Title: Book the Best BUSINESS Hotels in Little Italy in 2025 | Expedia.ca [Little Italy Travel Guide](https://expedia.ca/San-Diego-Little-Italy.dx6161280)[Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Little Italy Car Rentals](https://expedia.ca/Car-Rentals-In-Little-Italy.d6161280.Car-Rental-Guide)[Little Italy Vacations](https://expedia.ca/Little-Italy.d6161280.Destination-Travel-Guides) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/481000/481026-Little-Italy-San-Diego.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Little Italy, CA from CA $131 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Little Italy Business Hotels Tonight [Nov 3 - Nov 4](https://www.expedia.ca/Hotel-Search?regionId=6161280&startDate=2025-11-03&endDate=2025-11-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Nov 4 - Nov 5](https://www.expedia.ca/Hotel-Search?regionId=6161280&startDate=2025-11-04&endDate=2025-11-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6161280&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=6161280&startDate=2025-11-14&endDate=2025-11-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Top Little Italy Business Hotels ![Outdoor pool, open 7:00 AM to 10:00 PM, free cabanas, sun loungers](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/308d14a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/be46a39e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Harbour View | View from room](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/15c37db5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/14000000/13340000/13339900/13339817/dc05fea3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn San Diego Downtown/Bayside Downtown San Diego 8.6/10 Excellent (1183) "The staff were great and the hotel was very clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Randy CA $193 CA $224 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-Garden-Inn-San-Diego-DowntownBayside.h13339817.Hotel-Information) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/fc9f5c5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/62b86c17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/d450dfd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom, Non Smoking | Living area](https://images.trvl-media.com/lodging/1000000/560000/551900/551889/14ea58da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn San Diego-Downtown Downtown San Diego 8.2/10 Very good (2226) "Great place to stay before a cruise." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Suzanne CA $177 CA $205 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/San-Diego-Hotels-Hampton-Inn-San-Diego-Downtown.h551889.Hotel-Information) ![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/8000000/7350000/7341300/7341280/d0638ef7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/8000000/7350000/7341300/7341280/b8a10ffe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/8000000/7350000/7341300/7341280/ff1db9c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/8000000/7350000/7341300/7341280/3fc9f7d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Urban Boutique Hotel Downtown San Diego 8.6/10 Excellent (1288) "Very nice staff and good food nearby. They had issues with the card printer but was very quick and nice about helping me get into my room everytime I needed to." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fred CA $141 CA $160 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/San-Diego-Hotels-Urban-Boutique-Hotel.h7341280.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/236157bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/8114cbc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/dc860349.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/1000000/920000/914400/914373/e45ffdb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Pensione Hotel Downtown San Diego 8.6/10 Excellent (1925) "Very happy with our stay " ![Australia](https://a.travel-assets.com/egds/marks/flags/au.svg) Joseph CA $188 CA $214 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/San-Diego-Hotels-La-Pensione-Hotel.h914373.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/900000/893700/893673/89625d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/900000/893700/893673/3681c904.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed | Bathroom](https://images.trvl-media.com/lodging/1000000/900000/893700/893673/1df686f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/900000/893700/893673/a09a751d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Harborview Inn & Suites San Diego Harbor Downtown San Diego 7.2/10 Good (1017) "Great stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Candice CA $73 CA $131 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/San-Diego-Hotels-Harborview-Inn-Suites-San-Diego-Harbor.h893673.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/50000/41700/41635/e44ce490.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/1000000/50000/41700/41635/a2fbcf30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/41700/41635/856889b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/50000/41700/41635/942a830e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Porto Vista Hotel Downtown Downtown San Diego 6.6/10 (1197) "Great place to stay, with awesome staff (very helpful friendly and knowledgable" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tieng CA $152 CA $177 total includes taxes & fees Nov 4 - Nov 5 [](https://www.expedia.ca/San-Diego-Hotels-Porto-Vista-Hotel.h41635.