Title: Book the Best BUSINESS Hotels in La Mesa in 2026 | Expedia.ca [Hotels in La Mesa](https://expedia.ca/La-Mesa-Hotels.d8484.Travel-Guide-Hotels)[Vacation Rentals in La Mesa](https://expedia.ca/La-Mesa-Vacation-Rentals.d8484.Travel-Guide-VacationRentals)[Flights to La Mesa](https://expedia.ca/Cheap-Flights-To-La-Mesa.d8484.Travel-Guide-Flights)[La Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-La-Mesa.d8484.Car-Rental-Guide)[La Mesa Vacation Packages](https://expedia.ca/La-Mesa.d8484.Destination-Travel-Guides) ![View from Mount Helix, in La Mesa, near San Diego, California](https://images.trvl-media.com/place/8484/0fa3bc38-9bbb-4533-9232-a1a6e7720bc2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in La Mesa, CA from CA $136 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on La Mesa Business Hotels Tonight [Dec 12 - Dec 13](https://www.expedia.ca/Hotel-Search?regionId=8484&startDate=2025-12-12&endDate=2025-12-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=8484&startDate=2025-12-13&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=8484&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=8484&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for La Mesa business-friendly hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/aa7dcb3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/965cd455.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/bb4bfc7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/a7e21110.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus La Mesa San Diego [](https://www.expedia.ca/La-Mesa-Hotels-Best-Western-Plus-La-Mesa-San-Diego.h20454.Hotel-Information) La Mesa 8.2/10 Very good (1001) "Clean room, great breakfast, pleasant staff. It was comfortable. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vonda CA $123 CA $136 total includes taxes & fees Dec 22 - Dec 23 [](https://www.expedia.ca/La-Mesa-Hotels-Best-Western-Plus-La-Mesa-San-Diego.h20454.Hotel-Information) ![Suite, Multiple Beds, Kitchenette](https://images.trvl-media.com/lodging/1000000/30000/27000/26924/2f1c0503.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/27000/26924/53e8bbfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/27000/26924/0ae9a107.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/27000/26924/3e1b2acd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express La Mesa Near SDSU by IHG [](https://www.expedia.ca/La-Mesa-Hotels-Holiday-Inn-La-Mesa.h26924.Hotel-Information) La Mesa 8.2/10 Very good (451) "Great Stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jazmin CA $172 CA $190 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/La-Mesa-Hotels-Holiday-Inn-La-Mesa.h26924.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/f294be65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/1b688cf4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/d3b44b8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/48aa6044.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Crowne Plaza San Diego - Mission Valley by IHG [](https://www.expedia.ca/San-Diego-Hotels-Crowne-Plaza-San-Diego-Mission-Valley.h571545.Hotel-Information) Mission Valley 7.8/10 Good (1001) "Good value Nice place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John CA $122 CA $141 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/San-Diego-Hotels-Crowne-Plaza-San-Diego-Mission-Valley.h571545.Hotel-Information) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/9fc82331.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Californian cuisine, ocean views ](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/06f19e3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/2df2def5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, lobby lounge](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/ed2e1ba0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Bayfront [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Bayfront.h1871645.Hotel-Information) Downtown San Diego 8.6/10 Excellent (1857) "Enjoyed my stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brandon CA $137 CA $227 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Bayfront.h1871645.Hotel-Information) ![Standard Room, 1 King Bed, Non Smoking, Bay View](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/66a8936b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/1e0934c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/3eeea039.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The DEXTRO Little Italy, BW Premier Collection [](https://www.expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) Downtown San Diego 8.8/10 Excellent (727) "Great little boutique hotel ! Friendly staff as well" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Caroll CA $135 CA $156 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/1f4c359a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 restaurants, breakfast served](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/250333ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 restaurants, breakfast served](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/7910f1d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/91cdc1c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sycuan Casino Resort [](https://www.expedia.ca/El-Cajon-Hotels-Sycuan-Casino-Resort.h33661441.Hotel-Information) El Cajon 9.2/10 Wonderful (1630) "Nice hotel and friendly staff. Will definitely stay again ." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lorna CA $113 CA $140 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/El-Cajon-Hotels-Sycuan-Casino-Resort.h33661441.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/19000000/18360000/18350400/18350325/4aa3a53e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Californian cuisine ](https://images.trvl-media.com/lodging/19000000/18360000/18350400/18350325/23a1db86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 Bedroom, Accessible (Mobility & Hearing, Roll-in Shower) | Living area](https://images.trvl-media.com/lodging/19000000/18360000/18350400/18350325/w3840h2503x0y3-96b8613a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18360000/18350400/18350325/2515ff23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Monsaraz San Diego, Tapestry Collection by Hilton [](https://www.expedia.ca/San-Diego-Hotels-The-Monsaraz-San-Diego.h18350325.Hotel-Information) Point Loma 8.6/10 Excellent (616) "Great staff, was able to get checked in about an hour early…. Very nice property, lots of seating areas , outdoor patios …. Great Stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jude CA $175 CA $201 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/San-Diego-Hotels-The-Monsaraz-San-Diego.h18350325.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/4500/4415/036e1947.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4500/4415/7c98a26c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4500/4415/76b95bec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/10000/4500/4415/4a0531e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn San Diego/Mission Valley [](https://www.expedia.ca/San-Diego-Hotels-Hampton-Inn-San-Diego-Mission-Valley.h4415.Hotel-Information) Mission Valley 8.8/10 Excellent (1278) "Room was clean,buffet bkfast was good,staff were friendly & helpful!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Barry CA $132 CA $152 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Diego-Hotels-Hampton-Inn-San-Diego-Mission-Valley.h4415.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/27600/27516/1b87fc03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/27600/27516/2ba9fb5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/30000/27600/27516/ca66f35a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach nearby, white sand](https://images.trvl-media.com/lodging/1000000/30000/27600/27516/31f9c777.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin San Diego Bayview [](https://www.expedia.ca/San-Diego-Hotels-The-Westin-San-Diego-Downtown.h27516.Hotel-Information) Downtown San Diego 8.6/10 Excellent (1061) "I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alliyah CA $186 CA $256 total includes taxes & fees Dec 19 - Dec 20 [](https://www.expedia.ca/San-Diego-Hotels-The-Westin-San-Diego-Downtown.h27516.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/900000/898500/898447/e9d3f965.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/900000/898500/898447/29ee9bf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/900000/898500/898447/fcaa8786.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/900000/898500/898447/de4da698.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Republic San Diego, Autograph Collection [](https://www.expedia.ca/San-Diego-Hotels-Hotel-Republic-San-Diego.h898447.Hotel-Information) Downtown San Diego 9.0/10 Wonderful (1182) "Amazing stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Aaron CA $176 CA $268 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/San-Diego-Hotels-Hotel-Republic-San-Diego.h898447.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-26&endDate=2025-12-27®ionId=8484&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top La Mesa Hotel Reviews ![Best Western Plus Marina Gateway Hotel](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "Room was spotless. Staff were really nice." [](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "yes " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "Good staff" [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "Clean room great staff and amenities " [](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Breakfast was great " [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![San Diego Marriott La Jolla](https://images.trvl-media.com/lodging/1000000/10000/2100/2097/05285107_y.jpg) ### San Diego Marriott La Jolla 10/10 Excellent "Quiet and clean room! Comfortable bed! Friendly staff at check-in! It was wonderful!" [](https://expedia.ca/La-Jolla-Hotels-San-Diego-Marriott-La-Jolla.h2097.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](https://images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Magical" [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Kings Inn San Diego](https://images.trvl-media.com/lodging/1000000/20000/17000/16910/a5f26080_y.jpg) ### Kings Inn San Diego 10/10 Excellent "good" [](https://expedia.ca/San-Diego-Hotels-Kings-Inn-San-Diego-Seaworld-Zoo.h16910.Hotel-Information) ![Embassy Suites by Hilton San Diego La Jolla](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/49079311_y.jpg) ### Embassy Suites by Hilton San Diego La Jolla 10/10 Excellent "I stayed here every time we would come down here when I was younger on family trips. Now I’m back years later with my boyfriend everything was Perfect and great service all around " [](https://expedia.ca/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-La-Jolla.h8434.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in La Mesa cost? ### What are the best business-friendly hotels in La Mesa? ### How many business-friendly hotels are there in La Mesa? ### What are the best cheap business-friendly hotels in La Mesa? ### Are there any family-friendly hotels in La Mesa that are also business friendly? ### Are there any 5-star business-friendly hotels in La Mesa? ### Why book your business-friendly hotel in La Mesa with Expedia? ### How can I find cheap business-friendly hotels in La Mesa? ### What is there to do in La Mesa near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - More ways to book - [Beach Hotel Hotels in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Beach-Hotel.0-0-d6068523-tBeachHotel.Travel-Guide-Filter-Hotels) - 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