Title: Hotels by SPM Resorts in Lake Nona Medical City | Expedia.ca [Lake Nona Medical City Travel Guide](https://expedia.ca/Orlando-Lake-Nona-Medical-City.dx6197057)[Vacation Rentals in Orlando](https://expedia.ca/Orlando-Vacation-Rentals.d178294.Travel-Guide-VacationRentals)[Flights to Orlando](https://expedia.ca/Cheap-Flights-To-Orlando.d178294.Travel-Guide-Flights)[Things to do in Orlando](https://expedia.ca/Things-To-Do-In-Orlando.d178294.Travel-Guide-Activities)[Lake Nona Medical City Car Rentals](https://expedia.ca/Car-Rentals-In-Lake-Nona-Medical-City.d6197057.Car-Rental-Guide)[Lake Nona Medical City Vacations](https://expedia.ca/Lake-Nona-Medical-City.d6197057.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by SPM Resorts in Lake Nona Medical City ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 23 - Oct 24](https://www.expedia.ca/Hotel-Search?regionId=6197057&startDate=2025-10-23&endDate=2025-10-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 24 - Oct 25](https://www.expedia.ca/Hotel-Search?regionId=6197057&startDate=2025-10-24&endDate=2025-10-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6197057&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6197057&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Lake Nona Medical City SPM Resorts Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLake-Nona-Medical-City-Orlando-Hotels-SPM-Resorts.0-n6197057-0--bSPMResorts.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLake-Nona-Medical-City-Orlando-Hotels-SPM-Resorts.0-n6197057-0--bSPMResorts.Travel-Guide-Filter-Hotels) ## Top Lake Nona Medical City Hotel Reviews ![Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando](//images.trvl-media.com/lodging/1000000/30000/23200/23110/ade3b60d_y.jpg) ### Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando 10/10 Excellent "Always a great property to stay at. Been going since i was a toddler and back at 44 for another amazing stay. " [](https://expedia.ca/Orlando-Hotels-Sheraton-Vistana-Resort-Villas.h23110.Hotel-Information) ![Marriott's Grande Vista](//images.trvl-media.com/lodging/1000000/860000/853600/853519/77708f65_y.jpg) ### Marriott's Grande Vista 10/10 Excellent "Overall the stay was great, the resort was secluded so no traffic noise, nights by the pool were beautiful and the staff was very accommodating! Room was very clean and we had everything we would need for our stay!" [](https://expedia.ca/Orlando-Hotels-Marriotts-Grande-Vista.h853519.Hotel-Information) ![Sheraton Vistana Villages Resort Villas, I-Drive/Orlando](//images.trvl-media.com/lodging/1000000/540000/539500/539487/88f9edce_y.jpg) ### Sheraton Vistana Villages Resort Villas, I-Drive/Orlando 10/10 Excellent "Very nice place for families. " [](https://expedia.ca/Orlando-Hotels-Sheraton-Vistana-Villages-Resort-Villas.h539487.Hotel-Information) ![Residence Inn by Marriott Orlando Lake Buena Vista](//images.trvl-media.com/lodging/1000000/610000/602900/602872/cb4bb51d_y.jpg) ### Residence Inn by Marriott Orlando Lake Buena Vista 10/10 Excellent "Great hotel! We will be back. Amen & Pedro made our stay really nice. We also got upgraded to a two bedroom suite. " [](https://expedia.ca/Orlando-Hotels-Residence-Inn-By-Marriott-Orlando-Lake-Buena-Vista.h602872.Hotel-Information) ![DoubleTree by Hilton Orlando Airport](//images.trvl-media.com/lodging/1000000/20000/12300/12270/5d85f82f_y.jpg) ### DoubleTree by Hilton Orlando Airport 10/10 Excellent "The staff were amazing! " [](https://expedia.ca/Orlando-Hotels-DoubleTree-By-Hilton-Orlando-Airport.h12270.Hotel-Information) ![CoCo Key Hotel and Water Resort ](//images.trvl-media.com/lodging/1000000/10000/300/228/73a42af2_y.jpg) ### CoCo Key Hotel and Water Resort  10/10 Excellent "Excellent" [](https://expedia.ca/Orlando-Hotels-CoCo-Key-Hotel-And-Water-Resort-Orlando.h228.Hotel-Information)  ![Universal's Endless Summer Resort - Dockside Inn and Suites](//images.trvl-media.com/lodging/34000000/33780000/33770400/33770341/c8859517_y.jpg) ### Universal's Endless Summer Resort - Dockside Inn and Suites 10/10 Excellent "El cuarto lo limpiaban, pero es algo como por encima para salir del paso." [](https://expedia.ca/Orlando-Hotels-Universals-Endless-Summer-Dockside-Inn-Suites.h33770341.Hotel-Information) ![Universal's Cabana Bay Beach Resort](//images.trvl-media.com/lodging/6000000/5970000/5963300/5963292/63940f45_y.jpg) ### Universal's