Title: Book the Best BUSINESS Hotels in Greenville - Spartanburg in 2026 | Expedia.ca [Greenville - Spartanburg Travel Guide](https://expedia.ca/Greenville-Spartanburg.dx6035267)[Hotels in Greenville - Spartanburg](https://expedia.ca/Greenville-Spartanburg-Hotels.d6035267.Travel-Guide-Hotels)[Vacation Rentals in Greenville - Spartanburg](https://expedia.ca/Greenville-Spartanburg-Vacation-Rentals.d6035267.Travel-Guide-VacationRentals)[Flights to Greenville - Spartanburg](https://expedia.ca/Cheap-Flights-To-Greenville-Spartanburg.d6035267.Travel-Guide-Flights)[Things to do in Greenville - Spartanburg](https://expedia.ca/Things-To-Do-In-Greenville-Spartanburg.d6035267.Travel-Guide-Activities)[Greenville - Spartanburg Car Rentals](https://expedia.ca/Car-Rentals-In-Greenville-Spartanburg.d6035267.Car-Rental-Guide)[Greenville - Spartanburg Vacation Packages](https://expedia.ca/Greenville-Spartanburg.d6035267.Destination-Travel-Guides) ![Greenville - Spartanburg which includes a sunset, landscape views and religious aspects](https://images.trvl-media.com/place/6035267/f9a1c090-d6c5-46f5-b727-1be5c766cfdb.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Visit Greenville, South Carolina ![](https://images.trvl-media.com/place/6035267/f9a1c090-d6c5-46f5-b727-1be5c766cfdb.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Greenville - Spartanburg Business Hotels Tonight [Feb 5 - Feb 6](https://www.expedia.ca/Hotel-Search?regionId=6035267&startDate=2026-02-05&endDate=2026-02-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Feb 6 - Feb 7](https://www.expedia.ca/Hotel-Search?regionId=6035267&startDate=2026-02-06&endDate=2026-02-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6035267&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=6035267&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Greenville - Spartanburg business-friendly hotels ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/f09ffe86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/ac0c08fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/e91d409a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/fea97b11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Greenville I-385 Inn & Suites [](https://www.expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) Greenville 9.0/10 Wonderful (1,430 reviews) "The room was clean, staff was wonderful, quiet and convenient location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tammy CA $106 CA $116 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/12000000/11920000/11919200/11919192/b92579ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/12000000/11920000/11919200/11919192/c493a2e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11920000/11919200/11919192/81b93068.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/12000000/11920000/11919200/11919192/de1bb5e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Greenville Airport, SC [](https://www.expedia.ca/Greenville-Hotels-Hampton-Inn-Suites-Greenville-Airport.h11919192.Hotel-Information) Greenville 9.2/10 Wonderful (1,003 reviews) "Super friendly staff. Amenities were excellent. Nice breakfast with multiple options available." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $125 CA $138 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/Greenville-Hotels-Hampton-Inn-Suites-Greenville-Airport.h11919192.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/0007de95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/392b8db7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/w1021h678x3y4-70d9704c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/f59bfe6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Greenville Woodruff Road [](https://www.expedia.ca/Greenville-Hotels-DoubleTree-By-Hilton-Greenville-Woodruff-Road.h50828647.Hotel-Information) Greenville 9.4/10 Exceptional (1,001 reviews) "Room for was super clean! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kristina CA $170 CA $188 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Greenville-Hotels-DoubleTree-By-Hilton-Greenville-Woodruff-Road.h50828647.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/28000000/27050000/27043000/27042919/027a8aef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/28000000/27050000/27043000/27042919/dac522c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/28000000/27050000/27043000/27042919/48cb1308.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/28000000/27050000/27043000/27042919/0a338dee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Greenville Downtown [](https://www.expedia.ca/Greenville-Hotels-Hyatt-Place-GreenvilleDowntown.h27042919.Hotel-Information) Greenville Downtown 9.2/10 Wonderful (1,000 reviews) "Polite, attentive and timely staff at check in" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura CA $185 CA $203 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Greenville-Hotels-Hyatt-Place-GreenvilleDowntown.h27042919.