Title: Book the Best Knoxville LUXURY Hotels - Upscale Hotels in Knoxville, MD | Expedia.ca [Hotels in Knoxville](https://expedia.ca/Knoxville-Hotels.d6277693.Travel-Guide-Hotels)[Vacation Rentals in Knoxville](https://expedia.ca/Knoxville-Vacation-Rentals.d6277693.Travel-Guide-VacationRentals)[Knoxville Car Rentals](https://expedia.ca/Car-Rentals-In-Knoxville.d6277693.Car-Rental-Guide)[Knoxville Vacation Packages](https://expedia.ca/Knoxville.d6277693.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/f9f0e4f934227bfdb72378637c2ec3dc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Kayla Berry # Find luxury hotels in Knoxville, MD ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Knoxville Luxury Hotels Tonight [Oct 2 - Oct 3](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2025-10-02&endDate=2025-10-03&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 3 - Oct 4](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2025-10-03&endDate=2025-10-04&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2025-10-03&endDate=2025-10-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2025-10-10&endDate=2025-10-12&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Knoxville Luxury Hotels ![Exterior](https://images.trvl-media.com/lodging/7000000/6390000/6382400/6382320/e0190150.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast meal](https://images.trvl-media.com/lodging/7000000/6390000/6382400/6382320/00b668ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/7000000/6390000/6382400/6382320/0b49c83a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/7000000/6390000/6382400/6382320/0be861ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Hillside Hotel Knoxville 6.8/10 (424) "We enjoyed our time there " CA $88 CA $98 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Frederick-Hotels-The-Hillside-Hotel.h6382320.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-16&endDate=2025-10-17®ionId=6277693&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Top Knoxville Hotel Reviews ![Quality Inn](//images.trvl-media.com/lodging/1000000/30000/25200/25179/e301290f_y.jpg) ### Quality Inn 10/10 Excellent "Beds were super comfy and the front desk was very helpful!" [](https://expedia.ca/Martinsburg-Hotels-Quality-Inn.h25179.Hotel-Information) ![Clarion Inn Harpers Ferry - Charles Town](//images.trvl-media.com/lodging/1000000/980000/977400/977326/a9078e90_y.jpg) ### Clarion Inn Harpers Ferry - Charles Town 10/10 Excellent "Very good" [](https://expedia.ca/Martinsburg-Hotels-Clarion-Inn-Harpers-Ferry-Charles-Town.h977326.Hotel-Information) ![Red Roof Inn Leesburg, VA](//images.trvl-media.com/lodging/1000000/20000/17600/17577/610f0a4e_y.jpg) ### Red Roof Inn Leesburg, VA 10/10 Excellent "Clean room, friendly staff, flexible with our needs" [](https://expedia.ca/Leesburg-Hotels-Red-Roof-Inn-Leesburg.h17577.Hotel-Information) ![Lansdowne Resort and Spa](//images.trvl-media.com/lodging/1000000/30000/27700/27700/5ae32850_y.jpg) ### Lansdowne Resort and Spa 10/10 Excellent "It was very clean. The staff was friendly and accommodating. My stay was peaceful and I enjoyed sitting by the fire in the great room. " [](https://expedia.ca/Leesburg-Hotels-Lansdowne-Resort-And-Spa.h27700.Hotel-Information) ![Country Inn & Suites by Radisson, Frederick, MD](//images.trvl-media.com/lodging/1000000/60000/59600/59588/6e927b9b_y.jpg) ### Country Inn & Suites by Radisson, Frederick, MD 10/10 Excellent "Great location. Lots of restaurants and shopping. " [](https://expedia.ca/Frederick-Hotels-Country-Inn-Suites-By-Radisson.h59588.Hotel-Information) ![Days Inn by Wyndham Frederick](//images.trvl-media.com/lodging/1000000/20000/13000/12946/5af4bff3_y.jpg) ### Days Inn by Wyndham Frederick 10/10 Excellent "Excellent place to stay. Far enough from the interstate to be very quiet. Easy access." [](https://expedia.ca/Frederick-Hotels-Days-Inn-By-Wyndham-Frederick.h12946.Hotel-Information) ![Sleep Inn Frederick - Ballenger Creek](//images.trvl-media.com/lodging/1000000/530000/529900/529899/a247161f_y.jpg) ### Sleep Inn Frederick - Ballenger Creek 10/10 Excellent "Staff very nice" [](https://expedia.ca/Frederick-Hotels-Sleep-Inn-Frederick.h529899.Hotel-Information) ![Hampton Inn & Suites Frederick-Fort Detrick](//images.trvl-media.com/lodging/2000000/1250000/1246300/1246270/154d4273_y.jpg) ### Hampton Inn & Suites Frederick-Fort Detrick 10/10 Excellent "A fine hotel will stay again." [](https://expedia.ca/Frederick-Hotels-Hampton-Inn-Suites-Frederick-Fort-Detrick.h1246270.Hotel-Information) ![The Hillside Hotel](//images.trvl-media.com/lodging/7000000/6390000/6382400/6382320/e0190150_y.jpg) ### The Hillside Hotel 10/10 Excellent "We enjoyed our time there " [](https://expedia.ca/Frederick-Hotels-The-Hillside-Hotel.h6382320.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury trip to Knoxville? > Use Expedia and let us help you arrange a flight to Martinsburg, WV (MRB-Eastern West Virginia Regional) airport or Hagerstown, MD (HGR-Hagerstown Regional) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are an important consideration when you plan a vacation, so we make it easy to find what you need to make your stay special. If you want a posh hotel that has a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Knoxville offers. During your visit, you might want to enjoy the ferries which Knoxville is known for. ### When can I expect good weather in Knoxville? > Planning for the weather is a good way to make your trip to Knoxville relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 73°F, while the coldest months are January and February with an average of 37°F. Average annual precipitation for Knoxville is 48 inches. ### What's there to see and do in Knoxville? > Experience Knoxville and visit Maryland Heights, South Mountain State Park, and Chesapeake and Ohio Canal. 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