Title: Hotels by La Quinta Inn & Suites in Downtown South San Francisco from CA $127 | Expedia.ca [Downtown South San Francisco Travel Guide](https://expedia.ca/San-Francisco-Downtown-South-San-Francisco.dx553248635976481411)[Vacation Rentals in San Francisco](https://expedia.ca/San-Francisco-Vacation-Rentals.d178305.Travel-Guide-VacationRentals)[Flights to San Francisco](https://expedia.ca/Cheap-Flights-To-San-Francisco.d178305.Travel-Guide-Flights)[Things to do in San Francisco](https://expedia.ca/Things-To-Do-In-San-Francisco.d178305.Travel-Guide-Activities)[Downtown South San Francisco Car Rentals](https://expedia.ca/Car-Rentals-In-Downtown-South-San-Francisco.d553248635976481411.Car-Rental-Guide)[Downtown South San Francisco Vacations](https://expedia.ca/Downtown-South-San-Francisco.d553248635976481411.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/725c89ab119e5e14f388d99a019f3224.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Catherine Edejer-McCormick # Find Hotels by La Quinta Inn & Suites in Downtown South San Francisco from CA $127 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 17 - Oct 18](https://www.expedia.ca/Hotel-Search?regionId=553248635976481411&startDate=2025-10-17&endDate=2025-10-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 18 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976481411&startDate=2025-10-18&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976481411&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976481411&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Downtown South San Francisco La Quinta Inn & Suites Hotels ![Garden](https://images.trvl-media.com/lodging/1000000/30000/27000/26945/a57ff5b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/1000000/30000/27000/26945/9d0e9bfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, dishwasher, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/30000/27000/26945/91034226.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/27000/26945/2e422e8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Francisco Airport West Millbrae 8.6/10 Excellent (1435) "Breakfast is good; room is clean, and the staff are amazing." ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Ronald CA $180 CA $206 total includes taxes & fees Oct 25 - Oct 26 [](https://www.expedia.ca/San-Francisco-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Francisco-Airport-West.h26945.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/9400/9329/5d196618.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9400/9329/f426e9e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, Multiple Beds, Accessible, Non Smoking (Mobility/Hearing Impaired Accessible)](https://images.trvl-media.com/lodging/1000000/10000/9400/9329/6c7a44bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/9400/9329/4becccdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Francisco Airport N Downtown South San Francisco 8.0/10 Very good (2021) "Great place to stay " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Gladys CA $142 CA $167 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Francisco-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Francisco-Airport-N.h9329.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/8000/7973/413632c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/8000/7973/3372b98b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/8000/7973/5b3126f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/8000/7973/ea44aae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Oakland - Hayward Hayward 8.4/10 Very good (1049) "Great place to stay " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Francisco CA $111 CA $127 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Oakland-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Oakland-Hayward.h7973.