Title: 10 Best Hotels in South Main, Houston for 2026 | Expedia.ca [Vacation Rentals in Houston](https://expedia.ca/Houston-Vacation-Rentals.d178265.Travel-Guide-VacationRentals)[Flights to Houston](https://expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[South Main Car Rentals](https://expedia.ca/Car-Rentals-In-South-Main.d553248635976386992.Car-Rental-Guide)[South Main Vacations](https://expedia.ca/South-Main.d553248635976386992.Destination-Travel-Guides) ![](https://images.trvl-media.com/place/1503/2eeb9f80-ebf6-42ad-9574-1d77038420db.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Hotels in South Main, Houston - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 16 - Dec 17](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-12-16&endDate=2025-12-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 17 - Dec 18](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-12-17&endDate=2025-12-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Our top choices for South Main hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/904200/904192/0afdb877.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Individually decorated, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/904200/904192/d9a5db5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/910000/904200/904192/28e82f54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/910000/904200/904192/d9fe05fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Houston near Medical Center- NRG Stadium [](https://www.expedia.ca/Houston-Hotels-Comfort-Suites-Near-Texas-Medical-Center-NRG-Stadium.h904192.Hotel-Information) South Main 8.6/10 Excellent (1004) "Clean room, helpful staff and good location to hospital." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) George CA $122 CA $142 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Houston-Hotels-Comfort-Suites-Near-Texas-Medical-Center-NRG-Stadium.h904192.Hotel-Information) ![Hypo-allergenic bedding, in-room safe, individually decorated](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/3135be14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/1e7f9dd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/c101e36a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, individually decorated](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/572f60ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites NRG Park - Medical Center [](https://www.expedia.ca/Houston-Hotels-Quality-Inn-Suites-NRG-Park-Medical-Center.h17531.Hotel-Information) South Main 6.6/10 (1004) "Clean rooms, quiet property. We will be back again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Javier CA $77 CA $90 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Houston-Hotels-Quality-Inn-Suites-NRG-Park-Medical-Center.h17531.Hotel-Information) ![Gazebo](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/ab4b9445.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/6b2e094a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/98547457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/54d3b468.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wingate Houston near NRG Park/Medical Center [](https://www.expedia.ca/Houston-Hotels-Wingate-By-Wyndham-Houston-Reliant-Medical-Center.h66022895.Hotel-Information) South Main 6.6/10 (989) "Great staff, excellent service and convenient to the area we were wanting to be. Room was clean and bed was very comfortable." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roy CA $95 CA $111 total includes taxes & fees Dec 18 - Dec 19 [](https://www.expedia.ca/Houston-Hotels-Wingate-By-Wyndham-Houston-Reliant-Medical-Center.h66022895.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/w2558h1440x0y0-44773629.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pet-friendly](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/982edefb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 10:00 AM to 6:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/e04a9b51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/63833027.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Houston near NRG Park/Medical Center [](https://www.expedia.ca/Houston-Hotels-Wyndham-Houston-Near-NRG-ParkMedical-Center.h21297.Hotel-Information) South Main 7.2/10 Good (1203) "Love this place. Been staying here for many years. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Reynaldo CA $123 CA $143 total includes taxes & fees Dec 23 - Dec 24 [](https://www.expedia.ca/Houston-Hotels-Wyndham-Houston-Near-NRG-ParkMedical-Center.h21297.