Title: Book the Best Isernia LUXURY Hotels - Upscale Hotels in Isernia | Expedia.ca [Hotels in Isernia](https://expedia.ca/Isernia-Hotels.d6123603.Travel-Guide-Hotels)[Vacation Rentals in Isernia](https://expedia.ca/Isernia-Vacation-Rentals.d6123603.Travel-Guide-VacationRentals)[Flights to Isernia](https://expedia.ca/Cheap-Flights-To-Isernia.d6123603.Travel-Guide-Flights)[Things to do in Isernia](https://expedia.ca/Things-To-Do-In-Isernia.d6123603.Travel-Guide-Activities)[Isernia Car Rentals](https://expedia.ca/Car-Rentals-In-Isernia.d6123603.Car-Rental-Guide)[Isernia Vacation Packages](https://expedia.ca/Isernia.d6123603.Destination-Travel-Guides) ![Panoramica della piazza Andrea D'Isernia](https://images.trvl-media.com/place/6123603/c704aa8d-cbf6-47d6-bf54-a39d9f1f43b9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6123603/c704aa8d-cbf6-47d6-bf54-a39d9f1f43b9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Isernia Luxury Hotels Tonight [Jan 20 - Jan 21](https://www.expedia.ca/Hotel-Search?regionId=6123603&startDate=2026-01-20&endDate=2026-01-21&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Jan 21 - Jan 22](https://www.expedia.ca/Hotel-Search?regionId=6123603&startDate=2026-01-21&endDate=2026-01-22&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=6123603&startDate=2026-01-23&endDate=2026-01-25&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6123603&startDate=2026-01-30&endDate=2026-02-01&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Isernia Hotel Reviews ## Frequently asked questions ### Which area of Isernia is best to stay in for luxury hotels? > This central area is the heart of Isernia, featuring many of the city's important historical buildings and amenities. Corso Marcelli is the main street, lined with shops, cafes, and restaurants, and runs through the core of the old town. Piazza Celestino V, with its iconic Fontana Fraterna, is a key landmark and a pleasant spot to relax. The layout is quite walkable, allowing easy exploration of the ancient Roman and Samnite ruins. > > > Couples looking for a refined experience will find the historic centre appealing. It offers a blend of cultural exploration with convenient access to high-quality dining and sophisticated accommodation options. You'll be able to enjoy leisurely strolls through cobbled streets and discover local craft shops. > > > For travellers who appreciate convenience and a touch of elegance, hotels within this central zone often provide a higher standard of service and amenities. ### How much does a luxury hotel in Isernia cost? ### What luxury activities and experiences are there in Isernia? > Molise offers bespoke archaeological tours. You could arrange a private guided visit to the Palaeolithic site of La Pineta, one of Europe's most significant prehistoric discoveries, or explore the Roman ruins of Aesernia. These tours can be tailored to your interests, offering in-depth insights without the crowds. > > > For those who appreciate fine food and drink, Isernia and its surroundings provide excellent opportunities for private culinary experiences. This could include a truffle hunting excursion with a local expert and their trained dogs, followed by a private cooking class focusing on regional Molise dishes, often held in a historic villa or a family-run agriturismo. You might also enjoy exclusive wine tastings at local vineyards that produce the region's distinctive Tintilia wine. > > > Nature lovers can enjoy personalised excursions into the Matese Regional Park or the Abruzzo, Lazio and Molise National Park. This could involve guided hikes with a private naturalist, perhaps focusing on birdwatching or identifying local flora, or even a horseback riding tour through the picturesque Molise countryside, arranged with a focus on comfort and scenic routes. > > > For a relaxing and indulgent experience, consider booking a stay at one of Molise's charming boutique hotels or restored country estates. ### How can I save on a luxury hotel in Isernia with Expedia? ### Is it cheaper to book a luxury Isernia hotel and flights as a package? ### Can I cancel my luxury hotel reservation on Expedia? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [3 Star Hotels in Civitanova del Sannio ](https://www.expedia.ca/3Star-Civitanova-Del-Sannio-Hotels.s30-0-d3000028286.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Castelpetroso ](https://www.expedia.ca/4Star-Castelpetroso-Hotels.s40-0-d6143821.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Castelpetroso ](https://www.expedia.ca/5Star-Castelpetroso-Hotels.s50-0-d6143821.Travel-Guide-Filter-Hotels) - 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