Title: Book the Best Matlacha Isles-Matlacha Shores LUXURY Hotels - Upscale Hotels in Matlacha Isles-Matlacha Shores, FL | Expedia.ca [Matlacha Isles-Matlacha Shores Travel Guide](https://expedia.ca/Matlacha-Isles-Matlacha-Shores.dx553248635975849540)[Hotels in Matlacha Isles-Matlacha Shores](https://expedia.ca/Matlacha-Isles-Matlacha-Shores-Hotels.d553248635975849540.Travel-Guide-Hotels)[Vacation Rentals in Matlacha Isles-Matlacha Shores](https://expedia.ca/Matlacha-Isles-Matlacha-Shores-Vacation-Rentals.d553248635975849540.Travel-Guide-VacationRentals)[Matlacha Isles-Matlacha Shores Car Rentals](https://expedia.ca/Car-Rentals-In-Matlacha-Isles-Matlacha-Shores.d553248635975849540.Car-Rental-Guide)[Matlacha Isles-Matlacha Shores Vacation Packages](https://expedia.ca/Matlacha-Isles-Matlacha-Shores.d553248635975849540.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/luxury.jpeg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Matlacha Isles-Matlacha Shores, FL - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Matlacha Isles-Matlacha Shores Luxury Hotels Tonight [Dec 18 - Dec 19](https://www.expedia.ca/Hotel-Search?regionId=553248635975849540&startDate=2025-12-18&endDate=2025-12-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Dec 19 - Dec 20](https://www.expedia.ca/Hotel-Search?regionId=553248635975849540&startDate=2025-12-19&endDate=2025-12-20&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635975849540&startDate=2025-12-19&endDate=2025-12-21&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248635975849540&startDate=2025-12-26&endDate=2025-12-28&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Matlacha Isles-Matlacha Shores Hotel Reviews ![DiamondHead Beach Resort](https://images.trvl-media.com/lodging/1000000/210000/200700/200632/814c4388_y.jpg) ### DiamondHead Beach Resort 10/10 Excellent "Great view, good bar & grill, and umbrella & seats by the water… simply perfect!" [](https://expedia.ca/Fort-Myers-Hotels-DiamondHead-Beach-Resort.h200632.Hotel-Information) ![Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/16c0566c_y.jpg) ### Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park 10/10 Excellent "Exceptional hotel facility by Dayss Inn and Wyndham! By far, especially for the pricepoint, this was the best hotel experience I've shared with my family in quite some time. From the nice, very clean exterior of the building tp the walking inside to the lobby to our rooms, everything was exceptionally clean, well designed, and very, very comfortable! The area was very quiet. Far enough from the heavy traffic, but close enough to grest restaurants, eateries, and shopping centers. For us, it was only about 8 minutes from the Hertz Arena for our daughter's hockey tournament. Last, but not least, service and dtaff were exceptional from the moment we checked in to the time we left. We will definitely be back and will definitely HIGHLY recommend to our family and friends." [](https://expedia.ca/Fort-Myers-Hotels-Days-Inn-Suites-By-Wyndham-Fort-Myers-Near-JetBlue-Park.h798422.Hotel-Information) ![The Westin Cape Coral Resort At Marina Village](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/d961205e_y.jpg) ### The Westin Cape Coral Resort At Marina Village 10/10 Excellent "Muito bom especial " [](https://expedia.ca/Fort-Myers-Hotels-The-Westin-Cape-Coral-Resort-At-Marina-Village.h2721880.Hotel-Information) ![Pink Shell Beach Resort and Marina](https://images.trvl-media.com/lodging/1000000/20000/15700/15603/5f038ed2_y.jpg) ### Pink Shell Beach Resort and Marina 10/10 Excellent "It’s a beautiful place" [](https://expedia.ca/Fort-Myers-Hotels-Pink-Shell-Beach-Resort-And-Marina.h15603.Hotel-Information) ![Lani Kai Beachfront Resort](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/b5b17142_y.jpg) ### Lani Kai Beachfront Resort 10/10 Excellent "Everything was great. Highly recommend. " [](https://expedia.ca/Fort-Myers-Hotels-Lani-Kai-Beachfront-Resort.h438796.Hotel-Information) ![Hyatt Place Fort Myers/at The Forum](https://images.trvl-media.com/lodging/3000000/2850000/2847800/2847745/3f55519b_y.jpg) ### Hyatt Place Fort Myers/at The Forum 10/10 Excellent "All good. Breakfast great. " [](https://expedia.ca/Fort-Myers-Hotels-Hyatt-Place-Fort-Myersat-The-Forum.h2847745.Hotel-Information) ![Sundial Beach Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/5481c209_y.jpg) ### Sundial Beach Resort & Spa 10/10 Excellent "What you want and expect on a beach trip, loved it" [](https://expedia.ca/Sanibel-Hotels-Sundial-Beach-Resort-Spa.h1939.Hotel-Information) ![Baymont by Wyndham Fort Myers Central](https://images.trvl-media.com/lodging/1000000/30000/23400/23367/7ff8face_y.jpg) ### Baymont by Wyndham Fort Myers Central 10/10 Excellent "It was so nice...clean room, nice set up of the room, comfy bed and pillows and nice staff. Clean breakfast area and nice selection of foods to eat. " [](https://expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-By-Wyndham-Fort-Myers-Central.h23367.Hotel-Information) ![Marriott Sanibel Harbour Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/ac9a3a07_y.jpg) ### Marriott Sanibel Harbour Resort & Spa 10/10 Excellent "The staff was extremely friendly. Property is beautiful. " [](https://expedia.ca/Fort-Myers-Hotels-Marriott-Sanibel-Harbour-Resort-Spa.h3079.Hotel-Information) ## Frequently asked questions ### Are you searching for the perfect hotel for your luxury getaway to Matlacha Isles-Matlacha Shores? ### When can I expect good weather in Matlacha Isles-Matlacha Shores? ### What's there to see and do in Matlacha Isles-Matlacha Shores? ## Explore a world of travel with Expedia - Lodging - More ways to book - [Cheap Hotels in Alden Pines ](https://www.expedia.ca/Alden-Pines-Hotels-Cheap-Hotels.0-0-d553248635976474573-tCheapHotels.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Burnt Store ](https://www.expedia.ca/Burnt-Store-Cape-Coral-Hotels-Pet-Friendly-Hotel.0-n553248635976481229-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Florida ](https://www.expedia.ca/Destinations-In-Florida-Business-Hotel.0-0-d211-tBusinessHotel.Hotel-Filter-Destinations) - [Hotels & Resorts for Couples in Florida ](https://www.expedia.ca/Destinations-In-Florida-Couples-Resorts-Hotels.0-0-d211-tCouplesResortsHotels.Hotel-Filter-Destinations) - 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