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/168bdeac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/27e929b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/b0f701b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/14da1a00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Candlewood Suites Houston Medical Center by IHG [](https://www.expedia.ca/Houston-Hotels-Candlewood-Suites-Houston-Medical-Center.h2227000.Hotel-Information) South Main 7.4/10 Good (824) "This is a safe, friendly hotel close to MDA Cancer Center" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Myra CA $96 CA $113 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Houston-Hotels-Candlewood-Suites-Houston-Medical-Center.h2227000.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/aa7fafd4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/c91eaea0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/76e7278c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Club Quarters Hotel Downtown, Houston [](https://www.expedia.ca/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information) Houston Central Business District, 10.9 km from South Main 8.4/10 Very good (3947) "Rooms were great and the staff was absolutely amazing. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elmer CA $95 CA $112 total includes taxes & fees Dec 20 - Dec 21 [](https://www.expedia.ca/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1560000/1558900/1558836/dea49ca8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1560000/1558900/1558836/19af5d69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![One King Studio Suite Non-Smoking](https://images.trvl-media.com/lodging/2000000/1560000/1558900/1558836/241f867c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1560000/1558900/1558836/b27ae005.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Houston-Bush Intercontinental Aprt [](https://www.expedia.ca/Houston-Hotels-Hampton-Inn-Suites-Houston-Bush-Intercontinental-Airport.h1558836.Hotel-Information) 31.8 km from South Main 8.8/10 Excellent (1711) "Nice hotel, the staff was very friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debra CA $119 CA $140 total includes taxes & fees Jan 2 - Jan 3, 2026 [](https://www.expedia.ca/Houston-Hotels-Hampton-Inn-Suites-Houston-Bush-Intercontinental-Airport.h1558836.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/980000/976200/976144/09dd0b59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/980000/976200/976144/79245093.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/980000/976200/976144/w3840h2558x0y0-562426d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sundeck](https://images.trvl-media.com/lodging/1000000/980000/976200/976144/51d97881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Americas-Houston [](https://www.expedia.ca/Houston-Hotels-Hilton-Americas-Houston.h976144.Hotel-Information) 10.4 km from South Main 9.4/10 Exceptional (1604) "Great hotel. Lively bar, great breakfast, friendly staff, nice room, close to everything. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas CA $187 CA $221 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Houston-Hotels-Hilton-Americas-Houston.h976144.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/870000/861200/861181/w3835h2555x4y0-996a6f84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/870000/861200/861181/3ebd956b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/870000/861200/861181/f2c86566.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/870000/861200/861181/w3840h2557x0y0-0cc1eb32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Houston/Bush Intercontinental Airport [](https://www.expedia.ca/Houston-Hotels-Hilton-Garden-Inn-HoustonBush-Intercontinental-Airport.h861181.Hotel-Information) 31 km from South Main 8.2/10 Very good (1017) "Room was clean, staff friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica CA $117 CA $138 total includes taxes & fees Dec 20 - Dec 21 [](https://www.expedia.ca/Houston-Hotels-Hilton-Garden-Inn-HoustonBush-Intercontinental-Airport.h861181.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/25000000/24160000/24152700/24152630/a3abdbe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/25000000/24160000/24152700/24152630/d069ec9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/25000000/24160000/24152700/24152630/97731659.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/25000000/24160000/24152700/24152630/16a9741b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Houston Hobby Airport, TX [](https://www.expedia.ca/Houston-Hotels-Hilton-Garden-Inn-Houston-Hobby-Airport.h24152630.Hotel-Information) 15 km from South Main 8.8/10 Excellent (1011) "Staff was great and ver helpful. Food was amazing and I would stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Arlyne CA $98 CA $115 total includes taxes & fees Dec 22 - Dec 23 [](https://www.expedia.ca/Houston-Hotels-Hilton-Garden-Inn-Houston-Hobby-Airport.h24152630.