Title: Book the Best BUSINESS Hotels in East Side Pioneers in 2025 | Expedia.ca [Vacation Rentals in Rochester](https://expedia.ca/Rochester-Vacation-Rentals.d3041.Travel-Guide-VacationRentals)[Flights to Rochester](https://expedia.ca/Cheap-Flights-To-Rochester.d3041.Travel-Guide-Flights)[East Side Pioneers Car Rentals](https://expedia.ca/Car-Rentals-In-East-Side-Pioneers.d553248635976478182.Car-Rental-Guide)[East Side Pioneers Vacations](https://expedia.ca/East-Side-Pioneers.d553248635976478182.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in East Side Pioneers, MN from CA $108 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on East Side Pioneers Business Hotels Tonight [Oct 14 - Oct 15](https://www.expedia.ca/Hotel-Search?regionId=553248635976478182&startDate=2025-10-14&endDate=2025-10-15&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 15 - Oct 16](https://www.expedia.ca/Hotel-Search?regionId=553248635976478182&startDate=2025-10-15&endDate=2025-10-16&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976478182&startDate=2025-10-17&endDate=2025-10-19&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976478182&startDate=2025-10-24&endDate=2025-10-26&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top East Side Pioneers Business Hotels ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5400/5327/48e45010.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5400/5327/bd0b7bbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed](https://images.trvl-media.com/lodging/1000000/10000/5400/5327/290eee76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/5400/5327/f4426c19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Indigo Rochester – Mayo Clinic Area by IHG Downtown Rochester 8.8/10 Excellent (837) "Very convenient to Mayo clinic and good restaurants. " CA $94 CA $108 total includes taxes & fees Nov 1 - Nov 2 [](https://www.expedia.ca/Rochester-Hotels-Hotel-Indigo-Rochester-Downtown.h5327.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/b1555778.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/1213b471.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/f4c0d6e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/86063f91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Rochester Mayo Clinic Area Downtown Rochester 9.6/10 Exceptional (518) "Great hotel and location. Will definitely select this property again for my next stay in Rochester. " CA $241 CA $277 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Rochester-Hotels-Hilton-Rochester-Mayo-Clinic-Area.h27426319.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/14000000/13180000/13173700/13173672/a8a8ab63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/14000000/13180000/13173700/13173672/130f3b34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/14000000/13180000/13173700/13173672/a26fee5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/14000000/13180000/13173700/13173672/fa38f94a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Broadway Plaza, Trademark Collection by Wyndham Downtown Rochester 9.2/10 Wonderful (163) "Great spacious apartments for long stay. " CA $226 CA $260 total includes taxes & fees Oct 18 - Oct 19 [](https://www.expedia.ca/Rochester-Hotels-Broadway-Plaza.h13173672.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/60000000/59620000/59619600/59619526/21638bcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/60000000/59620000/59619600/59619526/bac0b2d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/60000000/59620000/59619600/59619526/3613a59b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/60000000/59620000/59619600/59619526/eabb718a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### EVEN Hotel Rochester - Mayo Clinic Area by IHG Kutzky Park 9.4/10 Exceptional (917) "Great stay! Looking forward to coming back next time we’re in the area!" CA $122 CA $160 total includes taxes & fees Nov 7 - Nov 8 [](https://www.expedia.ca/Rochester-Hotels-Even-Rochester-St-Marys-Area.h59619526.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2190000/2185000/2184971/62a372dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2190000/2185000/2184971/7af55238.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2190000/2185000/2184971/d03614d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds](https://images.trvl-media.com/lodging/3000000/2190000/2185000/2184971/2592d084.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Rochester South - Mayo Area by IHG Rochester 8.8/10 Excellent (1003) "Excellent hotel and have stayed here numerous times " CA $117 CA $134 total includes taxes & fees Oct 18 - Oct 19 [](https://www.expedia.ca/Rochester-Hotels-Comfort-Suites.h2184971.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Double Beds](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/f91e65d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/86c17899.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms | Living area](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/45535621.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kahler Grand Hotel Downtown Rochester 8.2/10 Very good (1666) "Great location, beautiful hotel!" CA $165 CA $191 total includes taxes & fees Oct 25 - Oct 26 [](https://www.expedia.ca/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/w3837h2557x3y3-c2ce9db3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/c7dc0b32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/34563649.