Title: Hotels by Omni in La Jolla Mesa | Expedia.ca [La Jolla Mesa Travel Guide](https://expedia.ca/La-Jolla-La-Jolla-Mesa.dx553248635976480832)[Vacation Rentals in La Jolla](https://expedia.ca/La-Jolla-Vacation-Rentals.d6126584.Travel-Guide-VacationRentals)[Flights to La Jolla](https://expedia.ca/Cheap-Flights-To-La-Jolla.d6126584.Travel-Guide-Flights)[Things to do in La Jolla](https://expedia.ca/Things-To-Do-In-La-Jolla.d6126584.Travel-Guide-Activities)[La Jolla Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-La-Jolla-Mesa.d553248635976480832.Car-Rental-Guide)[La Jolla Mesa Vacations](https://expedia.ca/La-Jolla-Mesa.d553248635976480832.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Omni in La Jolla Mesa ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 12 - Oct 13](https://www.expedia.ca/Hotel-Search?regionId=553248635976480832&startDate=2025-10-12&endDate=2025-10-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=553248635976480832&startDate=2025-10-13&endDate=2025-10-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976480832&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976480832&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top La Jolla Mesa Omni Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLa-Jolla-Mesa-La-Jolla-Hotels-Omni.0-n553248635976480832-0--bOmni.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLa-Jolla-Mesa-La-Jolla-Hotels-Omni.0-n553248635976480832-0--bOmni.Travel-Guide-Filter-Hotels) ## Top La Jolla Mesa Hotel Reviews ![Days Inn by Wyndham San Diego Hotel Circle](//images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Location, price amazing! Friendly staff" [](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](//images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "Very Convenient being a few blocks away from little italy and then the metro station was right there too!" [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![DoubleTree by Hilton San Diego - Del Mar](//images.trvl-media.com/lodging/1000000/20000/15300/15236/5afe6cec_y.jpg) ### DoubleTree by Hilton San Diego - Del Mar 10/10 Excellent "Nice staff.! " [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-San-Diego-Del-Mar.h15236.Hotel-Information) ![Palihotel San Diego Gaslamp Quarter](//images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/4480f6ef_y.jpg) ### Palihotel San Diego Gaslamp Quarter 10/10 Excellent "Staff was great location was great" [](https://expedia.ca/San-Diego-Hotels-Palihotel-San-Diego.h88398416.Hotel-Information) ![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Very clean, easy to move a lot things to do and Tourist Really love it" [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![The Sofia Hotel](//images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg) ### The Sofia Hotel 10/10 Excellent "Great location for the gaslamp" [](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Nice stay" [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Loved the location & ease of access to the city." [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Best Western Plus Marina Gateway Hotel](//images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "The soap dispenser in the shower was detached from the wall and the AC was blowing a weird smell...like wet clothes." [](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ## Find out more about La Jolla Mesa ## La Jolla Mesa Hotels Guide Expedia.ca offers a selection of 9083 hotels in La Jolla Mesa. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in La Jolla Mesa. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the La Jolla Mesa neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in La Jolla Mesa, La Jolla now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [4 Star Hotels in La Jolla](https://www.expedia.ca/4Star-La-Jolla-Hotels.s40-0-d6126584.Travel-Guide-Filter-Hotels) - [5 Star Hotels in La Jolla](https://www.expedia.ca/5Star-La-Jolla-Hotels.s50-0-d6126584.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Bay Ho](https://www.expedia.ca/Bay-Ho-San-Diego-Hotels-Marriott-Hotels-Resorts.0-n553248635976471756-0--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Hotels near Bird Rock](https://www.expedia.ca/Bird-Rock-Hotels.0-l553248621586065696-0.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Bird Rock](https://www.expedia.ca/Bird-Rock-La-Jolla-Hotels-All-Inclusive-Hotel.0-n641199223868248064-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Bird Rock](https://www.expedia.ca/Bird-Rock-La-Jolla-Hotels-Beach-Hotel.0-n641199223868248064-0-tBeachHotel.Travel-Guide-Filter-Hotels) - 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[Hotels near Tourmaline Surfing Park](https://www.expedia.ca/Tourmaline-Surfing-Park-Hotels.0-l553248632557178851-0.Travel-Guide-Filter-Hotels) - [Wyndham Hotels in University City](https://www.expedia.ca/University-City-San-Diego-Hotels-Wyndham-Hotels.0-n553248635976008131-0--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [Upper Hermosa Hotels](https://www.expedia.ca/Upper-Hermosa-La-Jolla-Hotels.0-n553248635976472387-0.Travel-Guide-Filter-Hotels) - [Flights to La Jolla](https://www.expedia.ca/Cheap-Flights-To-La-Jolla.d6126584.Travel-Guide-Flights) - [Flights to San Diego](https://www.expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights) - [Flights from La Jolla](https://www.expedia.ca/lp/flights/6126584/flights-from-la-jolla) - [Flights from Vancouver (YVR) to San Diego (SAN)](https://www.expedia.ca/lp/flights/yvr/san/vancouver-to-san-diego) - [Flights from Toronto (YYZ) to San Diego (SAN)](https://www.expedia.ca/lp/flights/yyz/san/toronto-to-san-diego) - [Visit Bird Rock](https://www.expedia.ca/La-Jolla-Bird-Rock.dx641199223868248064) - [Visit Muirlands](https://www.expedia.ca/La-Jolla-Muirlands.dx553248635976482382) - [La Jolla Vacations](https://www.expedia.ca/La-Jolla.d6126584.Destination-Travel-Guides) - [Visit La Jolla](https://www.expedia.ca/La-Jolla.dx6126584) - [Tourmaline Surfing Park](https://www.expedia.ca/Tourmaline-Surfing-Park-Pacific-Beach.d553248632557178851.Vacation-Attraction) - [Car rental La Jolla](https://www.expedia.ca/Car-Rentals-In-La-Jolla.d6126584.Car-Rental-Guide) - [Hertz Rental Cars in La Jolla](https://www.expedia.ca/Hertz-Car-Rentals-In-La-Jolla.d6126584-c40.Car-Rental-Guide-Suppliers) - [Thrifty Car Rental Rental Cars in La Jolla](https://www.expedia.ca/Thrifty-Car-Rental-Car-Rentals-In-La-Jolla.d6126584-c45.Car-Rental-Guide-Suppliers) - [La Jolla Vacation Rentals](https://www.expedia.ca/La-Jolla-Vacation-Rentals.d6126584.Travel-Guide-VacationRentals) - [Things to do in La Jolla](https://www.expedia.ca/Things-To-Do-In-La-Jolla.d6126584.Travel-Guide-Activities) - [Book Hotels in La Jolla Mesa on Expedia.com](https://www.expedia.com/La-Jolla-Mesa-La-Jolla-Hotels-Omni.0-n553248635976480832-0--bOmni.Travel-Guide-Filter-Hotels)