Title: Book the Best Great River Road LUXURY Hotels - Upscale Hotels in Great River Road | Expedia.ca [Great River Road Travel Guide](https://expedia.ca/Great-River-Road.dx702655377080487936)[Hotels in Great River Road](https://expedia.ca/Great-River-Road-Hotels.d702655377080487936.Travel-Guide-Hotels)[Vacation Rentals in Great River Road](https://expedia.ca/Great-River-Road-Vacation-Rentals.d702655377080487936.Travel-Guide-VacationRentals)[Flights to Great River Road](https://expedia.ca/Cheap-Flights-To-Great-River-Road.d702655377080487936.Travel-Guide-Flights)[Great River Road Car Rentals](https://expedia.ca/Car-Rentals-In-Great-River-Road.d702655377080487936.Car-Rental-Guide)[Great River Road Vacation Packages](https://expedia.ca/Great-River-Road.d702655377080487936.Destination-Travel-Guides) ![Bloomington](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/293000/293497-Bloomington.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Great River Road ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Great River Road Luxury Hotels Tonight [Oct 23 - Oct 24](https://www.expedia.ca/Hotel-Search?regionId=702655377080487936&startDate=2025-10-23&endDate=2025-10-24&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Oct 24 - Oct 25](https://www.expedia.ca/Hotel-Search?regionId=702655377080487936&startDate=2025-10-24&endDate=2025-10-25&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=702655377080487936&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=702655377080487936&startDate=2025-10-31&endDate=2025-11-02&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Great River Road Luxury Hotels ## Find out more about Great River Road ### Great River Roadand its attractions for luxury travelers The Great River Road, a scenic byway along the Mississippi River, presents a splendid mix of culture, adventure, and luxury for discerning travellers. Begin your journey in Galena, Illinois, where you can explore the charming 19th-century architecture and indulge in wine tasting at the local vineyards, all while enjoying exquisite accommodations at the historic DeSoto House Hotel. Continue your adventure to the breathtaking Effigy Mounds National Monument in Iowa, where you can hike among ancient burial mounds and enjoy a private guided tour tailored to your interests. As you cruise along the river, don't miss the opportunity to visit the stunning views from the bluffs at Dubuque, where luxury hotels like the Hotel Julien offer modern amenities combined with rich history. A stop in Madison, Wisconsin, allows you to immerse yourself in fine dining experiences, with the renowned L'Etoile restaurant serving locally sourced gourmet dishes. Finally, unwind at a riverside resort in La Crosse, where exclusive spa treatments await to rejuvenate your spirit after a day of exploration. Each location along the Great River Road is not only picturesque but also filled with opportunities for luxurious stays, ensuring that your journey is as enjoyable as the destinations themselves. ## Top Great River Road Hotel Reviews ![Sheraton New Orleans Hotel](//images.trvl-media.com/lodging/1000000/10000/7000/6914/4c8dc41d_y.jpg) ### Sheraton New Orleans Hotel 10/10 Excellent "Great location. Good size room" [](https://expedia.ca/New-Orleans-Hotels-Sheraton-New-Orleans-Hotel.h6914.Hotel-Information) ![Wyndham New Orleans - French Quarter](//images.trvl-media.com/lodging/1000000/20000/10800/10705/c443c5b2_y.jpg) ### Wyndham New Orleans - French Quarter 10/10 Excellent "From check in to check out the staff was so pleasant. The stay was nice and quiet. All the attractions were within walking distance. Literally everyone will point you in the right direction. " [](https://expedia.ca/New-Orleans-Hotels-Wyndham-New-Orleans-French-Quarter.h10705.Hotel-Information) ![Bourbon Orleans Hotel](//images.trvl-media.com/lodging/1000000/10000/3000/2969/e0d3604e_y.jpg) ### Bourbon Orleans Hotel 10/10 Excellent "Fine" [](https://expedia.ca/New-Orleans-Hotels-Bourbon-Orleans-Hotel.h2969.Hotel-Information) ![Hyatt Regency New Orleans](//images.trvl-media.com/lodging/1000000/20000/13400/13394/b1f1bb61_y.jpg) ### Hyatt Regency New Orleans 10/10 Excellent "Every was great accept restaurants and bar close early. " [](https://expedia.ca/New-Orleans-Hotels-Hyatt-Regency-New-Orleans.h13394.Hotel-Information) ![Hampton Inn & Suites New Orleans Convention Center](//images.trvl-media.com/lodging/1000000/460000/456300/456272/7d47bb2b_y.jpg) ### Hampton Inn & Suites New Orleans Convention Center 10/10 Excellent "Amazing " [](https://expedia.ca/New-Orleans-Hotels-Hampton-Inn-Suites-New-Orleans-Convention-Center.h456272.Hotel-Information) ![New Orleans Marriott](//images.trvl-media.com/lodging/1000000/10000/3400/3326/53ee1d77_y.jpg) ### New Orleans Marriott 10/10 Excellent "Clean room. Thermostat easy to use. TV remote needs some work. " [](https://expedia.ca/New-Orleans-Hotels-New-Orleans-Marriott.h3326.Hotel-Information) ![Crowne Plaza New Orleans French Qtr - Astor by IHG](//images.trvl-media.com/lodging/1000000/880000/878400/878332/e8249d3e_y.jpg) ### Crowne Plaza New Orleans French Qtr - Astor by IHG 10/10 Excellent " We stayed here a few months ago and had a great experience. We decided to book again, and as always, the service was wonderful, the customer service was great, and the hotel was very clean overall. It’s very convenient to New Orleans and everything it has to offer. We will definitely book again!" " [](https://expedia.ca/New-Orleans-Hotels-Astor-Crowne-Plaza-New-Orleans-French-Quarter.h878332.Hotel-Information) ![French Market Inn](//images.trvl-media.com/lodging/1000000/10000/6400/6309/1e813416_y.jpg) ### French Market Inn 10/10 Excellent "Fantastic location. Helpful staff. Very clean. " [](https://expedia.ca/New-Orleans-Hotels-French-Market-Inn.h6309.Hotel-Information) ![Omni Royal Orleans Hotel](//images.trvl-media.com/lodging/1000000/20000/19500/19423/870da50c_y.jpg) ### Omni Royal Orleans Hotel 10/10 Excellent "Yes" [](https://expedia.ca/New-Orleans-Hotels-Omni-Royal-Orleans-Hotel.h19423.Hotel-Information) ## Explore a world of travel with Expedia - More ways to book - [Book Luxury Hotels in Great River Road on Expedia.com](https://www.expedia.com/Great-River-Road-Hotels-Luxury-Hotel.0-0-d702655377080487936-tLuxuryHotel.Travel-Guide-Filter-Hotels)