit-Hotels-All-Inclusive-Hotel.0-n553248635976482504-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Brush Park](https://www.expedia.ca/Brush-Park-Detroit-Hotels-Boutique-Hotel.0-n553248635976482504-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Brush Park](https://www.expedia.ca/Brush-Park-Detroit-Hotels-Cheap-Hotels.0-n553248635976482504-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Family Hotels in Brush Park](https://www.expedia.ca/Brush-Park-Detroit-Hotels-Family-Hotel.0-n553248635976482504-0-tFamilyHotel.Travel-Guide-Filter-Hotels) - [Golf Hotels in Brush Park](https://www.expedia.ca/Brush-Park-Detroit-Hotels-Golf-Hotel.0-n553248635976482504-0-tGolfHotel.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in Brush Park](https://www.expedia.ca/Brush-Park-Detroit-Hotels-Hotels-With-Free-Airport-Shuttle.0-n553248635976482504-0-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Brush Park](https://www.expedia.ca/Brush-Park-Detroit-Hotels-Luxury-Hotel.0-n553248635976482504-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Mountain Hotels in Brush Park](https://www.expedia.ca/Brush-Park-Detroit-Hotels-Mountain-Hotels.0-n553248635976482504-0-tMountainHotels.Travel-Guide-Filter-Hotels) - [Oceanfront Hotels in Brush Park](https://www.expedia.ca/Brush-Park-Detroit-Hotels-Oceanfront-Hotels.0-n553248635976482504-0-tOceanfrontHotels.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Brush Park](https://www.expedia.ca/Brush-Park-Detroit-Hotels-Pet-Friendly-Hotel.0-n553248635976482504-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Brush Park](https://www.expedia.ca/Brush-Park-Detroit-Hotels-Romantic-Hotel.0-n553248635976482504-0-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Brush Park](https://www.expedia.ca/Brush-Park-Detroit-Hotels-Waterpark-Hotels.0-n553248635976482504-0-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Brush Park Hotels](https://www.expedia.ca/Brush-Park-Detroit-Hotels.0-n553248635976482504-0.Travel-Guide-Filter-Hotels) - [Hotels near Charles H. 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