Cabana Bay Beach Resort 10/10 Excellent "I had a beautiful view volcano bay from my hotel room and there was beautiful pool with a little restaurant by the pool" [](https://expedia.ca/Orlando-Hotels-Universals-Cabana-Bay-Beach-Resort.h5963292.Hotel-Information) ![Avanti International Resort](//images.trvl-media.com/lodging/1000000/10000/3900/3832/b0f81967_y.jpg) ### Avanti International Resort 10/10 Excellent "The theme park shuttle was extremely helpful!! " [](https://expedia.ca/Orlando-Hotels-Avanti-International-Resort.h3832.Hotel-Information) ## Find out more about Lake Nona Medical City ## Lake Nona Medical City Hotels Guide Expedia.ca offers a selection of 27479 hotels in Lake Nona Medical City. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Lake Nona Medical City. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Lake Nona Medical City neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Lake Nona Medical City, Orlando now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [5 Star Hotels in Lake Nona](https://www.expedia.ca/5Star-Lake-Nona-Orlando-Hotels.s50-n6209488-0.Travel-Guide-Filter-Hotels) - [Hotels near Austin-Tindall Regional Park](https://www.expedia.ca/Austin-Tindall-Regional-Park-Hotels.0-l553248635961253122-0.Travel-Guide-Filter-Hotels) - [Hotels near David Leadbetter Golf Academy](https://www.expedia.ca/David-Leadbetter-Golf-Academy-Hotels.0-l553248621532654245-0.Travel-Guide-Filter-Hotels) - [Hotels near Eagle Creek Golf Club](https://www.expedia.ca/Eagle-Creek-Golf-Club-Hotels.0-l6128540-0.Travel-Guide-Filter-Hotels) - [Drury Inn & Suites Hotels in Historic Downtown Kissimmee](https://www.expedia.ca/Historic-Downtown-Kissimmee-Orlando-Hotels-Drury-Inn-Suites.0-n800089-0--bDruryInnSuites.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Historic Downtown Kissimmee](https://www.expedia.ca/Historic-Downtown-Kissimmee-Orlando-Hotels-La-Quinta-Inn-Suites.0-n800089-0--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - 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[Flights to Orlando](https://www.expedia.ca/Cheap-Flights-To-Orlando.d178294.Travel-Guide-Flights) - [Flights from Orlando Intl.](https://www.expedia.ca/lp/airports/mco/flights-from-orlando-intl-airport) - [Flights from Bangor (BGR) to Orlando (MCO)](https://www.expedia.ca/lp/flights/bgr/mco/bangor-to-orlando) - [Flights from Buffalo (BUF) to Orlando (MCO)](https://www.expedia.ca/lp/flights/buf/mco/buffalo-to-orlando) - [Flights from Detroit (DTW) to Orlando (MCO)](https://www.expedia.ca/lp/flights/dtw/mco/detroit-to-orlando) - [Flights from Miami (MIA) to Orlando (MCO)](https://www.expedia.ca/lp/flights/mia/mco/miami-to-orlando) - [Flights from Syracuse (SYR) to Orlando (MCO)](https://www.expedia.ca/lp/flights/syr/mco/syracuse-to-orlando) - [Flights from Edmonton (YEG) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yeg/mco/edmonton-to-orlando) - [Flights from Hamilton (YHM) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yhm/mco/hamilton-to-orlando) - [Flights from Halifax (YHZ) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yhz/mco/halifax-to-orlando) - 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[Flights from Toronto (YYZ) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yyz/mco/toronto-to-orlando) - [Austin-Tindall Regional Park](https://www.expedia.ca/Austin-Tindall-Regional-Park-Orlando.d553248635961253122.Vacation-Attraction) - [Nemours Children's Hospital](https://www.expedia.ca/Nemours-Childrens-Hospital-Lake-Nona.d6154167.Vacation-Attraction) - [Visit Lake Hart](https://www.expedia.ca/Orlando-Lake-Hart.dx6360982) - [Visit Lake Nona](https://www.expedia.ca/Orlando-Lake-Nona.dx6209488) - [Walt Disney World® Resort](https://www.expedia.ca/Walt-Disney-World-Resort-Orlando.d6034120.Vacation-Attraction) - [Car rentals near Lake Nona](https://www.expedia.ca/Car-Rentals-In-Lake-Nona.d6209488.Car-Rental-Guide) - [Rental cars Orlando Intl. airport](https://www.expedia.ca/Car-Rentals-In-Orlando-Intl.d5194573.Car-Rental-Guide) - [Car rentals near Orlando](https://www.expedia.ca/Car-Rentals-In-Orlando.d178294.Car-Rental-Guide) - [Enterprise Rental Cars in Lake Nona](https://www.expedia.ca/Enterprise-Car-Rentals-In-Lake-Nona.d6209488-c15.Car-Rental-Guide-Suppliers) - 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