Title: Book the Best East Main Street SPA Resorts - Spa Hotels in East Main Street, Grand Junction | Expedia.ca [East Main Street Travel Guide](https://expedia.ca/Grand-Junction-East-Main-Street.dx905402989559472128)[Vacation Rentals in Grand Junction](https://expedia.ca/Grand-Junction-Vacation-Rentals.d1331.Travel-Guide-VacationRentals)[Flights to Grand Junction](https://expedia.ca/Cheap-Flights-To-Grand-Junction.d1331.Travel-Guide-Flights)[Things to do in Grand Junction](https://expedia.ca/Things-To-Do-In-Grand-Junction.d1331.Travel-Guide-Activities)[East Main Street Car Rentals](https://expedia.ca/Car-Rentals-In-East-Main-Street.d905402989559472128.Car-Rental-Guide)[East Main Street Vacations](https://expedia.ca/East-Main-Street.d905402989559472128.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/pool.jpeg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in East Main Street, Grand Junction - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on East Main Street Spa Hotels Tonight [Nov 1 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=905402989559472128&startDate=2025-11-01&endDate=2025-11-02&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 2 - Nov 3](https://www.expedia.ca/Hotel-Search?regionId=905402989559472128&startDate=2025-11-02&endDate=2025-11-03&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=905402989559472128&startDate=2025-11-07&endDate=2025-11-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=905402989559472128&startDate=2025-11-14&endDate=2025-11-16&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top East Main Street Spa Hotels ![Dinner served](https://images.trvl-media.com/lodging/3000000/2110000/2108700/2108693/3ecd4143.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2110000/2108700/2108693/2e7baa84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2110000/2108700/2108693/w3000h2022x0y2-11965b2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/3000000/2110000/2108700/2108693/dc628862.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wine Country Inn Palisade Palisade 9.6/10 Exceptional (1002) "We loved the location near the wineries. Great place to stay!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sara [](https://www.expedia.ca/Grand-Junction-Hotels-Wine-Country-Inn-Palisade.h2108693.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-15&endDate=2025-11-16®ionId=905402989559472128&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Find out more about East Main Street ### Top East Main Street attractions for a relaxing vacation In the vibrant East Main Street neighbourhood, travellers seeking spa hotels will find a delightful blend of relaxation and local charm. Begin your journey at the tranquil East Main Spa, where you can indulge in rejuvenating treatments that utilise locally sourced ingredients, providing a unique touch to your wellness experience. Just a short stroll away, the picturesque Riverside Park offers a serene escape with scenic walking trails and picnic spots, perfect for unwinding after a day of pampering. Art enthusiasts can explore the East Main Art Gallery, showcasing local artists and often hosting interactive workshops, adding a creative twist to your stay. For dining, the renowned Olive Bistro serves exquisite farm-to-table cuisine that pairs beautifully with a relaxing evening at your hotel. Finally, be sure to visit the East Main Market, where you can sample artisanal products and local crafts, offering a glimpse into the community's vibrant culture. Hotels in the area provide not just luxurious accommodations but also unique spa packages that cater to families, ensuring that every member is pampered, from soothing massages for adults to kid-friendly wellness activities. With attentive service and beautiful surroundings, your stay in East Main Street promises to be both restorative and enriching. ## Top East Main Street Hotel Reviews ![Grand Vista Hotel](//images.trvl-media.com/lodging/1000000/20000/14800/14746/7dc2f4eb_y.jpg) ### Grand Vista Hotel 10/10 Excellent "all of the above" [](https://expedia.ca/Grand-Junction-Hotels-Grand-Vista-Hotel.h14746.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Fruita](//images.trvl-media.com/lodging/2000000/1080000/1079800/1079744/a35bdb4c_y.jpg) ### La Quinta Inn & Suites by Wyndham Fruita 10/10 Excellent "Nice motel " [](https://expedia.ca/Grand-Junction-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Fruita.h1079744.Hotel-Information) ![Wine Country Inn Palisade](//images.trvl-media.com/lodging/3000000/2110000/2108700/2108693/3ecd4143_y.jpg) ### Wine Country Inn Palisade 10/10 Excellent "Close to the freeway, restaurant in house, rooms were great. Located in a real vineyard. Wines were amazing." [](https://expedia.ca/Grand-Junction-Hotels-Wine-Country-Inn-Palisade.h2108693.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Grand Junction](//images.trvl-media.com/lodging/1000000/90000/84500/84495/89cb7554_y.jpg) ### La Quinta Inn & Suites by Wyndham Grand Junction 10/10 Excellent "Hotel and amenities were a good value. Would stay there again." [](https://expedia.ca/Grand-Junction-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Grand-Junction.h84495.Hotel-Information) ![Clarion Inn Grand Junction](//images.trvl-media.com/lodging/1000000/20000/10400/10322/64eb32ff_y.jpg) ### Clarion Inn Grand Junction 10/10 Excellent "Airport shuttle was extra good. Good breakfast." [](https://expedia.ca/Grand-Junction-Hotels-Clarion-Inn-Grand-Junction.h10322.Hotel-Information) ![Comfort Inn & Suites](//images.trvl-media.com/lodging/1000000/480000/471200/471130/cdea8409_y.jpg) ### Comfort Inn & Suites 10/10 Excellent "Area was clean and quiet. I walked my dog at 3am and felt safe " [](https://expedia.ca/Grand-Junction-Hotels-Comfort-Inn-Suites.h471130.Hotel-Information) ![Doubletree Hotel Grand Junction](//images.trvl-media.com/lodging/1000000/10000/7900/7802/f1ef5dcf_y.jpg) ### Doubletree Hotel Grand Junction 10/10 Excellent "Friendly staff. It's distressing that a person has to pay $12 just to park in the hotel's own parking lot. Pretty much a rip off." [](https://expedia.ca/Grand-Junction-Hotels-Doubletree-Hotel-Grand-Junction.h7802.Hotel-Information) ## Frequently asked questions ### Looking to vacation at a spa hotel in East Main Street? > Book one of our lush spa hotels and pamper yourself from the moment you arrive. Spa hotels are a great way to break out of your routine and add a layer of luxury to your vacation. ### What's there to see and do in East Main Street? > Take in the sights and attractions that East Main Street offers with a visit to Western Colorado Botanical Gardens, Mesa County Fairgrounds, and Bananas Fun Park. If you have extra time while you're in the area, you might want to stop by Redlands Mesa Golf Club and Canyon View Park. ### What is a East Main Street spa hotel? > Spa hotels in East Main Street feature on-site spas which offer services such as facials and a selection of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. 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