Title: Book the Best BUSINESS Hotels in Little Italy in 2026 | Expedia.ca

[Little Italy Travel Guide](https://expedia.ca/San-Diego-Little-Italy.dx6161280)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Little Italy Car Rentals](https://expedia.ca/Car-Rentals-In-Little-Italy.d6161280.Car-Rental-Guide)[Little Italy Vacations](https://expedia.ca/Little-Italy.d6161280.Destination-Travel-Guides)

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# Find Business Hotels in Little Italy, CA from CA $104

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## Check availability on Little Italy Business Hotels

Tonight

[Jan 5 - Jan 6](https://www.expedia.ca/Hotel-Search?regionId=6161280&startDate=2026-01-05&endDate=2026-01-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Tomorrow

[Jan 6 - Jan 7](https://www.expedia.ca/Hotel-Search?regionId=6161280&startDate=2026-01-06&endDate=2026-01-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

This weekend

[Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=6161280&startDate=2026-01-09&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Next weekend

[Jan 16 - Jan 18](https://www.expedia.ca/Hotel-Search?regionId=6161280&startDate=2026-01-16&endDate=2026-01-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

## Our top choices for Little Italy business-friendly hotels

![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/fc9f5c5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/d450dfd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/62b86c17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Bedroom, Non Smoking | Living area](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/14ea58da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn San Diego-Downtown

[](https://www.expedia.ca/San-Diego-Hotels-Hampton-Inn-San-Diego-Downtown.h551889.Hotel-Information)

Downtown San Diego

8.2/10

Very good

(2335)

"Nice and convenient place to stay!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Esperanza

CA $145

CA $169 total

includes taxes & fees

Jan 21 - Jan 22

[](https://www.expedia.ca/San-Diego-Hotels-Hampton-Inn-San-Diego-Downtown.h551889.Hotel-Information)

![City view from property](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/db3040ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/f5805846.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from room](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/0339a25b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/47ab74dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Courtyard by Marriott San Diego Downtown Little Italy

[](https://www.expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information)

Downtown San Diego

8.8/10

Excellent

(192)

"Great stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Adilene

CA $178

CA $206 total

includes taxes & fees

Jan 8 - Jan 9

[](https://www.expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/1000000/900000/893700/893673/89625d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 Queen Bed | In-room dining](https://images.trvl-media.com/lodging/1000000/900000/893700/893673/ec05fe8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/900000/893700/893673/a09a751d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 Queen Bed | Bathroom](https://images.trvl-media.com/lodging/1000000/900000/893700/893673/1df686f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Harborview Inn & Suites San Diego Harbor

[](https://www.expedia.ca/San-Diego-Hotels-Harborview-Inn-Suites-San-Diego-Harbor.h893673.Hotel-Information)

Downtown San Diego

7.2/10

Good

(1006)

"Room.was great and clean. It also a good view it was a great stay after all "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Elsa

CA $70

CA $104 total

includes taxes & fees

Jan 7 - Jan 8

[](https://www.expedia.ca/San-Diego-Hotels-Harborview-Inn-Suites-San-Diego-Harbor.h893673.Hotel-Information)

![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/8000000/7350000/7341300/7341280/d0638ef7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hallway](https://images.trvl-media.com/lodging/8000000/7350000/7341300/7341280/ff1db9c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/8000000/7350000/7341300/7341280/3fc9f7d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Superior Room, 1 Queen Bed with Sofa bed](https://images.trvl-media.com/lodging/8000000/7350000/7341300/7341280/73e1a4c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Urban Boutique Hotel

[](https://www.expedia.ca/San-Diego-Hotels-Urban-Boutique-Hotel.h7341280.Hotel-Information)

Downtown San Diego

8.6/10

Excellent

(1271)

"Locations is excellent and the front desk lady was friendly "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Ju

CA $153

CA $174 total

includes taxes & fees

Jan 7 - Jan 8

[](https://www.expedia.ca/San-Diego-Hotels-Urban-Boutique-Hotel.h7341280.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/236157bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/dc860349.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast area](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/e45ffdb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/8114cbc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Pensione Hotel

[](https://www.expedia.ca/San-Diego-Hotels-La-Pensione-Hotel.h914373.Hotel-Information)

Downtown San Diego

8.6/10

Excellent

(1901)

"Great location! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kristin

CA $184

CA $209 total

includes taxes & fees

Jan 7 - Jan 8

[](https://www.expedia.ca/San-Diego-Hotels-La-Pensione-Hotel.h914373.Hotel-Information)

![Outdoor pool, open 7:00 AM to 10:00 PM, free cabanas, sun loungers](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/308d14a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Harbour View | View from room](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/15c37db5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/dc05fea3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Courtyard](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/be46a39e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton Garden Inn San Diego Downtown/Bayside

[](https://www.expedia.ca/San-Diego-Hotels-Hilton-Garden-Inn-San-Diego-DowntownBayside.h13339817.Hotel-Information)

