Title: Book the Best Guadalupe District SPA Resorts - Spa Hotels in Guadalupe District, Santa Fe | Expedia.ca [Guadalupe District Travel Guide](https://expedia.ca/Santa-Fe-Guadalupe-District.dx553248635976481064)[Vacation Rentals in Santa Fe](https://expedia.ca/Santa-Fe-Vacation-Rentals.d180028.Travel-Guide-VacationRentals)[Flights to Santa Fe](https://expedia.ca/Cheap-Flights-To-Santa-Fe.d180028.Travel-Guide-Flights)[Things to do in Santa Fe](https://expedia.ca/Things-To-Do-In-Santa-Fe.d180028.Travel-Guide-Activities)[Guadalupe District Car Rentals](https://expedia.ca/Car-Rentals-In-Guadalupe-District.d553248635976481064.Car-Rental-Guide)[Guadalupe District Vacations](https://expedia.ca/Guadalupe-District.d553248635976481064.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/f43c118afa88b3b1014949c6b0ffe655.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Rick Tuers # Find Spa Hotels in Guadalupe District, Santa Fe ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Guadalupe District Spa Hotels Tonight [Sep 27 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=553248635976481064&startDate=2025-09-27&endDate=2025-09-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 28 - Sep 29](https://www.expedia.ca/Hotel-Search?regionId=553248635976481064&startDate=2025-09-28&endDate=2025-09-29&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248635976481064&startDate=2025-10-03&endDate=2025-10-05&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635976481064&startDate=2025-10-10&endDate=2025-10-12&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Guadalupe District Spa Hotels ![Interior](https://images.trvl-media.com/lodging/35000000/34120000/34111700/34111637/01a0bf6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, table tennis, books](https://images.trvl-media.com/lodging/35000000/34120000/34111700/34111637/2254fdad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/35000000/34120000/34111700/34111637/24a0531e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/35000000/34120000/34111700/34111637/46287b23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Perfect downtown location in historic district- 9.5 walk score! Historic home. Downtown Santa Fe 9.8/10 Exceptional (96) "The space was very clean, roomy, and breakfast on the front porch every morning was breathtaking. This location is very walkable. " [](https://www.expedia.ca/Santa-Fe-Hotels-Perfect-Downtown-Location-In-Historic-District-95-Walk-Score.h34111637.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/91000000/90520000/90514100/90514030/7d512826.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/91000000/90520000/90514100/90514030/2a3e8d44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/91000000/90520000/90514100/90514030/506e2202.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/91000000/90520000/90514100/90514030/2ee1f2d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Alto Adventures - Walk to the Plaza Downtown Santa Fe 9.8/10 Exceptional (19) "The place was nice, clean, and close to the plaza. We enjoyed our stay. " [](https://www.expedia.ca/Santa-Fe-Hotels-Alto-Adventures-Walk-To-The-Plaza.h90514030.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/33000000/32710000/32707500/32707464/9ea5274c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/33000000/32710000/32707500/32707464/c321b261.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/33000000/32710000/32707500/32707464/19d9f79b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/33000000/32710000/32707500/32707464/84f3ec56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Live The Railyard Arts District In Style. Walk to restaurants and Plaza Downtown Santa Fe 10/10 Exceptional (70) "Thanks – you have a lovely property and we really enjoyed our stay" [](https://www.expedia.ca/Santa-Fe-Hotels-Live-The-Railyard-Arts-District-In-Style-Walk-To-Restaurants-And-Plaza.h32707464.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/101000000/100170000/100162000/100161956/0fd1a782.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/101000000/100170000/100162000/100161956/08d37db7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/101000000/100170000/100162000/100161956/def11174.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100170000/100162000/100161956/ae3101a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Historic and stylish downtown Railyard Adobe Downtown Santa Fe [](https://www.expedia.ca/Santa-Fe-Hotels-Historic-And-Stylish-Downtown-Railyard-Adobe.h100161956.Hotel-Information) ![House (AF: Bosque Casita)](https://images.trvl-media.com/lodging/60000000/59800000/59794100/59794011/d22df355.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (AF: Bosque Casita) | Living room](https://images.trvl-media.com/lodging/60000000/59800000/59794100/59794011/ac98a4f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (AF: Bosque Casita) | Private kitchen](https://images.trvl-media.com/lodging/60000000/59800000/59794100/59794011/48c3772f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (AF: Bosque Casita) | Private kitchen](https://images.trvl-media.com/lodging/60000000/59800000/59794100/59794011/aa8d5201.