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-01&endDate=2025-11-02®ionId=553248635976481411&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDowntown-South-San-Francisco-San-Francisco-Hotels-La-Quinta-Inn-Suites.0-n553248635976481411-0--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDowntown-South-San-Francisco-San-Francisco-Hotels-La-Quinta-Inn-Suites.0-n553248635976481411-0--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) ## Top Downtown South San Francisco Hotel Reviews ![Hyatt Regency San Francisco](//images.trvl-media.com/lodging/1000000/30000/23800/23774/1f7903cc_y.jpg) ### Hyatt Regency San Francisco 10/10 Excellent "Great location and views" [](https://expedia.ca/San-Francisco-Hotels-Hyatt-Regency-San-Francisco.h23774.Hotel-Information) ![Bay Landing San Francisco Airport Hotel](//images.trvl-media.com/lodging/2000000/1120000/1110800/1110785/0c231d9b_y.jpg) ### Bay Landing San Francisco Airport Hotel 10/10 Excellent "Very pleasant time" [](https://expedia.ca/San-Francisco-Hotels-Bay-Landing-San-Francisco-Airport-Hotel.h1110785.Hotel-Information) ![Hotel Caza Fisherman's Wharf](//images.trvl-media.com/lodging/39000000/38250000/38249400/38249309/0bf5bd4c_y.jpg) ### Hotel Caza Fisherman's Wharf 10/10 Excellent "Clean rooms. Excellent location" [](https://expedia.ca/San-Francisco-Hotels-Hotel-Caza.h38249309.Hotel-Information) ![Hilton San Francisco Financial District](//images.trvl-media.com/lodging/1000000/10000/4400/4302/77af977e_y.jpg) ### Hilton San Francisco Financial District 10/10 Excellent " Very clean, friendly and professional staff. " [](https://expedia.ca/San-Francisco-Hotels-Hilton-San-Francisco-Financial-District.h4302.Hotel-Information) ![Hyatt Centric Fisherman's Wharf San Francisco](//images.trvl-media.com/lodging/1000000/30000/22500/22500/1d699bf3_y.jpg) ### Hyatt Centric Fisherman's Wharf San Francisco 10/10 Excellent "Excellent" [](https://expedia.ca/San-Francisco-Hotels-Hyatt-Centric-Fishermans-Wharf-San-Francisco.h22500.Hotel-Information) ![DoubleTree by Hilton Hotel Berkeley Marina](//images.trvl-media.com/lodging/1000000/30000/23800/23800/ba0da8d5_y.jpg) ### DoubleTree by Hilton Hotel Berkeley Marina 10/10 Excellent "I love the clean, comfy beds and linens, the outdoor fireplace on the patio, the warm cookies, the tranquil atmosphere and the location on the water. The staff are friendly and supportive, offering smiles and warm choc chip cookies! I especially appreciated thier efforts to assist me when I needed to correct a date error in my reservation. All in all I love the hotel and always stay there when in the Bay Area. " [](https://expedia.ca/Oakland-Hotels-DoubleTree-By-Hilton-Hotel-Berkeley-Marina.h23800.Hotel-Information) ![Club Quarters Hotel in San Francisco](//images.trvl-media.com/lodging/1000000/920000/913000/912982/5ee1ba27_y.jpg) ### Club Quarters Hotel in San Francisco 10/10 Excellent "Great location clean room super nice staff ☺️" [](https://expedia.ca/San-Francisco-Hotels-Club-Quarters-Hotel-In-San-Francisco.h912982.Hotel-Information) ![Comfort Inn by the Bay](//images.trvl-media.com/lodging/1000000/10000/6000/5984/d439a184_y.jpg) ### Comfort Inn by the Bay 10/10 Excellent "Clean room, friendly staff, breakfast was a plus" [](https://expedia.ca/San-Francisco-Hotels-Comfort-Inn-By-The-Bay.h5984.Hotel-Information) ![Hotel Riu Plaza Fisherman's Wharf](//images.trvl-media.com/lodging/1000000/30000/24700/24625/6fb55356_y.jpg) ### Hotel Riu Plaza Fisherman's Wharf 10/10 Excellent "Breakfast was great for us with alot of choice . We found the location excellent. We actually walked to the cruise ship port rather than Uber because it was so close ! " [](https://expedia.ca/San-Francisco-Hotels-Hotel-Riu-Plaza-Fishermans-Wharf.h24625.Hotel-Information) ## Find out more about Downtown South San Francisco ## Downtown South San Francisco Hotels Guide Expedia.ca offers a selection of 4649 hotels in Downtown South San Francisco. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Downtown South San Francisco. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Downtown South San Francisco neighborhood you prefer. Go ahead. 