Title: Book The Best Hotels in Lyon, MS for 2025 from CA $115 - Fully Refundable Options - Expedia.ca [Vacation Rentals in Lyon](https://expedia.ca/Lyon-Vacation-Rentals.d553248634998705303.Travel-Guide-VacationRentals)[Lyon Car Rentals](https://expedia.ca/Car-Rentals-In-Lyon.d553248634998705303.Car-Rental-Guide)[Lyon Vacation Packages](https://expedia.ca/Lyon.d553248634998705303.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Lyon, MS from CA $115 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Sep 27 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=553248634998705303&startDate=2025-09-27&endDate=2025-09-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 28 - Sep 29](https://www.expedia.ca/Hotel-Search?regionId=553248634998705303&startDate=2025-09-28&endDate=2025-09-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248634998705303&startDate=2025-10-03&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248634998705303&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Compare 34 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable. ![Front of property](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/cc59a6f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/7467caab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/2680ddf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/f4c15177.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelers Hotel Clarksdale 9.8/10 Exceptional (270) "Though a bit different, there was a great artsy feel to the hotel. " CA $231 CA $252 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Clarksdale-Hotels-Travelers-Hotel.h34868083.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/c0e992b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/3c683cc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Smoking | Room amenity](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/09f42bac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Smoking](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/2606ec8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Americas Best Value Inn & Suites Clarksdale Clarksdale 5.8/10 (385) "Close to the blues music." CA $106 CA $115 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Clarksdale-Hotels-Americas-Best-Value-Inn-Suites-Clarksdale.h151226.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/e34ceb08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/20bde9f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/84d69b0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/55faa465.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Clarksdale Clarksdale 8.2/10 Very good (317) "We would stay there again." CA $167 CA $182 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Clarksdale-Hotels-Hampton-Inn-Clarksdale.h8273622.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/766fdf07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/e482f310.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/94b5934f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/e98cafb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Clarksdale 7.2/10 Good (692) "Quiet and comfortable " CA $123 CA $134 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Clarksdale-Hotels-Quality-Inn.h151227.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/82cb9926.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, towels, shampoo](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/92a31471.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City Single Room](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/fe1d9487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/94efd5b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Auberge Clarksdale Blues Hostel Clarksdale 9.6/10 Exceptional (85) "Very nice rooms and clean nice upgraded shared bathrooms" CA $163 CA $174 total includes taxes & fees Sep 29 - Sep 30 [](https://www.expedia.ca/Clarksdale-Hotels-Auberge-Clarksdale-Blues-Hostel.h38924451.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-11&endDate=2025-10-12®ionId=553248634998705303&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLyon-Hotels.d553248634998705303.Travel-Guide-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLyon-Hotels.d553248634998705303.Travel-Guide-Hotels) ## More cheap stays in Lyon ![Quality Inn](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/766fdf07_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Quality Inn 818 South State Street, Clarksdale, MS CA $123 CA $134 total Oct 5 - Oct 6 includes taxes & fees 7.2/10 Good! (692 reviews) [](https://expedia.ca/Clarksdale-Hotels-Quality-Inn.h151227.Hotel-Information) ![Hampton Inn Clarksdale](https://images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/e34ceb08_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn Clarksdale 15000 New Africa Rd, Clarksdale, MS CA $167 CA $182 total Oct 5 - Oct 6 includes taxes & fees 8/10 Very Good! (314 reviews) [](https://expedia.ca/Clarksdale-Hotels-Hampton-Inn-Clarksdale.h8273622.Hotel-Information) ![Americas Best Value Inn & Suites Clarksdale](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/c0e992b8_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Americas Best Value Inn & Suites Clarksdale 350 South State Street, Clarksdale, MS CA $106 CA $115 total Sep 28 - Sep 29 includes taxes & fees 5.8/10 (383 reviews) [](https://expedia.ca/Clarksdale-Hotels-Americas-Best-Value-Inn-Suites-Clarksdale.h151226.Hotel-Information) ![Travelers Hotel](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/cc59a6f5_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Travelers Hotel 212 3rd St, Clarksdale, MS CA $231 CA $252 total Sep 28 - Sep 29 includes taxes & fees 9.6/10 Exceptional! (270 reviews) [](https://expedia.ca/Clarksdale-Hotels-Travelers-Hotel.h34868083.Hotel-Information) ![Auberge Clarksdale Blues Hostel](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/82cb9926_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Auberge