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/589dc000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/b9808144.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, desk, blackout drapes](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/39d93722.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/a5e4dea1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Gaffney by IHG [](https://www.expedia.ca/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) Gaffney 8.8/10 Excellent (441 reviews) "Great people n place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janice CA $107 CA $116 total includes taxes & fees Feb 12 - Feb 13 [](https://www.expedia.ca/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/76f56d99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/2a4dd9e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/ffe59c14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Golf](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/6bd999f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Greenville Airport [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Comfort-Suites.h46116309.Hotel-Information) Greenville 9.2/10 Wonderful (1,004 reviews) "Hotel was perfect for my birthday weekend. Loved my room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patricia CA $134 CA $152 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Comfort-Suites.h46116309.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/b3b1b4a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/1ac2fb4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/0e19a728.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/84ae320a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Spartanburg [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Tru-By-Hilton-Spartanburg.h48251408.Hotel-Information) Spartanburg 9.2/10 Wonderful (843 reviews) "The place was perfect for our, trip" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ronald CA $125 CA $139 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Tru-By-Hilton-Spartanburg.h48251408.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/5971f25f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/92684d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gazebo](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/1fc30205.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Concierge desk](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/1d70fbe2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd. [](https://www.expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) Greenville 8.8/10 Excellent (118 reviews) "Great room, very clean and staff was friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $97 CA $110 total includes taxes & fees Feb 23 - Feb 24 [](https://www.expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/43500/43464/a55a98c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/43500/43464/4179b181.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed](https://images.trvl-media.com/lodging/1000000/50000/43500/43464/67359be4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/43500/43464/4f97c0ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wingate by Wyndham - Greenville-Airport [](https://www.expedia.ca/Greenville-Hotels-Wingate-By-Wyndham-Greenville-Airport.h43464.Hotel-Information) Greenville 8.4/10 Very good (1,003 reviews) "Clean room, friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tamara CA $121 CA $134 total includes taxes & fees Feb 7 - Feb 8 [](https://www.expedia.ca/Greenville-Hotels-Wingate-By-Wyndham-Greenville-Airport.h43464.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/7800/7800/22a42572.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cooked-to-order breakfast for a fee on weekdays](https://images.trvl-media.com/lodging/1000000/10000/7800/7800/5870dc37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/10000/7800/7800/w3998h2667x0y0-9d222bcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/7800/7800/137ad54f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Greenville Haywood Mall [](https://www.expedia.ca/Greenville-Hotels-Courtyard-By-Marriott-Greenville-Haywood-Mall.h7800.Hotel-Information) Greenville 8.8/10 Excellent (668 reviews) "Very clean room, parking lot very convenient" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marguerita CA $131 CA $144 total includes taxes & fees Feb 21 - Feb 22 [](https://www.expedia.ca/Greenville-Hotels-Courtyard-By-Marriott-Greenville-Haywood-Mall.h7800.