Title: Hotels by Red Roof Inn in Lake Nona Medical City from CA $72 | Expedia.ca [Lake Nona Medical City Travel Guide](https://expedia.ca/Orlando-Lake-Nona-Medical-City.dx6197057)[Vacation Rentals in Orlando](https://expedia.ca/Orlando-Vacation-Rentals.d178294.Travel-Guide-VacationRentals)[Flights to Orlando](https://expedia.ca/Cheap-Flights-To-Orlando.d178294.Travel-Guide-Flights)[Things to do in Orlando](https://expedia.ca/Things-To-Do-In-Orlando.d178294.Travel-Guide-Activities)[Lake Nona Medical City Car Rentals](https://expedia.ca/Car-Rentals-In-Lake-Nona-Medical-City.d6197057.Car-Rental-Guide)[Lake Nona Medical City Vacations](https://expedia.ca/Lake-Nona-Medical-City.d6197057.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Red Roof Inn in Lake Nona Medical City from CA $72 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Nov 27 - Nov 28](https://www.expedia.ca/Hotel-Search?regionId=6197057&startDate=2025-11-27&endDate=2025-11-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 28 - Nov 29](https://www.expedia.ca/Hotel-Search?regionId=6197057&startDate=2025-11-28&endDate=2025-11-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=6197057&startDate=2025-11-28&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6197057&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Lake Nona Medical City Red Roof Inn Hotels ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25900/25801/ac68a583.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/25900/25801/9fa1ec23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/30000/25900/25801/475a0026.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/30000/25900/25801/386ace9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Orlando South - Florida Mall Orlando 6.6/10 (1005) "The parking was only food factor." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anthony CA $64 CA $72 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Orlando-Hotels-Red-Roof-Inn-Orlando-South-Florida-Mall.h25801.Hotel-Information) ![Vending machine](https://images.trvl-media.com/lodging/1000000/70000/63300/63234/c5b0ff0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, 1 King Bed, Non Smoking, Kitchenette](https://images.trvl-media.com/lodging/1000000/70000/63300/63234/c8ef43a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/63300/63234/37b79a96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/70000/63300/63234/2476a351.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Kissimmee Kissimmee 7.8/10 Good (239) "Everything was amazing. Beautiful room, friendly staff very helpful. The whole stay was great. From now on this is the only place we will stay, Thank you" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paula CA $81 CA $92 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/Orlando-Hotels-Red-Roof-Inn-Kissimmee.h63234.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-11&endDate=2025-12-12®ionId=6197057&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLake-Nona-Medical-City-Orlando-Hotels-Red-Roof-Inn.0-n6197057-0--bRedRoofInn.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLake-Nona-Medical-City-Orlando-Hotels-Red-Roof-Inn.0-n6197057-0--bRedRoofInn.Travel-Guide-Filter-Hotels) ## Top Lake Nona Medical City Hotel Reviews ![Tru By Hilton Orlando Convention Center Area, FL](https://images.trvl-media.com/lodging/48000000/47050000/47041400/47041344/a264c3e2_y.jpg) ### Tru By Hilton Orlando Convention Center Area, FL 10/10 Excellent "Clean rooms, breakfast, fast service " [](https://expedia.ca/Orlando-Hotels-Tru-By-Hilton-Orlando-Convention-Center-Area.h47041344.Hotel-Information) ![Hyatt Regency Orlando](https://images.trvl-media.com/lodging/1000000/10000/9600/9574/1bb0a2ac_y.jpg) ### Hyatt Regency Orlando 10/10 Excellent "the room was very