Title: Book The Best Hotels in Lyon, MS for 2026 from CA $109 - Fully Refundable Options - Expedia.ca [Vacation Rentals in Lyon](https://expedia.ca/Lyon-Vacation-Rentals.d553248634998705303.Travel-Guide-VacationRentals)[Lyon Car Rentals](https://expedia.ca/Car-Rentals-In-Lyon.d553248634998705303.Car-Rental-Guide)[Lyon Vacation Packages](https://expedia.ca/Lyon.d553248634998705303.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Lyon, MS from CA $109 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Lyon Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Lyon%2C+Mississippi%2C+United+States+of+America®ionId=553248634998705303&latLong=34.217887%2C-90.542043&adults=2&startDate=2026-01-20&d1=2026-01-20&endDate=2026-01-22&d2=2026-01-22&amenities=PETS) ## Check prices for these dates Tonight [Jan 6 - Jan 7](https://www.expedia.ca/Hotel-Search?regionId=553248634998705303&startDate=2026-01-06&endDate=2026-01-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 7 - Jan 8](https://www.expedia.ca/Hotel-Search?regionId=553248634998705303&startDate=2026-01-07&endDate=2026-01-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=553248634998705303&startDate=2026-01-09&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 16 - Jan 18](https://www.expedia.ca/Hotel-Search?regionId=553248634998705303&startDate=2026-01-16&endDate=2026-01-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Lyon hotels ![Exterior](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/d859aa54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/7467caab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/2680ddf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![First Floor East](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/3bdb990c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelers Hotel [](https://www.expedia.ca/Clarksdale-Hotels-Travelers-Hotel.h34868083.Hotel-Information) Clarksdale 9.8/10 Exceptional (278) "Though a bit different, there was a great artsy feel to the hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) T CA $196 CA $214 total includes taxes & fees Jan 10 - Jan 11 [](https://www.expedia.ca/Clarksdale-Hotels-Travelers-Hotel.h34868083.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/ee0738d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/20bde9f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/0906c723.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/e34ceb08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Clarksdale [](https://www.expedia.ca/Clarksdale-Hotels-Hampton-Inn-Clarksdale.h8273622.Hotel-Information) Clarksdale 8.2/10 Very good (336) "We would stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrew Ray CA $187 CA $203 total includes taxes & fees Jan 18 - Jan 19 [](https://www.expedia.ca/Clarksdale-Hotels-Hampton-Inn-Clarksdale.h8273622.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/766fdf07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full breakfast for a fee](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/d6d31cff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/41578708.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/e98cafb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Clarksdale [](https://www.expedia.ca/Clarksdale-Hotels-Quality-Inn.h151227.Hotel-Information) Clarksdale 7.4/10 Good (710) "The rooms could be a little more clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Courtney CA $110 CA $120 total includes taxes & fees Jan 13 - Jan 14 [](https://www.expedia.ca/Clarksdale-Hotels-Quality-Inn.h151227.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/c0e992b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Smoking](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/2606ec8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/e3029007.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/3c683cc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Americas Best Value Inn & Suites Clarksdale [](https://www.expedia.ca/Clarksdale-Hotels-Americas-Best-Value-Inn-Suites-Clarksdale.h151226.Hotel-Information) Clarksdale 6.0/10 (405) "Good location in town" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samuel CA $100 CA $109 total includes taxes & fees Jan 23 - Jan 24 [](https://www.expedia.ca/Clarksdale-Hotels-Americas-Best-Value-Inn-Suites-Clarksdale.h151226.