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/fce6cfb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spark by Hilton Rochester South Rochester 9.4/10 Exceptional (211) "Check in was easy and staff was extremely helpful! We'll definitely stay here again. " CA $99 CA $114 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Rochester-Hotels-Spark-By-Hilton-Rochester-South.h11673145.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/569eb353.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/daff149b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Children's pool](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/f69df08f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/12906a03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S Rochester 7.2/10 Good (1010) "Thank you for a quick check in, beautiful and clean rooms. " CA $101 CA $116 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information) ![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/e56e7dae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV, pay movies](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/9d7d5e02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 7:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/41a1c74b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/5e158908.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kahler Inn and Suites - Mayo Clinic Area Downtown Rochester 8.0/10 Very good (1477) "Good location " CA $160 CA $185 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/91000000/90620000/90610700/90610605/bde7ad17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![16 bedrooms, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/91000000/90620000/90610700/90610605/24e0abff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/91000000/90620000/90610700/90610605/d3281bf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/91000000/90620000/90610700/90610605/7b075080.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn by Marriott Rochester Mayo Clinic Area South Rochester 9.6/10 Exceptional (226) "Great place" CA $159 CA $183 total includes taxes & fees Oct 24 - Oct 25 [](https://www.expedia.ca/Rochester-Hotels-Residence-Inn-By-Marriott-Rochester-Mayo-Clinic-Area-South.h90610605.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-28&endDate=2025-10-29®ionId=553248635976478182&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top East Side Pioneers Hotel Reviews ![Kahler Grand Hotel](//images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da_y.jpg) ### Kahler Grand Hotel 10/10 Excellent "Clean room, great options without having to go outside and easy access to parking ramp and skyway" [](https://expedia.ca/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![Hampton Inn Rochester-South](//images.trvl-media.com/lodging/1000000/20000/16600/16522/f90bd051_y.jpg) ### Hampton Inn Rochester-South 10/10 Excellent "Great place to stay. Awesome some breakfast." [](https://expedia.ca/Rochester-Hotels-Hampton-Inn-Rochester.h16522.Hotel-Information) ![Country Inn & Suites Rochester South Mayo Clinic](//images.trvl-media.com/lodging/1000000/460000/455600/455558/c3584a83_y.jpg) ### Country Inn & Suites Rochester South Mayo Clinic 10/10 Excellent "A very good value-- Pool, hot-tub, breakfast, suite-- all good." [](https://expedia.ca/Rochester-Hotels-Country-Inn-Suites-By-Radisson.h455558.Hotel-Information) ![Aspen Select](//images.trvl-media.com/lodging/13000000/12250000/12245300/12245240/92dc90b5_y.jpg) ### Aspen Select 10/10 Excellent "Friendly staff. Nice rooms. Several good restaurants nearby. Convenient access to the hospital." [](https://expedia.ca/Rochester-Hotels-Aspen-Select.h12245240.Hotel-Information) ![Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic](//images.trvl-media.com/lodging/1000000/120000/116600/116574/1b6617d7_y.jpg) ### Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic 10/10 Excellent "Clean room and friendly red hair lady behind front desk. Parking was convenient. Over all excellent except breakfast needs to hype up a little." [](https://expedia.ca/Rochester-Hotels-Microtel-Inn-Suites-By-Wyndham-Rochester-North-Mayo-Clinic.h116574.Hotel-Information) ![Med City Inn & Suites - Mayo Clinic Area](//images.trvl-media.com/lodging/1000000/10000/4200/4106/4b21fb74_y.jpg) ### Med City Inn & Suites - Mayo Clinic Area 10/10 Excellent "This is an average type travel hotel but for the price decent continental breakfast options are available, nice shuttle service, clean pool, hot tub and exercise area, walkable for Mayo buildings and other dining options and is pet friendly so for a budget hotel you give it a five star rating👍" [](https://expedia.ca/Rochester-Hotels-GuestHouse-Rochester.h4106.Hotel-Information) ![Kahler Inn and Suites - Mayo Clinic Area](//images.trvl-media.com/lodging/1000000/180000/171600/171566/e56e7dae_y.jpg) ### Kahler Inn and Suites - Mayo Clinic Area 10/10 Excellent "Good location " [](https://expedia.ca/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) ![Spark by Hilton Rochester South](//images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/w3837h2557x3y3-c2ce9db3_y.jpg) ### Spark by Hilton Rochester South 10/10 Excellent "Paul was kind and helpful!" [](https://expedia.ca/Rochester-Hotels-Spark-By-Hilton-Rochester-South.h11673145.Hotel-Information) ![AmericInn by Wyndham Rochester Near Mayo Clinic](//images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30_y.jpg) ### AmericInn by Wyndham Rochester Near Mayo Clinic 10/10 Excellent "It is a basic, clean, well-run place with very good rates on a quality room." 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