Title: Book the Best BUSINESS Hotels in Greenville - Spartanburg in 2026 | Expedia.ca [Greenville - Spartanburg Travel Guide](https://expedia.ca/Greenville-Spartanburg.dx6035267)[Hotels in Greenville - Spartanburg](https://expedia.ca/Greenville-Spartanburg-Hotels.d6035267.Travel-Guide-Hotels)[Vacation Rentals in Greenville - Spartanburg](https://expedia.ca/Greenville-Spartanburg-Vacation-Rentals.d6035267.Travel-Guide-VacationRentals)[Flights to Greenville - Spartanburg](https://expedia.ca/Cheap-Flights-To-Greenville-Spartanburg.d6035267.Travel-Guide-Flights)[Things to do in Greenville - Spartanburg](https://expedia.ca/Things-To-Do-In-Greenville-Spartanburg.d6035267.Travel-Guide-Activities)[Greenville - Spartanburg Car Rentals](https://expedia.ca/Car-Rentals-In-Greenville-Spartanburg.d6035267.Car-Rental-Guide)[Greenville - Spartanburg Vacation Packages](https://expedia.ca/Greenville-Spartanburg.d6035267.Destination-Travel-Guides) ![Greenville - Spartanburg which includes a sunset, landscape views and religious aspects](https://images.trvl-media.com/place/6035267/f9a1c090-d6c5-46f5-b727-1be5c766cfdb.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Visit Greenville, South Carolina ![](https://images.trvl-media.com/place/6035267/f9a1c090-d6c5-46f5-b727-1be5c766cfdb.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Greenville - Spartanburg Business Hotels Tonight [Feb 2 - Feb 3](https://www.expedia.ca/Hotel-Search?regionId=6035267&startDate=2026-02-02&endDate=2026-02-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Feb 3 - Feb 4](https://www.expedia.ca/Hotel-Search?regionId=6035267&startDate=2026-02-03&endDate=2026-02-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6035267&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=6035267&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Greenville - Spartanburg business-friendly hotels ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/f09ffe86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/fea97b11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/b54ae3f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/e91d409a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Greenville I-385 Inn & Suites [](https://www.expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) Greenville 9.0/10 Wonderful (1,435 reviews) "The room was clean, staff was wonderful, quiet and convenient location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tammy CA $105 CA $116 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/12000000/11920000/11919200/11919192/b92579ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/12000000/11920000/11919200/11919192/c493a2e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11920000/11919200/11919192/81b93068.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![42-inch flat-screen TV with cable channels, TV, pay movies](https://images.trvl-media.com/lodging/12000000/11920000/11919200/11919192/42a43161.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Greenville Airport, SC [](https://www.expedia.ca/Greenville-Hotels-Hampton-Inn-Suites-Greenville-Airport.h11919192.Hotel-Information) Greenville 9.2/10 Wonderful (1,001 reviews) "Super friendly staff. Amenities were excellent. Nice breakfast with multiple options available." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $134 CA $147 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/Greenville-Hotels-Hampton-Inn-Suites-Greenville-Airport.h11919192.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/6d7853ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/d0e00d56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/164da543.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/5e60bd70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Greenville [](https://www.expedia.ca/Greenville-Hotels-Drury-Inn-Suites-Greenville.h1533439.Hotel-Information) Greenville 9.4/10 Exceptional (1,004 reviews) "Very clean, great breakfast, helpful staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mike CA $147 CA $162 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Greenville-Hotels-Drury-Inn-Suites-Greenville.h1533439.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/0007de95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/392b8db7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/074f4a70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/51000000/50830000/50828700/50828647/f59bfe6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Greenville Woodruff Road [](https://www.expedia.ca/Greenville-Hotels-DoubleTree-By-Hilton-Greenville-Woodruff-Road.h50828647.Hotel-Information) Greenville 9.4/10 Exceptional (1,000 reviews) "Room for was super clean! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kristina CA $156 CA $171 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Greenville-Hotels-DoubleTree-By-Hilton-Greenville-Woodruff-Road.h50828647.