Title: Book the Best Knoxville SPA Resorts from CA $263 - Spa Hotels in Knoxville, MD | Expedia.ca [Hotels in Knoxville](https://expedia.ca/Knoxville-Hotels.d6277693.Travel-Guide-Hotels)[Vacation Rentals in Knoxville](https://expedia.ca/Knoxville-Vacation-Rentals.d6277693.Travel-Guide-VacationRentals)[Knoxville Car Rentals](https://expedia.ca/Car-Rentals-In-Knoxville.d6277693.Car-Rental-Guide)[Knoxville Vacation Packages](https://expedia.ca/Knoxville.d6277693.Destination-Travel-Guides) ![Potomac River View from Weverton Cliffs, Appalachian Trail - Knoxville, Maryland](https://images.trvl-media.com/place/6277693/d99dc226-705d-4ec9-818a-597af440867d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6277693/d99dc226-705d-4ec9-818a-597af440867d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Knoxville Spa Hotels Tonight [Mar 6 - Mar 7](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2026-03-06&endDate=2026-03-07&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 7 - Mar 8](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2026-03-07&endDate=2026-03-08&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 6 - Mar 8](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2026-03-06&endDate=2026-03-08&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 13 - Mar 15](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2026-03-13&endDate=2026-03-15&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Knoxville hotels with a spa ![Front of property](https://images.trvl-media.com/lodging/17000000/16290000/16281800/16281705/f4cdce70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/17000000/16290000/16281800/16281705/5afc8cca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gazebo](https://images.trvl-media.com/lodging/17000000/16290000/16281800/16281705/170acaf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/17000000/16290000/16281800/16281705/827ae686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stone Manor Boutique Inn [](https://www.expedia.ca/Lovettsville-Hotels-Stone-Manor-Boutique-Inn.h16281705.Hotel-Information) Lovettsville 9.6/10 Exceptional (96 reviews) "The breakfast was fabulous and the room great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) MICHEL CA $261 CA $298 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/Lovettsville-Hotels-Stone-Manor-Boutique-Inn.h16281705.Hotel-Information) ![Couples treatment rooms](https://images.trvl-media.com/lodging/4000000/3090000/3082200/3082115/b5a24271.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/4000000/3090000/3082200/3082115/7b9d69e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/4000000/3090000/3082200/3082115/f0afdbe1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (The Overlook)](https://images.trvl-media.com/lodging/4000000/3090000/3082200/3082115/8ab65f08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hillbrook Inn [](https://www.expedia.ca/Martinsburg-Hotels-Hillbrook-Inn.h3082115.Hotel-Information) Charles Town 8.6/10 Excellent (674 reviews) "Wonderful staff, and fall cottage was lovely." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Henrik CA $204 CA $263 total includes taxes & fees Mar 15 - Mar 16 [](https://www.expedia.ca/Martinsburg-Hotels-Hillbrook-Inn.h3082115.Hotel-Information) ![Deep-tissue massages, Swedish massages, prenatal massages](https://images.trvl-media.com/lodging/115000000/114280000/114275900/114275854/c155be43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/115000000/114280000/114275900/114275854/b5788cac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, rooftop bar](https://images.trvl-media.com/lodging/115000000/114280000/114275900/114275854/9a999e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/115000000/114280000/114275900/114275854/e9092373.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Burg [](https://www.expedia.ca/Leesburg-Hotels-Hotel-Burg.h114275854.Hotel-Information) Leesburg's Old and Historic District 9.6/10 Exceptional (52 reviews) "Wonderful quaint hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Evette CA $395 CA $494 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/Leesburg-Hotels-Hotel-Burg.h114275854.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-20&endDate=2026-03-21®ionId=6277693&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Choose what matters most at spa hotels in Knoxville Pool Breakfast included Hot tub 4 stars 5 stars ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=AFFINITY_SPRING_PROMO_6277693) ## Top Knoxville Hotel Reviews ![Hilton Garden Inn Frederick](https://images.trvl-media.com/lodging/2000000/1610000/1608200/1608110/6e2ddf4e_y.jpg) ### Hilton Garden Inn Frederick 10/10 Excellent "friendly staff" [](https://expedia.ca/Frederick-Hotels-Hilton-Garden-Inn-Frederick.h1608110.Hotel-Information) ![Holiday Inn Express & Suites Leesburg - Historic District by IHG](https://images.trvl-media.com/lodging/1000000/600000/596500/596430/c6a38a54_y.jpg) ### Holiday Inn Express & Suites Leesburg - Historic District by IHG 10/10 Excellent "very good" [](https://expedia.ca/Leesburg-Hotels-Holiday-Inn-Express-And-Suites-Leesburg-Historic-District.h596430.Hotel-Information) ![Lansdowne Resort and Spa](https://images.trvl-media.com/lodging/1000000/30000/27700/27700/5ae32850_y.jpg) ### Lansdowne Resort and Spa 8/10 Good "Excellent rooms, spa, staff, everything. Very enjoyable stay. The only reason it is not 5 stars is because there isn't enough variety of food on the menus. Please offer more vegetarian options. But otherwise, wonderful stay!" [](https://expedia.ca/Leesburg-Hotels-Lansdowne-Resort-And-Spa.h27700.Hotel-Information) ![Hampton Inn & Suites Frederick-Fort Detrick](https://images.trvl-media.com/lodging/2000000/1250000/1246300/1246270/154d4273_y.jpg) ### Hampton Inn & Suites Frederick-Fort Detrick 6/10 Okay "Unfortunately, my room was right next to heat pumps which kept turning off and on all night, unable to sleep due to noise." [](https://expedia.ca/Frederick-Hotels-Hampton-Inn-Suites-Frederick-Fort-Detrick.h1246270.Hotel-Information) ## Frequently asked questions ### Looking to vacation at a spa hotel in Knoxville? ### What's there to see and do in Knoxville? ### What is a Knoxville spa hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - More ways to book - [1 Star Hotels in Sharpsburg ](https://www.expedia.ca/1Star-Sharpsburg-Hotels.s10-0-d157080.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Adamstown ](https://www.expedia.ca/Adamstown-Hotels-Luxury-Hotel.0-0-d6338378-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Adamstown Hotels ](https://www.expedia.ca/Adamstown-Hotels.d6338378.Travel-Guide-Hotels) - [B&B in Antietam ](https://www.expedia.ca/Antietam-Bed-And-Breakfast.d553248635975871648-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Hotels near Antietam Creek ](https://www.expedia.ca/Antietam-Creek-Hotels.0-l553248621532662485-0.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Antietam ](https://www.expedia.ca/Antietam-Hotels-Cheap-Hotels.0-0-d553248635975871648-tCheapHotels.Travel-Guide-Filter-Hotels) - 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