Title: Book the Best BUSINESS Hotels in Greater South Side in 2025 | Expedia.ca [Vacation Rentals in Des Moines](https://expedia.ca/Des-Moines-Vacation-Rentals.d601690.Travel-Guide-VacationRentals)[Flights to Des Moines](https://expedia.ca/Cheap-Flights-To-Des-Moines.d601690.Travel-Guide-Flights)[Things to do in Des Moines](https://expedia.ca/Things-To-Do-In-Des-Moines.d601690.Travel-Guide-Activities)[Greater South Side Car Rentals](https://expedia.ca/Car-Rentals-In-Greater-South-Side.d553248635976468957.Car-Rental-Guide)[Greater South Side Vacations](https://expedia.ca/Greater-South-Side.d553248635976468957.Destination-Travel-Guides) ![Grays Lake which includes a lake or waterhole](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/268000/268861-Des-Moines.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Greater South Side, IA from CA $103 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Greater South Side Business Hotels Tonight [Oct 17 - Oct 18](https://www.expedia.ca/Hotel-Search?regionId=553248635976468957&startDate=2025-10-17&endDate=2025-10-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Oct 18 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976468957&startDate=2025-10-18&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976468957&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976468957&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Top Greater South Side Business Hotels ![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/50000/49900/49826/23994ff1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/49900/49826/1d6533f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free cribs/infant beds, rollaway beds](https://images.trvl-media.com/lodging/1000000/50000/49900/49826/4d99d3ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/49900/49826/cadbe689.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn & Suites by Wyndham Des Moines Airport Greater South Side 8.6/10 Excellent (1632) "Check in agent was great, very helpful, good recommendations for local dinner. " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Francis CA $105 CA $117 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Des-Moines-Hotels-Days-Inn-Suites-By-Wyndham-Des-Moines-Airport.h49826.Hotel-Information) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/18000/17922/063c0fb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18000/17922/cc20cb5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/18000/17922/f3ccd201.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/20000/18000/17922/8010eef2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Des Moines Airport Greater South Side 7.2/10 Good (1003) "Are room was clean and nice had a good stay." ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeremy CA $92 CA $103 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Des-Moines-Hotels-Quality-Inn-Suites-Des-Moines-Airport.h17922.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/860000/856000/855969/6f15108b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/860000/856000/855969/ca4e10b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/860000/856000/855969/f44ceb77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/860000/856000/855969/2f607891.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AmericInn by Wyndham Des Moines Airport Greater South Side 7.8/10 Good (1013) "Staff was friendly and helpful, nice rooms, parking and room was clean. " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Tashina CA $97 CA $108 total includes taxes & fees Nov 4 - Nov 5 [](https://www.expedia.ca/Des-Moines-Hotels-AmericInn-By-Wyndham-Des-Moines-Airport.h855969.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/21000000/20010000/20009600/20009550/b8e5a701.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/21000000/20010000/20009600/20009550/18f02d97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/21000000/20010000/20009600/20009550/daca4610.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/21000000/20010000/20009600/20009550/38d83aab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites West Des Moines - Jordan Creek by IHG West Des Moines 9.2/10 Wonderful (961) "Was a great place to stay! " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Sam CA $134 CA $150 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Des-Moines-Hotels-Holiday-Inn-Express-Suites-West-Des-Moines-Jordan-Creek.h20009550.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/77600/77590/01d93670.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed with Sofa bed](https://images.trvl-media.com/lodging/1000000/80000/77600/77590/cf87adb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/80000/77600/77590/6b178c72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/77600/77590/09fcb0cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn and Suites by Marriott Des Moines West West Des Moines 9.0/10 Wonderful (1029) "Great stay, staff very friendly " ![](https://a.travel-assets.com/egds/marks/flags/ca.svg) Matthew CA $129 CA $145 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Des-Moines-Hotels-Fairfield-Inn-And-Suites-By-Marriott-Des-Moines-West.h77590.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1840000/1836200/1836184/2af2a76d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/2000000/1840000/1836200/1836184/1c7816ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1840000/1836200/1836184/d7a55c7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1840000/1836200/1836184/7aea1f22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites West Des Moines West Des Moines 9.6/10 Exceptional (1019) "Short stay, but nice!" ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Tracy CA $126 CA $142 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Des-Moines-Hotels-Drury-Inn-Suites-West-Des-Moines.h1836184.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/16000000/15030000/15022400/15022303/e07c1310.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15030000/15022400/15022303/241d42aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15030000/15022400/15022303/752bc43b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/16000000/15030000/15022400/15022303/04d249cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Altoona-Des Moines Altoona 9.2/10 Wonderful (649) "Comfortable beds and nice updated rooms." ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Chris CA $138 CA $155 total includes taxes & fees Nov 8 - Nov 9 [](https://www.expedia.ca/Des-Moines-Hotels-Hampton-Inn-Suites-Altoona-Des-Moines.h15022303.