Title: Book the Best Irvine Research Center WINERY Hotels in 2025 | Expedia.ca [Vacation Rentals in Irvine](https://expedia.ca/Irvine-Vacation-Rentals.d7819.Travel-Guide-VacationRentals)[Flights to Irvine](https://expedia.ca/Cheap-Flights-To-Irvine.d7819.Travel-Guide-Flights)[Things to do in Irvine](https://expedia.ca/Things-To-Do-In-Irvine.d7819.Travel-Guide-Activities)[Irvine Research Center Car Rentals](https://expedia.ca/Car-Rentals-In-Irvine-Research-Center.d553248635976470092.Car-Rental-Guide)[Irvine Research Center Vacations](https://expedia.ca/Irvine-Research-Center.d553248635976470092.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Winery Hotels in Irvine Research Center, CA from CA $157 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Irvine Research Center Winery Hotels Tonight [Oct 12 - Oct 13](https://www.expedia.ca/Hotel-Search?regionId=553248635976470092&startDate=2025-10-12&endDate=2025-10-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=553248635976470092&startDate=2025-10-13&endDate=2025-10-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976470092&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976470092&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Irvine Research Center Winery Hotels ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/7600/7583/828b11f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, coffee/tea maker, eco-friendly cleaning products](https://images.trvl-media.com/lodging/1000000/10000/7600/7583/6fb9d45a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/7600/7583/d45bfd5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/10000/7600/7583/f61fb311.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dana Point Marina Inn Dana Point Harbor 8.0/10 Very good (1772) "Great place to stay everything you need near by" CA $148 CA $165 total includes taxes & fees Nov 13 - Nov 14 [](https://www.expedia.ca/Dana-Point-Hotels-Dana-Point-Marina-Inn.h7583.Hotel-Information) ![Deluxe Double Room, 2 Queen Beds, Non Smoking | Bathroom](https://images.trvl-media.com/lodging/32000000/31910000/31901700/31901603/4724d6e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/32000000/31910000/31901700/31901603/91c19808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Room, Multiple Beds, Accessible, Non Smoking | Terrace/patio](https://images.trvl-media.com/lodging/32000000/31910000/31901700/31901603/562da772.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Double Room, Multiple Beds, Non Smoking](https://images.trvl-media.com/lodging/32000000/31910000/31901700/31901603/7b77bc6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Nomads Hotel - Near San Clemente Pier San Clemente 8.8/10 Excellent (340) "Best beautiful boutique hotel in San Clemente!!" CA $129 CA $157 total includes taxes & fees Oct 14 - Oct 15 [](https://www.expedia.ca/San-Clemente-Hotels-Nomads-Hotel.h31901603.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/43000000/42250000/42244000/42243962/c578c250.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/43000000/42250000/42244000/42243962/449f4e08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/43000000/42250000/42244000/42243962/0b8f0f4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/43000000/42250000/42244000/42243962/b39b7086.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn at the Mission San Juan Capistrano, Autograph Collection by Marriott San Juan Capistrano 9.2/10 Wonderful (341) "Hotel was clean, and the staff was lovely " CA $377 CA $477 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Juan-Capistrano-Hotels-Inn-At-The-Mission-San-Juan-Capistrano.h42243962.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/106000000/105860000/105859100/105859064/c945e5a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/106000000/105860000/105859100/105859064/884f85b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, foosball, music library](https://images.trvl-media.com/lodging/106000000/105860000/105859100/105859064/38c46eb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/106000000/105860000/105859100/105859064/7f8b3b5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Farmhouse with 360° Nature Views in Trabuco Canyon Trabuco Canyon 10/10 Exceptional (12) "It was everything as promised in the description and very dog friendly. " CA $307 CA $504 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/Trabuco-Canyon-Hotels-Farmhouse-With-360-Nature-Views-In-Trabuco-Canyon.h105859064.Hotel-Information) ![Luxury House, 3 Bedrooms | Garden view](https://images.trvl-media.com/lodging/2000000/1500000/1496300/1496209/233cc170.