Title: Book the Best Knoxville LUXURY Hotels - Upscale Hotels in Knoxville, MD | Expedia.ca [Hotels in Knoxville](https://expedia.ca/Knoxville-Hotels.d6277693.Travel-Guide-Hotels)[Vacation Rentals in Knoxville](https://expedia.ca/Knoxville-Vacation-Rentals.d6277693.Travel-Guide-VacationRentals)[Knoxville Car Rentals](https://expedia.ca/Car-Rentals-In-Knoxville.d6277693.Car-Rental-Guide)[Knoxville Vacation Packages](https://expedia.ca/Knoxville.d6277693.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/f9f0e4f934227bfdb72378637c2ec3dc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Kayla Berry # Find luxury hotels in Knoxville, MD ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Knoxville Luxury Hotels Tonight [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2025-10-14&endDate=2025-10-15&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 15 - Oct 16](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2025-10-15&endDate=2025-10-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Knoxville Luxury Hotels ![Exterior](https://images.trvl-media.com/lodging/7000000/6390000/6382400/6382320/e0190150.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/7000000/6390000/6382400/6382320/0be861ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/7000000/6390000/6382400/6382320/8788795d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/7000000/6390000/6382400/6382320/0b49c83a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Hillside Hotel Knoxville 6.8/10 (425) "We enjoyed our time there " CA $88 CA $99 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Frederick-Hotels-The-Hillside-Hotel.h6382320.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-28&endDate=2025-10-29®ionId=6277693&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Top Knoxville Hotel Reviews ![Days Inn by Wyndham Frederick](//images.trvl-media.com/lodging/1000000/20000/13000/12946/5af4bff3_y.jpg) ### Days Inn by Wyndham Frederick 10/10 Excellent "Yes " [](https://expedia.ca/Frederick-Hotels-Days-Inn-By-Wyndham-Frederick.h12946.Hotel-Information) ![Quality Inn](//images.trvl-media.com/lodging/1000000/30000/25200/25179/e301290f_y.jpg) ### Quality Inn 10/10 Excellent "On the Appalachian Trail, staff is kind and helpful. " [](https://expedia.ca/Martinsburg-Hotels-Quality-Inn.h25179.Hotel-Information) ![Country Inn & Suites by Radisson, Frederick, MD](//images.trvl-media.com/lodging/1000000/60000/59600/59588/6e927b9b_y.jpg) ### Country Inn & Suites by Radisson, Frederick, MD 10/10 Excellent "Not what I would have expected from a Radisson property. " [](https://expedia.ca/Frederick-Hotels-Country-Inn-Suites-By-Radisson.h59588.Hotel-Information) ![Clarion Inn Harpers Ferry - Charles Town](//images.trvl-media.com/lodging/1000000/980000/977400/977326/a9078e90_y.jpg) ### Clarion Inn Harpers Ferry - Charles Town 10/10 Excellent "Room was great-parking was always easy and conv. Staff were all very friendly and helpful. This was my 3rd time staying here and was again a wonderful experience. " [](https://expedia.ca/Martinsburg-Hotels-Clarion-Inn-Harpers-Ferry-Charles-Town.h977326.Hotel-Information) ![Red Roof Inn Leesburg, VA](//images.trvl-media.com/lodging/1000000/20000/17600/17577/610f0a4e_y.jpg) ### Red Roof Inn Leesburg, VA 10/10 Excellent "It was a good cozy stay for after visiting for a wedding and I would stay here again. " [](https://expedia.ca/Leesburg-Hotels-Red-Roof-Inn-Leesburg.h17577.Hotel-Information) ![Lansdowne Resort and Spa](//images.trvl-media.com/lodging/1000000/30000/27700/27700/5ae32850_y.jpg) ### Lansdowne Resort and Spa 10/10 Excellent "Hotel has a lot of amenities, we also used the spa, pool and hot tub. Also took one of the free workout classes." [](https://expedia.ca/Leesburg-Hotels-Lansdowne-Resort-And-Spa.h27700.Hotel-Information) ![Motel 6 Frederick, MD - Fort Detrick](//images.trvl-media.com/lodging/1000000/20000/16200/16162/66134e7a_y.jpg) ### Motel 6 Frederick, MD - Fort Detrick 10/10 Excellent "Clean rooms and parking lot. Hotel staff has zero tolerance for loitering and nonsense. " [](https://expedia.ca/Frederick-Hotels-Motel-6-Frederick.h16162.Hotel-Information) ![Clarion Hotel & Conference Center Leesburg](//images.trvl-media.com/lodging/1000000/30000/24400/24372/8c4e2827_y.jpg) ### Clarion Hotel & Conference Center Leesburg 10/10 Excellent "Great location. Loved the restaurant service and food. Clean property although older. " [](https://expedia.ca/Leesburg-Hotels-Clarion-Hotel-Conference-Center-Leesburg.h24372.Hotel-Information) ![Sleep Inn Frederick - Ballenger Creek](//images.trvl-media.com/lodging/1000000/530000/529900/529899/a247161f_y.jpg) ### Sleep Inn Frederick - Ballenger Creek 10/10 Excellent "Staff very nice" [](https://expedia.ca/Frederick-Hotels-Sleep-Inn-Frederick.h529899.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury trip to Knoxville? > Use Expedia and let us help you arrange a flight to Martinsburg, WV (MRB-Eastern West Virginia Regional) airport or Hagerstown, MD (HGR-Hagerstown Regional) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are an important consideration when you plan a vacation, so we make it easy to find what you need to make your stay special. If you want a posh hotel that has a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Knoxville offers. During your visit, you might want to enjoy the ferries which Knoxville is known for. ### When can I expect good weather in Knoxville? > Planning for the weather is a good way to make your trip to Knoxville relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 73°F, while the coldest months are January and February with an average of 37°F. Average annual precipitation for Knoxville is 48 inches. ### What's there to see and do in Knoxville? > Experience Knoxville and visit Maryland Heights, Lockhouse 33, and South Mountain State Park. 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