Title: Book the Best BUSINESS Hotels in Fort Myers River District in 2026 | Expedia.ca [Vacation Rentals in Fort Myers](https://expedia.ca/Fort-Myers-Vacation-Rentals.d602729.Travel-Guide-VacationRentals)[Flights to Fort Myers](https://expedia.ca/Cheap-Flights-To-Fort-Myers.d602729.Travel-Guide-Flights)[Things to do in Fort Myers](https://expedia.ca/Things-To-Do-In-Fort-Myers.d602729.Travel-Guide-Activities)[Fort Myers River District Car Rentals](https://expedia.ca/Car-Rentals-In-Fort-Myers-River-District.d6296330.Car-Rental-Guide)[Fort Myers River District Vacations](https://expedia.ca/Fort-Myers-River-District.d6296330.Destination-Travel-Guides) ![Florida Repertory Theater](https://images.trvl-media.com/place/6296330/bdea2cf6-6941-4ecb-bb61-a136ad5c4327.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Fort Myers River District, FL from CA $106 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Fort Myers River District Business Hotels Tonight [Dec 17 - Dec 18](https://www.expedia.ca/Hotel-Search?regionId=6296330&startDate=2025-12-17&endDate=2025-12-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 18 - Dec 19](https://www.expedia.ca/Hotel-Search?regionId=6296330&startDate=2025-12-18&endDate=2025-12-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6296330&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6296330&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Fort Myers River District business-friendly hotels ![Restaurant](https://images.trvl-media.com/lodging/46000000/45780000/45771200/45771139/bece32b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/46000000/45780000/45771200/45771139/0eb7805b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges](https://images.trvl-media.com/lodging/46000000/45780000/45771200/45771139/c13417c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, minibar, in-room safe, individually furnished](https://images.trvl-media.com/lodging/46000000/45780000/45771200/45771139/c6b6658b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Luminary Hotel & Co., Autograph Collection [](https://www.expedia.ca/Fort-Myers-Hotels-Luminary-Hotel-Co.h45771139.Hotel-Information) Fort Myers River District 9.2/10 Wonderful (478) "Top floor bar was a great place to get away from things" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eugene CA $326 CA $364 total includes taxes & fees Dec 23 - Dec 24 [](https://www.expedia.ca/Fort-Myers-Hotels-Luminary-Hotel-Co.h45771139.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1920000/1916900/1916874/w5762h3835x5y5-9feeae4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/2000000/1920000/1916900/1916874/d99aa2c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sports facility](https://images.trvl-media.com/lodging/2000000/1920000/1916900/1916874/w5749h3840x5y0-525deb5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1920000/1916900/1916874/w5751h3835x5y5-83f86631.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Banyan Hotel Fort Myers, Tapestry Collection by Hilton [](https://www.expedia.ca/Fort-Myers-Hotels-The-Banyan-Hotel-Fort-Myers.h1916874.Hotel-Information) Fort Myers River District 8.6/10 Excellent (838) "Staff was friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer CA $213 CA $238 total includes taxes & fees Dec 23 - Dec 24 [](https://www.expedia.ca/Fort-Myers-Hotels-The-Banyan-Hotel-Fort-Myers.h1916874.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/96000000/95380000/95374500/95374467/1d3dd931.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/96000000/95380000/95374500/95374467/w5757h3835x0y5-08d2d15a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/96000000/95380000/95374500/95374467/w5757h3835x0y5-c3d31148.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/96000000/95380000/95374500/95374467/w5756h3840x5y0-f898050c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Fort Myers Downtown [](https://www.expedia.ca/Fort-Myers-Hotels-Hampton-Inn-Fort-Myers-Downtown.h95374467.Hotel-Information) Fort Myers River District 9.2/10 Wonderful (814) "The room was clean, staff was very helpful and pleasant. Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bryant CA $179 CA $199 total includes taxes & fees Dec 24 - Dec 25 [](https://www.expedia.ca/Fort-Myers-Hotels-Hampton-Inn-Fort-Myers-Downtown.h95374467.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/118000000/117840000/117833700/117833624/b258534c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/118000000/117840000/117833700/117833624/5f78c7a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/118000000/117840000/117833700/117833624/bd9583cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/118000000/117840000/117833700/117833624/61517481.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Gather friends and family in this historical home. [](https://www.expedia.ca/Fort-Myers-Hotels-Gather-Friends-And-Family-In-This-Historical-Home.h117833624.Hotel-Information) Fort Myers River District 8.0/10 Very good (2) "Good" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luis L. CA $365 CA $661 total includes taxes & fees Jan 6 - Jan 7, 2026 [](https://www.expedia.ca/Fort-Myers-Hotels-Gather-Friends-And-Family-In-This-Historical-Home.h117833624.