Title: Book the Best La Mesilla LUXURY Hotels - Upscale Hotels in La Mesilla, NM | Expedia.ca [Hotels in La Mesilla](https://expedia.ca/La-Mesilla-Hotels.d553248635975872198.Travel-Guide-Hotels)[Vacation Rentals in La Mesilla](https://expedia.ca/La-Mesilla-Vacation-Rentals.d553248635975872198.Travel-Guide-VacationRentals)[La Mesilla Car Rentals](https://expedia.ca/Car-Rentals-In-La-Mesilla.d553248635975872198.Car-Rental-Guide)[La Mesilla Vacation Packages](https://expedia.ca/La-Mesilla.d553248635975872198.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/luxury.jpeg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/luxury.jpeg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on La Mesilla Luxury Hotels Tonight [Jan 26 - Jan 27](https://www.expedia.ca/Hotel-Search?regionId=553248635975872198&startDate=2026-01-26&endDate=2026-01-27&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Jan 27 - Jan 28](https://www.expedia.ca/Hotel-Search?regionId=553248635975872198&startDate=2026-01-27&endDate=2026-01-28&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248635975872198&startDate=2026-01-30&endDate=2026-02-01&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248635975872198&startDate=2026-02-06&endDate=2026-02-08&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for La Mesilla luxury hotels ![Indoor pool, seasonal outdoor pool, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/3000000/2060000/2059000/2058957/8424680e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed](https://images.trvl-media.com/lodging/3000000/2060000/2059000/2058957/2bd32ee5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/3000000/2060000/2059000/2058957/a175ea0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2060000/2059000/2058957/866cf9af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Santa Fe Buffalo Thunder [](https://www.expedia.ca/Santa-Fe-Hotels-Hilton-Santa-Fe-Buffalo-Thunder.h2058957.Hotel-Information) Santa Fe 8.8/10 Excellent (1,005 reviews) "It was clean and during the time we stayed it was really affordable. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sabrina CA $149 CA $171 total includes taxes & fees Feb 11 - Feb 12 [](https://www.expedia.ca/Santa-Fe-Hotels-Hilton-Santa-Fe-Buffalo-Thunder.h2058957.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/50000/40800/40731/31eee379.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 9:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/50000/40800/40731/7f6e9855.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, body treatments, hot stone massages](https://images.trvl-media.com/lodging/1000000/50000/40800/40731/459f0ba7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, garden views ](https://images.trvl-media.com/lodging/1000000/50000/40800/40731/76b8c646.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Resort Rancho Encantado Santa Fe [](https://www.expedia.ca/Santa-Fe-Hotels-Four-Seasons-Resort-Rancho-Encantado-Santa-Fe.h40731.Hotel-Information) Santa Fe 9.4/10 Exceptional (268 reviews) "Great service and property " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sharmin CA $671 CA $839 total includes taxes & fees Feb 25 - Feb 26 [](https://www.expedia.ca/Santa-Fe-Hotels-Four-Seasons-Resort-Rancho-Encantado-Santa-Fe.h40731.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40800/40737/4b0bf4d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40800/40737/dc73db0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Bunkhouse)](https://images.trvl-media.com/lodging/1000000/50000/40800/40737/ff2c1212.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite (Kiva) | View from room](https://images.trvl-media.com/lodging/1000000/50000/40800/40737/fa4f6dac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bishop's Lodge, Auberge Collection [](https://www.expedia.ca/Santa-Fe-Hotels-Bishops-Lodge.h40737.Hotel-Information) Tesuque 9.4/10 Exceptional (97 reviews) "Everyone was so kind and attentive and the rooms and grounds were so beautiful and clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Liza [](https://www.expedia.ca/Santa-Fe-Hotels-Bishops-Lodge.h40737.