Title: Book the Best Jeffersonville - Clarksville SPA Resorts from CA $141 - Spa Hotels in Jeffersonville - Clarksville, IN | Expedia.ca [Jeffersonville - Clarksville Travel Guide](https://expedia.ca/Jeffersonville-Clarksville.dx6059638)[Hotels in Jeffersonville - Clarksville](https://expedia.ca/Jeffersonville-Clarksville-Hotels.d6059638.Travel-Guide-Hotels)[Vacation Rentals in Jeffersonville - Clarksville](https://expedia.ca/Jeffersonville-Clarksville-Vacation-Rentals.d6059638.Travel-Guide-VacationRentals)[Flights to Jeffersonville - Clarksville](https://expedia.ca/Cheap-Flights-To-Jeffersonville-Clarksville.d6059638.Travel-Guide-Flights)[Jeffersonville - Clarksville Car Rentals](https://expedia.ca/Car-Rentals-In-Jeffersonville-Clarksville.d6059638.Car-Rental-Guide)[Jeffersonville - Clarksville Vacation Packages](https://expedia.ca/Jeffersonville-Clarksville.d6059638.Destination-Travel-Guides) ![View of Louisville from the Falls of the Ohio at Golden Hour. #BVSblue](https://images.trvl-media.com/place/3108/df34b2a2-a0fe-4fea-b211-931e06d4c702.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Eric O ![](https://images.trvl-media.com/place/3108/df34b2a2-a0fe-4fea-b211-931e06d4c702.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Jeffersonville - Clarksville Spa Hotels Tonight [Jan 23 - Jan 24](https://www.expedia.ca/Hotel-Search?regionId=6059638&startDate=2026-01-23&endDate=2026-01-24&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 24 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=6059638&startDate=2026-01-24&endDate=2026-01-25&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=6059638&startDate=2026-01-23&endDate=2026-01-25&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6059638&startDate=2026-01-30&endDate=2026-02-01&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Jeffersonville - Clarksville hotels with a spa ![3 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/54f0e03a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/a36c57b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/80fbdedc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/506c167d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Caesars Southern Indiana - A Caesars Rewards Destination [](https://www.expedia.ca/Elizabeth-Hotels-Caesars-Southern-Indiana.h795844.Hotel-Information) Elizabeth 8.2/10 Very good (1,006 reviews) "Ceasars is a very nice hotel and entertainment venue!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $102 CA $141 total includes taxes & fees Feb 23 - Feb 24 [](https://www.expedia.ca/Elizabeth-Hotels-Caesars-Southern-Indiana.h795844.Hotel-Information) ![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/e725185b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms, Non Smoking (East Twr, Waterview, 2 Queens, 1 King)](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/38ee770d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/9c82234b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/23521baa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galt House Hotel Trademark Collection by Wyndham [](https://www.expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) Downtown Louisville 9.0/10 Wonderful (4,008 reviews) "Great hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lazaro CA $186 CA $219 total includes taxes & fees Jan 29 - Jan 30 [](https://www.expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Room (Asleep in the Cyclone)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/22b7d23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/aaadeb96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/06213b95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville [](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) Downtown Louisville 9.4/10 Exceptional (1,001 reviews) "Location and the staff was fabulous." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Madeline CA $193 CA $234 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Sauna, body treatments, aromatherapy, hot stone massages](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/4c7c479b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, cocktail bar, lobby lounge](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/547de83e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, cocktail bar, lobby lounge](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/78105fdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 6:30 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/e2fb9d56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni Louisville Hotel [](https://www.expedia.ca/Louisville-Hotels-Omni-Louisville-Hotel.h21106192.Hotel-Information) Downtown Louisville 9.2/10 Wonderful (1,762 reviews) "Amazing hotel! Always a great experience!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $164 CA $193 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Louisville-Hotels-Omni-Louisville-Hotel.h21106192.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/95d9177a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/787112cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/1e2d6baa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/62c45f98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Central Park Bed & Breakfast [](https://www.expedia.ca/Louisville-Hotels-Central-Park-Bed-Breakfast.h106915308.Hotel-Information) Old Louisville 9.2/10 Wonderful (61 reviews) "My partner and I do regular romantic staycations at Central Park Inn and we love it. The rooms are comfortable and unique and the staff we've met are lovely. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amanda CA $176 CA $205 total includes taxes & fees Jan 28 - Jan 29 [](https://www.expedia.ca/Louisville-Hotels-Central-Park-Bed-Breakfast.h106915308.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/12000000/11690000/11688300/11688222/40c412dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Apartment, Multiple Beds, Pets Allowed, Garden View | Living area](https://images.trvl-media.com/lodging/12000000/11690000/11688300/11688222/3fd39b2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11690000/11688300/11688222/82066f84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/12000000/11690000/11688300/11688222/e77d0e77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pillow and Paddock B&B [](https://www.expedia.ca/Louisville-Hotels-Pillow-And-Paddock-BB.h11688222.Hotel-Information) La Grange 10/10 Exceptional (52 reviews) "Courteous staff and the room was outstanding. It was our second stay at the inn. Everything is first class. We highly recommend it." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fran CA $481 CA $531 total includes taxes & fees Feb 23 - Feb 24 [](https://www.expedia.ca/Louisville-Hotels-Pillow-And-Paddock-BB.h11688222.Hotel-Information) ![32-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/00e4c915.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/eec2d0c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/071da00d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/2ec829de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Reserve on Main [](https://www.expedia.ca/Louisville-Hotels-The-Reserve-On-Main.h121877336.Hotel-Information) Downtown Louisville 10/10 Exceptional (1 review) "Incredible stay. This stay was clean and inspiring for anyone wishing to take a break and recharge. We highly recommend this stay to everyone staying in the city. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) georgios CA $227 CA $333 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Louisville-Hotels-The-Reserve-On-Main.h121877336.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-06&endDate=2026-02-07®ionId=6059638&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Jeffersonville - Clarksville Hotel Reviews ![Caesars Southern Indiana - A Caesars Rewards Destination](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/80fbdedc_y.jpg) ### Caesars Southern Indiana - A Caesars Rewards Destination 10/10 Excellent "Ceasars is a very nice hotel and entertainment venue!" [](https://expedia.ca/Elizabeth-Hotels-Caesars-Southern-Indiana.h795844.Hotel-Information) ![Galt House Hotel Trademark Collection by Wyndham](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg) ### Galt House Hotel Trademark Collection by Wyndham 10/10 Excellent "The breakfast was delicious, the staff was amazing to be with and supper attended. " [](https://expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Hampton Inn New Albany Louisville West](https://images.trvl-media.com/lodging/1000000/30000/25400/25301/eb53eba8_y.jpg) ### Hampton Inn New Albany Louisville West 10/10 Excellent "nice staff and warm, comfy lobby. " [](https://expedia.ca/Louisville-Hotels-Hampton-Inn-New-Albany-Louisville-West.h25301.Hotel-Information) ![21c Museum Hotel Louisville](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a_y.jpg) ### 21c Museum Hotel Louisville 10/10 Excellent "Location and the staff was fabulous." [](https://expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Hawthorn Suites by Wyndham Louisville East](https://images.trvl-media.com/lodging/1000000/890000/890000/889990/00fe98fb_y.jpg) ### Hawthorn Suites by Wyndham Louisville East 10/10 Excellent "Everything was amazing. The room was beyond my expectations and the staff were super nice. I was really surprised how the room was slightly furnished like a small apartment. Definitely a place I would highly recommend." 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