Lake City Vacation Rentals

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Our top choices for Lake City vacation rentals

Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.

Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.
Florence
8.8 out of 10, Excellent, (3 reviews)
"Convenient location"
United States
Bonney W.
The price is CA $168
CA $650 total
includes taxes & fees
Feb 11 - Feb 12
Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.

Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.
Florence
9.8 out of 10, Exceptional, (42 reviews)
"Everything was great!"
United States
Debra B.
The price is CA $183
CA $319 total
includes taxes & fees
Feb 16 - Feb 17
Walking distance from one of South Carolina's top Medical centers.

Creekside Country Cottage- minutes away from I-95

Creekside Country Cottage- minutes away from I-95
Manning
10.0 out of 10, Exceptional, (9 reviews)
"Great place beautiful and the dogs loved it"
United States
Jennifer T.
The price is CA $308
CA $597 total
includes taxes & fees
Feb 11 - Feb 12
Creekside Country Cottage- minutes away from I-95

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
Florence
10.0 out of 10, Exceptional, (44 reviews)
"I would definitely stay again! Great location."
United States
LaDara D.
The price is CA $309
CA $394 total
includes taxes & fees
Feb 15 - Feb 16
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Lake City Hotel Reviews

Find out more about Lake City

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Lake City. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Frequently asked questions

Can I find a vacation rental in Lake City?

Yes, we offer vacation rentals in Lake City near Moore Farms Botanical Garden, or you can choose a secluded option if you want a relaxing stay. Visitors to Lake City speak positively about the lakeside and restaurants in this destination. Make sure you have time to check out the shopping and parks during your trip.

What are some of the best vacation rentals that Lake City has to offer?

Walking distance from one of South Carolina's top Medical centers.: This vacation home rental outside of Lake City offers a garden, a selection of games, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

What can I see and do in Lake City?

Moore Farms Botanical Garden and Ronald E. McNair Life History Center are a couple of lovely local spots to get outside and enjoy nature. The Country Club at Lake City and Lions Park are other places to visit while you're in town.

What are vacation rentals like in Lake City?

Vacation rentals are private properties you can stay in for a couple days or more in Lake City. Vacation rentals feature amenities such as WiFi and washers and dryers so your stay will be comfortable. If you're concerned about a clean environment, vacation rentals can offer a sense of seclusion away from public hotel elevators and bustling concierge desks while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a great choice for family trips or small group gatherings.