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/20000000/19720000/19716300/19716268/66da1da6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/20000000/19720000/19716300/19716268/70d04980.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/20000000/19720000/19716300/19716268/4ccd149b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/20000000/19720000/19716300/19716268/ba58a987.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Houston Intercontinental Airport [](https://www.expedia.ca/Houston-Hotels-Courtyard-By-Marriott-Houston-Intercontinental-Airport.h19716268.Hotel-Information) 31.8 km from South Main 9.0/10 Wonderful (1081) "Courteous staff, clean rooms, excellent location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rebecca CA $139 CA $163 total includes taxes & fees Dec 26 - Dec 27 [](https://www.expedia.ca/Houston-Hotels-Courtyard-By-Marriott-Houston-Intercontinental-Airport.h19716268.Hotel-Information) ![Exclusive Room, Multiple Beds, Non Smoking](https://images.trvl-media.com/lodging/2000000/1250000/1240800/1240788/dcc5346d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1250000/1240800/1240788/6c2cf751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1250000/1240800/1240788/w800h584x0y0-b8e2ff5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1250000/1240800/1240788/1b778599.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Platinum Inn & Suites Webster [](https://www.expedia.ca/Houston-Hotels-Platinum-Inn-Suites-Webster.h1240788.Hotel-Information) 30.8 km from South Main 7.8/10 Good (1014) "Location and cleanliness were wonderful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cory CA $72 CA $85 total includes taxes & fees Dec 22 - Dec 23 [](https://www.expedia.ca/Houston-Hotels-Platinum-Inn-Suites-Webster.h1240788.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/28000000/27300000/27293900/27293821/a403ab12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/28000000/27300000/27293900/27293821/522c66f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/28000000/27300000/27293900/27293821/2b2d8506.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/28000000/27300000/27293900/27293821/81b3d19c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Houston Webster NASA [](https://www.expedia.ca/Houston-Hotels-Tru-By-Hilton-Houston-Webster-NASA.h27293821.Hotel-Information) 30.8 km from South Main 9.0/10 Wonderful (1006) "The staff was super nice and the location worked great for us! " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Valeria CA $104 CA $121 total includes taxes & fees Jan 15 - Jan 16, 2026 [](https://www.expedia.ca/Houston-Hotels-Tru-By-Hilton-Houston-Webster-NASA.h27293821.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2970000/2964300/2964240/69d373fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2970000/2964300/2964240/6bc32cc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/3000000/2970000/2964300/2964240/1da2c869.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/3000000/2970000/2964300/2964240/f9e5bd86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SpringHill Suites by Marriott Houston Intercontinental Arprt [](https://www.expedia.ca/Houston-Hotels-SpringHill-Suites-By-Marriott-Houston-Intercontinental-Arprt.h2964240.Hotel-Information) 31.8 km from South Main 9.0/10 Wonderful (1616) "The rooms have been excellent each time I come in town and stay there. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dalmon CA $128 CA $149 total includes taxes & fees Dec 26 - Dec 27 [](https://www.expedia.ca/Houston-Hotels-SpringHill-Suites-By-Marriott-Houston-Intercontinental-Arprt.h2964240.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/13000000/12300000/12294900/12294828/36442d5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12300000/12294900/12294828/d494aa11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/13000000/12300000/12294900/12294828/50dbd8d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/13000000/12300000/12294900/12294828/723fc697.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Houston/Galleria [](https://www.expedia.ca/Houston-Hotels-Hyatt-Place-HoustonGalleria.h12294828.Hotel-Information) 8.7 km from South Main 8.8/10 Excellent (1268) "Great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ramon Alejandro Caballero CA $136 CA $160 total includes taxes & fees Dec 23 - Dec 24 [](https://www.expedia.ca/Houston-Hotels-Hyatt-Place-HoustonGalleria.h12294828.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/9874e960.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, City View | View from room](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/a6761ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/5506d9bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/b032cc4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Royal Sonesta Houston Galleria [](https://www.expedia.ca/Houston-Hotels-Royal-Sonesta-Houston-Galleria.h878652.Hotel-Information) The Galleria, 8.8 km from South Main 8.4/10 Very good (1466) "Wonderful hotel!