Clarksdale Blues Hostel 164 Delta Ave, Clarksdale, MS CA $163 CA $174 total Sep 29 - Sep 30 includes taxes & fees 9.6/10 Exceptional! (85 reviews) [](https://expedia.ca/Clarksdale-Hotels-Auberge-Clarksdale-Blues-Hostel.h38924451.Hotel-Information) ![High Cotton Condos](https://images.trvl-media.com/lodging/8000000/7380000/7374500/7374432/7583d1b4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### High Cotton Condos 249 Delta Ave, Clarksdale, MS [Get rates](https://expedia.ca/Hotel-Search?startDate=11%2F10%2F2025&endDate=12%2F10%2F2025&selected=7374432&PinnedHotelID=7374432&HadPinnedHotel=true®ionId=553248634998705303) [](https://expedia.ca/Clarksdale-Hotels-High-Cotton-Condos.h7374432.Hotel-Information) ## Hotels in Lyon with star-rating ![3 Star Hotels](https://images.trvl-media.com/lodging/105000000/104560000/104550500/104550412/79b184e2_w.jpg) 3 Star Hotels 3 properties [](https://expedia.ca/3Star-Lyon-Hotels.s30-0-d553248634998705303.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/766fdf07_w.jpg) 2 Star Hotels 6 properties [](https://expedia.ca/2Star-Lyon-Hotels.s20-0-d553248634998705303.Travel-Guide-Filter-Hotels) ## Recent reviews of Lyon hotels ![Hampton Inn Clarksdale](//images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/e34ceb08_y.jpg) ### Hampton Inn Clarksdale 5/5 Excellent "Clean and comfortable. Very helpful staff. Will certainly stay again." A verified traveller stayed at Hampton Inn Clarksdale Posted 12 days ago [](https://expedia.ca/Clarksdale-Hotels-Hampton-Inn-Clarksdale.h8273622.Hotel-Information) ![Travelers Hotel](//images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/cc59a6f5_y.jpg) ### Travelers Hotel 5/5 Excellent "Wonderful room & fantastic property. Highly recommend !" A verified traveller stayed at Travelers Hotel Posted 2 weeks ago [](https://expedia.ca/Clarksdale-Hotels-Travelers-Hotel.h34868083.Hotel-Information) ![Only a mile from historic downtown Clarksdale!](//images.trvl-media.com/lodging/77000000/76040000/76031100/76031053/ecc9aaad_y.jpg) ### Only a mile from historic downtown Clarksdale! 5/5 Excellent "Amazing pool, perfect home, and location!" A verified traveller stayed at Only a mile from historic downtown Clarksdale! Posted 3 weeks ago [](https://expedia.ca/Clarksdale-Hotels-Only-A-Mile-From-Historic-Downtown-Clarksdale.h76031053.Hotel-Information) ![Quality Inn](//images.trvl-media.com/lodging/1000000/160000/151300/151227/766fdf07_y.jpg) ### Quality Inn 5/5 Excellent "Quiet and comfortable " A verified traveller stayed at Quality Inn Posted 3 weeks ago [](https://expedia.ca/Clarksdale-Hotels-Quality-Inn.h151227.Hotel-Information) ![Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale](//images.trvl-media.com/lodging/114000000/113250000/113243700/113243634/467c648a_y.jpg) ### Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale 5/5 Excellent "Was the perfect stay. Very nice accommodations. " A verified traveller stayed at Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale Posted 2 months ago [](https://expedia.ca/Clarksdale-Hotels-Charming-2-Bedroom-House-In-Lovely-Clarksdale-With-WiFi.h113243634.Hotel-Information) ![Sunset Log Cabin](//images.trvl-media.com/lodging/97000000/96760000/96758600/96758575/07f49a54_y.jpg) ### Sunset Log Cabin 5/5 Excellent goin up to the country to relax "Small cabin but perfect for us. the porch makes it a much larger space than it seems at first. The host was very attentive." A verified traveller stayed at Sunset Log Cabin Posted 2 months ago [](https://expedia.ca/Clarksdale-Hotels-Sunset-Log-Cabin.h96758575.Hotel-Information) ![Americas Best Value Inn & Suites Clarksdale](//images.trvl-media.com/lodging/1000000/160000/151300/151226/c0e992b8_y.jpg) ### Americas Best Value Inn & Suites Clarksdale 5/5 Excellent "Experience was wonderful " A verified traveller stayed at Americas Best Value Inn & Suites Clarksdale Posted 2 months ago [](https://expedia.ca/Clarksdale-Hotels-Americas-Best-Value-Inn-Suites-Clarksdale.h151226.Hotel-Information) ![Auberge Clarksdale Blues Hostel](//images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/82cb9926_y.jpg) ### Auberge Clarksdale Blues Hostel 5/5 Excellent "I stay here every time I visit Clarkesdale. The bedscare clean and comfortable, rooms spacious and ckean, even a fan to use! I have never stayed in a hostel where the bathrooms are this ckean. They supply shampoo, deodorant, all you need." A verified traveller stayed at Auberge Clarksdale Blues Hostel Posted 2 months ago [](https://expedia.ca/Clarksdale-Hotels-Auberge-Clarksdale-Blues-Hostel.h38924451.Hotel-Information) ![Get to BLUES-in' at Rusty's Roost, adjacent to downtown Clarksdale, MS](//images.trvl-media.com/lodging/102000000/101150000/101144900/101144826/12bbff96_y.jpg) ### Get to BLUES-in' at Rusty's Roost, adjacent to downtown Clarksdale, MS 5/5 Excellent Beautiful Home "Jess the manager was great. Very quick to respond and help. The house was very clean and smelled amazing. We will be back!" A verified traveller stayed at Get to BLUES-in' at Rusty's Roost, adjacent to downtown Clarksdale, MS Posted 3 months ago [](https://expedia.ca/Clarksdale-Hotels-Get-To-BLUES-In-At-Rustys-Roost.h101144826.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Alligator Hotels](https://www.expedia.ca/Alligator-Hotels.d553248635975866196.Travel-Guide-Hotels) - [Villas in Alligator](https://www.expedia.ca/Alligator-Villas.d553248635975866196-aaVillas.Travel-Guide-Accommodation) - [Arkabutla Hotels](https://www.expedia.ca/Arkabutla-Hotels.d553248635974904595.Travel-Guide-Hotels) - [Batesville Hotels](https://www.expedia.ca/Batesville-Hotels.d6711.Travel-Guide-Hotels) - [Hotels near Bologna Performing Arts Center](https://www.expedia.ca/Bologna-Performing-Arts-Center-Hotels.0-l553248621532644997-0.Travel-Guide-Filter-Hotels) - [Cascilla Hotels](https://www.expedia.ca/Cascilla-Hotels.d553248635974902903.Travel-Guide-Hotels) - 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