Title: Book the Best BUSINESS Hotels in Little Italy in 2026 | Expedia.ca [Little Italy Travel Guide](https://expedia.ca/San-Diego-Little-Italy.dx6161280)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Little Italy Car Rentals](https://expedia.ca/Car-Rentals-In-Little-Italy.d6161280.Car-Rental-Guide)[Little Italy Vacations](https://expedia.ca/Little-Italy.d6161280.Destination-Travel-Guides) ![Little Italy](https://images.trvl-media.com/place/6161280/027d3836-740c-44f0-bb0a-a8fb158f401a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Little Italy, CA from CA $102 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Little Italy Business Hotels Tonight [Dec 29 - Dec 30](https://www.expedia.ca/Hotel-Search?regionId=6161280&startDate=2025-12-29&endDate=2025-12-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 30 - Dec 31](https://www.expedia.ca/Hotel-Search?regionId=6161280&startDate=2025-12-30&endDate=2025-12-31&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6161280&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=6161280&startDate=2026-01-09&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Little Italy business-friendly hotels ![City view from property](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/db3040ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served, Mediterranean cuisine](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/0b312e6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/f5805846.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/47ab74dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott San Diego Downtown Little Italy [](https://www.expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) Downtown San Diego 9.0/10 Wonderful (149) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jacorey CA $167 CA $193 total includes taxes & fees Jan 7 - Jan 8, 2026 [](https://www.expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/fc9f5c5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/62b86c17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom, Non Smoking | Living area](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/14ea58da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/d450dfd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn San Diego-Downtown [](https://www.expedia.ca/San-Diego-Hotels-Hampton-Inn-San-Diego-Downtown.h551889.Hotel-Information) Downtown San Diego 8.2/10 Very good (2318) "Nice and convenient place to stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Esperanza CA $142 CA $165 total includes taxes & fees Jan 18 - Jan 19, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Hampton-Inn-San-Diego-Downtown.h551889.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/900000/893700/893673/89625d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/900000/893700/893673/3681c904.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed | Bathroom](https://images.trvl-media.com/lodging/1000000/900000/893700/893673/1df686f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/900000/893700/893673/a09a751d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Harborview Inn & Suites San Diego Harbor [](https://www.expedia.ca/San-Diego-Hotels-Harborview-Inn-Suites-San-Diego-Harbor.h893673.Hotel-Information) Downtown San Diego 7.2/10 Good (1003) "Room.was great and clean. It also a good view it was a great stay after all " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elsa CA $69 CA $102 total includes taxes & fees Jan 29 - Jan 30, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Harborview-Inn-Suites-San-Diego-Harbor.h893673.Hotel-Information) ![Outdoor pool, open 7:00 AM to 10:00 PM, free cabanas, sun loungers](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/308d14a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Harbour View | View from room](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/15c37db5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/a15a7e64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/be46a39e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn San Diego Downtown/Bayside [](https://www.expedia.ca/San-Diego-Hotels-Hilton-Garden-Inn-San-Diego-DowntownBayside.h13339817.Hotel-Information) Downtown San Diego 8.6/10 Excellent (1234) "Great location, great hotel. Will stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Felicia CA $210 CA $243 total includes taxes & fees Jan 3 - Jan 4, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-Garden-Inn-San-Diego-DowntownBayside.h13339817.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/236157bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/dc860349.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/8114cbc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/e45ffdb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Pensione Hotel [](https://www.expedia.ca/San-Diego-Hotels-La-Pensione-Hotel.h914373.Hotel-Information) Downtown San Diego 8.6/10 Excellent (1890) "Great check-in experience, convenient parking, the room was clean and bed was comfortable. The city view option was exceptionally pleasant. Will stay again! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mike [](https://www.expedia.ca/San-Diego-Hotels-La-Pensione-Hotel.h914373.Hotel-Information) ![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/8000000/7350000/7341300/7341280/d0638ef7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, 1 Queen Bed with Sofa bed](https://images.trvl-media.com/lodging/8000000/7350000/7341300/7341280/73e1a4c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/8000000/7350000/7341300/7341280/b8a10ffe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/8000000/7350000/7341300/7341280/3fc9f7d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Urban Boutique Hotel [](https://www.expedia.ca/San-Diego-Hotels-Urban-Boutique-Hotel.h7341280.Hotel-Information) Downtown San Diego 8.6/10 Excellent (1270) "Locations is excellent and the front desk lady was friendly " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Ju CA $152 CA $173 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Urban-Boutique-Hotel.h7341280.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/50000/41700/41635/e44ce490.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop pool](https://images.trvl-media.com/lodging/1000000/50000/41700/41635/feebe7fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/41700/41635/856889b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/1000000/50000/41700/41635/a2fbcf30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Porto Vista Hotel Downtown [](https://www.expedia.ca/San-Diego-Hotels-Porto-Vista-Hotel.h41635.Hotel-Information) Downtown San Diego 6.8/10 (1205) "Nice stay, staff excellent, friendly, helpful and great customer service. Hotel ok older" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mizael CA $119 CA $145 total includes taxes & fees Jan 14 - Jan 15, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Porto-Vista-Hotel.h41635.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/210000/202600/202525/708362b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/210000/202600/202525/w4000h2662x0y0-f1e0e5b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/210000/202600/202525/w4000h2663x0y0-1b4025f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/210000/202600/202525/w4000h2662x0y0-2729c08e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn by Marriott San Diego Downtown [](https://www.expedia.ca/San-Diego-Hotels-Residence-Inn-By-Marriott-San-Diego-Downtown.h202525.Hotel-Information) Downtown San Diego 8.4/10 Very good (1003) "Close to the harbor." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Evelyn CA $223 CA $259 total includes taxes & fees Jan 15 - Jan 16, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Residence-Inn-By-Marriott-San-Diego-Downtown.h202525.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/900/858/c5325c92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/10000/900/858/543624c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Down comforters, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/10000/900/858/93b051f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Penthouse](https://images.trvl-media.com/lodging/1000000/10000/900/858/36c2b78d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Mission Bay Spa and Marina [](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information) Mission Bay 8.4/10 Very good (1586) "Totally Recommend! Rooms are really clean and comfortable, the staff are great as well. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fernando CA $176 CA $275 total includes taxes & fees Jan 3 - Jan 4, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information) ![Outdoor pool, open 7:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/bbcdbd6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/de48676b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/eae398b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/c2cecb91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Diego Mission Bay Resort [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Mission-Bay-Resort.h25598.Hotel-Information) Mission Bay 8.4/10 Very good (1318) "Room was super clean and updated, location up against the bay was perfect. We really enjoyed our stay and want to come back soon!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Haley CA $188 CA $288 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Mission-Bay-Resort.h25598.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-13&endDate=2026-01-14®ionId=6161280&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Little Italy Hotel Reviews ![Best Western Plus Marina Gateway Hotel](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "Room and bathroom were very clean. The bathtub was a little shallow and was hard to take a bath in. " [](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![DoubleTree by Hilton Hotel San Diego - Mission Valley](https://images.trvl-media.com/lodging/1000000/10000/400/332/8e34f752_y.jpg) ### DoubleTree by Hilton Hotel San Diego - Mission Valley 10/10 Excellent "Don't know about the bar, did not eat breakfast" [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "Would stay there again had a great stay staff was amazing from front desk to security even housekeeping . " [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "The staff was very friendly all throughout the resort. They checked us in at 1:30PM & upgraded our room which was a nice surprise. The s'mores after dinner at the firepits was a nice conclusion to our evening." [](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) ![Best Western Seven Seas](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf_y.jpg) ### Best Western Seven Seas 10/10 Excellent "Clean, quiet, and comfortable. Also conveniently located." [](https://expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "No complaints we are definitely going back " [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Courtyard by Marriott San Diego Downtown Little Italy](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/db3040ff_y.jpg) ### Courtyard by Marriott San Diego Downtown Little Italy 10/10 Excellent "Excellent " [](https://expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "The room was very clean and comfortable and the staff were friendly and helpful. A great value! " [](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Four Points by Sheraton San Diego](https://images.trvl-media.com/lodging/1000000/30000/23700/23651/d216d27d_y.jpg) ### Four Points by Sheraton San Diego 10/10 Excellent " Good" [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego.h23651.Hotel-Information) ## Frequently asked questions ### Why book your business-friendly hotel in Little Italy with Expedia? ### How can I find cheap business-friendly hotels in Little Italy? ## Explore a world of travel with Expedia - Lodging - More ways to book - [All Inclusive Resorts and in Bankers Hill ](https://www.expedia.ca/Bankers-Hill-San-Diego-Hotels-All-Inclusive-Hotel.0-n553248635976473812-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Bankers Hill ](https://www.expedia.ca/Bankers-Hill-San-Diego-Hotels-Beach-Hotel.0-n553248635976473812-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Bankers Hill ](https://www.expedia.ca/Bankers-Hill-San-Diego-Hotels-Cheap-Hotels.0-n553248635976473812-0-tCheapHotels.Travel-Guide-Filter-Hotels) - 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