Title: Book the Best Knoxville LUXURY Hotels - Upscale Hotels in Knoxville, MD | Expedia.ca [Hotels in Knoxville](https://expedia.ca/Knoxville-Hotels.d6277693.Travel-Guide-Hotels)[Vacation Rentals in Knoxville](https://expedia.ca/Knoxville-Vacation-Rentals.d6277693.Travel-Guide-VacationRentals)[Knoxville Car Rentals](https://expedia.ca/Car-Rentals-In-Knoxville.d6277693.Car-Rental-Guide)[Knoxville Vacation Packages](https://expedia.ca/Knoxville.d6277693.Destination-Travel-Guides) ![Potomac River View from Weverton Cliffs, Appalachian Trail - Knoxville, Maryland](https://images.trvl-media.com/place/6277693/d99dc226-705d-4ec9-818a-597af440867d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6277693/d99dc226-705d-4ec9-818a-597af440867d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Knoxville Luxury Hotels Tonight [Feb 2 - Feb 3](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2026-02-02&endDate=2026-02-03&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Feb 3 - Feb 4](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2026-02-03&endDate=2026-02-04&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2026-02-06&endDate=2026-02-08&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=6277693&startDate=2026-02-13&endDate=2026-02-15&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for Knoxville luxury hotels ![Indoor pool, seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/27700/27700/5ae32850.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/30000/27700/27700/bb096491.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Presidential Suite | Living room](https://images.trvl-media.com/lodging/1000000/30000/27700/27700/3fc4910e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Yoga](https://images.trvl-media.com/lodging/1000000/30000/27700/27700/48879e92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lansdowne Resort and Spa [](https://www.expedia.ca/Leesburg-Hotels-Lansdowne-Resort-And-Spa.h27700.Hotel-Information) Leesburg 8.8/10 Excellent (1,002 reviews) "Great place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joyce [](https://www.expedia.ca/Leesburg-Hotels-Lansdowne-Resort-And-Spa.h27700.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/4000000/3090000/3082200/3082115/7b9d69e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/4000000/3090000/3082200/3082115/f0afdbe1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/4000000/3090000/3082200/3082115/80e06b30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (The Overlook)](https://images.trvl-media.com/lodging/4000000/3090000/3082200/3082115/8ab65f08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hillbrook Inn [](https://www.expedia.ca/Martinsburg-Hotels-Hillbrook-Inn.h3082115.Hotel-Information) Charles Town 8.6/10 Excellent (674 reviews) "Wonderful staff, and fall cottage was lovely." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Henrik CA $210 CA $270 total includes taxes & fees Mar 3 - Mar 4 [](https://www.expedia.ca/Martinsburg-Hotels-Hillbrook-Inn.h3082115.Hotel-Information) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/115000000/114280000/114275900/114275854/e9092373.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, rooftop bar](https://images.trvl-media.com/lodging/115000000/114280000/114275900/114275854/9a999e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/115000000/114280000/114275900/114275854/b5788cac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City shuttle](https://images.trvl-media.com/lodging/115000000/114280000/114275900/114275854/8eb9ca38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Burg [](https://www.expedia.ca/Leesburg-Hotels-Hotel-Burg.h114275854.Hotel-Information) Leesburg's Old and Historic District 9.6/10 Exceptional (50 reviews) "Wonderful quaint hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Evette CA $376 CA $472 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Leesburg-Hotels-Hotel-Burg.h114275854.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-16&endDate=2026-02-17®ionId=6277693&adults=2&sort=LUXURY&star=40,50&openPlayBack=true) ## Top Knoxville Hotel Reviews ![Hampton Inn & Suites Frederick-Fort Detrick](https://images.trvl-media.com/lodging/2000000/1250000/1246300/1246270/154d4273_y.jpg) ### Hampton Inn & Suites Frederick-Fort Detrick 10/10 Excellent "Very clean and spacious room. All amenities were available. Breakfast was on point and staff was friendly, thanks!" [](https://expedia.ca/Frederick-Hotels-Hampton-Inn-Suites-Frederick-Fort-Detrick.h1246270.Hotel-Information) ![Country Inn & Suites by Radisson, Hagerstown, MD](https://images.trvl-media.com/lodging/2000000/1220000/1216300/1216228/31529ad2_y.jpg) ### Country Inn & Suites by Radisson, Hagerstown, MD 10/10 Excellent "Breakfast has hot and cold choices, clean rooms." [](https://expedia.ca/Hagerstown-Hotels-Country-Inn-Suites-By-Radisson.h1216228.Hotel-Information) ![Hampton Inn Hagerstown](https://images.trvl-media.com/lodging/1000000/60000/59800/59778/w3840h2557x0y3-59fd052e_y.jpg) ### Hampton Inn Hagerstown 10/10 Excellent "Clean and well keep. Great location." [](https://expedia.ca/Hagerstown-Hotels-Hampton-Inn-Hagerstown.h59778.Hotel-Information) ![Country Inn & Suites by Radisson, Frederick, MD](https://images.trvl-media.com/lodging/1000000/60000/59600/59588/6e927b9b_y.jpg) ### Country Inn & Suites by Radisson, Frederick, MD 10/10 Excellent "clean, easy check in/out adequate breakfast" [](https://expedia.ca/Frederick-Hotels-Country-Inn-Suites-By-Radisson.h59588.Hotel-Information) ![Lansdowne Resort and Spa](https://images.trvl-media.com/lodging/1000000/30000/27700/27700/5ae32850_y.jpg) ### Lansdowne Resort and Spa 10/10 Excellent "The resort was in great condition and very clean. The food at Coton & Rye was good for the price. Service throughout the weekend was excellent. " [](https://expedia.ca/Leesburg-Hotels-Lansdowne-Resort-And-Spa.h27700.Hotel-Information) ![Clarion Hotel & Conference Center Leesburg](https://images.trvl-media.com/lodging/1000000/30000/24400/24372/8c4e2827_y.jpg) ### Clarion Hotel & Conference Center Leesburg 10/10 Excellent "Clean and reasonable rate closer to my conferences." [](https://expedia.ca/Leesburg-Hotels-Clarion-Hotel-Conference-Center-Leesburg.h24372.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury trip to Knoxville? ### When can I expect good weather in Knoxville? ### What's there to see and do in Knoxville? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - More ways to book - [1 Star Hotels in Sharpsburg ](https://www.expedia.ca/1Star-Sharpsburg-Hotels.s10-0-d157080.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Adamstown ](https://www.expedia.ca/Adamstown-Hotels-Luxury-Hotel.0-0-d6338378-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Adamstown Hotels ](https://www.expedia.ca/Adamstown-Hotels.d6338378.Travel-Guide-Hotels) - [B&B in Antietam ](https://www.expedia.ca/Antietam-Bed-And-Breakfast.d553248635975871648-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Hotels near Antietam Creek ](https://www.expedia.ca/Antietam-Creek-Hotels.0-l553248621532662485-0.Travel-Guide-Filter-Hotels) - 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