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/e0dd2ca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, towels, shampoo](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/92a31471.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/3e64df31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/82cb9926.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Auberge Clarksdale Blues Hostel [](https://www.expedia.ca/Clarksdale-Hotels-Auberge-Clarksdale-Blues-Hostel.h38924451.Hotel-Information) Clarksdale 9.6/10 Exceptional (90) "Expedia sucks. No email with instructions until after I called directly to the hosts. The hostel was accommodating and friendly. I appreciated our stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Reva [](https://www.expedia.ca/Clarksdale-Hotels-Auberge-Clarksdale-Blues-Hostel.h38924451.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-21&endDate=2026-01-22®ionId=553248634998705303&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLyon-Hotels.d553248634998705303.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLyon-Hotels.d553248634998705303.Travel-Guide-Hotels) ## More cheap stays in Lyon ![Americas Best Value Inn & Suites Clarksdale](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/c0e992b8_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Americas Best Value Inn & Suites Clarksdale 350 South State Street Clarksdale MS CA $100 CA $109 total Jan 23 - Jan 24 includes taxes & fees 5.8/10 (405 reviews) [](https://expedia.ca/Clarksdale-Hotels-Americas-Best-Value-Inn-Suites-Clarksdale.h151226.Hotel-Information) ![Quality Inn](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/766fdf07_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Quality Inn 818 South State Street Clarksdale MS CA $110 CA $120 total Jan 13 - Jan 14 includes taxes & fees 7.2/10 Good! (709 reviews) [](https://expedia.ca/Clarksdale-Hotels-Quality-Inn.h151227.Hotel-Information) ![Hampton Inn Clarksdale](https://images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/e34ceb08_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn Clarksdale 15000 New Africa Rd Clarksdale MS CA $187 CA $203 total Jan 18 - Jan 19 includes taxes & fees 8/10 Very Good! (335 reviews) [](https://expedia.ca/Clarksdale-Hotels-Hampton-Inn-Clarksdale.h8273622.Hotel-Information) ![Travelers Hotel](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/cc59a6f5_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Travelers Hotel 212 3rd St Clarksdale MS CA $196 CA $214 total Jan 10 - Jan 11 includes taxes & fees 9.6/10 Exceptional! (277 reviews) [](https://expedia.ca/Clarksdale-Hotels-Travelers-Hotel.h34868083.Hotel-Information) ![Auberge Clarksdale Blues Hostel](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/82cb9926_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Auberge Clarksdale Blues Hostel 164 Delta Ave Clarksdale MS [Get rates](https://expedia.ca/Hotel-Search?startDate=21%2F01%2F2026&endDate=22%2F01%2F2026&selected=38924451&PinnedHotelID=38924451&HadPinnedHotel=true®ionId=553248634998705303) 9.6/10 Exceptional! (89 reviews) [](https://expedia.ca/Clarksdale-Hotels-Auberge-Clarksdale-Blues-Hostel.h38924451.Hotel-Information) ![High Cotton Condos](https://images.trvl-media.com/lodging/8000000/7380000/7374500/7374432/7583d1b4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### High Cotton Condos 249 Delta Ave Clarksdale MS [Get rates](https://expedia.ca/Hotel-Search?startDate=21%2F01%2F2026&endDate=22%2F01%2F2026&selected=7374432&PinnedHotelID=7374432&HadPinnedHotel=true®ionId=553248634998705303) [](https://expedia.ca/Clarksdale-Hotels-High-Cotton-Condos.h7374432.Hotel-Information) ## Hotels in Lyon with star-rating ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 3 properties [](https://expedia.ca/3Star-Lyon-Hotels.s30-0-d553248634998705303.