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[Aparthotels in South San Francisco Station](https://www.expedia.ca/South-San-Francisco-Station-Apart-Hotels.d6173603-aaApartHotels.Travel-Guide-Accommodation) - [B&B in South San Francisco Station](https://www.expedia.ca/South-San-Francisco-Station-Bed-And-Breakfast.d6173603-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Hotels near South San Francisco Station](https://www.expedia.ca/South-San-Francisco-Station-Hotels.d6173603.Travel-Guide-Hotels) - [Townhomes in South San Francisco](https://www.expedia.ca/South-San-Francisco-Townhomes.d6773-aaTownhomes.Travel-Guide-Accommodation) - [Motel 6 Hotels in St. Francis](https://www.expedia.ca/St-Francis-San-Francisco-Hotels-Motel-6.0-n553248635976469752-0--bMotel6.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in The East Side](https://www.expedia.ca/The-East-Side-San-Francisco-Hotels-Hotels-With-Free-Airport-Shuttle.0-n553248635976472836-0-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels with Free Breakfast in The East Side](https://www.expedia.ca/The-East-Side-San-Francisco-Hotels-Hotels-With-Free-Breakfast.0-n553248635976472836-0-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels) - [Romantic Hotels in The East Side](https://www.expedia.ca/The-East-Side-San-Francisco-Hotels-Romantic-Hotel.0-n553248635976472836-0-tRomanticHotel.Travel-Guide-Filter-Hotels) - [The East Side Hotels](https://www.expedia.ca/The-East-Side-San-Francisco-Hotels.0-n553248635976472836-0.Travel-Guide-Filter-Hotels) - [Wyndham Extra Holidays Hotels in West Portal](https://www.expedia.ca/West-Portal-San-Francisco-Hotels-Wyndham-Extra-Holidays.0-n553248635976008348-0--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Westwood Highlands](https://www.expedia.ca/Westwood-Highlands-San-Francisco-Hotels-Motel-6.0-n553248635976476546-0--bMotel6.Travel-Guide-Filter-Hotels) - [Flights to San Francisco](https://www.expedia.ca/Cheap-Flights-To-San-Francisco.d178305.Travel-Guide-Flights) - [Flights to South San Francisco](https://www.expedia.ca/Cheap-Flights-To-South-San-Francisco.d6773.Travel-Guide-Flights) - [Flights from Los Angeles (LAX) to San Francisco (SFO)](https://www.expedia.ca/lp/flights/lax/sfo/los-angeles-to-san-francisco) - [Flights from Edmonton (YEG) to San Francisco (SFO)](https://www.expedia.ca/lp/flights/yeg/sfo/edmonton-to-san-francisco) - [Flights from Montreal (YUL) to San Francisco (SFO)](https://www.expedia.ca/lp/flights/yul/sfo/montreal-to-san-francisco) - [Flights from Vancouver (YVR) to San Francisco (SFO)](https://www.expedia.ca/lp/flights/yvr/sfo/vancouver-to-san-francisco) - [Flights from Calgary (YYC) to San Francisco (SFO)](https://www.expedia.ca/lp/flights/yyc/sfo/calgary-to-san-francisco) - [Flights from Toronto (YYZ) to San Francisco (SFO)](https://www.expedia.ca/lp/flights/yyz/sfo/toronto-to-san-francisco) - [Visit Paradise Valley](https://www.expedia.ca/San-Francisco-Paradise-Valley.dx553248635976473811) - [South San Francisco Vacations](https://www.expedia.ca/South-San-Francisco.d6773.Destination-Travel-Guides) - [Visit South San Francisco](https://www.expedia.ca/South-San-Francisco.dx6773) - [Rental cars San Francisco Intl. airport](https://www.expedia.ca/Car-Rentals-In-San-Francisco-Intl.d5195347.Car-Rental-Guide) - [Car rental South San Francisco](https://www.expedia.ca/Car-Rentals-In-South-San-Francisco.d6773.Car-Rental-Guide) - [Enterprise Rental Cars in South San Francisco](https://www.expedia.ca/Enterprise-Car-Rentals-In-South-San-Francisco.d6773-c15.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in South San Francisco](https://www.expedia.ca/Hertz-Car-Rentals-In-South-San-Francisco.d6773-c40.Car-Rental-Guide-Suppliers) - [South San Francisco Vacation Rentals](https://www.expedia.ca/South-San-Francisco-Vacation-Rentals.d6773.Travel-Guide-VacationRentals) - [Things to do in South San Francisco](https://www.expedia.ca/Things-To-Do-In-South-San-Francisco.d6773.Travel-Guide-Activities) - [Book Hotels in Downtown South San Francisco on Expedia.com](https://www.expedia.com/Downtown-South-San-Francisco-San-Francisco-Hotels-La-Quinta-Inn-Suites.0-n553248635976481411-0--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels)