Title: La Mesilla Vacation Home Rentals from CA $325: Search Top Private Vacation Homes for Rent | Expedia.ca [Hotels in La Mesilla](https://expedia.ca/La-Mesilla-Hotels.d553248635975872198.Travel-Guide-Hotels)[Vacation Rentals in La Mesilla](https://expedia.ca/La-Mesilla-Vacation-Rentals.d553248635975872198.Travel-Guide-VacationRentals)[La Mesilla Car Rentals](https://expedia.ca/Car-Rentals-In-La-Mesilla.d553248635975872198.Car-Rental-Guide)[La Mesilla Vacation Packages](https://expedia.ca/La-Mesilla.d553248635975872198.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # La Mesilla Vacation Rentals - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248635975872198&startDate=2025-11-07&endDate=2025-11-09&adults=2&lodging=VACATION_HOME&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=553248635975872198&startDate=2025-11-14&endDate=2025-11-16&adults=2&lodging=VACATION_HOME&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=553248635975872198&startDate=2025-11-28&endDate=2025-11-30&adults=2&lodging=VACATION_HOME&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248635975872198&startDate=2025-12-26&endDate=2025-12-28&adults=2&lodging=VACATION_HOME&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Browse Select La Mesilla Vacation Homes ![Interior](https://images.trvl-media.com/lodging/120000000/119610000/119601500/119601479/9f79b5a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/120000000/119610000/119601500/119601479/06a960f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/120000000/119610000/119601500/119601479/b0603c2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/120000000/119610000/119601500/119601479/e6ae35e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Centrally-located, sweeping mountain views! Española 10/10 Exceptional (5) CA $189 CA $325 total includes taxes & fees Nov 4 - Nov 5 [](https://www.expedia.ca/Espanola-Hotels-Centrally-Located-Home-In-Beautiful.h119601479.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/106000000/105460000/105453000/105452958/ebc4230c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/106000000/105460000/105453000/105452958/8137c1aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/106000000/105460000/105453000/105452958/a1d216cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/106000000/105460000/105453000/105452958/3de8ebc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Happy Ram: Views! Beautiful. Peaceful. Upscale. Secluded. Tesuque 10/10 Exceptional (19) "House was clean and in a beautiful area. Would definitely stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shelly A. CA $326 CA $575 total includes taxes & fees Dec 3 - Dec 4 [](https://www.expedia.ca/Santa-Fe-Hotels-Views-Beautiful-Peaceful-Upscale-Secluded-Santa-Fe-Plaza-14-Minutes.h105452958.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-17&endDate=2025-11-18®ionId=553248635975872198&adults=2&lodging=VACATION_HOME&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLa-Mesilla-Private-Vacation-Homes.d553248635975872198-aaPrivateVacationHomes.Travel-Guide-Accommodation)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLa-Mesilla-Private-Vacation-Homes.d553248635975872198-aaPrivateVacationHomes.Travel-Guide-Accommodation) ## Top La Mesilla Hotel Reviews ![Hilton Santa Fe Buffalo Thunder](//images.trvl-media.com/lodging/3000000/2060000/2059000/2058957/c6ba74ab_y.jpg) ### Hilton Santa Fe Buffalo Thunder 10/10 Excellent "Absolutely Stunning! " [](https://expedia.ca/Santa-Fe-Hotels-Hilton-Santa-Fe-Buffalo-Thunder.h2058957.Hotel-Information) ![Homewood Suites by Hilton Santa Fe-North](//images.trvl-media.com/lodging/2000000/1190000/1184600/1184592/97badd85_y.jpg) ### Homewood