Title: Book the Best Downtown Gainesville LUXURY Hotels - Upscale Hotels in Downtown Gainesville, Gainesville | Expedia.ca [Downtown Gainesville Travel Guide](https://expedia.ca/Gainesville-Downtown-Gainesville.dx939293992653533184)[Vacation Rentals in Gainesville](https://expedia.ca/Gainesville-Vacation-Rentals.d6048189.Travel-Guide-VacationRentals)[Flights to Gainesville](https://expedia.ca/Cheap-Flights-To-Gainesville.d6048189.Travel-Guide-Flights)[Things to do in Gainesville](https://expedia.ca/Things-To-Do-In-Gainesville.d6048189.Travel-Guide-Activities)[Downtown Gainesville Car Rentals](https://expedia.ca/Car-Rentals-In-Downtown-Gainesville.d939293992653533184.Car-Rental-Guide)[Downtown Gainesville Vacations](https://expedia.ca/Downtown-Gainesville.d939293992653533184.Destination-Travel-Guides) ![Gainesville, Florida, USA Skyline](https://images.trvl-media.com/place/939293992653533184/e7dd1f4a-fd98-436e-b9bc-d5bca93f6e46.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Luxury Hotels in Downtown Gainesville, Gainesville - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Downtown Gainesville Luxury Hotels Tonight [Dec 12 - Dec 13](https://www.expedia.ca/Hotel-Search?regionId=939293992653533184&startDate=2025-12-12&endDate=2025-12-13&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=939293992653533184&startDate=2025-12-13&endDate=2025-12-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=939293992653533184&startDate=2025-12-12&endDate=2025-12-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=939293992653533184&startDate=2025-12-19&endDate=2025-12-21&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Downtown Gainesville Hotel Reviews ![Comfort Inn University](https://images.trvl-media.com/lodging/1000000/800000/793600/793525/78ca2e85_y.jpg) ### Comfort Inn University 10/10 Excellent "It was clean. No people noises. No party. Was kind of silent I like quiet because I want to sleep. Keep the noise down and clean. Thank you. " [](https://expedia.ca/Gainesville-Hotels-Comfort-Inn-University.h793525.Hotel-Information) ![Sleep Inn & Suites University/Shands](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/3c8617a9_y.jpg) ### Sleep Inn & Suites University/Shands 10/10 Excellent "The staff seemed invested in my happiness. Welcoming touches in the foyer and quick response was great. This is an older hotel that is well taken care of." [](https://expedia.ca/Gainesville-Hotels-Sleep-Inn-Suites-UniversityShands.h1932346.Hotel-Information) ![Country Inn & Suites by Radisson, Gainesville, FL](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/8584a629_y.jpg) ### Country Inn & Suites by Radisson, Gainesville, FL 10/10 Excellent "Great Staff! Clean facility. Good breakfast selections" [](https://expedia.ca/Gainesville-Hotels-Country-Inn-Suites-By-Radisson.h1289043.Hotel-Information) ![Hilton University of Florida Conference Center Gainesville](https://images.trvl-media.com/lodging/1000000/480000/475300/475205/7dbdcf15_y.jpg) ### Hilton University of Florida Conference Center Gainesville 10/10 Excellent "I will recommend my friends and family to come at this location anytime they are in gainesville " [](https://expedia.ca/Gainesville-Hotels-Hilton-University-Of-Florida-Conference-Center-Gainesville.h475205.Hotel-Information) ![Super 8 by Wyndham Gainesville I-75 Hospital University Area](https://images.trvl-media.com/lodging/1000000/440000/439800/439799/1210da70_y.jpg) ### Super 8 by Wyndham Gainesville I-75 Hospital University Area 10/10 Excellent "perfect" [](https://expedia.ca/Gainesville-Hotels-Super-8-By-Wyndham-Gainesville.h439799.Hotel-Information) ![Hampton Inn & Suites Gainesville-Downtown](https://images.trvl-media.com/lodging/3000000/2880000/2874000/2873991/6ce917d9_y.jpg) ### Hampton Inn & Suites Gainesville-Downtown 10/10 Excellent "clean room, nice locations" [](https://expedia.ca/Gainesville-Hotels-Hampton-Inn-Suites-Gainesville-Downtown.h2873991.Hotel-Information) ![Best Western Gateway Grand](https://images.trvl-media.com/lodging/1000000/160000/151100/151041/9a241e09_y.jpg) ### Best Western Gateway Grand 10/10 Excellent "Great" [](https://expedia.ca/Gainesville-Hotels-Best-Western-Gateway-Grand.h151041.Hotel-Information) ![DoubleTree by Hilton Gainesville](https://images.trvl-media.com/lodging/1000000/50000/49700/49617/ff7eaa86_y.jpg) ### DoubleTree by Hilton Gainesville 10/10 Excellent "Love how clean and spacious the lobby is, staff is excellent and you get warm cookies upon check in, which was an unexpected surprise. " [](https://expedia.ca/Gainesville-Hotels-DoubleTree-By-Hilton-Gainesville.h49617.Hotel-Information) ![Days Inn by Wyndham Gainesville University I-75](https://images.trvl-media.com/lodging/1000000/20000/19600/19555/d3372ae4_y.jpg) ### Days Inn by Wyndham Gainesville University I-75 10/10 Excellent "Clean room. Great staff!!" [](https://expedia.ca/Gainesville-Hotels-Days-Inn-By-Wyndham-Gainesville-University-I-75.h19555.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury getaway to Downtown Gainesville? ### What's there to see and do in Downtown Gainesville? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - [4 Star Hotels in Gainesville ](https://www.expedia.ca/4Star-Gainesville-Hotels.s40-0-d6048189.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Innovation District ](https://www.expedia.ca/4Star-Innovation-District-Gainesville-Hotels.s40-n553248635976478922-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Gainesville ](https://www.expedia.ca/5Star-Gainesville-Hotels.s50-0-d6048189.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in Amelia Island ](https://www.expedia.ca/Amelia-Island-Hotels-Hotel-With-Pool.0-0-d10814-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Green Hotels in Daytona Beach ](https://www.expedia.ca/Daytona-Beach-Hotels-Green-Sustainable.0-0-d6023995-tGreenSustainable.Travel-Guide-Filter-Hotels) - 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