clean, safe walkable area. Descend 21 is quite overpriced but expected for hotel restaurant. " [](https://expedia.ca/Orlando-Hotels-Hyatt-Regency-Orlando.h9574.Hotel-Information) ![Holiday Inn Resort Orlando - Lake Buena Vista by IHG](https://images.trvl-media.com/lodging/1000000/20000/19600/19535/aa564e7f_y.jpg) ### Holiday Inn Resort Orlando - Lake Buena Vista by IHG 10/10 Excellent "This was a surprisingly excellent stay. The bus transportation we could not use because of the hours were off so we used uber. Close to Disney. After a long day at the park the two hot tubs were awesome. Beds comfy. Applebees attached to the hotel was very convenient. Will stay at this hotel again for sure. " [](https://expedia.ca/Orlando-Hotels-Holiday-Inn-Resort-Orlando-Lake-Buena-Vista.h19535.Hotel-Information) ![Rosen Inn Lake Buena Vista](https://images.trvl-media.com/lodging/1000000/10000/1300/1264/2a9be677_y.jpg) ### Rosen Inn Lake Buena Vista 10/10 Excellent "The staff was very helpful! We enjoyed the room we stayed in!" [](https://expedia.ca/Orlando-Hotels-Rosen-Inn-Lake-Buena-Vista.h1264.Hotel-Information) ![Hilton Orlando Lake Buena Vista - Disney Springs® Area](https://images.trvl-media.com/lodging/1000000/20000/11700/11652/0a79f404_y.jpg) ### Hilton Orlando Lake Buena Vista - Disney Springs® Area 10/10 Excellent "I gave it a nine because I did not even see the bkfst reasturant until da going home. We are bkfst out if mkt place. It was good. " [](https://expedia.ca/Orlando-Hotels-Hilton-Orlando-Lake-Buena-Vista-Disney-Springs-Area.h11652.Hotel-Information) ![CoCo Key Hotel and Water Resort ](https://images.trvl-media.com/lodging/1000000/10000/300/228/73a42af2_y.jpg) ### CoCo Key Hotel and Water Resort  10/10 Excellent "The room was clean and the staff were wonderful. However what made this resort excellent are the amenities offered. The pool area was ideal for celebrating my daughter’s 6th birthday. She had a blast and she so happy therefore I was ecstatic. Loved this resort and I will be back and tell others about it! Thank you 😍" [](https://expedia.ca/Orlando-Hotels-CoCo-Key-Hotel-And-Water-Resort-Orlando.h228.Hotel-Information)  ![DoubleTree by Hilton Hotel Orlando at SeaWorld](https://images.trvl-media.com/lodging/1000000/20000/18900/18874/69019073_y.jpg) ### DoubleTree by Hilton Hotel Orlando at SeaWorld 10/10 Excellent "Clean and staff very nice " [](https://expedia.ca/Orlando-Hotels-DoubleTree-By-Hilton-Hotel-Orlando-At-SeaWorld.h18874.Hotel-Information) ![DoubleTree by Hilton at the Entrance to Universal Orlando](https://images.trvl-media.com/lodging/1000000/10000/5400/5398/4997b5df_y.jpg) ### DoubleTree by Hilton at the Entrance to Universal Orlando 10/10 Excellent "Yes" [](https://expedia.ca/Orlando-Hotels-DoubleTree-By-Hilton-At-The-Entrance-To-Universal-Orlando.h5398.Hotel-Information) ![Sheraton Vistana Villages Resort Villas, I-Drive/Orlando](https://images.trvl-media.com/lodging/1000000/540000/539500/539487/88f9edce_y.jpg) ### Sheraton Vistana Villages Resort Villas, I-Drive/Orlando 10/10 Excellent "Rooms was very clean and comfortable. Very quiet! The staff was polite. " [](https://expedia.ca/Orlando-Hotels-Sheraton-Vistana-Villages-Resort-Villas.h539487.Hotel-Information) ## Find out more about Lake Nona Medical City ## Lake Nona Medical City Hotels Guide Expedia.ca offers a selection of 27681 hotels in Lake Nona Medical City. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Lake Nona Medical City. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Lake Nona Medical City neighborhood you prefer. Go ahead. 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[Flights to Orlando](https://www.expedia.ca/Cheap-Flights-To-Orlando.d178294.Travel-Guide-Flights) - [Flights from Orlando Intl.](https://www.expedia.ca/lp/airports/mco/flights-from-orlando-intl-airport) - [Flights from Bangor (BGR) to Orlando (MCO)](https://www.expedia.ca/lp/flights/bgr/mco/bangor-to-orlando) - [Flights from Buffalo (BUF) to Orlando (MCO)](https://www.expedia.ca/lp/flights/buf/mco/buffalo-to-orlando) - [Flights from Detroit (DTW) to Orlando (MCO)](https://www.expedia.ca/lp/flights/dtw/mco/detroit-to-orlando) - [Flights from Miami (MIA) to Orlando (MCO)](https://www.expedia.ca/lp/flights/mia/mco/miami-to-orlando) - [Flights from Syracuse (SYR) to Orlando (MCO)](https://www.expedia.ca/lp/flights/syr/mco/syracuse-to-orlando) - [Flights from Edmonton (YEG) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yeg/mco/edmonton-to-orlando) - [Flights from Hamilton (YHM) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yhm/mco/hamilton-to-orlando) - [Flights from Halifax (YHZ) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yhz/mco/halifax-to-orlando) - [Flights from Kitchener (YKF) to Orlando (MCO)](https://www.expedia.ca/lp/flights/ykf/mco/kitchener-to-orlando) - [Flights from Ottawa (YOW) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yow/mco/ottawa-to-orlando) - [Flights from Windsor (YQG) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yqg/mco/windsor-to-orlando) - [Flights from Moncton (YQM) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yqm/mco/moncton-to-orlando) - [Flights from Montreal (YUL) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yul/mco/montreal-to-orlando) - [Flights from Vancouver (YVR) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yvr/mco/vancouver-to-orlando) - [Flights from Winnipeg (YWG) to Orlando (MCO)](https://www.expedia.ca/lp/flights/ywg/mco/winnipeg-to-orlando) - [Flights from London (YXU) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yxu/mco/london-to-orlando) - [Flights from Calgary (YYC) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yyc/mco/calgary-to-orlando) - [Flights from St. John's (YYT) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yyt/mco/st-johns-to-orlando) - [Flights from Toronto (YYZ) to Orlando (MCO)](https://www.expedia.ca/lp/flights/yyz/mco/toronto-to-orlando) - [Austin-Tindall Regional Park](https://www.expedia.ca/Austin-Tindall-Regional-Park-Orlando.d553248635961253122.Vacation-Attraction) - [Nemours Children's Hospital](https://www.expedia.ca/Nemours-Childrens-Hospital-Lake-Nona.d6154167.Vacation-Attraction) - [Visit Lake Hart](https://www.expedia.ca/Orlando-Lake-Hart.dx6360982) - [Visit Lake Nona](https://www.expedia.ca/Orlando-Lake-Nona.dx6209488) - [Walt Disney World® Resort](https://www.expedia.ca/Walt-Disney-World-Resort-Orlando.d6034120.Vacation-Attraction) - [Car rentals near Lake Nona](https://www.expedia.ca/Car-Rentals-In-Lake-Nona.d6209488.Car-Rental-Guide) - [Rental cars Orlando Intl. airport](https://www.expedia.ca/Car-Rentals-In-Orlando-Intl.d5194573.Car-Rental-Guide) - [Car rentals near Orlando](https://www.expedia.ca/Car-Rentals-In-Orlando.d178294.Car-Rental-Guide) - [Enterprise Rental Cars in Lake Nona](https://www.expedia.ca/Enterprise-Car-Rentals-In-Lake-Nona.d6209488-c15.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Lake Nona](https://www.expedia.ca/Hertz-Car-Rentals-In-Lake-Nona.d6209488-c40.Car-Rental-Guide-Suppliers) - [United Rental Cars in Southeast Orlando](https://www.expedia.ca/United-Car-Rentals-In-Southeast-Orlando.d553248635976478881-c1088.Car-Rental-Guide-Suppliers) - [Zezgo Rental Cars in Southeast Orlando](https://www.expedia.ca/ZezGo-Car-Rentals-In-Southeast-Orlando.d553248635976478881-c1122.Car-Rental-Guide-Suppliers) - [Book Hotels in Lake Nona Medical City on Expedia.com](https://www.expedia.com/Lake-Nona-Medical-City-Orlando-Hotels-Red-Roof-Inn.0-n6197057-0--bRedRoofInn.Travel-Guide-Filter-Hotels)