Title: Book the Best Knoxville SPA Resorts from CA $266 - Spa Hotels in Knoxville, MD | Expedia.ca [Hotels in Knoxville](https://expedia.ca/Knoxville-Hotels.d6277693.Travel-Guide-Hotels)[Vacation Rentals in Knoxville](https://expedia.ca/Knoxville-Vacation-Rentals.d6277693.Travel-Guide-VacationRentals)[Knoxville Car Rentals](https://expedia.ca/Car-Rentals-In-Knoxville.d6277693.Car-Rental-Guide)[Knoxville Vacation Packages](https://expedia.ca/Knoxville.d6277693.Destination-Travel-Guides) ![Potomac River View from Weverton Cliffs, Appalachian Trail - Knoxville, Maryland](https://images.trvl-media.com/place/6277693/d99dc226-705d-4ec9-818a-597af440867d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6277693/d99dc226-705d-4ec9-818a-597af440867d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Knoxville Spa Hotels Tonight [Mar 7 - Mar 8](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2026-03-07&endDate=2026-03-08&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 8 - Mar 9](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2026-03-08&endDate=2026-03-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 13 - Mar 15](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2026-03-13&endDate=2026-03-15&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Mar 20 - Mar 22](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2026-03-20&endDate=2026-03-22&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Knoxville hotels with a spa ![Front of property](https://images.trvl-media.com/lodging/17000000/16290000/16281800/16281705/f4cdce70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite, 1 King Bed, Hot Tub, Garden View](https://images.trvl-media.com/lodging/17000000/16290000/16281800/16281705/686105c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/17000000/16290000/16281800/16281705/5afc8cca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/17000000/16290000/16281800/16281705/827ae686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stone Manor Boutique Inn [](https://www.expedia.ca/Lovettsville-Hotels-Stone-Manor-Boutique-Inn.h16281705.Hotel-Information) Lovettsville 9.6/10 Exceptional (97 reviews) "The breakfast was fabulous and the room great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) MICHEL CA $260 CA $296 total includes taxes & fees Mar 9 - Mar 10 [](https://www.expedia.ca/Lovettsville-Hotels-Stone-Manor-Boutique-Inn.h16281705.Hotel-Information) ![Couples treatment rooms](https://images.trvl-media.com/lodging/4000000/3090000/3082200/3082115/b5a24271.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (The Overlook)](https://images.trvl-media.com/lodging/4000000/3090000/3082200/3082115/8ab65f08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/4000000/3090000/3082200/3082115/f0afdbe1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/4000000/3090000/3082200/3082115/7b9d69e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hillbrook Inn [](https://www.expedia.ca/Martinsburg-Hotels-Hillbrook-Inn.h3082115.Hotel-Information) Charles Town 8.6/10 Excellent (674 reviews) "Wonderful staff, and fall cottage was lovely." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Henrik CA $207 CA $266 total includes taxes & fees Mar 24 - Mar 25 [](https://www.expedia.ca/Martinsburg-Hotels-Hillbrook-Inn.h3082115.Hotel-Information) ![Deep-tissue massages, Swedish massages, prenatal massages](https://images.trvl-media.com/lodging/115000000/114280000/114275900/114275854/c155be43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/115000000/114280000/114275900/114275854/b5788cac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114280000/114275900/114275854/376fcf9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, rooftop bar](https://images.trvl-media.com/lodging/115000000/114280000/114275900/114275854/9a999e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Burg [](https://www.expedia.ca/Leesburg-Hotels-Hotel-Burg.h114275854.Hotel-Information) Leesburg's Old and Historic District 9.6/10 Exceptional (52 reviews) "Wonderful quaint hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Evette CA $347 CA $439 total includes taxes & fees Apr 6 - Apr 7 [](https://www.expedia.ca/Leesburg-Hotels-Hotel-Burg.h114275854.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-22&endDate=2026-03-23®ionId=6277693&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Choose what matters most at spa hotels in Knoxville Pool Breakfast included Hot tub 4 stars 5 stars ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=AFFINITY_SPRING_PROMO_6277693) ## Top Knoxville Hotel Reviews ![Lansdowne Resort and Spa](https://images.trvl-media.com/lodging/1000000/30000/27700/27700/5ae32850_y.jpg) ### Lansdowne Resort and Spa 10/10 Excellent "I have stayed at Landsdowne many years, typically for girls spa weekends or overnight stay while I’m in town. The Spa Experience is always phenomenal. The staff is friendly all around. I continue to enjoy my stays!" [](https://expedia.ca/Leesburg-Hotels-Lansdowne-Resort-And-Spa.h27700.Hotel-Information) ![Hilton Garden Inn Frederick](https://images.trvl-media.com/lodging/2000000/1610000/1608200/1608110/6e2ddf4e_y.jpg) ### Hilton Garden Inn Frederick 8/10 Good "Clean room; very kind staff" [](https://expedia.ca/Frederick-Hotels-Hilton-Garden-Inn-Frederick.h1608110.Hotel-Information) ![Holiday Inn Express & Suites Leesburg - Historic District by IHG](https://images.trvl-media.com/lodging/1000000/600000/596500/596430/c6a38a54_y.jpg) ### Holiday Inn Express & Suites Leesburg - Historic District by IHG 10/10 Excellent "very good" [](https://expedia.ca/Leesburg-Hotels-Holiday-Inn-Express-And-Suites-Leesburg-Historic-District.h596430.Hotel-Information) ## Frequently asked questions ### Looking to vacation at a spa hotel in Knoxville? ### What's there to see and do in Knoxville? ### What is a Knoxville spa hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - More ways to book - 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