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-19&endDate=2026-02-20®ionId=6035267&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Greenville - Spartanburg Hotel Reviews ![Hyatt Place Greenville/Haywood](https://images.trvl-media.com/lodging/1000000/70000/64600/64570/9a71f6a4_y.jpg) ### Hyatt Place Greenville/Haywood 10/10 Excellent "Room was very clean & the front desk staff were wonderful. So welcoming and polite!" [](https://expedia.ca/Greenville-Hotels-Hyatt-Place-GreenvilleHaywood.h64570.Hotel-Information) ![Best Western Plus Greenville I-385 Inn & Suites](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/20a0c66a_y.jpg) ### Best Western Plus Greenville I-385 Inn & Suites 10/10 Excellent "Outstanding staff and one of the best free breakfast selections we’ve experienced in a long time. The room was spacious, clean, and comfortable. The fitness center was great too. Everything far exceeded our expectations. We will stay again the next time we’re in Greenville." [](https://expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Embassy Suites by Hilton Greenville Downtown Riverplace](https://images.trvl-media.com/lodging/16000000/15060000/15052000/15051911/b5c8aa89_y.jpg) ### Embassy Suites by Hilton Greenville Downtown Riverplace 10/10 Excellent "Yes everything and everyone was amazing!" [](https://expedia.ca/Greenville-Hotels-Embassy-Suites-By-Hilton-Greenville-Downtown-Riverplace.h15051911.Hotel-Information) ![Drury Inn & Suites Greenville](https://images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/6d7853ae_y.jpg) ### Drury Inn & Suites Greenville 10/10 Excellent "Staff was great. Service was excellent." [](https://expedia.ca/Greenville-Hotels-Drury-Inn-Suites-Greenville.h1533439.Hotel-Information) ![Hampton Inn & Suites Greenville-Downtown-RiverPlace](https://images.trvl-media.com/lodging/2000000/1470000/1460400/1460359/d9184989_y.jpg) ### Hampton Inn & Suites Greenville-Downtown-RiverPlace 10/10 Excellent "Clean and great location " [](https://expedia.ca/Greenville-Hotels-Hampton-Inn-Suites-Greenville-Downtown-RiverPlace.h1460359.Hotel-Information) ![Hyatt Regency Greenville](https://images.trvl-media.com/lodging/1000000/30000/22300/22252/fa37e256_y.jpg) ### Hyatt Regency Greenville 10/10 Excellent "The staff was great to us during the ice storm! Lots of places to hang out. " [](https://expedia.ca/Greenville-Hotels-Hyatt-Regency-Greenville.h22252.Hotel-Information) ![Sleep Inn Spartanburg Southwest](https://images.trvl-media.com/lodging/1000000/50000/42900/42867/5eb71761_y.jpg) ### Sleep Inn Spartanburg Southwest 10/10 Excellent "Room was very spotless and clean great staff and pet friendly hotel i would recommend anyone to come here 😀 me and my girlfriend had an amazing stay" [](https://expedia.ca/Spartanburg-Hotels-Sleep-Inn.h42867.Hotel-Information) ![Embassy Suites Greenville Golf Resort & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/31b0d05e_y.jpg) ### Embassy Suites Greenville Golf Resort & Conference Center 10/10 Excellent "Great evening reception and breakfast " [](https://expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![Fairfield Inn by Marriott Greenville-Spartanburg Airport](https://images.trvl-media.com/lodging/1000000/70000/67800/67753/97563107_y.jpg) ### Fairfield Inn by Marriott Greenville-Spartanburg Airport 10/10 Excellent "Staff was fantastic, so accommodating and friendly, made sure we had everything we needed. Room clean. Shuttle to airport right on time at 4:10am, quick & again so friendly. Parking free for our time away of 10 days. Would definitely stay again. " [](https://expedia.ca/Greenville-Hotels-Fairfield-Inn-By-Marriott-Greenville-Spartanburg-Airport.h67753.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Greenville - Spartanburg cost? ### What are the best business-friendly hotels in Greenville - Spartanburg? ### How many business-friendly hotels are there in Greenville - Spartanburg? ### What are the best cheap business-friendly hotels in Greenville - Spartanburg? ### What are the top business-friendly motels in Greenville - Spartanburg? ### Are there any family-friendly hotels in Greenville - Spartanburg that are also business friendly? ### Are there any 5-star business-friendly hotels in Greenville - Spartanburg? ### Why book your business-friendly hotel in Greenville - Spartanburg with Expedia? ### How can I find cheap business-friendly hotels in Greenville - Spartanburg? ### What is there to do in Greenville - Spartanburg near my business-friendly hotel? ## Explore a world of travel with Expedia - 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