Title: Book the Best Keowee LUXURY Hotels - Upscale Hotels in Keowee, SC | Expedia.ca [Hotels in Keowee](https://expedia.ca/Keowee-Hotels.d553248635975848347.Travel-Guide-Hotels)[Vacation Rentals in Keowee](https://expedia.ca/Keowee-Vacation-Rentals.d553248635975848347.Travel-Guide-VacationRentals)[Keowee Car Rentals](https://expedia.ca/Car-Rentals-In-Keowee.d553248635975848347.Car-Rental-Guide)[Keowee Vacation Packages](https://expedia.ca/Keowee.d553248635975848347.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/luxury.jpeg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Keowee, SC - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Keowee Luxury Hotels Tonight [Dec 11 - Dec 12](https://www.expedia.ca/Hotel-Search?regionId=553248635975848347&startDate=2025-12-11&endDate=2025-12-12&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Dec 12 - Dec 13](https://www.expedia.ca/Hotel-Search?regionId=553248635975848347&startDate=2025-12-12&endDate=2025-12-13&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248635975848347&startDate=2025-12-12&endDate=2025-12-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635975848347&startDate=2025-12-19&endDate=2025-12-21&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Keowee Hotel Reviews ![Baymont by Wyndham Anderson Clemson](https://images.trvl-media.com/lodging/1000000/540000/533900/533878/b60fead8_y.jpg) ### Baymont by Wyndham Anderson Clemson 10/10 Excellent "Well lit parking and safe area around the hotel" [](https://expedia.ca/Anderson-Hotels-Baymont-By-Wyndham-Anderson-Clemson.h533878.Hotel-Information) ![Quality Inn Clemson near University](https://images.trvl-media.com/lodging/1000000/10000/2600/2544/01de7c97_y.jpg) ### Quality Inn Clemson near University 8/10 Good "Yes very" [](https://expedia.ca/Anderson-Hotels-Quality-Inn-Clemson-Near-University.h2544.Hotel-Information) ![Quality Inn Seneca Clemson Area US-123](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2_y.jpg) ### Quality Inn Seneca Clemson Area US-123 10/10 Excellent "Property, room, and front desk were all very nice. Safety strips in the bathtub would be my only suggestion. " [](https://expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ## Frequently asked questions ### Are you looking for a luxury hotel for your stay in Keowee? ### When can I expect good weather in Keowee? ### What's there to see and do in Keowee? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Aparthotels in Central ](https://www.expedia.ca/Central-Apart-Hotels.d10503-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Central ](https://www.expedia.ca/Central-Bed-And-Breakfast.d10503-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Boutique Hotels in Central ](https://www.expedia.ca/Central-Hotels-Boutique-Hotel.0-0-d10503-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Central ](https://www.expedia.ca/Central-Hotels-Business-Hotel.0-0-d10503-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Golf Hotels in Central ](https://www.expedia.ca/Central-Hotels-Golf-Hotel.0-0-d10503-tGolfHotel.Travel-Guide-Filter-Hotels) - 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