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/2000000/1500000/1496300/1496209/77ef984b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Porch](https://images.trvl-media.com/lodging/2000000/1500000/1496300/1496209/f58837fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/2000000/1500000/1496300/1496209/ede666af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Always Inn San Clemente Bed & Breakfast San Clemente 8.8/10 Excellent (113) "Everything about my stay was perfect. The host’s hospitality and the delicious homemade breakfast exceeded my expectations. Thank you for making my trip so memorable." CA $221 CA $250 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Clemente-Hotels-Always-Inn-San-Clemente-Bed-Breakfast.h1496209.Hotel-Information) ![Beach nearby](https://images.trvl-media.com/lodging/54000000/53200000/53195800/53195720/8c62fc2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/54000000/53200000/53195800/53195720/7cf9203b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/54000000/53200000/53195800/53195720/6618ddd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/54000000/53200000/53195800/53195720/f5daf2d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 95 walk score Bikes Cook's Kitchen 5starpromise San Clemente 10/10 Exceptional (32) "Great location!! The condo has everything you could need, very comfortable and just an overall pleasant stay. The hosts were so accommodating and available. We're happy to have found this gem!" CA $286 CA $564 total includes taxes & fees Nov 4 - Nov 5 [](https://www.expedia.ca/San-Clemente-Hotels-95-Walk-Score-Cooks-Kitch-Bikes-5starpromise.h53195720.Hotel-Information) ![Premium bedding, individually decorated, individually furnished](https://images.trvl-media.com/lodging/5000000/4670000/4663700/4663648/4eef0074.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/5000000/4670000/4663700/4663648/f9204eee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/5000000/4670000/4663700/4663648/c467cb16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/5000000/4670000/4663700/4663648/b3c8aba1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dorymans Oceanfront Inn Balboa Peninsula 9.2/10 Wonderful (1009) "Beautiful hotel very antique!" CA $314 CA $345 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Newport-Beach-Hotels-Dorymans-Oceanfront-Inn.h4663648.Hotel-Information) ![On the beach](https://images.trvl-media.com/lodging/78000000/77950000/77949200/77949116/41527346.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/78000000/77950000/77949200/77949116/de345b20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/78000000/77950000/77949200/77949116/e9ee8a2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, offices](https://images.trvl-media.com/lodging/78000000/77950000/77949200/77949116/fa087a8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Walk to Beach - KING Apt In #1 Area! - AB San Clemente 9.6/10 Exceptional (15) "Stayed here before great location and good size place" CA $256 CA $483 total includes taxes & fees Nov 4 - Nov 5 [](https://www.expedia.ca/San-Clemente-Hotels-Signature-KING-1BR-In-Top-Beach-Location.h77949116.Hotel-Information) ![Beach](https://images.trvl-media.com/lodging/84000000/83290000/83288100/83288017/639b5bef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/84000000/83290000/83288100/83288017/ab247eac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/84000000/83290000/83288100/83288017/7a5a546d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/84000000/83290000/83288100/83288017/00c8cdf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 95 walk score - Quiet & Cozy Bikes! 5starpromise San Clemente 10/10 Exceptional (31) "We had a great stay. The hosts were terrific at sending information and proving everything our family and dog needed. The location cannot be beat! Thank you!" CA $223 CA $413 total includes taxes & fees Oct 21 - Oct 22 [](https://www.expedia.ca/San-Clemente-Hotels-95-Walk-Score-Quiet-Cozy-Bikes-5starpromise.h83288017.Hotel-Information) ![Outdoor pool, a heated pool](https://images.trvl-media.com/lodging/112000000/111830000/111823100/111823005/72247d94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, foosball, table tennis, books](https://images.trvl-media.com/lodging/112000000/111830000/111823100/111823005/78ee67c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/112000000/111830000/111823100/111823005/5d4bd1d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/112000000/111830000/111823100/111823005/05777202.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Disney Oasis with Pool and Games Henninger Park 10/10 Exceptional (4) "We loved our family vacation and made some wonderful memories! We were very comfortable in the rental home. We loved playing in the backyard and game room. " CA $441 CA $835 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Santa-Ana-Hotels-Tasteful-Retro-Disney-Cottage-WPool.h111823005.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-27&endDate=2025-10-28®ionId=553248635976470092&adults=2&location_highlights_explore=winery&sort=RECOMMENDED&openPlayBack=true) ## Top Irvine Research Center Hotel Reviews ![Anaheim Majestic Garden Hotel](//images.trvl-media.com/lodging/1000000/30000/24200/24131/b67790ff_y.jpg) ### Anaheim Majestic Garden Hotel 10/10 Excellent "Everything was very good I will definitely be back in the next vacation time !" 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