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debbie CA $153 CA $179 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Houston-Hotels-Royal-Sonesta-Houston-Galleria.h878652.Hotel-Information) ![Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/9a708987.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, in-room safe, desk](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/e4ab6d84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/5138e12a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, in-room safe, desk](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/55e246fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Houston/Galleria [](https://www.expedia.ca/Houston-Hotels-Hyatt-Regency-HoustonGalleria.h10620692.Hotel-Information) The Galleria, 8.7 km from South Main 9.0/10 Wonderful (1175) "Staff was very courteous, Vallet was super helpful and nice, and room was excellent. Hotel was beautifully decorated for holidays. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Coleen CA $147 CA $214 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/Houston-Hotels-Hyatt-Regency-HoustonGalleria.h10620692.Hotel-Information) ![Sundeck](https://images.trvl-media.com/lodging/1000000/30000/25200/25188/294f3d50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/1000000/30000/25200/25188/f2e085ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/30000/25200/25188/f8ddb5e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/25200/25188/8964faa3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Houston Plaza/Medical Center [](https://www.expedia.ca/Houston-Hotels-Hilton-Houston-Plaza-Medical-Center.h25188.Hotel-Information) 4.4 km from South Main 8.4/10 Very good (1758) "Loved the room, clean, friendly staff. Would reccomend :)" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rolando CA $122 CA $144 total includes taxes & fees Dec 25 - Dec 26 [](https://www.expedia.ca/Houston-Hotels-Hilton-Houston-Plaza-Medical-Center.h25188.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/13000000/12530000/12526500/12526454/a9738659.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/13000000/12530000/12526500/12526454/4f24c5ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/13000000/12530000/12526500/12526454/97822fd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/13000000/12530000/12526500/12526454/23505ae1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Houston Downtown [](https://www.expedia.ca/Houston-Hotels-Hampton-Inn-Houston-Downtown.h12526454.Hotel-Information) 10.8 km from South Main 8.8/10 Excellent (1007) "Clean rooms and nice staff! They were very accommodating for our event with late check out! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gwen CA $146 CA $170 total includes taxes & fees Dec 23 - Dec 24 [](https://www.expedia.ca/Houston-Hotels-Hampton-Inn-Houston-Downtown.h12526454.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/1000000/170000/165600/165562/0afb5a51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/170000/165600/165562/1eac58c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/170000/165600/165562/ca311507.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/170000/165600/165562/4382ed41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Houston Bush IAH South [](https://www.expedia.ca/Houston-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Houston-Bush-IAH-South.h165562.Hotel-Information) 31.2 km from South Main 8.2/10 Very good (1191) "Nice, comfortable room by airport" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Douglas CA $92 CA $107 total includes taxes & fees Jan 16 - Jan 17, 2026 [](https://www.expedia.ca/Houston-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Houston-Bush-IAH-South.h165562.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-30&endDate=2025-12-31®ionId=553248635976386992&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Where to stay in South Main Find the best South Main areas and neighborhoods for the activities you enjoy most. - Downtown Houston - The Galleria - Texas Medical Center - Northside - Montrose ![Discovery Green which includes city views, a square or plaza and a skyscraper](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/23000/23540-Discovery-Green.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Discovery Green showing a park, a skyscraper and street scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34453-Discovery-Green.