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/76f56d99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Golf](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/6bd999f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/ffe59c14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Individually decorated, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/992ec477.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Greenville Airport [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Comfort-Suites.h46116309.Hotel-Information) Greenville 9.4/10 Exceptional (1,003 reviews) "Hotel was perfect for my birthday weekend. Loved my room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patricia CA $134 CA $152 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Comfort-Suites.h46116309.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/28000000/27050000/27043000/27042919/027a8aef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/28000000/27050000/27043000/27042919/48cb1308.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/28000000/27050000/27043000/27042919/dac522c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/28000000/27050000/27043000/27042919/0a338dee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Greenville Downtown [](https://www.expedia.ca/Greenville-Hotels-Hyatt-Place-GreenvilleDowntown.h27042919.Hotel-Information) Greenville Downtown 9.2/10 Wonderful (1,002 reviews) "Polite, attentive and timely staff at check in" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura CA $185 CA $203 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Greenville-Hotels-Hyatt-Place-GreenvilleDowntown.h27042919.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/5971f25f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily local cuisine breakfast](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/9966f479.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gazebo](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/1fc30205.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/92684d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd. [](https://www.expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) Greenville 8.6/10 Excellent (115 reviews) "Great room, very clean and staff was friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $97 CA $110 total includes taxes & fees Feb 7 - Feb 8 [](https://www.expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/7800/7800/22a42572.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cooked-to-order breakfast for a fee on weekdays](https://images.trvl-media.com/lodging/1000000/10000/7800/7800/5870dc37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/7800/7800/137ad54f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/10000/7800/7800/w3998h2667x0y0-9d222bcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Greenville Haywood Mall [](https://www.expedia.ca/Greenville-Hotels-Courtyard-By-Marriott-Greenville-Haywood-Mall.h7800.Hotel-Information) Greenville 8.8/10 Excellent (668 reviews) "Very clean room, parking lot very convenient" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marguerita CA $120 CA $132 total includes taxes & fees Feb 21 - Feb 22 [](https://www.expedia.ca/Greenville-Hotels-Courtyard-By-Marriott-Greenville-Haywood-Mall.h7800.Hotel-Information) ![Coffee service](https://images.trvl-media.com/lodging/1000000/30000/25000/24994/840ecd1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25000/24994/c7fda445.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25000/24994/44ceaa16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/30000/25000/24994/3d48190d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Greenville - Haywood Mall [](https://www.expedia.ca/Greenville-Hotels-Comfort-Inn-Greenville-Haywood-Mall.h24994.Hotel-Information) Greenville 8.0/10 Very good (1,005 reviews) "This is my go to hotel when in greenville. Nice, clean hotel. Great breakfast. Very attentive staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Yer CA $119 CA $135 total includes taxes & fees Feb 4 - Feb 5 [](https://www.expedia.ca/Greenville-Hotels-Comfort-Inn-Greenville-Haywood-Mall.h24994.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2890000/2884600/2884544/4d2c32ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, soundproofing](https://images.trvl-media.com/lodging/3000000/2890000/2884600/2884544/de18ff4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2890000/2884600/2884544/c2acbfe9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/3000000/2890000/2884600/2884544/4df1aaf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Greenville [](https://www.expedia.ca/Greenville-Hotels-Hilton-Garden-Inn-Greenville.h2884544.Hotel-Information) Greenville 9.0/10 Wonderful (1,002 reviews) "The room was clean and the staff was friendly. We had a great stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tamberli CA $133 CA $150 total includes taxes & fees Feb 20 - Feb 21 [](https://www.expedia.ca/Greenville-Hotels-Hilton-Garden-Inn-Greenville.h2884544.