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/46330a76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/a840448a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/d3248701.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/1fa522a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park [](https://www.expedia.ca/Fort-Myers-Hotels-Days-Inn-Suites-By-Wyndham-Fort-Myers-Near-JetBlue-Park.h798422.Hotel-Information) Daniels Corridor 8.0/10 Very good (1500) "Nice and beautiful place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maguenne CA $95 CA $106 total includes taxes & fees Dec 18 - Dec 19 [](https://www.expedia.ca/Fort-Myers-Hotels-Days-Inn-Suites-By-Wyndham-Fort-Myers-Near-JetBlue-Park.h798422.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/50000000/49160000/49152700/49152700/a69cd385.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/50000000/49160000/49152700/49152700/bd66e5bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Accessible (Communications, Accessible Tub)](https://images.trvl-media.com/lodging/50000000/49160000/49152700/49152700/2f0290ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/50000000/49160000/49152700/49152700/798de6a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG [](https://www.expedia.ca/Fort-Myers-Hotels-Holiday-Inn-Express-Suites-Ft-Myers-Beach-Sanibel-Gateway.h49152700.Hotel-Information) Fort Myers Beach 9.4/10 Exceptional (1001) "Great rooms, good staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dedan CA $139 CA $155 total includes taxes & fees Dec 19 - Dec 20 [](https://www.expedia.ca/Fort-Myers-Hotels-Holiday-Inn-Express-Suites-Ft-Myers-Beach-Sanibel-Gateway.h49152700.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/5f870412.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/7cc18ae8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/42212932.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/f6f6cea7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Fort Myers Inn & Suites [](https://www.expedia.ca/Fort-Myers-Hotels-Best-Western-Fort-Myers-Inn-Suites.h17131.Hotel-Information) Fort Myers 8.8/10 Excellent (1107) "Clean room, friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary CA $110 CA $123 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Fort-Myers-Hotels-Best-Western-Fort-Myers-Inn-Suites.h17131.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/2deb021c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/6f1c6d7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/eec3b567.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/a683180f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Fort Myers Airport [](https://www.expedia.ca/Fort-Myers-Hotels-Comfort-Inn-Suites-Airport.h1746276.Hotel-Information) Daniels Corridor 8.8/10 Excellent (1120) "I arrived late in the evening and the front desk was friendly and helpful. Room was comfy and clean and all close to the airport. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Donna CA $106 CA $118 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Fort-Myers-Hotels-Comfort-Inn-Suites-Airport.h1746276.Hotel-Information) ![On the beach, sun loungers, beach towels](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/f97bdde8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/w2247h1500x326y0-2ea06bb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/aa9b23b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, sun loungers, beach towels](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/6b3a0fb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sanibel Island Beach Resort [](https://www.expedia.ca/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) Mid Island 9.2/10 Wonderful (1471) "The resort was very clean and the staff were all friendly. It was an excellent stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Zachary CA $259 CA $324 total includes taxes & fees Dec 18 - Dec 19 [](https://www.expedia.ca/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/3000000/2630000/2625800/2625745/ece913ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2630000/2625800/2625745/5f2e6784.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/3000000/2630000/2625800/2625745/e00a9bae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/3000000/2630000/2625800/2625745/ef17c48f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn by Marriott Fort Myers Sanibel [](https://www.expedia.ca/Fort-Myers-Hotels-Residence-Inn-By-Marriott-Fort-Myers-Sanibel.h2625745.Hotel-Information) Fort Myers 8.6/10 Excellent (1005) "The property was clean and the breakfast was excellent the staff was friendly and convenient to Sanibel Island" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) robert CA $131 CA $146 total includes taxes & fees Dec 18 - Dec 19 [](https://www.expedia.ca/Fort-Myers-Hotels-Residence-Inn-By-Marriott-Fort-Myers-Sanibel.h2625745.