Downtown San Diego

8.6/10

Excellent

(1235)

"Great location, great hotel. Will stay again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Felicia

CA $210

CA $244 total

includes taxes & fees

Jan 18 - Jan 19

[](https://www.expedia.ca/San-Diego-Hotels-Hilton-Garden-Inn-San-Diego-DowntownBayside.h13339817.Hotel-Information)

![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/50000/41700/41635/e44ce490.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Food and drink](https://images.trvl-media.com/lodging/1000000/50000/41700/41635/a2fbcf30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/50000/41700/41635/942a830e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Rooftop pool](https://images.trvl-media.com/lodging/1000000/50000/41700/41635/feebe7fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Porto Vista Hotel Downtown

[](https://www.expedia.ca/San-Diego-Hotels-Porto-Vista-Hotel.h41635.Hotel-Information)

Downtown San Diego

6.8/10

(1211)

"Great stay, clean rooms and centrally located"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Samuel

[](https://www.expedia.ca/San-Diego-Hotels-Porto-Vista-Hotel.h41635.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/1000000/210000/202600/202525/708362b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/210000/202600/202525/w4000h2663x0y0-1b4025f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/1000000/210000/202600/202525/w4000h2662x0y0-2729c08e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/210000/202600/202525/w4000h2662x0y0-f1e0e5b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Residence Inn by Marriott San Diego Downtown

[](https://www.expedia.ca/San-Diego-Hotels-Residence-Inn-By-Marriott-San-Diego-Downtown.h202525.Hotel-Information)

Downtown San Diego

8.4/10

Very good

(1001)

"Close to the harbor."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Evelyn

CA $234

CA $271 total

includes taxes & fees

Jan 22 - Jan 23

[](https://www.expedia.ca/San-Diego-Hotels-Residence-Inn-By-Marriott-San-Diego-Downtown.h202525.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/900/858/c5325c92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Penthouse](https://images.trvl-media.com/lodging/1000000/10000/900/858/36c2b78d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/10000/900/858/c6795882.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/10000/900/858/543624c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Regency Mission Bay Spa and Marina

[](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information)

Mission Bay

8.4/10

Very good

(1596)

"Great staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Samuel

CA $205

CA $308 total

includes taxes & fees

Jan 9 - Jan 10

[](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information)

![Outdoor pool, open 7:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/bbcdbd6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/de48676b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![On the beach, white sand, windsurfing, beach volleyball](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/c20f7d47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/c2cecb91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### San Diego Mission Bay Resort

[](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Mission-Bay-Resort.h25598.Hotel-Information)

Mission Bay

8.4/10

Very good

(1328)

"Loved the bay front room with the large grass area right out the door!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Todd and Danielle

CA $209

CA $313 total

includes taxes & fees

Jan 25 - Jan 26

[](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Mission-Bay-Resort.h25598.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-20&endDate=2026-01-21&regionId=6161280&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true)

## Top Little Italy Hotel Reviews

![Best Western Plus Marina Gateway Hotel](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg)

### Best Western Plus Marina Gateway Hotel

10/10 Excellent

"Could have drain the tub better . But either then that I enjoy my stay. Always come back to this location. "

[](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information)

![San Diego Marriott La Jolla](https://images.trvl-media.com/lodging/1000000/10000/2100/2097/05285107_y.jpg)

### San Diego Marriott La Jolla

10/10 Excellent

"Best hotel staff and stay "

[](https://expedia.ca/La-Jolla-Hotels-San-Diego-Marriott-La-Jolla.h2097.Hotel-Information)

![Marriott Marquis San Diego Marina](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/9078a9ee_y.jpg)

### Marriott Marquis San Diego Marina

10/10 Excellent

"Great service "

[](https://expedia.ca/San-Diego-Hotels-Marriott-Marquis-San-Diego-Marina.h24394.Hotel-Information)

![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg)

### The DEXTRO Little Italy, BW Premier Collection

10/10 Excellent

"Yes "

[](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information)

![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg)

### Sheraton San Diego Resort

10/10 Excellent

"Great "

[](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information)

![Hilton San Diego Mission Valley](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15_y.jpg)

### Hilton San Diego Mission Valley

10/10 Excellent

"Very courteous lady at the front counter. Great beds. "

[](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information)

![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg)

### Hard Rock Hotel San Diego

10/10 Excellent

"Was perfect "

[](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information)

![Best Western Seven Seas](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf_y.jpg)

### Best Western Seven Seas

10/10 Excellent

"Room was good and staff was very friendly and helpful."

[](https://expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information)

![DoubleTree by Hilton Hotel San Diego - Mission Valley](https://images.trvl-media.com/lodging/1000000/10000/400/332/8e34f752_y.jpg)

### DoubleTree by Hilton Hotel San Diego - Mission Valley

10/10 Excellent

"Good "

[](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information)

## Frequently asked questions

### Why book your business-friendly hotel in Little Italy with Expedia?

### How can I find cheap business-friendly hotels in Little Italy?

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