Title: Hotels by La Quinta Inn & Suites in Matlacha Isles from CA $93 | Expedia.ca [Matlacha Isles Travel Guide](https://expedia.ca/Cape-Coral-Matlacha-Isles.dx553248635976471942)[Vacation Rentals in Cape Coral](https://expedia.ca/Cape-Coral-Vacation-Rentals.d6521.Travel-Guide-VacationRentals)[Flights to Cape Coral](https://expedia.ca/Cheap-Flights-To-Cape-Coral.d6521.Travel-Guide-Flights)[Things to do in Cape Coral](https://expedia.ca/Things-To-Do-In-Cape-Coral.d6521.Travel-Guide-Activities)[Matlacha Isles Car Rentals](https://expedia.ca/Car-Rentals-In-Matlacha-Isles.d553248635976471942.Car-Rental-Guide)[Matlacha Isles Vacations](https://expedia.ca/Matlacha-Isles.d553248635976471942.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by La Quinta Inn & Suites in Matlacha Isles from CA $93 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 16 - Oct 17](https://www.expedia.ca/Hotel-Search?regionId=553248635976471942&startDate=2025-10-16&endDate=2025-10-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 17 - Oct 18](https://www.expedia.ca/Hotel-Search?regionId=553248635976471942&startDate=2025-10-17&endDate=2025-10-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976471942&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976471942&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Matlacha Isles La Quinta Inn & Suites Hotels ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11200/11134/b06bf9be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/11200/11134/w3000h1997x0y3-c76bf6b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11200/11134/dd5699df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11200/11134/4ec8c9b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway Fort Myers 8.0/10 Very good (1004) "Great place to stay and breakfast was delicious " CA $117 CA $130 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Ft-Myers-Sanibel-Gateway.h11134.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1560000/1551400/1551348/9b4d626a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/2000000/1560000/1551400/1551348/851990d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1560000/1551400/1551348/1f7729f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1560000/1551400/1551348/24b97ddc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn and Suites Fort Myers I-75 Daniels Corridor 6.6/10 (1012) "Pleasant and helpful staff, quiet hotel" CA $83 CA $93 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Fort-Myers-Airport.h1551348.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-30&endDate=2025-10-31®ionId=553248635976471942&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMatlacha-Isles-Cape-Coral-Hotels-La-Quinta-Inn-Suites.0-n553248635976471942-0--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMatlacha-Isles-Cape-Coral-Hotels-La-Quinta-Inn-Suites.0-n553248635976471942-0--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) ## Top Matlacha Isles Hotel Reviews ![Holiday Inn Express Cape Coral-Fort Myers Area by IHG](//images.trvl-media.com/lodging/1000000/30000/26900/26860/ab39b98c_y.jpg) ### Holiday Inn Express Cape Coral-Fort Myers Area by IHG 10/10 Excellent "Ricardo was very helpful and accommodating. Thank you for a great experience!" [](https://expedia.ca/Fort-Myers-Hotels-Holiday-Inn-Express-Cape-Coral-Fort-Myers-Area.h26860.Hotel-Information) ![Lani Kai Beachfront Resort](//images.trvl-media.com/lodging/1000000/440000/438800/438796/b5b17142_y.jpg) ### Lani Kai Beachfront Resort 10/10 Excellent "Liked that all rooms are gulf view and have balconys." [](https://expedia.ca/Fort-Myers-Hotels-Lani-Kai-Beachfront-Resort.h438796.Hotel-Information) ![Doubletree by Hilton Fort Myers at Bell Tower Shops](//images.trvl-media.com/lodging/1000000/20000/12400/12375/704cf90c_y.jpg) ### Doubletree by Hilton Fort Myers at Bell Tower Shops 10/10 Excellent "Perfect " [](https://expedia.ca/Fort-Myers-Hotels-Doubletree-By-Hilton-Fort-Myers-At-Bell-Tower-Shops.h12375.Hotel-Information) ![Sanibel Island Beach Resort](//images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/w2247h1500x326y0-2ea06bb5_y.jpg) ### Sanibel Island Beach Resort 10/10 Excellent "Steps from the beach for long walks Onsite coffee house and Burger place were awesome. Tiki bar staff friendly and nice pool area. Beds were comfy and the air conditioning worked like a charm! Only warning when you check in get the spray…those little sand bugs or whatever they are called come out and that oil was a save our legs MUST!!!" [](https://expedia.ca/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) ![Marriott Sanibel Harbour Resort & Spa](//images.trvl-media.com/lodging/1000000/10000/3100/3079/ac9a3a07_y.jpg) ### Marriott Sanibel Harbour Resort & Spa 10/10 Excellent "It is a beautiful resort! It had everything, dining , pool, very relaxing. The staff and rooms were incredible." [](https://expedia.ca/Fort-Myers-Hotels-Marriott-Sanibel-Harbour-Resort-Spa.h3079.Hotel-Information) ![Pink Shell Beach Resort and Marina](//images.trvl-media.com/lodging/1000000/20000/15700/15603/5f038ed2_y.jpg) ### Pink Shell Beach Resort and Marina 10/10 Excellent "View was excellent from balcony. Room was very clean. Staff went out of their way to accommodate us." [](https://expedia.ca/Fort-Myers-Hotels-Pink-Shell-Beach-Resort-And-Marina.h15603.Hotel-Information) ![Hilton Garden Inn Ft Myers](//images.trvl-media.com/lodging/1000000/850000/848800/848740/d8bd559a_y.jpg) ### Hilton Garden Inn Ft Myers 10/10 Excellent "I really liked that it wascebtrally located as i used public transportation and felt i could get downtown and the beach easily. Staff were super nice!" [](https://expedia.ca/Fort-Myers-Hotels-Hilton-Garden-Inn-Ft-Myers.h848740.