Title: Hotels by Best Western in Matlacha Isles from CA $115 | Expedia.ca [Matlacha Isles Travel Guide](https://expedia.ca/Cape-Coral-Matlacha-Isles.dx553248635976471942)[Vacation Rentals in Cape Coral](https://expedia.ca/Cape-Coral-Vacation-Rentals.d6521.Travel-Guide-VacationRentals)[Flights to Cape Coral](https://expedia.ca/Cheap-Flights-To-Cape-Coral.d6521.Travel-Guide-Flights)[Things to do in Cape Coral](https://expedia.ca/Things-To-Do-In-Cape-Coral.d6521.Travel-Guide-Activities)[Matlacha Isles Car Rentals](https://expedia.ca/Car-Rentals-In-Matlacha-Isles.d553248635976471942.Car-Rental-Guide)[Matlacha Isles Vacations](https://expedia.ca/Matlacha-Isles.d553248635976471942.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Best Western in Matlacha Isles from CA $115 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=553248635976471942&startDate=2025-10-13&endDate=2025-10-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=553248635976471942&startDate=2025-10-14&endDate=2025-10-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976471942&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976471942&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Matlacha Isles Best Western Hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/cebf36b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking, Microwave](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/55b8bfc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/d9380a64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/5f870412.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Fort Myers Inn & Suites Fort Myers 8.6/10 Excellent (1041) "Nice place and awesome breakfast" CA $103 CA $115 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Fort-Myers-Hotels-Best-Western-Fort-Myers-Inn-Suites.h17131.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/50500/50468/ce27f724.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/60000/50500/50468/a4ca1a35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/60000/50500/50468/ffc7e96f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/60000/50500/50468/aeb2a2ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Fort Myers Waterfront Hancock 7.2/10 Good (1007) "Nice breakfast and great river views. Had nice pool too. " CA $142 CA $158 total includes taxes & fees Oct 14 - Oct 15 [](https://www.expedia.ca/Fort-Myers-Hotels-Best-Western-Fort-Myers-Waterfront.h50468.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-27&endDate=2025-10-28®ionId=553248635976471942&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMatlacha-Isles-Cape-Coral-Hotels-Best-Western.0-n553248635976471942-0--bBestWestern.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMatlacha-Isles-Cape-Coral-Hotels-Best-Western.0-n553248635976471942-0--bBestWestern.Travel-Guide-Filter-Hotels) ## Top Matlacha Isles Hotel Reviews ![Hilton Garden Inn Ft Myers](//images.trvl-media.com/lodging/1000000/850000/848800/848740/d8bd559a_y.jpg) ### Hilton Garden Inn Ft Myers 10/10 Excellent "I really liked that it wascebtrally located as i used public transportation and felt i could get downtown and the beach easily. Staff were super nice!" [](https://expedia.ca/Fort-Myers-Hotels-Hilton-Garden-Inn-Ft-Myers.h848740.Hotel-Information) ![Margaritaville Beach Resort Fort Myers ](//images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/w3998h2821x0y0-a77e6574_y.jpg) ### Margaritaville Beach Resort Fort Myers 10/10 Excellent "Excellent stay great customer service in every encounter. Lots to do on site! Will definitely return!" [](https://expedia.ca/Fort-Myers-Beach-Hotels-Margaritaville-Beach-Resort-Fort-Myers.h95126992.Hotel-Information) ![DiamondHead Beach Resort](//images.trvl-media.com/lodging/1000000/210000/200700/200632/814c4388_y.jpg) ### DiamondHead Beach Resort 10/10 Excellent " Nice, large room. This hotel on the beach has everything: on the beach, great views, nice pool/hot tubs, food/bar, and some entertainment. Needs a sit down breakfast option." [](https://expedia.ca/Fort-Myers-Hotels-DiamondHead-Beach-Resort.h200632.Hotel-Information) ![Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park](//images.trvl-media.com/lodging/1000000/800000/798500/798422/16c0566c_y.jpg) ### Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park 10/10 Excellent "It was a nice clean room at a great price!" [](https://expedia.ca/Fort-Myers-Hotels-Days-Inn-Suites-By-Wyndham-Fort-Myers-Near-JetBlue-Park.h798422.Hotel-Information) ![The Westin Cape Coral Resort At Marina Village](//images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/d961205e_y.jpg) ### The Westin Cape Coral Resort At Marina Village 10/10 Excellent "Great space and great location. Staff extremely helpful." [](https://expedia.ca/Fort-Myers-Hotels-The-Westin-Cape-Coral-Resort-At-Marina-Village.h2721880.Hotel-Information) ![Lani Kai Beachfront Resort](//images.trvl-media.com/lodging/1000000/440000/438800/438796/b5b17142_y.jpg) ### Lani Kai Beachfront Resort 10/10 Excellent "Property Is all new however still some construction" [](https://expedia.ca/Fort-Myers-Hotels-Lani-Kai-Beachfront-Resort.h438796.Hotel-Information) ![Hyatt Place Fort Myers/at The Forum](//images.trvl-media.com/lodging/3000000/2850000/2847800/2847745/3f55519b_y.jpg) ### Hyatt Place Fort Myers/at The Forum 10/10 Excellent "Friendly helpful and professional staff" [](https://expedia.ca/Fort-Myers-Hotels-Hyatt-Place-Fort-Myersat-The-Forum.h2847745.Hotel-Information) ![Pink Shell Beach Resort and Marina](//images.trvl-media.com/lodging/1000000/20000/15700/15603/5f038ed2_y.jpg) ### Pink Shell Beach Resort and Marina 10/10 Excellent "Very satisfied with the hotel, amenities and our stay. We will be back! " [](https://expedia.ca/Fort-Myers-Hotels-Pink-Shell-Beach-Resort-And-Marina.h15603.Hotel-Information) ![Extended Stay America Premier Suites - Fort Myers - Airport](//images.trvl-media.com/lodging/97000000/96930000/96929600/96929542/a2675737_y.jpg) ### Extended Stay America Premier Suites - Fort Myers - Airport 10/10 Excellent "Clean room " [](https://expedia.ca/Fort-Myers-Hotels-Extended-Stay-America-Premier-Suites-Fort-Myers-Airport.h96929542.Hotel-Information) ## Find out more about Matlacha Isles ## Matlacha Isles Hotels Guide Expedia.ca offers a selection of 13901 hotels in Matlacha Isles. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Matlacha Isles. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Matlacha Isles neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Matlacha Isles, Cape Coral now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - More ways to book - [2 Star Hotels in Burnt Store](https://www.expedia.ca/2Star-Burnt-Store-Cape-Coral-Hotels.s20-n553248635976481229-0.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Burnt Store](https://www.expedia.ca/Burnt-Store-Cape-Coral-Hotels-Pet-Friendly-Hotel.0-n553248635976481229-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Burnt Store Hotels](https://www.expedia.ca/Burnt-Store-Cape-Coral-Hotels.0-n553248635976481229-0.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Cape Coral](https://www.expedia.ca/Cape-Coral-Hotels-Best-Western.0-0-d6521--bBestWestern.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Cape Coral](https://www.expedia.ca/Cape-Coral-Hotels-Hilton-Hotels.0-0-d6521--bHiltonHotels.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Cape Coral](https://www.expedia.ca/Cape-Coral-Hotels-La-Quinta-Inn-Suites.0-0-d6521--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - 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