Mayo Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your Mayo Vacation

Experience the unique character and personality of Mayo with a customized Mayo vacation package. From its rural countryside to its spectacular views, you'll never have a dull moment in this city. If seeing the sights is on your to-do list during your trip to Mayo, check out major attractions such as Lafayette Blue Springs State Park. Don't put off exploring this destination any longer. Your perfect Mayo vacation is a couple of clicks away with Expedia.

Ready to book your vacation to Mayo?

 

Choose your dates

Mayo Hotel Deals

Suwannee River Rendezvous

Suwannee River Rendezvous

2.5 out of 5
828 NE Primrose Rd Mayo FL
The price is CA $36 per night from May 14 to May 15
CA $36
CA $58 total
May 14 - May 15
includes taxes & fees
8.6/10 Excellent! (28 reviews)
No, no,no, 11 feral cats loose on property. When there's Nothing good to say about a place or person it's more Honorable to say Nothing.

Reviewed on Apr 3, 2026

Suwannee River Rendezvous
Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Mayo FL
The price is CA $60 per night from May 10 to May 11
CA $60
CA $92 total
May 10 - May 11
includes taxes & fees
9.8/10 Exceptional! (10 reviews)
Host was great, room was clean. Quiet and peaceful.

Reviewed on May 9, 2026

Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,
Cindys Motel

Cindys Motel

2.5 out of 5
487 W Main St Mayo FL
Fully refundableReserve now, pay when you stay
The price is CA $110 per night from May 14 to May 15
CA $110
CA $119 total
May 14 - May 15
includes taxes & fees
8.8/10 Excellent! (130 reviews)
Easy parking. Friendly staff. We extended our stay and had to switch rooms. The 1st kingsize bad was great. But when we changed rooms the queen size bed sagged in the middle.

Reviewed on Mar 11, 2026

Cindys Motel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.