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-17&endDate=2026-02-18®ionId=6035267&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Greenville - Spartanburg Hotel Reviews ![Embassy Suites by Hilton Greenville Downtown Riverplace](https://images.trvl-media.com/lodging/16000000/15060000/15052000/15051911/b5c8aa89_y.jpg) ### Embassy Suites by Hilton Greenville Downtown Riverplace 10/10 Excellent "Yes everything and everyone was amazing!" [](https://expedia.ca/Greenville-Hotels-Embassy-Suites-By-Hilton-Greenville-Downtown-Riverplace.h15051911.Hotel-Information) ![Hampton Inn & Suites Greenville-Downtown-RiverPlace](https://images.trvl-media.com/lodging/2000000/1470000/1460400/1460359/d9184989_y.jpg) ### Hampton Inn & Suites Greenville-Downtown-RiverPlace 10/10 Excellent "Clean and great location " [](https://expedia.ca/Greenville-Hotels-Hampton-Inn-Suites-Greenville-Downtown-RiverPlace.h1460359.Hotel-Information) ![Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG](https://images.trvl-media.com/lodging/1000000/10000/1400/1379/91409d5a_y.jpg) ### Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG 10/10 Excellent "The room was so clean and everything was quiet. I will be back " [](https://expedia.ca/Greenville-Hotels-Crowne-Plaza-Hotel-Greenville-I-385-Roper-Mtn-Rd.h1379.Hotel-Information) ![Best Western Plus Greenville I-385 Inn & Suites](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/20a0c66a_y.jpg) ### Best Western Plus Greenville I-385 Inn & Suites 10/10 Excellent "Great location " [](https://expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Hyatt Regency Greenville](https://images.trvl-media.com/lodging/1000000/30000/22300/22252/fa37e256_y.jpg) ### Hyatt Regency Greenville 10/10 Excellent "The staff was great to us during the ice storm! Lots of places to hang out. " [](https://expedia.ca/Greenville-Hotels-Hyatt-Regency-Greenville.h22252.Hotel-Information) ![Sleep Inn Spartanburg Southwest](https://images.trvl-media.com/lodging/1000000/50000/42900/42867/5eb71761_y.jpg) ### Sleep Inn Spartanburg Southwest 10/10 Excellent "Room was very spotless and clean great staff and pet friendly hotel i would recommend anyone to come here 😀 me and my girlfriend had an amazing stay" [](https://expedia.ca/Spartanburg-Hotels-Sleep-Inn.h42867.Hotel-Information) ![Embassy Suites Greenville Golf Resort & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/31b0d05e_y.jpg) ### Embassy Suites Greenville Golf Resort & Conference Center 10/10 Excellent "Great evening reception and breakfast " [](https://expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![Fairfield Inn by Marriott Greenville-Spartanburg Airport](https://images.trvl-media.com/lodging/1000000/70000/67800/67753/97563107_y.jpg) ### Fairfield Inn by Marriott Greenville-Spartanburg Airport 10/10 Excellent "Staff was fantastic, so accommodating and friendly, made sure we had everything we needed. Room clean. Shuttle to airport right on time at 4:10am, quick & again so friendly. Parking free for our time away of 10 days. Would definitely stay again. " [](https://expedia.ca/Greenville-Hotels-Fairfield-Inn-By-Marriott-Greenville-Spartanburg-Airport.h67753.Hotel-Information) ![The Westin Poinsett Greenville](https://images.trvl-media.com/lodging/1000000/580000/576000/575983/3e47bf88_y.jpg) ### The Westin Poinsett Greenville 10/10 Excellent "Great hotel Great location Great room Friendly and courteous staff" [](https://expedia.ca/Greenville-Hotels-The-Westin-Poinsett-Greenville.h575983.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Greenville - Spartanburg cost? ### What are the best business-friendly hotels in Greenville - Spartanburg? ### How many business-friendly hotels are there in Greenville - Spartanburg? ### What are the best cheap business-friendly hotels in Greenville - Spartanburg? ### What are the top business-friendly motels in Greenville - Spartanburg? ### Are there any family-friendly hotels in Greenville - Spartanburg that are also business friendly? ### Are there any 5-star business-friendly hotels in Greenville - Spartanburg? ### Why book your business-friendly hotel in Greenville - Spartanburg with Expedia? ### How can I find cheap business-friendly hotels in Greenville - Spartanburg? ### What is there to do in Greenville - Spartanburg near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [3 Star Hotels in Greenville ](https://www.expedia.ca/3Star-Greenville-Hotels.s30-0-d1388.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Greenville ](https://www.expedia.ca/5Star-Greenville-Hotels.s50-0-d1388.Travel-Guide-Filter-Hotels) - [Hotels near Bon Secours Wellness Arena ](https://www.expedia.ca/Bon-Secours-Wellness-Arena-Hotels.0-l6082715-0.Travel-Guide-Filter-Hotels) - [Lgbt Friendly Hotels in Colonel Elias Earle Historic District ](https://www.expedia.ca/Colonel-Elias-Earle-Historic-District-Greenville-Hotels-LGBT-Friendly-Hotel.0-n6348165-0-tLGBTFriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotel Wedding Venues Hotels in Colonel Elias Earle Historic District ](https://www.expedia.ca/Colonel-Elias-Earle-Historic-District-Greenville-Hotels-Wedding-Hotels.0-n6348165-0-tWeddingHotels.Travel-Guide-Filter-Hotels) - 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