Title: Book the Best Medical Center Hotels with Early Check-in in 2026 from CA $109 | Expedia.ca [Vacation Rentals in Detroit](https://expedia.ca/Detroit-Vacation-Rentals.d178255.Travel-Guide-VacationRentals)[Flights to Detroit](https://expedia.ca/Cheap-Flights-To-Detroit.d178255.Travel-Guide-Flights)[Things to do in Detroit](https://expedia.ca/Things-To-Do-In-Detroit.d178255.Travel-Guide-Activities)[Medical Center Car Rentals](https://expedia.ca/Car-Rentals-In-Medical-Center.d802472874695356416.Car-Rental-Guide)[Medical Center Vacations](https://expedia.ca/Medical-Center.d802472874695356416.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels with Early Check-in in Medical Center, MI from CA $109 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Medical Center Hotels with Early Check-in Tonight [Dec 17 - Dec 18](https://www.expedia.ca/Hotel-Search?regionId=802472874695356416&startDate=2025-12-17&endDate=2025-12-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 18 - Dec 19](https://www.expedia.ca/Hotel-Search?regionId=802472874695356416&startDate=2025-12-18&endDate=2025-12-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=802472874695356416&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=802472874695356416&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Medical Center hotels with express check-in ![Reception](https://images.trvl-media.com/lodging/4000000/3380000/3374600/3374525/2846a8d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3380000/3374600/3374525/w3837h2557x3y3-db843046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/4000000/3380000/3374600/3374525/w3837h2556x3y4-e69e507f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/4000000/3380000/3374600/3374525/w3837h2556x3y4-b463f31e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Detroit / Airport - Romulus [](https://www.expedia.ca/Detroit-Hotels-Hampton-Inn-Suites-Detroit-Airport-Romulus.h3374525.Hotel-Information) Romulus 9.2/10 Wonderful (1169) "The hotel was nice, clean and the staff was excellent " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roger CA $155 CA $172 total includes taxes & fees Dec 29 - Dec 30 [](https://www.expedia.ca/Detroit-Hotels-Hampton-Inn-Suites-Detroit-Airport-Romulus.h3374525.Hotel-Information) ![Premium Suite, 1 King Bed](https://images.trvl-media.com/lodging/1000000/10000/900/897/9970518c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast for a fee](https://images.trvl-media.com/lodging/1000000/10000/900/897/20ff8d5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![42-inch plasma TV with cable channels, TV, pay movies](https://images.trvl-media.com/lodging/1000000/10000/900/897/w8266h5513x0y0-79adfb6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/900/897/c6aa222f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Atheneum Suite Hotel [](https://www.expedia.ca/Detroit-Hotels-Atheneum-Suite-Hotel.h897.Hotel-Information) Downtown Detroit 9.2/10 Wonderful (2048) "Nice clean rooms, staff was great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Benjamin CA $204 CA $237 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Detroit-Hotels-Atheneum-Suite-Hotel.h897.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/17000000/16710000/16700200/16700164/35be62bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/17000000/16710000/16700200/16700164/db4c8cda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/17000000/16710000/16700200/16700164/b78b731d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds (Additional Living Area)](https://images.trvl-media.com/lodging/17000000/16710000/16700200/16700164/eadbb55e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Southgate - Detroit Area by IHG [](https://www.expedia.ca/Detroit-Hotels-Holiday-Inn-Express-Suites-Southgate-Detroit-Area.h16700164.Hotel-Information) Southgate 8.8/10 Excellent (598) "The room was very clean! Staff were excellent! Location was great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christine CA $107 CA $120 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Detroit-Hotels-Holiday-Inn-Express-Suites-Southgate-Detroit-Area.h16700164.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19000/18964/6c93149c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/19000/18964/e1ba0afb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19000/18964/ed614cd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/19000/18964/2f5818bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wingate by Wyndham Utica [](https://www.expedia.ca/Detroit-Hotels-Comfort-Inn-Utica.h18964.Hotel-Information) Utica 8.4/10 Very good (1000) "Rooms were clean and staff was friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas CA $98 CA $109 total includes taxes & fees Dec 18 - Dec 19 [](https://www.expedia.ca/Detroit-Hotels-Comfort-Inn-Utica.h18964.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/20000/15700/15682/bc464996.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Refrigerator (Separate Living Room;with Sofabed)](https://images.trvl-media.com/lodging/1000000/20000/15700/15682/5048e6e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/15700/15682/f17194d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking, Refrigerator](https://images.trvl-media.com/lodging/1000000/20000/15700/15682/0fb24a00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Skyline Hotel Detroit Airport, SureStay Collection by BW [](https://www.expedia.ca/Detroit-Hotels-Skyline-Hotel-Detroit-Airport.h15682.Hotel-Information) Romulus 8.2/10 Very good (1000) "The Skyline Hotel was good" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wayne CA $146 CA $168 total includes taxes & fees Dec 24 - Dec 25 [](https://www.expedia.ca/Detroit-Hotels-Skyline-Hotel-Detroit-Airport.h15682.