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/507000/507468-downtown-houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/507000/507497-downtown-houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Discovery Green showing a statue or sculpture, a high-rise building and modern architecture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34451-Discovery-Green.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=800037) ![Downtown Houston map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:s%7CrtDz%7BbeQiQ_%40eEcBgCkDuQ%7D_%40m%5EeQ%7EMi%5DoAePiLi%60%40m%40%7DTlCsl%40pNj%5CxWzUxS%60Bv%7CAhmAcg%40ncAuI%60DmZx%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=WgKNf3zxiTWREKGzy8I1t3uy5Hs=) ### Downtown Houston Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines. [See properties](https://www.expedia.ca/Hotel-Search?regionId=800037) ![](https://mediaim.expedia.com/destination/1/733d46a93b53c864b5c00945f6416b51.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/1/d7dc12b9d267be169566d38db8ea7eac.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/7/01538c9f6eb646ea96e3df2059618b27.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/7/374a9a687602bd093583e97522a04bc6.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/9/aadfd687906d99829a520409ec046d47.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=501263) ![The Galleria map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7DxptDn%7DteQ_AcXqKr%40mHsB%7BXT%5DgYeZY%3F%7D%60%40jGi%40rA_HxCyFTuIpzAsBbBt%7D%40fw%40%60NdA%7Ce%40szAdB&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=5e77b0krOIeDwBK5_jkO84swezY=) ### The Galleria Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower. [See properties](https://www.expedia.ca/Hotel-Search?regionId=501263) ![](https://mediaim.expedia.com/destination/1/f4655cac96c82fca6c00f4ab3162178c.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/7/29187be13ac57fa24b0f672247c7afbc.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/7/52a59f2a0bfb2cf153bbc44f917f7275.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/9/921ad7f5733a42c9202d8d16c78f3830.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=6143504) ![Texas Medical Center map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:wbftD%7C%60keQyBu%40u%5DkXgZySqC%7EG%7DEnG%7DQrDyAw%60%40aa%40gYrCsKe%5BcW%7CM_UbGi%40%60LmLjQmE%5DmPvB%60%40vEoQhGyJnDgKjKlC%7DDbTqAUq%40lDrYtHbGdd%40nKsDlOe%40bW%60Oj%40d_%40%7BFd%40%3FdRmCpA%3FdAtC%7CDL%60_%40eF%3F%7B%40uFiDf%40AqAwBB%7BC%60Ae%40yCm%40OlBhOjId%60%40hAnC&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=-txg4h32BKxrIPBjQzTWKWRnz0I=) ### Texas Medical Center Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience. [See properties](https://www.expedia.ca/Hotel-Search?regionId=6143504) ![](https://mediaim.expedia.com/destination/7/b249298face16fd5795cf74face8ed8d.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/7/7f180593ef78263134eb6f20e72fd6c3.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635976387525) ![Northside map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:muquD%60e%7DeQS_uAwHCiF%7B%40eOkIi%40dAf%40oAhOnIfFz%40%7CHB%3Ff%40bqCs%40%3FqP%7CBA%3FgKkUFzCeb%40%60u%40%5BJlx%40tq%40%3FV%7BOrD_GhAsKxG%7BG%40aB%7DS%7CJwIgSn%5Bo%5Bc%60A%5EUanAmEqAsFwCcGr%40yITqExA%7BBMQkXpJAEkNiFDBaS%7EFaJ%7E%5Eq%5EoBszBgmA%5Ci%40myAgFF%3FeAiDFIoIsYFYcEaBmFuoAj%40eaAgCNf%60%40__AZZzv%40hGx%5Ez%40VJvAk%40l%40HnI%7DQD%40pkA%60%40rMqSJ%3FfEoB%40AgEsKB_%40k%7EAaEyFoC%3F_EkEcEuCtCAY_SmKBBbIqHDgDgDu%40mBGcFnPF%60J_%40CwLqy%40ZD%7Ef%40aG%40%40tMw%40bJEvGcq%40RJyg%40aLC%3FsBzBcFjHC%3Fs%5DkFnBwCxBiS%60W_D%3FW%7Bl%40zd%40mG%3FmGlLM%3FbD%7ENoBhi%40i%40bVaArH%7D%40o%40geB%7DXJMif%40fJGUux%40tdCy_%40vB%7ERj%40dRlOEDtK%7BOHC%7EKnBA%40%7CK%60bBi%40x%40dbBpIVltA%7D%40jIn%40nmCg%40i%40mgCOgAiM%7EG%5D%7BqAmFC%3FrCcHA%40nC%7D%5E%40CaQaVT%40%5EsNaMoARg%40wGj%5DwEl%60A%7DOOe%5D%7EHAHzZdScDvJVw%40csCiLcAcDfBcDf%40Iyh%40jVOHwZvZvNMqfBayCg%7D%40Sc%60%40kq%40E%40u%40%7DF%40AqEyP%3FKkWkZNI%7DZee%40Zl%40eF%7CBC%40%60C%60D%3FGiVxpAk%40NpO%60KIPbn%40ve%40O%5Bqz%40jd%40OEya%40vLEAmHts%40W%5Da_B%60lCrjCjZ_CtfB%7CAXsObgDc%40JxYj%5E%5EpaAzrCvuCXjEtQfl%40vZqG%60R%7DN%7EP%7C%40%7CUhHdSmSrCuBzWvDzNeEbf%40uYnGwRwe%40cCd_ArSfu%40s%60%40%7E%60%40u_%40%7EZiKhk%40dQtm%40uAxaB_JDIpSkK%7CJfFfLC%7EHsK%7DBku%40dDj%40fJaLmAApX%7CLxDcItPeIlFuF%7CNkc%40fN%7BOpNoA%7E%5BsLdPiPjb%40ut%40nYq%40ti%40gNr%5EbAlaAsfC%7EwCkDKw%40mJtCcGavBu%40aZuJoEBn%40%7C%7EAyq%40%5CgCp%5C%7B%60B%3F%5DcfAgwCbuA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=SL4qRZsnUhbIVHkfA1was5maM1w=) ### Northside While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635976387525) ![Menil Collection which includes interior views and art](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/23000/23619-Menil-Collection.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Menil Collection featuring interior views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/23000/23623-Menil-Collection.