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 6 properties [](https://expedia.ca/2Star-Lyon-Hotels.s20-0-d553248634998705303.Travel-Guide-Filter-Hotels) ## Recent reviews of Lyon hotels ![Cottage on riverbank one mile from Clarksdale in gated community](https://images.trvl-media.com/lodging/79000000/79000000/78996000/78995934/9f913091_y.jpg) ### Cottage on riverbank one mile from Clarksdale in gated community 5/5 Excellent "The property was wonderful. The beds are absolutely the most comfortable ever, as was the sofa. Very quiet and peaceful. Just what we were looking for." A verified traveller stayed at Cottage on riverbank one mile from Clarksdale in gated community Posted 7 days ago [](https://expedia.ca/Clarksdale-Hotels-Cottage-On-The-Sunflower-River.h78995934.Hotel-Information) ![Quality Inn](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/766fdf07_y.jpg) ### Quality Inn 5/5 Excellent "Dent eat " A verified traveller stayed at Quality Inn Posted 2 weeks ago [](https://expedia.ca/Clarksdale-Hotels-Quality-Inn.h151227.Hotel-Information) ![Sunset Log Cabin](https://images.trvl-media.com/lodging/97000000/96760000/96758600/96758575/07f49a54_y.jpg) ### Sunset Log Cabin 5/5 Excellent "A true cabin experience but feels comfortable like home. It is close to the road but I was able to tune out the car noises. The view of sunset is amazing even in the winter time with the already harvested cotton field. All the necessary accessories are provided and very close to town. I’d suggest staying here. " A verified traveller stayed at Sunset Log Cabin Posted 3 weeks ago [](https://expedia.ca/Clarksdale-Hotels-Sunset-Log-Cabin.h96758575.Hotel-Information) ![Hampton Inn Clarksdale](https://images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/e34ceb08_y.jpg) ### Hampton Inn Clarksdale 5/5 Excellent "The cook was amazing, the room was nice and the customer service was great" A verified traveller stayed at Hampton Inn Clarksdale Posted 3 weeks ago [](https://expedia.ca/Clarksdale-Hotels-Hampton-Inn-Clarksdale.h8273622.Hotel-Information) ![Travelers Hotel](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/cc59a6f5_y.jpg) ### Travelers Hotel 5/5 Excellent "Room was excellent. Bed comfy. Loved the hotel's concept. " A verified traveller stayed at Travelers Hotel Posted 3 weeks ago [](https://expedia.ca/Clarksdale-Hotels-Travelers-Hotel.h34868083.Hotel-Information) ![Get to BLUES-in' at Rusty's Roost, adjacent to downtown Clarksdale, MS](https://images.trvl-media.com/lodging/102000000/101150000/101144900/101144826/12bbff96_y.jpg) ### Get to BLUES-in' at Rusty's Roost, adjacent to downtown Clarksdale, MS 5/5 Excellent "On a quiet street with nice homes just a two minute drive or walk to the music center. " A verified traveller stayed at Get to BLUES-in' at Rusty's Roost, adjacent to downtown Clarksdale, MS Posted 2 months ago [](https://expedia.ca/Clarksdale-Hotels-Get-To-BLUES-In-At-Rustys-Roost.h101144826.Hotel-Information) ![Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale](https://images.trvl-media.com/lodging/114000000/113250000/113243700/113243634/467c648a_y.jpg) ### Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale 5/5 Excellent "Feels like home!!!My parents and I over enjoyed our stay here. It was just as pictured, if not better. House was very clean, and spacious. Easy to find and in a good area, close to downtown. Already looking forward to my next stay. Wish i could give more stars! " A verified traveller stayed at Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale Posted 2 months ago [](https://expedia.ca/Clarksdale-Hotels-Casa-DAmore-Adorable-Home-Less-Than-12-Mile-From-Downtown-Clarksdale.h113243634.Hotel-Information) ![Auberge Clarksdale Blues Hostel](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/82cb9926_y.jpg) ### Auberge Clarksdale Blues Hostel 5/5 Excellent "Gorgeous hostel! Inside was clean and so spacious! The kitchen was perfect for a quick breakfast. The bedrooms were all wonderfully designed and decorated." A verified traveller stayed at Auberge Clarksdale Blues Hostel Posted 2 months ago [](https://expedia.ca/Clarksdale-Hotels-Auberge-Clarksdale-Blues-Hostel.h38924451.Hotel-Information) ![Americas Best Value Inn & Suites Clarksdale](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/c0e992b8_y.jpg) ### Americas Best Value Inn & Suites Clarksdale 5/5 Excellent "Yes" A verified traveller stayed at Americas Best Value Inn & Suites Clarksdale Posted 2 months ago [](https://expedia.ca/Clarksdale-Hotels-Americas-Best-Value-Inn-Suites-Clarksdale.h151226.Hotel-Information) ## Frequently asked questions ### What's the best place for a stay in Lyon? ### What are some of the best vacation rentals that Lyon has to offer? ### If I need to cancel my hotel reservation in Lyon, will I receive a refund? ### What is staying in Lyon like? ### What should I do while I'm visiting Lyon? ### What's the seasonal weather like in Lyon? ## Explore a world of travel with Expedia - Lodging - Flights - 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