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AF: Bosque Casita Downtown Santa Fe [](https://www.expedia.ca/Santa-Fe-Hotels-AF-Bosque-Casita.h59794011.Hotel-Information) ![House (AF: Chama Casita)](https://images.trvl-media.com/lodging/59000000/58910000/58907700/58907652/bbb4c7ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (AF: Chama Casita) | Private kitchen](https://images.trvl-media.com/lodging/59000000/58910000/58907700/58907652/cd6c3b5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (AF: Chama Casita) | Living room](https://images.trvl-media.com/lodging/59000000/58910000/58907700/58907652/b301b5f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (AF: Chama Casita) | Living room](https://images.trvl-media.com/lodging/59000000/58910000/58907700/58907652/4f43ba1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AF: Chama Casita Downtown Santa Fe [](https://www.expedia.ca/Santa-Fe-Hotels-AF-Chama-Casita.h58907652.Hotel-Information) ![House (AF: Dulce Casita) | Balcony](https://images.trvl-media.com/lodging/59000000/58900000/58899100/58899077/4ebc63d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (AF: Dulce Casita)](https://images.trvl-media.com/lodging/59000000/58900000/58899100/58899077/b6e2c953.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (AF: Dulce Casita) | Living room](https://images.trvl-media.com/lodging/59000000/58900000/58899100/58899077/136cb97c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (AF: Dulce Casita) | Private kitchen](https://images.trvl-media.com/lodging/59000000/58900000/58899100/58899077/899cd015.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AF: Dulce Casita Downtown Santa Fe [](https://www.expedia.ca/Santa-Fe-Hotels-AF-Dulce-Casita.h58899077.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-11&endDate=2025-10-12®ionId=553248635976481064&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Guadalupe District Hotel Reviews ![Hotel St Francis](//images.trvl-media.com/lodging/1000000/50000/41100/41085/06d33ddf_y.jpg) ### Hotel St Francis 10/10 Excellent "The friendly staff." [](https://expedia.ca/Santa-Fe-Hotels-Hotel-St-Francis.h41085.Hotel-Information) ![Eldorado Hotel & Spa](//images.trvl-media.com/lodging/1000000/20000/13600/13524/d784e9ab_y.jpg) ### Eldorado Hotel & Spa 10/10 Excellent "Only concern was hot tub was 120 degrees, and the other one was 113. Waited and waited for it to be turned down and it never was." [](https://expedia.ca/Santa-Fe-Hotels-Eldorado-Hotel-Spa.h13524.Hotel-Information) ![El Sendero Inn, an Ascend Collection Hotel](//images.trvl-media.com/lodging/1000000/920000/915700/915648/7123cfce_y.jpg) ### El Sendero Inn, an Ascend Collection Hotel 10/10 Excellent "This was a wonderful property for the money. Location was fabulous for walking around town, eateries and shopping. I'd come back!" [](https://expedia.ca/Santa-Fe-Hotels-El-Sendero-Inn.h915648.Hotel-Information) ![Inn at Santa Fe, SureStay Collection by Best Western](//images.trvl-media.com/lodging/1000000/160000/159300/159254/d630f07d_y.jpg) ### Inn at Santa Fe, SureStay Collection by Best Western 10/10 Excellent "Really enjoyed talking to the staff. Breakfast was good. Our room is comfortable." [](https://expedia.ca/Santa-Fe-Hotels-Inn-At-Santa-Fe.h159254.Hotel-Information) ![The Sage Hotel](//images.trvl-media.com/lodging/1000000/30000/26300/26295/95e1e199_y.jpg) ### The Sage Hotel 10/10 Excellent "Close to downtown shops, food, entertainment " [](https://expedia.ca/Santa-Fe-Hotels-The-Sage-Hotel.h26295.Hotel-Information) ![Inn and Spa at Loretto](//images.trvl-media.com/lodging/1000000/30000/26300/26264/b1f202d6_y.jpg) ### Inn and Spa at Loretto 10/10 Excellent "Love it!" [](https://expedia.ca/Santa-Fe-Hotels-Inn-And-Spa-At-Loretto.h26264.Hotel-Information) ![Hilton Santa Fe Buffalo Thunder](//images.trvl-media.com/lodging/3000000/2060000/2059000/2058957/c6ba74ab_y.jpg) ### Hilton Santa Fe Buffalo Thunder 10/10 Excellent "Clean room, friendly staff" [](https://expedia.ca/Santa-Fe-Hotels-Hilton-Santa-Fe-Buffalo-Thunder.h2058957.Hotel-Information) ![Hotel Santa Fe](//images.trvl-media.com/lodging/1000000/20000/19400/19360/1968861c_y.jpg) ### Hotel Santa Fe 10/10 Excellent "We enjoyed our stay here. No complaints " [](https://expedia.ca/Santa-Fe-Hotels-Hotel-Santa-Fe.h19360.Hotel-Information) ![Drury Plaza Hotel in Santa Fe](//images.trvl-media.com/lodging/9000000/8200000/8199200/8199136/8f424b4a_y.jpg) ### Drury Plaza Hotel in Santa Fe 10/10 Excellent "Grwat service and amenities. Very comfortable room. Highly recommended!" [](https://expedia.ca/Santa-Fe-Hotels-Drury-Plaza-Hotel-In-Santa-Fe.h8199136.Hotel-Information) ## Frequently asked questions ### Looking for a spa hotel in Guadalupe District? > Book one of our lush spa hotels and pamper yourself from the moment you arrive. Hotels with spas are a great way to break out of your routine and add a layer of luxury to your weekend away. ### What's there to see and do in Guadalupe District? > Experience all that Guadalupe District has to offer when you visit Santa Fe Railyard, Santa Fe Farmers Market, and TAI Modern. If you have a little extra time during your trip, you might want to make a stop at Santuario De Nuestra Senora de Guadalupe and El Museo Cultural. ### What is a Guadalupe District spa hotel? > Spa hotels in Guadalupe District provide lodging and have a full on-site spa which offers services like therapies as well as beauty treatments. Some also offer in-room treatments. 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