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-31&endDate=2026-01-01®ionId=6296330&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Fort Myers River District Hotel Reviews ![DiamondHead Beach Resort](https://images.trvl-media.com/lodging/1000000/210000/200700/200632/814c4388_y.jpg) ### DiamondHead Beach Resort 10/10 Excellent "Great view, good bar & grill, and umbrella & seats by the water… simply perfect!" [](https://expedia.ca/Fort-Myers-Hotels-DiamondHead-Beach-Resort.h200632.Hotel-Information) ![Sanibel Island Beach Resort](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/w2247h1500x326y0-2ea06bb5_y.jpg) ### Sanibel Island Beach Resort 10/10 Excellent "Room was clean, staff was nice, will Return!" [](https://expedia.ca/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) ![Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral](https://images.trvl-media.com/lodging/1000000/130000/129300/129295/81b75b6a_y.jpg) ### Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral 10/10 Excellent "Extremely nice staff! Check in and check out was a breeze! Very quiet and clean. Very close to stores and restaurants. I will definitely stay again! " [](https://expedia.ca/Fort-Myers-Hotels-Fairfield-Inn-Suites-By-Marriott-Ft-MyersCape-Coral.h129295.Hotel-Information) ![The Banyan Hotel Fort Myers, Tapestry Collection by Hilton](https://images.trvl-media.com/lodging/2000000/1920000/1916900/1916874/d99aa2c5_y.jpg) ### The Banyan Hotel Fort Myers, Tapestry Collection by Hilton 10/10 Excellent "The hotel was perfectly located in downtown. We walked to lots of shops and restaurants. Also walked 1 mile to the Ford Edison compound. This city is very clean and felt safe. Ainnette checked us into our room and was so helpful and cheerful every time we met. The hotel was recently remodeled and very clean. The rooms were huge and we like having additional seating with a couch and chair/desk setup. We had breakfast one morning and the food was very good. We also watched the sunset from the rooftop bar before going out to a club that night. We would definitely stay here on our next visit to Ft. Meyers. " [](https://expedia.ca/Fort-Myers-Hotels-The-Banyan-Hotel-Fort-Myers.h1916874.Hotel-Information) ![Holiday Inn Express Cape Coral-Fort Myers Area by IHG](https://images.trvl-media.com/lodging/1000000/30000/26900/26860/ab39b98c_y.jpg) ### Holiday Inn Express Cape Coral-Fort Myers Area by IHG 10/10 Excellent "Will stay here again." [](https://expedia.ca/Fort-Myers-Hotels-Holiday-Inn-Express-Cape-Coral-Fort-Myers-Area.h26860.Hotel-Information) ![Holiday Inn Express Hotel & Suites Fort Myers East - The Forum by IHG](https://images.trvl-media.com/lodging/3000000/2450000/2445500/2445450/5b470199_y.jpg) ### Holiday Inn Express Hotel & Suites Fort Myers East - The Forum by IHG 10/10 Excellent "Very nice room " [](https://expedia.ca/Fort-Myers-Hotels-Holiday-Inn-Express-Hotel-Suites-Fort-Myers-East-The-Forum.h2445450.Hotel-Information) ![Doubletree by Hilton Fort Myers at Bell Tower Shops](https://images.trvl-media.com/lodging/1000000/20000/12400/12375/704cf90c_y.jpg) ### Doubletree by Hilton Fort Myers at Bell Tower Shops 10/10 Excellent "In a plaza with a lot of options! Staff was great!" [](https://expedia.ca/Fort-Myers-Hotels-Doubletree-By-Hilton-Fort-Myers-At-Bell-Tower-Shops.h12375.Hotel-Information) ![Pink Shell Beach Resort and Marina](https://images.trvl-media.com/lodging/1000000/20000/15700/15603/5f038ed2_y.jpg) ### Pink Shell Beach Resort and Marina 10/10 Excellent "It’s a beautiful place" [](https://expedia.ca/Fort-Myers-Hotels-Pink-Shell-Beach-Resort-And-Marina.h15603.Hotel-Information) ![Lani Kai Beachfront Resort](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/b5b17142_y.jpg) ### Lani Kai Beachfront Resort 10/10 Excellent "Everything was great. Highly recommend. " [](https://expedia.ca/Fort-Myers-Hotels-Lani-Kai-Beachfront-Resort.h438796.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Fort Myers River District cost? ### How many business-friendly hotels are there in Fort Myers River District? ### Why book your business-friendly hotel in Fort Myers River District with Expedia? ### How can I find cheap business-friendly hotels in Fort Myers River District? ## Explore a world of travel with Expedia - Lodging - More ways to book - [Business Hotels in Florida ](https://www.expedia.ca/Destinations-In-Florida-Business-Hotel.0-0-d211-tBusinessHotel.Hotel-Filter-Destinations) - [Hotels & Resorts for Couples in Florida ](https://www.expedia.ca/Destinations-In-Florida-Couples-Resorts-Hotels.0-0-d211-tCouplesResortsHotels.Hotel-Filter-Destinations) - [Historic Hotels in Florida ](https://www.expedia.ca/Destinations-In-Florida-Historic-Hotel.0-0-d211-tHistoricHotel.Hotel-Filter-Destinations) - [Hotels with Early Check-in in Florida ](https://www.expedia.ca/Destinations-In-Florida-Hotel-With-Early-Check-In.0-0-d211-thotelwithearlycheckin.Hotel-Filter-Destinations) - 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