Title: Book the Best BUSINESS Hotels in Lyon Street in 2025 | Expedia.ca [Lyon Street Travel Guide](https://expedia.ca/Columbia-Lyon-Street.dx896347438500220928)[Vacation Rentals in Columbia](https://expedia.ca/Columbia-Vacation-Rentals.d764.Travel-Guide-VacationRentals)[Flights to Columbia](https://expedia.ca/Cheap-Flights-To-Columbia.d764.Travel-Guide-Flights)[Things to do in Columbia](https://expedia.ca/Things-To-Do-In-Columbia.d764.Travel-Guide-Activities)[Lyon Street Car Rentals](https://expedia.ca/Car-Rentals-In-Lyon-Street.d896347438500220928.Car-Rental-Guide)[Lyon Street Vacations](https://expedia.ca/Lyon-Street.d896347438500220928.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/business.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Lyon Street, SC from CA $112 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Lyon Street Business Hotels Tonight [Oct 29 - Oct 30](https://www.expedia.ca/Hotel-Search?regionId=896347438500220928&startDate=2025-10-29&endDate=2025-10-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Oct 30 - Oct 31](https://www.expedia.ca/Hotel-Search?regionId=896347438500220928&startDate=2025-10-30&endDate=2025-10-31&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=896347438500220928&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=896347438500220928&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Top Lyon Street Business Hotels ![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/77000000/76600000/76599300/76599223/e2b9c83a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/77000000/76600000/76599300/76599223/394acd2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, Egyptian cotton sheets, premium bedding, pillowtop beds](https://images.trvl-media.com/lodging/77000000/76600000/76599300/76599223/7e60c677.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/77000000/76600000/76599300/76599223/a292ceed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cambria Hotel Columbia Downtown The Vista Downtown Columbia 9.4/10 Exceptional (1122) "Room was very clean and comfortable; nice and friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marcus CA $153 CA $171 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/Columbia-Hotels-Cambria-Hotel-Columbia-Downtown-The-Vista.h76599223.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/32000000/31360000/31356900/31356801/72a817b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/32000000/31360000/31356900/31356801/97130b24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/32000000/31360000/31356900/31356801/6b778e7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/32000000/31360000/31356900/31356801/86cca9d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Columbia Killian Road Columbia 9.2/10 Wonderful (1007) "I absolutely enjoyed my stay! There was fresh coffee available all day long, the room was spacious and very clean, the bed was comfortable, and the hotel had a really nice, welcoming, calm ambiance. I highly recommend staying here!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) richelle CA $139 CA $156 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Columbia-Hotels-Hampton-Inn-Suites-Columbia-Killian-Road.h31356801.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/f8933df9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/7b635fb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/0a695ca8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/45d8f751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Columbia/Harbison Columbia 9.0/10 Wonderful (1781) "Amazing stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ozie CA $125 CA $140 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Columbia-Hotels-Hilton-Garden-Inn-ColumbiaHarbison.h1513707.Hotel-Information) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/18000000/17370000/17370000/17369973/9eb183a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/18000000/17370000/17370000/17369973/e288e3a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/18000000/17370000/17370000/17369973/7f5dfdba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/18000000/17370000/17370000/17369973/191bc09f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Columbia Cayce Cayce 9.0/10 Wonderful (646) "Quite place with small restraunt and bar" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jordan CA $153 CA $170 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/Columbia-Hotels-Courtyard-By-Marriott-Columbia-Cayce.h17369973.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/330000/327100/327027/68fe8568.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/330000/327100/327027/319d53d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/330000/327100/327027/67e72d6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/330000/327100/327027/355b44a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Columbia/Harbison Irmo 7.8/10 Good (1008) "Clean spacious room, friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Zee CA $100 CA $112 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Columbia-Hotels-Hyatt-Place-ColumbiaHarbison.h327027.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/38e4995a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/5c21e195.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/aeeef90b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/40000000/39640000/39637100/39637010/30a1e4b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Columbia Greystone Columbia 9.2/10 Wonderful (1007) "Great Stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sucorya CA $145 CA $166 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/Columbia-Hotels-Tru-By-Hilton-Columbia-Greystone.h39637010.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/78000000/77820000/77814700/77814689/e6cbdb45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/78000000/77820000/77814700/77814689/273b3a44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/78000000/77820000/77814700/77814689/134485b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking, Garden View](https://images.trvl-media.com/lodging/78000000/77820000/77814700/77814689/80fc7486.