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway](//images.trvl-media.com/lodging/1000000/20000/11200/11134/b06bf9be_y.jpg) ### La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway 10/10 Excellent "We were greeted by Roopa who was very nice! We explained how the hotel was hard to find by gps. She explained that if you add service Rd to the address it will guide you correctly. Parking was easy. There was a circle K next door & a publix down the road along with a Gator Bites Pub which we decided on for dinner after our late arrival. Our room was clean & spacious. A comfy, clean bed. I would have liked more down pillows. There were like 5 pillows so plenty to choose from. I prefer down so you can fluff it as neccessary. There was a love seat and side table which was adequate for a drink, snack etc. There really wasn't enough dresser space for our week long stay but it was sufficient for a couple of nights. The room was cleaned daily. The free breakfast was good. I made self waffles. Tea & coffee were available 24/7. The pool is hugh! It's great for laps. The hotel is located on a quieter street so that was nice. It was also located nearby to main streets for easy access. We went to Bunche Beach preserve nearby which was great for a walk & I found some nice 🐚 shells. We were able to feed gators while mini golfing at Smugglers Cove. We had breakfast twice at Sunflower Cafe after waking up too late for the free breakfast. It was delicious, the staff was friendly & the service was fast. We would definately stay at this LaQuinta again!" [](https://expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Ft-Myers-Sanibel-Gateway.h11134.Hotel-Information) ![Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway](//images.trvl-media.com/lodging/1000000/560000/551900/551886/8158a459_y.jpg) ### Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway 10/10 Excellent "Clean room " [](https://expedia.ca/Fort-Myers-Beach-Hotels-Hampton-Inn-Suites-Fort-Myers-BeachSanibel-Gateway.h551886.Hotel-Information) ## Find out more about Matlacha Isles ## Matlacha Isles Hotels Guide Expedia.ca offers a selection of 13931 hotels in Matlacha Isles. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Matlacha Isles. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Matlacha Isles neighborhood you prefer. Go ahead. 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[Independent Hotels in Sanibel Captiva Island](https://www.expedia.ca/Sanibel-Captiva-Island-Hotels-Independent.0-0-d6326115--bIndependent.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Sanibel Captiva Island](https://www.expedia.ca/Sanibel-Captiva-Island-Hotels-La-Quinta-Inn-Suites.0-0-d6326115--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Noble House Hotels in Sanibel Captiva Island](https://www.expedia.ca/Sanibel-Captiva-Island-Hotels-Noble-House.0-0-d6326115--bNobleHouse.Travel-Guide-Filter-Hotels) - [Best Western Hotels in South Fort Myers](https://www.expedia.ca/South-Fort-Myers-Fort-Myers-Hotels-Best-Western.0-n894118002916675584-0--bBestWestern.Travel-Guide-Filter-Hotels) - [Equity Lifestyle Hotels in Southwest Coast Florida](https://www.expedia.ca/Southwest-Coast-Florida-Hotels-Equity-Lifestyle.0-0-d6048100--bEquityLifestyle.Travel-Guide-Filter-Hotels) - [Noble House Hotels in Southwest Coast Florida](https://www.expedia.ca/Southwest-Coast-Florida-Hotels-Noble-House.0-0-d6048100--bNobleHouse.Travel-Guide-Filter-Hotels) - 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[Pine Island Vacations](https://www.expedia.ca/Pine-Island.d553248635083900600.Destination-Travel-Guides) - [Visit Pine Island](https://www.expedia.ca/Pine-Island.dx553248635083900600) - [Sun Splash Water Park](https://www.expedia.ca/Sun-Splash-Water-Park-Hancock.d6127772.Vacation-Attraction) - [Car rental Matlacha](https://www.expedia.ca/Car-Rentals-In-Matlacha.d601098.Car-Rental-Guide) - [Car rentals near Pine Island](https://www.expedia.ca/Car-Rentals-In-Pine-Island.d553248635083900600.Car-Rental-Guide) - [Zezgo Rental Cars in Pine Island](https://www.expedia.ca/ZezGo-Car-Rentals-In-Pine-Island.d553248635083900600-c1122.Car-Rental-Guide-Suppliers) - [Things to do in Matlacha](https://www.expedia.ca/Things-To-Do-In-Matlacha.d601098.Travel-Guide-Activities) - [Things to do in Pine Island](https://www.expedia.ca/Things-To-Do-In-Pine-Island.d553248635083900600.Travel-Guide-Activities) - [Book Hotels in Matlacha Isles on Expedia.com](https://www.expedia.com/Matlacha-Isles-Fort-Myers-Hotels-La-Quinta-Inn-Suites.0-n553248635976471942-0--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels)