East Cape Girardeau Vacation Rentals

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
Jul 18 - Jul 20
In two weeks
Jul 25 - Jul 27
In one month
Aug 8 - Aug 10
In two months
Sep 5 - Sep 7

Browse Select East Cape Girardeau Vacation Homes

Serenity South -- Gardens, River-Views, and Refreshing Space
Enjoy cooking in this well-equipped kitchen with a refrigerator, microwave, and coffee maker.

Serenity South -- Gardens, River-Views, and Refreshing Space

10.0 out of 10, Exceptional, (134)
"The property was exactly as listed with so many little touches that made it special. Communication was great and we were close to downtown shops and the casino. We will definitely stay again when we are in the area."
The price is CA $205
CA $335 total
includes taxes & fees
Jul 14 - Jul 15
Serenity South -- Gardens, River-Views, and Refreshing Space
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau
Enjoy cooking in this well-equipped kitchen with a central island, stove, and stainless steel refrigerator.

"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau

10.0 out of 10, Exceptional, (19)
"Chip was an excellent host, always available to provide tips about restaurants and answer any questions about the property. Property was in great condition and would not hesitate to recommend."
"Brickyard" Remodeled 1920's Dutch Colonial Revival in Downtown Cape Girardeau
Welcome campers, hikers, fishermen, girls' weekend wine getaways!!
Situated on a patio, this gazebo offers a cozy retreat with a warm glow.

Welcome campers, hikers, fishermen, girls' weekend wine getaways!!

2.0 star property
9.8 out of 10, Exceptional, (15)
"Family and I came to southern IL to hunt snow geese, the house was perfect location, and just as described in the listing and pictures. Hosts were fantastic and very helpful. We will stay here again if we are back in the area! "
Welcome campers, hikers, fishermen, girls' weekend wine getaways!!
Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen
Stroll through this tranquil indoor garden, surrounded by lush potted plants and a serene water feature.

Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen

9.8 out of 10, Exceptional, (151)
"House was clean and comfortable and fun. Would stay again!"
Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen
Little Blue Cottage on Spanish
Kitchen area with sink, cabinets, and countertop.

Little Blue Cottage on Spanish

8.6 out of 10, Excellent, (41)
"Has everything you need. Comfy and in a great location. "
The price is CA $111
CA $138 total
includes taxes & fees
Jul 16 - Jul 17
Little Blue Cottage on Spanish
Quaint, Beautiful Home next to SEMO and Hospital
Situated in a suburban neighborhood, this two-story house features a gabled roof and a front entrance.

Quaint, Beautiful Home next to SEMO and Hospital

9.8 out of 10, Exceptional, (36)
"Great stay, great location! "
Quaint, Beautiful Home next to SEMO and Hospital
Spacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck
Relax in a stylish seating area with a sofa, wicker chair, and glass table.

Spacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck

9.8 out of 10, Exceptional, (23)
"We enjoyed our stay. The place was clean and quiet. The hot tub was nice as well. "
Spacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Enjoy a tranquil retreat with a pool and lush surroundings.

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

8.8 out of 10, Excellent, (31)
"all was so nice and we enjoyed our stay. grandkids and us loved having pool table and card games and all the peace and quiet there. thank u again for contacting me and giving us address. we appreciated that very much. "
The price is CA $245
CA $373 total
includes taxes & fees
Jul 16 - Jul 17
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
Enjoy cooking in this well-equipped kitchen with a stainless steel range hood, oven, and double sink.

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

10.0 out of 10, Exceptional, (7)
"Lovely home with historic architectural features in tact. Fully stocked, great location, quite neighborhood. We thoroughly enjoyed our stay."
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
Luxury 4BR w/ King Bed | Fast Wi-Fi | Private Yard
Enjoy cooking in this well-equipped kitchen with a granite countertop, stainless steel appliances, and a dishwasher.

Luxury 4BR w/ King Bed | Fast Wi-Fi | Private Yard

10.0 out of 10, Exceptional, (1)
Luxury 4BR w/ King Bed | Fast Wi-Fi | Private Yard
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Enjoy an outdoor space with a well-maintained lawn and a circular swimming pool.

