Book The Best Hotels in Lithium, MO for 2026 from CA $102 - Fully Refundable Options

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Our top choices for Lithium hotels

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.

A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

1. Super 8 by Wyndham Perryville

Perryville

Matthew

CA $97

CA $111 total

includes taxes & fees

Nov 8 - Nov 9

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A gym with treadmills, elliptical machines, and weight equipment.

A Holiday Inn Express & Suites building with a covered entrance and multiple windows.

A kitchen counter with a coffee machine, a kettle, and storage boxes.

2. Holiday Inn Express & Suites Perryville by IHG

Perryville

Lisa

CA $144

CA $165 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a large bed, a bathroom with a bathtub, and a mirror reflecting the room.

A hotel hallway with a patterned carpet, blue walls, and a sign indicating an office.

A swimming pool with a metal ladder, a Days Inn sign, and a blue water tower in the background.

A kitchen with wooden cabinets, a dining area with a table and chairs, and various kitchen appliances.

3. Days Inn by Wyndham Perryville

Perryville

karen

CA $96

CA $110 total

includes taxes & fees

Oct 14 - Oct 15

A hotel room with a bed, a desk with a chair, a small table, a sofa, a bathtub, and a window with curtains.

A modern bathroom with a large bathtub, a wooden floor, and a dark wall with a colorful abstract painting.

A breakfast area with a counter, seating, and kitchen appliances.

A room with a fireplace, a mounted deer head, a bookshelf, and two armchairs.

4. Baymont by Wyndham Chester IL

Chester

Keng

CA $114

CA $127 total

includes taxes & fees

Nov 8 - Nov 9

A lobby with a TV, framed pictures, a plant, and patterned chairs.

A hotel room with a large bathtub, a bed with two pillows, a nightstand, and a wall-mounted lamp.

A hotel room with a desk, a television, a coffee maker, a chair, and a window with curtains.

A hotel reception desk with a sign that reads "Quality by Choice Hotels."

5. Quality Inn Perryville I-55

Perryville

Evelynmaryeka

CA $91

CA $104 total

includes taxes & fees

Nov 2 - Nov 3

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

A building with a sign that reads "The Atrium Boutique Hotel".

6. The Atrium - A Boutique Hotel

Perryville

Brian

CA $126

CA $144 total

includes taxes & fees

Oct 18 - Oct 19

A row of single-story houses with attached garages, a paved driveway, and a clear sky.

A modern living room with a flat-screen TV, a desk with a computer, two armchairs, a coffee table, and large windows with a view.

A reception desk with a digital map of the USA, a wooden reception area, and a sign for 'MICROHOTEL BY JYNDHAMI'.

A hotel dining area with tables and chairs, a kitchen area, and a flat-screen TV mounted on the wall.

7. Microtel Inn & Suites by Wyndham Sainte Genevieve

Ste Genevieve

Samantha

CA $121

CA $142 total

includes taxes & fees

Nov 1 - Nov 2

A rustic cabin-style lodging with a covered porch, picnic tables, and a fire pit.

A swimming pool with a small water slide, surrounded by lounge chairs and umbrellas.

A lakeside RV resort with wooden cabins, a picnic area, and a reflection in the water.

A playground with a wooden playhouse, a slide, and two animal-shaped swings.

8. Perryville RV Resort

Perryville

Kevin

CA $95

CA $108 total

includes taxes & fees

Oct 18 - Oct 19

A parking lot with a sign for Triangle Inn.

A room with a wooden table, two patterned chairs, a framed artwork on the wall, and a window with brown curtains.

A compact kitchen with black cabinets, a black refrigerator, a microwave, and a sink.

9. Triangle Inn Motel

Ste Genevieve

Kimmy

CA $87

CA $102 total

includes taxes & fees

Oct 21 - Oct 22

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A hallway with exposed brick walls, wooden flooring, and a white door.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

10. Urban Lofts

Perryville

Grace

CA $288

CA $444 total

includes taxes & fees

Oct 14 - Oct 15

A modern kitchen with stainless steel appliances, a large window, and a green cabinet.

A two-story building with a balcony, a front door with a wreath, and a sign indicating a restaurant.

A wooden interior with a dining area, staircase, and a television mounted on the wall.

A kitchen with a large black sink, a window with a view of trees, and a microwave on the counter.

11. The Mediterranean House 1858

Perryville

CA $554

CA $968 total

includes taxes & fees

Oct 14 - Oct 15

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Top Lithium Hotel Reviews

Quality Inn Perryville I-55

8/10 Good

"Utilitarian hotel room. Clean, neat, well maintained. Refrigerators have freezer compartments. Outlets on lamp bases but no USB charging ports."

Cozy Haven Our Little Gem Sleeps 4

10/10 Excellent

"The cozy cottage had just about everything you could need for a weekend stay. It was the perfect base for all the things we wanted to do - sightseeing, hiking, visiting wineries and relaxing. We would definitely stay here again when in St. Genevieve."

Triangle Inn Motel

8/10 Good

"Very clean and bed was comfortable for an old motel"

Microtel Inn & Suites by Wyndham Sainte Genevieve

10/10 Excellent

"Every one were friendly and helpful"

⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4

10/10 Excellent

"Had a Girl's Weekend to relax ans enjoy the area. This house was adorable, full of historical charm. Still had everything we needed."

Beautiful Modern Loft In Wine Country!

10/10 Excellent

"My Wife and I had a wonderful stay at GooseHill loft. Great view of nice property with lake. Very clean and tidy. Great location near Charlesville. My wife loved the playful kittens."

Days Inn by Wyndham Perryville

8/10 Good

"."

Super 8 by Wyndham Perryville

10/10 Excellent

"Quick and easy check in. Friendly staff."

Hot Tub & Creek Views: Secluded Perryville Cabin

10/10 Excellent

"Wonderful location with the necessities to enjoy your time without taking away from the beauty of where you are"