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Garden Columbia/Ft. Jackson Columbia 7.8/10 Good (1292) "would stay here again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard CA $113 CA $127 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Columbia-Hotels-Hotel-Columbia-Inn-Suites.h77814689.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/6000000/5090000/5087800/5087799/e562fa52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5090000/5087800/5087799/66f4a5f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/6000000/5090000/5087800/5087799/f4da5da6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/6000000/5090000/5087800/5087799/9caae4c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Columbia/Southeast-Ft. Jackson Columbia 8.0/10 Very good (1002) "Very nice family stop overnight " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Frank CA $136 CA $152 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Columbia-Hotels-Hampton-Inn-Suites-ColumbiaSoutheast-Ft-Jackson.h5087799.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/ba61cb6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/647c5c2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/24bdaf71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/5e830f88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Columbia Downtown Hotel Downtown Columbia 8.4/10 Very good (1002) "Wonderful stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura CA $173 CA $194 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Columbia-Hotels-Sheraton-Columbia-Downtown-Hotel.h1805074.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/eaf0f22f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/5d845c04.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/0ecadb7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Graduate by Hilton Columbia SC Downtown Columbia 9.4/10 Exceptional (1000) "Great place to stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kerrie CA $179 CA $204 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-12&endDate=2025-11-13®ionId=896347438500220928&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Lyon Street Hotel Reviews ![Hampton Inn Columbia-I-26 Airport](//images.trvl-media.com/lodging/1000000/10000/7600/7503/e8ace719_y.jpg) ### Hampton Inn Columbia-I-26 Airport 10/10 Excellent "Great hotel!" [](https://expedia.ca/Columbia-Hotels-Hampton-Inn-Columbia-I-26-Airport.h7503.Hotel-Information) ![Comfort Suites Columbia at Harbison](//images.trvl-media.com/lodging/1000000/870000/861100/861091/1443fa25_y.jpg) ### Comfort Suites Columbia at Harbison 10/10 Excellent "Very nice hotel" [](https://expedia.ca/Columbia-Hotels-Comfort-Suites-Columbia-At-Harbison.h861091.Hotel-Information) ![ La Quinta Inn by Wyndham Columbia NE/Fort Jackson](//images.trvl-media.com/lodging/1000000/50000/43600/43541/ebebcc50_y.jpg) ### La Quinta Inn by Wyndham Columbia NE/Fort Jackson 10/10 Excellent "Very healthy breakfast!!" [](https://expedia.ca/Columbia-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Columbia-NE-Fort-Jackson.h43541.Hotel-Information) ![Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG](//images.trvl-media.com/lodging/1000000/690000/688700/688607/805d082b_y.jpg) ### Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG 10/10 Excellent "The room was clean and the front desk staff was very friendly. " [](https://expedia.ca/Columbia-Hotels-Holiday-Inn-Express-Suites-Columbia-I-26-Harbison-Blvd.h688607.Hotel-Information) ![Country Inn & Suites by Radisson, Columbia, SC](//images.trvl-media.com/lodging/1000000/210000/202900/202867/04e820c9_y.jpg) ### Country Inn & Suites by Radisson, Columbia, SC 10/10 Excellent "It is an older hotel but for the price it was great and it was very convenient to what we needed to do. Thank you very much." [](https://expedia.ca/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h202867.Hotel-Information) ![Hyatt Place Columbia/Harbison](//images.trvl-media.com/lodging/1000000/330000/327100/327027/68fe8568_y.jpg) ### Hyatt Place Columbia/Harbison 10/10 Excellent "While I didn’t really use any of the amenities. I do like that I could walk to get something to eat if I wanted to or places were close by. The staff was friendly and the room I had was very spacious. " [](https://expedia.ca/Columbia-Hotels-Hyatt-Place-ColumbiaHarbison.h327027.Hotel-Information) ![Hilton Garden Inn Columbia/Harbison](//images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/f8933df9_y.jpg) ### Hilton Garden Inn Columbia/Harbison 10/10 Excellent "Pool had ants crawling near lift chair" [](https://expedia.ca/Columbia-Hotels-Hilton-Garden-Inn-ColumbiaHarbison.h1513707.Hotel-Information) ![Sleep Inn Columbia](//images.trvl-media.com/lodging/1000000/130000/127000/126908/de238acf_y.jpg) ### Sleep Inn Columbia 10/10 Excellent "Rooms & service was real good. Just wish had bacon, sausage, & eggs included in the breakfast." [](https://expedia.ca/Columbia-Hotels-Sleep-Inn-At-Bush-River-Road.h126908.Hotel-Information) ![Courtyard by Marriott Columbia Downtown at USC](//images.trvl-media.com/lodging/1000000/10000/2300/2289/w3996h2667x0y0-8dd1e3e0_y.jpg) ### Courtyard by Marriott Columbia Downtown at USC 10/10 Excellent "Hotel was very clean overall. Never made it to breakfast. The staff was extremely friendly. Great location, Highly recommend" [](https://expedia.ca/Columbia-Hotels-Courtyard-By-Marriott-Columbia-Downtown-At-USC.h2289.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [5 Star Hotels in Columbia](https://www.expedia.ca/5Star-Columbia-Hotels.s50-0-d764.Travel-Guide-Filter-Hotels) - [Hotels near Allen University](https://www.expedia.ca/Allen-University-Hotels.0-l6245638-0.Travel-Guide-Filter-Hotels) - [Hotels near Benedict College](https://www.expedia.ca/Benedict-College-Hotels.0-l553248635056398076-0.Travel-Guide-Filter-Hotels) - [Apartments in Columbia](https://www.expedia.ca/Columbia-Apartments.d764-aaApartments.Travel-Guide-Accommodation) - [B&B in Columbia](https://www.expedia.ca/Columbia-Bed-And-Breakfast.d764-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Castles in Columbia](https://www.expedia.ca/Columbia-Castles.d764-aaCastles.Travel-Guide-Accommodation) - [Condo Rentals in Columbia](https://www.expedia.ca/Columbia-Condos.d764-aaCondos.Travel-Guide-Accommodation) - 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