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5400/5334/72686de7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down comforters, in-room safe](https://images.trvl-media.com/lodging/1000000/10000/5400/5334/4ccdfd9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5400/5334/e0852218.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/5400/5334/0bb2ae91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Detroit Metro Airport [](https://www.expedia.ca/Detroit-Hotels-Sheraton-Detroit-Metro-Airport.h5334.Hotel-Information) Romulus 8.4/10 Very good (1008) "Very comfortable and great amenities " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leeat CA $153 CA $184 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Detroit-Hotels-Sheraton-Detroit-Metro-Airport.h5334.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/1000000/550000/543800/543746/ce917fe8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/550000/543800/543746/f3eb09c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/550000/543800/543746/3ac7dc6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/550000/543800/543746/6fec5f4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Indigo Detroit Downtown by IHG [](https://www.expedia.ca/Detroit-Hotels-Hotel-Indigo-Detroit-Downtown.h543746.Hotel-Information) Downtown Detroit 8.2/10 Very good (1079) "Room was perfect for our needs and staff was friendly! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $162 CA $188 total includes taxes & fees Dec 22 - Dec 23 [](https://www.expedia.ca/Detroit-Hotels-Hotel-Indigo-Detroit-Downtown.h543746.Hotel-Information) ![2 bars/lounges](https://images.trvl-media.com/lodging/2000000/1710000/1705900/1705854/fce3c587.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1710000/1705900/1705854/a2709361.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/2000000/1710000/1705900/1705854/935dd327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, minibar, in-room safe](https://images.trvl-media.com/lodging/2000000/1710000/1705900/1705854/b057aacb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### MGM Grand Detroit [](https://www.expedia.ca/Detroit-Hotels-MGM-Grand-Detroit.h1705854.Hotel-Information) Downtown Detroit 8.4/10 Very good (1027) "The whole place was nice and well kept. The staff was courteous and helpful and the room was nice." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brian CA $260 CA $340 total includes taxes & fees Dec 22 - Dec 23 [](https://www.expedia.ca/Detroit-Hotels-MGM-Grand-Detroit.h1705854.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/7500/7472/17650526.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/10000/7500/7472/fe444da7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/7500/7472/0f16ebeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/10000/7500/7472/d3e6f05b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Detroit Marriott at the Renaissance Center [](https://www.expedia.ca/Detroit-Hotels-Detroit-Marriott-At-The-Renaissance-Center.h7472.Hotel-Information) Downtown Detroit 7.6/10 Good (1002) "Hospitality, location, cleanliness " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anthony CA $232 CA $270 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Detroit-Hotels-Detroit-Marriott-At-The-Renaissance-Center.h7472.Hotel-Information) ![Deluxe Suite, 1 Queen Bed with Sofa bed, City View | Private kitchen](https://images.trvl-media.com/lodging/45000000/44280000/44275000/44274993/75f20619.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Individually decorated, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/45000000/44280000/44275000/44274993/56b94743.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/45000000/44280000/44275000/44274993/3a98dc30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, 1 Queen Bed with Sofa bed | Living area](https://images.trvl-media.com/lodging/45000000/44280000/44275000/44274993/e13d7ccf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kasa Cadillac Square Detroit [](https://www.expedia.ca/Detroit-Hotels-Sonder-The-Randolph.h44274993.Hotel-Information) Downtown Detroit 8.8/10 Excellent (637) "The location was perfect. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brian CA $159 CA $175 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Detroit-Hotels-Sonder-The-Randolph.h44274993.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-31&endDate=2026-01-01®ionId=802472874695356416&adults=2&property_amenities_group_explore=express_checkin&sort=RECOMMENDED&openPlayBack=true) ## Top Medical Center Hotel Reviews ![MotorCity Casino Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1764800/1764738/f5b46796_y.jpg) ### MotorCity Casino Hotel 10/10 Excellent "Nice place. Clean. Lots to do. " [](https://expedia.ca/Detroit-Hotels-MotorCity-Casino-Hotel.h1764738.Hotel-Information) ![Hollywood Casino at Greektown](https://images.trvl-media.com/lodging/3000000/2420000/2413900/2413847/fcac1d7f_y.jpg) ### Hollywood Casino at Greektown 10/10 Excellent "This hotel was Excellent, very clean room and extremely comfortable bedding. I am excited to come back and join the membership so I can play and earn free rooms. I absolutely loved the night I stayed and I am thinking about staying another night. I love in Detroit, but love giving myself staycations so this was a great choice. Great food selections in the casino and the staff are very professional and great I loved it!" 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