Title: Top Hotels in Antofagasta de la Sierra Department | Expedia.ca [Vacation Rentals in Antofagasta de la Sierra Department](https://expedia.ca/Destinations-In-Antofagasta-De-La-Sierra-Department.d553248635975749483.Vacation-Rental-Destinations)[Antofagasta de la Sierra Department Car Rentals](https://expedia.ca/Destinations-In-Antofagasta-De-La-Sierra-Department.d553248635975749483.Car-Rental-Destinations)[Antofagasta de la Sierra Department Vacations](https://expedia.ca/Antofagasta-De-La-Sierra-Department.d553248635975749483.Destination-Travel-Guides) ![Salar or Salt Desert of Antofalla in La Puna de Atacama, in the province of Catamarca in the department of Antofagasta de la Sierra. Argentina, South America, America](https://images.trvl-media.com/place/553248635975749483/23517b45-75d9-415f-936e-1a8925f481d0.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248635975749483/23517b45-75d9-415f-936e-1a8925f481d0.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Top Cities in Antofagasta de la Sierra Department ![This area is of an incredible diversity, it is part of the Argentine Puna. #roadtrip](https://images.trvl-media.com/place/6348231/b8d035fc-a159-4a83-8987-4fe3b3c3e54e.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Antofagasta de la Sierra [](https://expedia.ca/Antofagasta-De-La-Sierra-Hotels.d6348231.Travel-Guide-Hotels) ## