Title: Hotels by Motel 6 in La Jolla Mesa | Expedia.ca [La Jolla Mesa Travel Guide](https://expedia.ca/La-Jolla-La-Jolla-Mesa.dx553248635976480832)[Vacation Rentals in La Jolla](https://expedia.ca/La-Jolla-Vacation-Rentals.d6126584.Travel-Guide-VacationRentals)[Flights to La Jolla](https://expedia.ca/Cheap-Flights-To-La-Jolla.d6126584.Travel-Guide-Flights)[Things to do in La Jolla](https://expedia.ca/Things-To-Do-In-La-Jolla.d6126584.Travel-Guide-Activities)[La Jolla Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-La-Jolla-Mesa.d553248635976480832.Car-Rental-Guide)[La Jolla Mesa Vacations](https://expedia.ca/La-Jolla-Mesa.d553248635976480832.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Motel 6 in La Jolla Mesa ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=553248635976480832&startDate=2025-10-13&endDate=2025-10-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=553248635976480832&startDate=2025-10-14&endDate=2025-10-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976480832&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976480832&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top La Jolla Mesa Motel 6 Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLa-Jolla-Mesa-La-Jolla-Hotels-Motel-6.0-n553248635976480832-0--bMotel6.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLa-Jolla-Mesa-La-Jolla-Hotels-Motel-6.0-n553248635976480832-0--bMotel6.Travel-Guide-Filter-Hotels) ## Top La Jolla Mesa Hotel Reviews ![Legacy Resort Hotel & Spa](//images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/0bbd67f4_y.jpg) ### Legacy Resort Hotel & Spa 10/10 Excellent "Nice hotel right on Hotel Circle. Nice rooms, easy parking and good service. " [](https://expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) ![Hilton San Diego Mission Valley](//images.trvl-media.com/lodging/1000000/20000/16100/16019/w3839h2160x1y0-98566ca3_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "Clean rooms, nice staff etc.." [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Handlery Hotel](//images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55_y.jpg) ### Handlery Hotel 10/10 Excellent "The hotel is very clean, pool and spa are fantastic, the food at the hotel was excellent " [](https://expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![Wyndham Garden San Diego Near SeaWorld](//images.trvl-media.com/lodging/1000000/50000/41000/40962/76b78879_y.jpg) ### Wyndham Garden San Diego Near SeaWorld 10/10 Excellent "Staff was super friendly, room and propert was clean. Great experience!" [](https://expedia.ca/San-Diego-Hotels-Wyndham-Garden-San-Diego-Near-SeaWorld.h40962.Hotel-Information) ![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Best place to stay for city center activities. Close to everything and hotel is well-appointed. " [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](//images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "I really liked this place, it is quiet, clean and is located in a nice place, the only think I didn't like is that I had to pay $35 to use the parking lot." [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Palihotel San Diego Gaslamp Quarter](//images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/4480f6ef_y.jpg) ### Palihotel San Diego Gaslamp Quarter 10/10 Excellent "Drinks were very good, food is good happy hour food great, room clean, staff is great and helpful. " [](https://expedia.ca/San-Diego-Hotels-Palihotel-San-Diego.h88398416.Hotel-Information) ![Manchester Grand Hyatt San Diego](//images.trvl-media.com/lodging/1000000/20000/12100/12073/w3840h2092x0y3-447c77a4_y.jpg) ### Manchester Grand Hyatt San Diego 10/10 Excellent "Always great! Room and view were beautiful. Only thing was the hallway had bits of trash throughout. " [](https://expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) ![Best Western Plus Marina Gateway Hotel](//images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "The hotel is clean and relaxing. The staff is courteous and always eager to accommodate. The best part was the coffee machine in the lobby. I'll be returning. " [](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ## Find out more about La Jolla Mesa ## La Jolla Mesa Hotels Guide Expedia.ca offers a selection of 9083 hotels in La Jolla Mesa. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in La Jolla Mesa. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the La Jolla Mesa neighborhood you prefer. Go ahead. 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[Hotels near Tourmaline Surfing Park](https://www.expedia.ca/Tourmaline-Surfing-Park-Hotels.0-l553248632557178851-0.Travel-Guide-Filter-Hotels) - [Wyndham Hotels in University City](https://www.expedia.ca/University-City-San-Diego-Hotels-Wyndham-Hotels.0-n553248635976008131-0--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [Upper Hermosa Hotels](https://www.expedia.ca/Upper-Hermosa-La-Jolla-Hotels.0-n553248635976472387-0.Travel-Guide-Filter-Hotels) - [Flights to La Jolla](https://www.expedia.ca/Cheap-Flights-To-La-Jolla.d6126584.Travel-Guide-Flights) - [Flights to San Diego](https://www.expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights) - [Flights from La Jolla](https://www.expedia.ca/lp/flights/6126584/flights-from-la-jolla) - [Flights from Vancouver (YVR) to San Diego (SAN)](https://www.expedia.ca/lp/flights/yvr/san/vancouver-to-san-diego) - [Flights from Toronto (YYZ) to San Diego (SAN)](https://www.expedia.ca/lp/flights/yyz/san/toronto-to-san-diego) - [Visit Bird Rock](https://www.expedia.ca/La-Jolla-Bird-Rock.dx641199223868248064) - [Visit Muirlands](https://www.expedia.ca/La-Jolla-Muirlands.dx553248635976482382) - [La Jolla Vacations](https://www.expedia.ca/La-Jolla.d6126584.Destination-Travel-Guides) - [Visit La Jolla](https://www.expedia.ca/La-Jolla.dx6126584) - [Tourmaline Surfing Park](https://www.expedia.ca/Tourmaline-Surfing-Park-Pacific-Beach.d553248632557178851.Vacation-Attraction) - [Car rental La Jolla](https://www.expedia.ca/Car-Rentals-In-La-Jolla.d6126584.Car-Rental-Guide) - [Hertz Rental Cars in La Jolla](https://www.expedia.ca/Hertz-Car-Rentals-In-La-Jolla.d6126584-c40.Car-Rental-Guide-Suppliers) - [Thrifty Car Rental Rental Cars in La Jolla](https://www.expedia.ca/Thrifty-Car-Rental-Car-Rentals-In-La-Jolla.d6126584-c45.Car-Rental-Guide-Suppliers) - [La Jolla Vacation Rentals](https://www.expedia.ca/La-Jolla-Vacation-Rentals.d6126584.Travel-Guide-VacationRentals) - [Things to do in La Jolla](https://www.expedia.ca/Things-To-Do-In-La-Jolla.d6126584.Travel-Guide-Activities) - [Book Hotels in La Jolla Mesa on Expedia.com](https://www.expedia.com/La-Jolla-Mesa-La-Jolla-Hotels-Motel-6.0-n553248635976480832-0--bMotel6.Travel-Guide-Filter-Hotels)