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Menil Collection showing interior views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34667-Menil-Collection.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Menil Collection featuring a garden](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34665-Menil-Collection.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34668-Menil-Collection.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=3000663145) ![Montrose map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:wiptDf%7CieQmBWy%7E%40R%7BAe%40qByG_CiCwQJiG%60%40X%7BBoAyGIeOwDsLe%40qDh%40uJ%7D%40sCSsDuCkJJyE%60AsGLaMnD%7DQBcLreAQGwItTKI_MvFAb%40a%40rNdApW%40nf%40l%5D%60BlBnFpdBf%40tTElUyoA%5C&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=FA9GMjOoslAVD7SwHDyMnspJbfU=) ### Montrose Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area. [See properties](https://www.expedia.ca/Hotel-Search?regionId=3000663145) ## Top South Main Hotel Reviews ![Hilton Americas-Houston](https://images.trvl-media.com/lodging/1000000/980000/976200/976144/09dd0b59_y.jpg) ### Hilton Americas-Houston 10/10 Excellent "Beautiful amenities, excellent service and good staff" [](https://expedia.ca/Houston-Hotels-Hilton-Americas-Houston.h976144.Hotel-Information) ![Club Quarters Hotel Downtown, Houston](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd_y.jpg) ### Club Quarters Hotel Downtown, Houston 10/10 Excellent "Broken elevator was a slight frustration but overall, i liked the property." [](https://expedia.ca/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information) ![The Westin Oaks Houston at the Galleria](https://images.trvl-media.com/lodging/1000000/10000/2800/2734/0b01ce73_y.jpg) ### The Westin Oaks Houston at the Galleria 10/10 Excellent "The room was large, beautifully decorated, comfortable mattress and pillows and very clean. We live in Houston and stayed at the Westin for a week while having work done in our house. The hotel was great and it was so nice to be connected to the Galleria for shopping and so many restaurants. The elevator system is very good and security is excellent. Self parking in the garage is free. The gym is nice and has 4 Pelotons." [](https://expedia.ca/Houston-Hotels-The-Westin-Oaks-Houston-At-The-Galleria.h2734.Hotel-Information) ![DoubleTree by Hilton Hotel Houston - Greenway Plaza](https://images.trvl-media.com/lodging/1000000/30000/20200/20177/682ca680_y.jpg) ### DoubleTree by Hilton Hotel Houston - Greenway Plaza 10/10 Excellent "Perfect " [](https://expedia.ca/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Houston-Greenway-Plaza.h20177.Hotel-Information) ![Omni Houston Hotel](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/37423ee4_y.jpg) ### Omni Houston Hotel 10/10 Excellent "A great place to stay " [](https://expedia.ca/Houston-Hotels-Omni-Houston-Hotel.h17746.Hotel-Information) ![Hilton Houston Plaza/Medical Center](https://images.trvl-media.com/lodging/1000000/30000/25200/25188/294f3d50_y.jpg) ### Hilton Houston Plaza/Medical Center 10/10 Excellent "Clean room" [](https://expedia.ca/Houston-Hotels-Hilton-Houston-Plaza-Medical-Center.h25188.Hotel-Information) ![Crowne Plaza Houston Med Ctr-Galleria Area by IHG](https://images.trvl-media.com/lodging/1000000/30000/28100/28060/38218191_y.jpg) ### Crowne Plaza Houston Med Ctr-Galleria Area by IHG 10/10 Excellent "Staff and location" [](https://expedia.ca/Houston-Hotels-Crowne-Plaza-Houston-River-Oaks.h28060.Hotel-Information) ![Hotel Zaza Houston Museum District](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/47c5ade4_y.jpg) ### Hotel Zaza Houston Museum District 10/10 Excellent "Best margaritas and great bar vibe!" [](https://expedia.ca/Houston-Hotels-Hotel-Zaza-Houston-Museum-District.h3306.Hotel-Information) ![Blossom Hotel Houston, Curio Collection by Hilton](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/db7ae93f_y.jpg) ### Blossom Hotel Houston, Curio Collection by Hilton 10/10 Excellent "The rooms are truly beautiful and the restroom is so spacious." [](https://expedia.ca/Houston-Hotels-Blossom-Hotel-Houston.h58985846.Hotel-Information) ## Frequently asked questions ### What are the best hotels in South Main that travellers recommend? > For families, [Wingate Houston near NRG Park/Medical Center](https://www.expedia.ca/Houston-Hotels-Wingate-By-Wyndham-Houston-Reliant-Medical-Center.h66022895.Hotel-Information) is another great option. With a complimentary continental breakfast to fuel your adventures and a refreshing outdoor pool, it caters superbly to parents and kids alike. The accessible fitness centre allows for some family fun, while the hotel's pet-friendly policies make it a fantastic choice for those traveling with furry companions. With a focus on