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/38000000/37770000/37760100/37760010/53e01cfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/38000000/37770000/37760100/37760010/dc8e5938.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/38000000/37770000/37760100/37760010/30456c96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/38000000/37770000/37760100/37760010/1f39e752.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta by Wyndham Altoona Des Moines Altoona 9.0/10 Wonderful (1576) "Great room and a nice breakfast. " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Kenneth CA $126 CA $142 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Des-Moines-Hotels-La-Quinta-By-Wyndham-Altoona-Des-Moines.h37760010.Hotel-Information) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278540/351de79c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278540/8333844b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278540/1eea3575.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278540/96af39b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Ankeny IA - Des Moines IA Ankeny 9.2/10 Wonderful (1013) "Absolutely great staff and place to stay" ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Delores CA $122 CA $137 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Des-Moines-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Ankeny-IA-Des-Moines-IA.h1278540.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/14000000/13310000/13300700/13300681/91d6d514.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/14000000/13310000/13300700/13300681/4f60096d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/14000000/13310000/13300700/13300681/69b6786e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/14000000/13310000/13300700/13300681/dd13e7b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Staybridge Suites Des Moines Downtown by IHG Downtown Des Moines 9.4/10 Exceptional (1005) "Would definitely stay here again " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelly CA $146 CA $164 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Des-Moines-Hotels-Staybridge-Suites-Des-Moines-Downtown.h13300681.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-31&endDate=2025-11-01®ionId=553248635976468957&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Greater South Side Hotel Reviews ![Hampton Inn Des Moines-Airport](//images.trvl-media.com/lodging/1000000/20000/17400/17394/11ef309e_y.jpg) ### Hampton Inn Des Moines-Airport 10/10 Excellent "Close to airport " [](https://expedia.ca/Des-Moines-Hotels-Hampton-Inn-Des-Moines-Airport.h17394.Hotel-Information) ![Wildwood Lodge](//images.trvl-media.com/lodging/8000000/7600000/7599000/7598985/c7d37989_y.jpg) ### Wildwood Lodge 10/10 Excellent "Yes " [](https://expedia.ca/Des-Moines-Hotels-Wildwood-Lodge.h7598985.Hotel-Information) ![Holiday Inn Downtown - Mercy Area by IHG](//images.trvl-media.com/lodging/1000000/20000/18900/18835/822a9f1f_y.jpg) ### Holiday Inn Downtown - Mercy Area by IHG 10/10 Excellent "Walking distance to the Casey Event Center. " [](https://expedia.ca/Des-Moines-Hotels-Holiday-Inn-Downtown-Mercy-Area.h18835.Hotel-Information) ![Revel Hotel Des Moines Urbandale, Tapestry Collection by Hilton](//images.trvl-media.com/lodging/1000000/120000/119100/119096/b673e89d_y.jpg) ### Revel Hotel Des Moines Urbandale, Tapestry Collection by Hilton 10/10 Excellent "We love Revel, Good location, easy parking, Clean, Excellent service" [](https://expedia.ca/Des-Moines-Hotels-Revel-Hotel-Des-Moines-Urbandale.h119096.Hotel-Information) ![Ramada Tropics Resort & Conf Center by Wyndham Des Moines](//images.trvl-media.com/lodging/1000000/10000/1600/1547/b8de3671_y.jpg) ### Ramada Tropics Resort & Conf Center by Wyndham Des Moines 10/10 Excellent "Pool" [](https://expedia.ca/Des-Moines-Hotels-Ramada-Tropics-Resort-Conf-Center-By-Wyndham-Des-Moines.h1547.Hotel-Information) ![Stoney Creek Hotel Des Moines - Johnston](//images.trvl-media.com/lodging/2000000/1160000/1152300/1152222/8b967b66_y.jpg) ### Stoney Creek Hotel Des Moines - Johnston 10/10 Excellent "Room was clean upon entry and stocked with appropriate items. Staff was friendly and knowledgeable making check in and out easy!" [](https://expedia.ca/Des-Moines-Hotels-Stoney-Creek-Hotel-Des-Moines-Johnston.h1152222.Hotel-Information) ![Motel 6 West Des Moines, IA](//images.trvl-media.com/lodging/1000000/990000/986100/986072/e3428772_y.jpg) ### Motel 6 West Des Moines, IA 10/10 Excellent "The room each huge but it was clean and I got a good sleep there. Worth it for the price. " [](https://expedia.ca/Des-Moines-Hotels-Motel-6-West-Des-Moines.h986072.Hotel-Information) ![Fairfield Inn and Suites by Marriott Des Moines West](//images.trvl-media.com/lodging/1000000/80000/77600/77590/01d93670_y.jpg) ### Fairfield Inn and Suites by Marriott Des Moines West 10/10 Excellent "Room was clean, large and bed was comfortable. I would recommend and stay again. Water pressure was good and 4th floor was quiet. Nice to have restaurants within walking distance." [](https://expedia.ca/Des-Moines-Hotels-Fairfield-Inn-And-Suites-By-Marriott-Des-Moines-West.h77590.Hotel-Information) ![Days Inn & Suites by Wyndham Des Moines Airport](//images.trvl-media.com/lodging/1000000/50000/49900/49826/23994ff1_y.jpg) ### Days Inn & Suites by Wyndham Des Moines Airport 10/10 Excellent "Easy access to airport. Room was spacious and clean" [](https://expedia.ca/Des-Moines-Hotels-Days-Inn-Suites-By-Wyndham-Des-Moines-Airport.h49826.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [5 Star Hotels in Des Moines](https://www.expedia.ca/5Star-Des-Moines-Hotels.s50-0-d601690.Travel-Guide-Filter-Hotels) - [Hotels near 801 Grand](https://www.expedia.ca/801-Grand-Hotels.0-l6075062-0.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in Court District](https://www.expedia.ca/Court-District-Des-Moines-Hotels-Hotels-With-Free-Airport-Shuttle.0-n6170624-0-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Court District](https://www.expedia.ca/Court-District-Des-Moines-Hotels-Waterpark-Hotels.0-n6170624-0-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Court District Hotels](https://www.expedia.ca/Court-District-Des-Moines-Hotels.0-n6170624-0.Travel-Guide-Filter-Hotels) - [B&B in Des Moines](https://www.expedia.ca/Des-Moines-Bed-And-Breakfast.d601690-aaBedAndBreakfast.Travel-Guide-Accommodation) - 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