Title: Book the Best Isernia LUXURY Hotels - Upscale Hotels in Isernia | Expedia.ca [Hotels in Isernia](https://expedia.ca/Isernia-Hotels.d6123603.Travel-Guide-Hotels)[Vacation Rentals in Isernia](https://expedia.ca/Isernia-Vacation-Rentals.d6123603.Travel-Guide-VacationRentals)[Flights to Isernia](https://expedia.ca/Cheap-Flights-To-Isernia.d6123603.Travel-Guide-Flights)[Things to do in Isernia](https://expedia.ca/Things-To-Do-In-Isernia.d6123603.Travel-Guide-Activities)[Isernia Car Rentals](https://expedia.ca/Car-Rentals-In-Isernia.d6123603.Car-Rental-Guide)[Isernia Vacation Packages](https://expedia.ca/Isernia.d6123603.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/luxury.jpeg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Isernia ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Isernia Luxury Hotels Tonight [Sep 25 - Sep 26](https://www.expedia.ca/Hotel-Search?regionId=6123603&startDate=2025-09-25&endDate=2025-09-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 26 - Sep 27](https://www.expedia.ca/Hotel-Search?regionId=6123603&startDate=2025-09-26&endDate=2025-09-27&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Sep 26 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=6123603&startDate=2025-09-26&endDate=2025-09-28&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6123603&startDate=2025-10-03&endDate=2025-10-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Isernia Luxury Hotels ## Top Isernia Hotel Reviews ## Frequently asked questions ### Are you looking for a luxury hotel for your Isernia vacation? > Amenities are important when you plan a vacation, so we make it easy to get what you want to make your stay special. If you want an upscale hotel that has fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Isernia offers. Isernia has some interesting things to see and do including Cathedral of Isernia and National Museum of the Paleolithic, so you might want to take in the local sights during your visit. ### When can I expect good weather in Isernia? > Planning for the weather is a good way to make your trip to Isernia relaxing and enjoyable, especially when you're splurging. The hottest months are usually August and July with an average temp of 69°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Isernia is 51 inches. ### What's there to see and do in Isernia? > Take in the sights and attractions that Isernia offers with a visit to Cathedral of Isernia, Basilica Minore dell'Addolorata, and Cipresseta di Fontegreca. If you have a little extra time during your trip, you might want to make a stop at Lago di Castel San Vincenzo and Campitello Matese Ski Resort. ### How can I get around Isernia? > It's easier to get around town comfortably when you know your options. 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