Title: Book the Best BUSINESS Hotels in Louisiana in 2025 | Expedia.ca [Hotels in Louisiana](https://expedia.ca/Louisiana-Hotels.d127811.Travel-Guide-Hotels)[Vacation Rentals in Louisiana](https://expedia.ca/Louisiana-Vacation-Rentals.d127811.Travel-Guide-VacationRentals)[Flights to Louisiana](https://expedia.ca/Cheap-Flights-To-Louisiana.d127811.Travel-Guide-Flights)[Louisiana Car Rentals](https://expedia.ca/Car-Rentals-In-Louisiana.d127811.Car-Rental-Guide)[Louisiana Vacation Packages](https://expedia.ca/Louisiana.d127811.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Louisiana, MO from CA $113 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Louisiana Business Hotels Tonight [Oct 2 - Oct 3](https://www.expedia.ca/Hotel-Search?regionId=127811&startDate=2025-10-02&endDate=2025-10-03&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 3 - Oct 4](https://www.expedia.ca/Hotel-Search?regionId=127811&startDate=2025-10-03&endDate=2025-10-04&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=127811&startDate=2025-10-03&endDate=2025-10-05&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=127811&startDate=2025-10-10&endDate=2025-10-12&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Louisiana Business Hotels ![Exterior](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/0683cbec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/cb88733c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/987b9fd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/863ee254.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn & Suites Hannibal 9.6/10 Exceptional (1000) "Great place with a very nice breakfast. " CA $141 CA $163 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Hannibal-Hotels-Sleep-Inn-Suites.h11308942.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/983700/983646/13b9e861.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/983700/983646/12a7ffe8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/1000000/990000/983700/983646/664b263a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/990000/983700/983646/937d7fc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Hannibal Hannibal 8.0/10 Very good (1019) "Wonderful facility and great breakfast. " CA $132 CA $152 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Hannibal-Hotels-Quality-Inn-Suites-Hannibal.h983646.Hotel-Information) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/70000/64300/64231/e4d50f81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/64300/64231/87b01476.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/70000/64300/64231/3ec3fc7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/70000/64300/64231/2719bcec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites - Hannibal Hannibal 7.6/10 Good (639) "The beds were super comfy" CA $129 CA $152 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Hannibal-Hotels-Comfort-Inn-Suites-Hannibal.h64231.Hotel-Information) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/4000000/3800000/3790200/3790159/69dacd1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3800000/3790200/3790159/df66a518.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/4000000/3800000/3790200/3790159/ad87f56f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/4000000/3800000/3790200/3790159/d2c89a48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Hannibal Hannibal 6.2/10 (709) "It was definitely a nice place. Kinda odd that you could only be on the 1st floor. Pool area was nice and huge. But hardly anyone stayed here. " CA $98 CA $113 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Hannibal-Hotels-Hannibal-Inn.h3790159.Hotel-Information) ![Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/16300/16249/b520e740.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16249/ba8e13b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/1000000/20000/16300/16249/721fce3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/16300/16249/74fd9989.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western On The River Hannibal 8.6/10 Excellent (1002) "Great Location." CA $153 CA $176 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Hannibal-Hotels-Best-Western-On-The-River.h16249.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/9990000/9986700/9986625/a368327c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/10000000/9990000/9986700/9986625/7da0a008.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/10000000/9990000/9986700/9986625/c466d62d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking, Refrigerator (New building)](https://images.trvl-media.com/lodging/10000000/9990000/9986700/9986625/2c579c3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Green Acres Hotel Pittsfield 8.6/10 Excellent (139) "Wonderful stay - was staying with a number of family members and it all worked out" CA $152 CA $167 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Pittsfield-Hotels-Green-Acres-Hotel.h9986625.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-16&endDate=2025-10-17®ionId=127811&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Louisiana Hotel Reviews ![Super 8 by Wyndham Hannibal](//images.trvl-media.com/lodging/1000000/460000/459700/459674/087ffe43_y.jpg) ### Super 8 by Wyndham Hannibal 10/10 Excellent "Wonderful staff" [](https://expedia.ca/Hannibal-Hotels-Super-8-By-Wyndham-Hannibal.h459674.Hotel-Information) ![Quality Inn & Suites Hannibal](//images.trvl-media.com/lodging/1000000/990000/983700/983646/13b9e861_y.jpg) ### Quality Inn & Suites Hannibal 10/10 Excellent "After a 14 days itinerary on the South-West driving home, we stoped in Hannibal, MO to visit the town and enjoy a Mark Twain Cruise on the Mississippi. It was the first time we stayed at a Choice Hotel. Ive chosen Quality Inn & Suites because the good reviews. And the reviews were true. I was impressed how beautiful and well preserved is this property. Huge lobby, clean and pleasant. They have even a Bar. FD people and Breakfast person were amazing. We had the best Breakfast in 14 days. The owner, a young man, I'm sorry I don't recall his name, was extremely polite and pleasant. As a former General Manager for Marriott and IHG I was realy impressed of this property. Congratulations to all of you! You are doing a great job! Thank you. " [](https://expedia.ca/Hannibal-Hotels-Quality-Inn-Suites-Hannibal.h983646.Hotel-Information) ![Best Western On The River](//images.trvl-media.com/lodging/1000000/20000/16300/16249/b520e740_y.jpg) ### Best Western On The River 10/10 Excellent "Really like the room. It was quiet and clean. It was close to the river and within walking distance to shop and dine. Think we may come back again. We will stay there again." [](https://expedia.ca/Hannibal-Hotels-Best-Western-On-The-River.h16249.Hotel-Information) ![Baymont by Wyndham Hannibal](//images.trvl-media.com/lodging/4000000/3800000/3790200/3790159/69dacd1b_y.jpg) ### Baymont by Wyndham Hannibal 10/10 Excellent "It was definitely a nice place. Kinda odd that you could only be on the 1st floor. Pool area was nice and huge. But hardly anyone stayed here. " [](https://expedia.ca/Hannibal-Hotels-Hannibal-Inn.h3790159.Hotel-Information) ![William Watson Hotel](//images.trvl-media.com/lodging/7000000/6660000/6659600/6659525/080807c1_y.jpg) ### William Watson Hotel 10/10 Excellent "Great place to stay off the beaten path!" [](https://expedia.ca/Pittsfield-Hotels-William-Watson-Hotel.h6659525.Hotel-Information) ![Sleep Inn & Suites](//images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/0683cbec_y.jpg) ### Sleep Inn & Suites 10/10 Excellent "Trash in green areas. Nasty parking lot. Needs power wash" [](https://expedia.ca/Hannibal-Hotels-Sleep-Inn-Suites.h11308942.Hotel-Information) ![Days Inn by Wyndham Hannibal](//images.trvl-media.com/lodging/1000000/20000/13000/12968/a819ab14_y.jpg) ### Days Inn by Wyndham Hannibal 10/10 Excellent "Nice place" [](https://expedia.ca/Hannibal-Hotels-Days-Inn-By-Wyndham-Hannibal.h12968.Hotel-Information) ![Comfort Inn & Suites - Hannibal](//images.trvl-media.com/lodging/1000000/70000/64300/64231/e4d50f81_y.jpg) ### Comfort Inn & Suites - Hannibal 10/10 Excellent "Nice property. 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