Title: Book the Best Great River Road LUXURY Hotels - Upscale Hotels in Great River Road | Expedia.ca [Great River Road Travel Guide](https://expedia.ca/Great-River-Road.dx702655377080487936)[Hotels in Great River Road](https://expedia.ca/Great-River-Road-Hotels.d702655377080487936.Travel-Guide-Hotels)[Vacation Rentals in Great River Road](https://expedia.ca/Great-River-Road-Vacation-Rentals.d702655377080487936.Travel-Guide-VacationRentals)[Flights to Great River Road](https://expedia.ca/Cheap-Flights-To-Great-River-Road.d702655377080487936.Travel-Guide-Flights)[Great River Road Car Rentals](https://expedia.ca/Car-Rentals-In-Great-River-Road.d702655377080487936.Car-Rental-Guide)[Great River Road Vacation Packages](https://expedia.ca/Great-River-Road.d702655377080487936.Destination-Travel-Guides) ![Galena which includes a city](https://images.trvl-media.com/place/7956/10192ec4-1419-451d-9e2e-50909ca12beb.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Great River Road - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Great River Road Luxury Hotels Tonight [Dec 27 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=702655377080487936&startDate=2025-12-27&endDate=2025-12-28&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Dec 28 - Dec 29](https://www.expedia.ca/Hotel-Search?regionId=702655377080487936&startDate=2025-12-28&endDate=2025-12-29&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=702655377080487936&startDate=2026-01-02&endDate=2026-01-04&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) In two weeks [Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=702655377080487936&startDate=2026-01-09&endDate=2026-01-11&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Find out more about Great River Road ### Great River Roadand its attractions for luxury travelers The Great River Road, a scenic byway along the Mississippi River, presents a splendid mix of culture, adventure, and luxury for discerning travellers. Begin your journey in Galena, Illinois, where you can explore the charming 19th-century architecture and indulge in wine tasting at the local vineyards, all while enjoying exquisite accommodations at the historic DeSoto House Hotel. Continue your adventure to the breathtaking Effigy Mounds National Monument in Iowa, where you can hike among ancient burial mounds and enjoy a private guided tour tailored to your interests. As you cruise along the river, don't miss the opportunity to visit the stunning views from the bluffs at Dubuque, where luxury hotels like the Hotel Julien offer modern amenities combined with rich history. A stop in Madison, Wisconsin, allows you to immerse yourself in fine dining experiences, with the renowned L'Etoile restaurant serving locally sourced gourmet dishes. Finally, unwind at a riverside resort in La Crosse, where exclusive spa treatments await to rejuvenate your spirit after a day of exploration. Each location along the Great River Road is not only picturesque but also filled with opportunities for luxurious stays, ensuring that your journey is as enjoyable as the destinations themselves. ## Top Great River Road Hotel Reviews ![New Orleans Marriott](https://images.trvl-media.com/lodging/1000000/10000/3400/3326/697a140a_y.jpg) ### New Orleans Marriott 10/10 Excellent "Amazing room amd view. Super clean" [](https://expedia.ca/New-Orleans-Hotels-New-Orleans-Marriott.h3326.Hotel-Information) ![Hyatt Regency New Orleans](https://images.trvl-media.com/lodging/1000000/20000/13400/13394/b1f1bb61_y.jpg) ### Hyatt Regency New Orleans 10/10 Excellent "The location of the hotel was good and the lobby is nice. The rooms were average, expected nicer rooms. Overall decent stay. " [](https://expedia.ca/New-Orleans-Hotels-Hyatt-Regency-New-Orleans.h13394.Hotel-Information) ![Hyatt Centric French Quarter](https://images.trvl-media.com/lodging/1000000/20000/14500/14429/47959064_y.jpg) ### Hyatt Centric French Quarter 10/10 Excellent "Maria from the reception was great, gave us very good advices. Everything was amazing." [](https://expedia.ca/New-Orleans-Hotels-Hyatt-Centric-French-Quarter.h14429.Hotel-Information) ![Le Richelieu Hotel](https://images.trvl-media.com/lodging/1000000/860000/859800/859720/e1bd2d77_y.jpg) ### Le Richelieu Hotel 10/10 Excellent "Yes " [](https://expedia.ca/New-Orleans-Hotels-Le-Richelieu-In-The-French-Quarter.h859720.Hotel-Information) ![The Roosevelt New Orleans, A Waldorf Astoria Hotel](https://images.trvl-media.com/lodging/3000000/2670000/2661400/2661313/6b04cc50_y.jpg) ### The Roosevelt New Orleans, A Waldorf Astoria Hotel 10/10 Excellent "Amazing stay with incredible service. " [](https://expedia.ca/New-Orleans-Hotels-The-Roosevelt-New-Orleans.h2661313.Hotel-Information) ![InterContinental New Orleans by IHG](https://images.trvl-media.com/lodging/1000000/20000/14600/14550/ecab4255_y.jpg) ### InterContinental New Orleans by IHG 10/10 Excellent "Excellent Valet and restaurant staff " [](https://expedia.ca/New-Orleans-Hotels-InterContinental-New-Orleans.h14550.Hotel-Information) ![The Westin New Orleans](https://images.trvl-media.com/lodging/1000000/10000/9700/9637/92224143_y.jpg) ### The Westin New Orleans 10/10 Excellent "The room was spacious and clean. The bathroom was sparse as well with a wonderful shower head. I loved the room and the staff was super friendly." [](https://expedia.ca/New-Orleans-Hotels-The-Westin-New-Orleans.h9637.Hotel-Information) ![Hotel Monteleone, New Orleans](https://images.trvl-media.com/lodging/1000000/10000/8700/8698/021a0dda_y.jpg) ### Hotel Monteleone, New Orleans 10/10 Excellent "Everything great. Location, ambience for the holidays, great cocktails, comfortable beds" [](https://expedia.ca/New-Orleans-Hotels-Hotel-Monteleone.h8698.Hotel-Information) ![Bourbon Orleans Hotel](https://images.trvl-media.com/lodging/1000000/10000/3000/2969/e0d3604e_y.jpg) ### Bourbon Orleans Hotel 10/10 Excellent "Great hotel, friendly staff courtyard and pool area beautiful and relaxing." [](https://expedia.ca/New-Orleans-Hotels-Bourbon-Orleans-Hotel.h2969.Hotel-Information) ## Explore a world of travel with Expedia - More ways to book - [Book Luxury Hotels in Great River Road on Expedia.com ](https://www.expedia.com/Great-River-Road-Hotels-Luxury-Hotel.0-0-d702655377080487936-tLuxuryHotel.Travel-Guide-Filter-Hotels)