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/db3040ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/a7d908f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/bf663de6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/20000/13300/13205/0339a25b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott San Diego Downtown Little Italy Downtown San Diego 8.2/10 Very good (1170) "Great location and hotel! Loved my stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Banesa CA $171 CA $198 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/210000/202600/202525/708362b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/210000/202600/202525/w4000h2663x0y0-1b4025f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/210000/202600/202525/w4000h2662x0y0-2729c08e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/210000/202600/202525/w4000h2662x0y0-f1e0e5b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn by Marriott San Diego Downtown Downtown San Diego 8.6/10 Excellent (1000) "Great locatio " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle CA $208 CA $242 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/San-Diego-Hotels-Residence-Inn-By-Marriott-San-Diego-Downtown.h202525.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/676f55ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/37cb1415.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, pool views ](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/1f20ac82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bay Club Hotel & Marina Point Loma 9.0/10 Wonderful (3065) "We really enjoyed our stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joseph CA $155 CA $178 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ![Standard Room, 1 King Bed, Non Smoking, City View](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/1bec6ce5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/3eeea039.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/52ba7ddb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/66a8936b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The DEXTRO Little Italy, BW Premier Collection Downtown San Diego 8.8/10 Excellent (607) "Great central hotel ...close to everything " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) joel CA $145 CA $168 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-17&endDate=2025-11-18®ionId=6161280&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Little Italy Hotel Reviews ![Hilton San Diego Mission Valley](//images.trvl-media.com/lodging/1000000/20000/16100/16019/w3839h2160x1y0-98566ca3_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "Amazing! " [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "The room and service was excellent. " [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Handlery Hotel](//images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55_y.jpg) ### Handlery Hotel 10/10 Excellent "Clean room, friendly staff, and great service." [](https://expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Airport shuttle was the best. Rooms are ok with nice views. " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![The Dana on Mission Bay](//images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "Beautiful location and loved the pools." [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Courtyard by Marriott San Diego Downtown Little Italy](//images.trvl-media.com/lodging/1000000/20000/13300/13205/0339a25b_y.jpg) ### Courtyard by Marriott San Diego Downtown Little Italy 10/10 Excellent "Great place " [](https://expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![Hampton Inn & Suites by Hilton San Diego SeaWorld](//images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/cc52443d_y.jpg) ### Hampton Inn & Suites by Hilton San Diego SeaWorld 10/10 Excellent "Good people " [](https://expedia.ca/San-Diego-Hotels-Hampton-Inn-Suites-San-Diego-Point-Loma.h12963301.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "The room was amazing as well as location, staff and restaurants." [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Hampton Inn San Diego-Downtown](//images.trvl-media.com/lodging/1000000/560000/551900/551889/fc9f5c5b_y.jpg) ### Hampton Inn San Diego-Downtown 10/10 Excellent "Perfect star to stay. So much to do! Nice Hotel with very nice staff. Definitely coming back" [](https://expedia.ca/San-Diego-Hotels-Hampton-Inn-San-Diego-Downtown.h551889.Hotel-Information) ## Frequently asked questions ### Why book your business-friendly hotel in Little Italy with Expedia? > Here at Expedia, our job is to help you choose the ideal stay at the right price. From deluxe, corporate-friendly getaways to affordable hotels loaded with conveniences, you'll have your next work trip booked in a few easy clicks. ### How can I find cheap business-friendly hotels in Little Italy? > When you're travelling for work in Little Italy, our "business friendly" filter will help you find the ideal hotel. From fast WiFi to meeting rooms and workspaces, they have the amenities you need to get the job done. Another tip? Refine your search by your preferred star rating and budget to see the most affordable accommodations. ## Explore a world of travel with Expedia - Lodging - More ways to book - [All Inclusive Resorts and in Bankers Hill](https://www.expedia.ca/Bankers-Hill-San-Diego-Hotels-All-Inclusive-Hotel.0-n553248635976473812-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Bankers Hill](https://www.expedia.ca/Bankers-Hill-San-Diego-Hotels-Beach-Hotel.0-n553248635976473812-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Bankers Hill](https://www.expedia.ca/Bankers-Hill-San-Diego-Hotels-Cheap-Hotels.0-n553248635976473812-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Bankers Hill](https://www.expedia.ca/Bankers-Hill-San-Diego-Hotels-Luxury-Hotel.0-n553248635976473812-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Camp Pendleton Marine Corps Base](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Beach-Hotel.0-0-d6068523-tBeachHotel.Travel-Guide-Filter-Hotels) - 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