convenience and value, this hotel provides excellent amenities while keeping everyone comfortable. ### What are the best family hotels in South Main? > Another excellent option is the [Candlewood Suites Houston Medical Center by IHG](https://www.expedia.ca/Houston-Hotels-Candlewood-Suites-Houston-Medical-Center.h2227000.Hotel-Information), which boasts a family-friendly atmosphere with its free cribs, connecting rooms, and a sofa bed, making it great for families needing extra space. Guests appreciate the convenience of in-room kitchen amenities like a microwave and dishwasher, allowing for easy meal prep during your stay. It has a review score of 7.6, reflecting its appeal to families on the go. > > > For those seeking a place with a pool, the [Quality Inn & Suites NRG Park - Medical Center](https://www.expedia.ca/Houston-Hotels-Quality-Inn-Suites-NRG-Park-Medical-Center.h17531.Hotel-Information) is a great choice. With its inviting pool area, free meals for children, and options for rollaway beds at no extra charge, families can enjoy a splash-filled vacation while also benefiting from daily housekeeping and snack options. > > > Lastly, the [Wyndham Houston near NRG Park/Medical Center](https://www.expedia.ca/Houston-Hotels-Wyndham-Houston-Near-NRG-ParkMedical-Center.h21297.Hotel-Information) features child-friendly window designs and connecting rooms, catering specifically to families' needs. The presence of kitchenettes adds to the convenience, allowing families to prepare snacks or meals together. This property has a traveller rating of 7.2, making it a reliable choice for family stays. > > > These hotels exemplify quality and convenience, ensuring that your family's adventure in South Main is both enjoyable and comfortable. ### What hotels in South Main offer free breakfast? > Another great choice is [Quality Inn & Suites NRG Park - Medical Center](https://www.expedia.ca/Houston-Hotels-Quality-Inn-Suites-NRG-Park-Medical-Center.h17531.Hotel-Information), which also provides a free breakfast, including options for those on the go. This family-friendly hotel offers spacious suites with balconies and patios, allowing families to unwind outdoors. The outdoor pool invites guests to relax and enjoy the Texas sunshine, while the complimentary area shuttle makes it simple to explore the attractions nearby. > > > For those traveling without children, the [Wingate Houston near NRG Park/Medical Center](https://www.expedia.ca/Houston-Hotels-Wingate-By-Wyndham-Houston-Reliant-Medical-Center.h66022895.Hotel-Information) presents a delightful blend of comfort and accessibility. With an outdoor pool and fitness centre, it caters to adults looking for a rejuvenating getaway. The hotel's continental breakfast is another perk that guarantees a satisfying start to your morning adventures. ### What are the best budget hotels in South Main? > For another appealing choice, [Candlewood Suites Houston Medical Center by IHG](https://www.expedia.ca/Houston-Hotels-Candlewood-Suites-Houston-Medical-Center.h2227000.Hotel-Information) stands out with a review score of 7.6\. This property is superb for families, as it features kitchenettes in the rooms, allowing for meal preparation and snacks on the go. Kids can also enjoy the complimentary cribs and sofa beds, making it a comfortable stay for everyone. Additionally, the hotel offers a free area shuttle, which is great for exploring local attractions without the hassle of driving. > > > If you're traveling with your partner or friends, the [Wyndham Houston near NRG Park/Medical Center](https://www.expedia.ca/Houston-Hotels-Wyndham-Houston-Near-NRG-ParkMedical-Center.h21297.Hotel-Information) offers a more relaxed atmosphere with a lower review score of 7.2\. This hotel features outdoor pool access and convenient amenities, including a kitchenette in some rooms, which can appeal to those looking for a home-like experience while away. > > > No matter your travel group, these options in South Main cater to various needs while ensuring a comfortable and enjoyable stay. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a South Main hotel booking with Expedia? ### How much is the nightly rate at a South Main hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - More ways to book - [Casino Hotels in Astrodome ](https://www.expedia.ca/Astrodome-Houston-Hotels-Casino-Hotel.0-n553248635976007975-0-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Astrodome ](https://www.expedia.ca/Astrodome-Houston-Hotels-Cheap-Hotels.0-n553248635976007975-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Astrodome ](https://www.expedia.ca/Astrodome-Houston-Hotels-Luxury-Hotel.0-n553248635976007975-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - 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