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

9.0 out of 10, Wonderful, (4)
"Great property would recommend 100%. We did not have to leave the house it had everything we needed for nine adult women to have a great streetlight"
The price is CA $431
CA $674 total
includes taxes & fees
Jul 27 - Jul 28
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Next Door to Mercy Hospital - Pet Friendly - Fast Wifi
Enjoy cooking in this well-equipped kitchen with a central island, dining table, and sink.

Next Door to Mercy Hospital - Pet Friendly - Fast Wifi

9.4 out of 10, Exceptional, (3)
"Great place for our family to have a quick get together in short notice."
Next Door to Mercy Hospital - Pet Friendly - Fast Wifi
Charming 3-bedroom house near downtown
Relax in a hanging chair with a cushioned seat and backrest, paired with a small ottoman for added comfort.

Charming 3-bedroom house near downtown

2.0 star property
10.0 out of 10, Exceptional, (2)
"My husband and I along with one other couple stayed here while in Cape for a wedding. The location was nice and was a short distance for driving or Ubering around town. The price was great!! Highly recommend."
Charming 3-bedroom house near downtown
Urban 2-bedroom Escape in Downtown Cape Girardeau
Enjoy cooking in this well-equipped kitchen with a refrigerator, oven, sink, and ample counter space.

Urban 2-bedroom Escape in Downtown Cape Girardeau

10.0 out of 10, Exceptional, (3)
"We had the best girls’ getaway here! The place was super clean and well decorated. We had everything we needed, and the host was friendly and quick to respond. The location was perfect—lots of shops, restaurants, and even a spa all within walking distance. We couldn’t have asked for a better spot!"
Urban 2-bedroom Escape in Downtown Cape Girardeau
Super cute family friendly 3-bedroom house in Cape Girardeau with AC, WiFi
Enjoy cooking in this well-equipped kitchen with a large island, sink, and ample natural light.

Super cute family friendly 3-bedroom house in Cape Girardeau with AC, WiFi

Super cute family friendly 3-bedroom house in Cape Girardeau with AC, WiFi
Steps to Southeast Hospital - Fast Wifi - King Bed
Enjoy cooking in this well-equipped kitchen with a refrigerator, cabinetry, and countertop.

Steps to Southeast Hospital - Fast Wifi - King Bed

10.0 out of 10, Exceptional, (6)
"This was the perfect place for us to have a small group weekend getaway! All the beds were comfy! High quality sheets! Very clean! "
Steps to Southeast Hospital - Fast Wifi - King Bed
Coastal Comfort at The Salty Nest: Pet-Friendly with King Bed & Fast WiFi!
Enjoy cooking in this well-equipped kitchen with a central island, oven, and refrigerator.

Coastal Comfort at The Salty Nest: Pet-Friendly with King Bed & Fast WiFi!

10.0 out of 10, Exceptional, (1)
"We absolutely loved our time at The Salty Nest! The home is beautifully decorated, flooded with natural light from large windows (all of which open and shade perfectly), and immaculately clean. The kitchen is a dream—stocked with a pristine Keurig and flavored pods, a drip coffee maker with Folgers and filters, and even a French press.The recliner couch was more comfortable than ours at home, and every bed and pillow was incredibly restful. The refrigerator was spotless, the washer was top...
Coastal Comfort at The Salty Nest: Pet-Friendly with King Bed & Fast WiFi!
Historic 2-Story Foursquare Home - C.1847 - River Views - Fast Wifi
Modern kitchen with stainless steel appliances, ample workspace, and a brick accent wall.

Historic 2-Story Foursquare Home - C.1847 - River Views - Fast Wifi

9.6 out of 10, Exceptional, (15)
"Great location, only a few blocks from downtown."
Historic 2-Story Foursquare Home - C.1847 - River Views - Fast Wifi
Cozy Anna Home Near Southern Illinois Attractions!
Kitchen area with white cabinetry, stainless steel sink, and coffee maker.

Cozy Anna Home Near Southern Illinois Attractions!

10.0 out of 10, Exceptional, (8)
"We had a great experience staying here. It was the perfect location! "
Cozy Anna Home Near Southern Illinois Attractions!
Charming 2-bedroom house in delightful Jackson with AC, WiFi
Kitchen features a central island, microwave, toaster, and refrigerator.

Charming 2-bedroom house in delightful Jackson with AC, WiFi

10.0 out of 10, Exceptional, (4)
"Nice clean property second stay."
Charming 2-bedroom house in delightful Jackson with AC, WiFi
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free