Suites by Hilton Santa Fe-North 10/10 Excellent "Very clean rooms! Quite! No complaints!" [](https://expedia.ca/Santa-Fe-Hotels-Homewood-Suites-By-Hilton-Santa-Fe-North.h1184592.Hotel-Information) ![Bishop's Lodge, Auberge Collection](//images.trvl-media.com/lodging/1000000/50000/40800/40737/dc73db0b_y.jpg) ### Bishop's Lodge, Auberge Collection 10/10 Excellent "The Best service we have received in any of our travels- fabulous!!!! " [](https://expedia.ca/Santa-Fe-Hotels-Bishops-Lodge.h40737.Hotel-Information) ![The Inn at the Delta](//images.trvl-media.com/lodging/2000000/1590000/1581300/1581298/a0789287_y.jpg) ### The Inn at the Delta 10/10 Excellent "Charming place to stay. The parking lot could use some work." [](https://expedia.ca/Santa-Fe-Hotels-The-Inn-At-The-Delta.h1581298.Hotel-Information) ![Hampton Inn & Suites Los Alamos White Rock](//images.trvl-media.com/lodging/1000000/910000/908700/908632/4901e7b8_y.jpg) ### Hampton Inn & Suites Los Alamos White Rock 10/10 Excellent "Clean" [](https://expedia.ca/Santa-Fe-Hotels-Hampton-Inn-Suites-Los-Alamos-White-Rock.h908632.Hotel-Information) ![Holiday Inn Express & Suites Los Alamos Entrada Park by IHG](//images.trvl-media.com/lodging/3000000/2980000/2976500/2976403/65b278ef_y.jpg) ### Holiday Inn Express & Suites Los Alamos Entrada Park by IHG 10/10 Excellent "Clean large room. " [](https://expedia.ca/Santa-Fe-Hotels-Holiday-Inn-Express-Hotel-Suites-Los-Alamos.h2976403.Hotel-Information) ![Hotel Glorieta](//images.trvl-media.com/lodging/1000000/10000/3200/3139/951776db_y.jpg) ### Hotel Glorieta 10/10 Excellent "Recently updated. Bed is very comfortable." [](https://expedia.ca/Santa-Fe-Hotels-Hotel-Glorieta.h3139.Hotel-Information) ![Casa Escondida Bed & Breakfast](//images.trvl-media.com/lodging/1000000/530000/521400/521375/a25f16f6_y.jpg) ### Casa Escondida Bed & Breakfast 10/10 Excellent "This was our first Bed & Breakfast and let me tell you it did not disappoint. We cannot say enough great things about our experience. The staff was kind and had great suggestions on what to do while in town. The food was excellent, the property was quaint and full of character. We cannot wait to come back and visit. " [](https://expedia.ca/Santa-Fe-Hotels-Casa-Escondida-Bed-Breakfast.h521375.Hotel-Information) ![Cities Of Gold Casino](//images.trvl-media.com/lodging/1000000/130000/120800/120761/4dd42a18_y.jpg) ### Cities Of Gold Casino 10/10 Excellent "Room was very clean, staff was friendly and helpful, didn't go to the casino. In the morn, no coffee. Pots were empty." [](https://expedia.ca/Santa-Fe-Hotels-Cities-Of-Gold-Casino.h120761.Hotel-Information) ## Find out more about La Mesilla ## La Mesilla Vacation Homes information | Number of reviews | 22 | | --- | --- | | Accommodation | 129 Vacation Homes | | Lowest Price | CA $325 | | Highest Price | CA $575 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [5 Star Hotels in El Valle de Arroyo Seco](https://www.expedia.ca/5Star-El-Valle-De-Arroyo-Seco-Hotels.s50-0-d553248634983124254.Travel-Guide-Filter-Hotels) - [Alcalde Hotels](https://www.expedia.ca/Alcalde-Hotels.d3000421609.Travel-Guide-Hotels) - [B&B in Chimayo](https://www.expedia.ca/Chimayo-Bed-And-Breakfast.d89282-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Chimayo Hotels](https://www.expedia.ca/Chimayo-Hotels.d89282.Travel-Guide-Hotels) - [Townhomes in Chimayo](https://www.expedia.ca/Chimayo-Townhomes.d89282-aaTownhomes.Travel-Guide-Accommodation) - [Apartments in El Rancho](https://www.expedia.ca/El-Rancho-Apartments.d553248634983116795-aaApartments.Travel-Guide-Accommodation) - 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