Title: Book the Best Mayesville LUXURY Hotels - Upscale Hotels in Mayesville, SC | Expedia.ca

[Hotels in Mayesville](https://expedia.ca/Mayesville-Hotels.d3000456025.Travel-Guide-Hotels)[Vacation Rentals in Mayesville](https://expedia.ca/Mayesville-Vacation-Rentals.d3000456025.Travel-Guide-VacationRentals)[Mayesville Car Rentals](https://expedia.ca/Car-Rentals-In-Mayesville.d3000456025.Car-Rental-Guide)[Mayesville Vacation Packages](https://expedia.ca/Mayesville.d3000456025.Destination-Travel-Guides)

![Somewhere in rural South Carolina off a back road to my hometown. Saw the sunflower field and had to stop. ](https://images.trvl-media.com/place/3000456025/6a3c56a6-b58b-4522-a79c-15e608af44bf.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Caroline Nunez

# Find luxury hotels in Mayesville, SC

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## Check availability on Mayesville Luxury Hotels

Tonight

[Dec 11 - Dec 12](https://www.expedia.ca/Hotel-Search?regionId=3000456025&startDate=2025-12-11&endDate=2025-12-12&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

Tomorrow

[Dec 12 - Dec 13](https://www.expedia.ca/Hotel-Search?regionId=3000456025&startDate=2025-12-12&endDate=2025-12-13&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

This weekend

[Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=3000456025&startDate=2025-12-12&endDate=2025-12-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

Next weekend

[Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=3000456025&startDate=2025-12-19&endDate=2025-12-21&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

## Top Mayesville Hotel Reviews

![Comfort Suites Sumter](https://images.trvl-media.com/lodging/1000000/50000/42900/42862/8963a411_y.jpg)

### Comfort Suites Sumter

10/10 Excellent

"Yes"

[](https://expedia.ca/Sumter-Hotels-Comfort-Suites-Sumter.h42862.Hotel-Information)

![SureStay Hotel by Best Western Manning](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/e6b95688_y.jpg)

### SureStay Hotel by Best Western Manning

10/10 Excellent

"Staff was very courteous "

[](https://expedia.ca/Sumter-Hotels-SureStay-Hotel-By-Best-Western-Manning.h569301.Hotel-Information)

## Frequently asked questions

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