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-10&endDate=2026-02-11®ionId=553248635975872198&adults=2&sort=LUXURY&star=40,50&openPlayBack=true) ## Top La Mesilla Hotel Reviews ![The Inn at the Delta](https://images.trvl-media.com/lodging/2000000/1590000/1581300/1581298/a0789287_y.jpg) ### The Inn at the Delta 10/10 Excellent "Staff friendly and helpful." [](https://expedia.ca/Santa-Fe-Hotels-The-Inn-At-The-Delta.h1581298.Hotel-Information) ![Homewood Suites by Hilton Santa Fe-North](https://images.trvl-media.com/lodging/2000000/1190000/1184600/1184592/97badd85_y.jpg) ### Homewood Suites by Hilton Santa Fe-North 10/10 Excellent "Beautiful room" [](https://expedia.ca/Santa-Fe-Hotels-Homewood-Suites-By-Hilton-Santa-Fe-North.h1184592.Hotel-Information) ![Cities Of Gold Casino](https://images.trvl-media.com/lodging/1000000/130000/120800/120761/4dd42a18_y.jpg) ### Cities Of Gold Casino 10/10 Excellent "Room was comfortable. No noises. Will stay here again " [](https://expedia.ca/Santa-Fe-Hotels-Cities-Of-Gold-Casino.h120761.Hotel-Information) ![Hilton Santa Fe Buffalo Thunder](https://images.trvl-media.com/lodging/3000000/2060000/2059000/2058957/c6ba74ab_y.jpg) ### Hilton Santa Fe Buffalo Thunder 10/10 Excellent "Room was excellent. Staff at restaurants were all fabulous " [](https://expedia.ca/Santa-Fe-Hotels-Hilton-Santa-Fe-Buffalo-Thunder.h2058957.Hotel-Information) ![Hotel Glorieta](https://images.trvl-media.com/lodging/1000000/10000/3200/3139/912a4f46_y.jpg) ### Hotel Glorieta 10/10 Excellent "Wonderful 👍. Thank you " [](https://expedia.ca/Santa-Fe-Hotels-Hotel-Glorieta.h3139.Hotel-Information) ![Bishop's Lodge, Auberge Collection](https://images.trvl-media.com/lodging/1000000/50000/40800/40737/dc73db0b_y.jpg) ### Bishop's Lodge, Auberge Collection 10/10 Excellent "Great place, going back this year " [](https://expedia.ca/Santa-Fe-Hotels-Bishops-Lodge.h40737.Hotel-Information) ![Four Seasons Resort Rancho Encantado Santa Fe](https://images.trvl-media.com/lodging/1000000/50000/40800/40731/eb9982cf_y.jpg) ### Four Seasons Resort Rancho Encantado Santa Fe 10/10 Excellent "Great service and property " [](https://expedia.ca/Santa-Fe-Hotels-Four-Seasons-Resort-Rancho-Encantado-Santa-Fe.h40731.Hotel-Information) ![Days Inn by Wyndham Espanola](https://images.trvl-media.com/lodging/1000000/20000/19700/19678/c2604840_y.jpg) ### Days Inn by Wyndham Espanola 10/10 Excellent "Breakfast very limited" [](https://expedia.ca/Santa-Fe-Hotels-Days-Inn-By-Wyndham-Espanola.h19678.Hotel-Information) ## Frequently asked questions ### Which area of La Mesilla is best to stay in for luxury hotels? > This area is centred around the historic Mesilla Plaza, a well-preserved square surrounded by adobe buildings housing art galleries, boutiques, and restaurants. It's a very walkable area where you can easily explore the local culture and history, including the Basilica of San Albino. The streets here are generally quiet, especially in the evenings, offering a relaxing atmosphere. > > > Couples looking for a refined experience will find the hotels around the Historic Plaza particularly appealing. Many establishments here offer a blend of historic charm with modern comforts, often featuring amenities like high-end fitness equipment, spa services, and fine dining restaurants within walking distance. ### How much does a luxury hotel in La Mesilla cost? ### What luxury activities and experiences are there in La Mesilla? > This neighbourhood is the heart of the village, centred around the historic Old Mesilla Plaza, a national historic landmark. You'll find charming adobe buildings housing art galleries, local shops, and restaurants, all within easy walking distance. The streets are pedestrian-friendly, making it simple to explore the local culture. > > > Couples looking for a romantic escape will find this area particularly appealing. You can enjoy strolls around the Plaza, dine at excellent local restaurants offering New Mexican cuisine, and explore unique boutiques. Many accommodations here are boutique hotels or guesthouses housed in historic buildings, offering a more intimate experience. > > > For those interested in history and local culture, staying near the Plaza offers direct access to sites like the Basilica of San Albino and the Gadsden Purchase building. ### How can I save on a luxury hotel in La Mesilla with Expedia? ### Is it cheaper to book a luxury La Mesilla hotel and flights as a package? ### Can I cancel my luxury hotel reservation on Expedia? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [5 Star Hotels in El Valle de Arroyo Seco ](https://www.expedia.ca/5Star-El-Valle-De-Arroyo-Seco-Hotels.s50-0-d553248634983124254.Travel-Guide-Filter-Hotels) - [Lake Hotels in Albuquerque ](https://www.expedia.ca/Albuquerque-Hotels-Lake-Hotels.0-0-d602663-tLakeHotels.Travel-Guide-Filter-Hotels) - [Oceanfront Hotels in Albuquerque ](https://www.expedia.ca/Albuquerque-Hotels-Oceanfront-Hotels.0-0-d602663-tOceanfrontHotels.Travel-Guide-Filter-Hotels) - 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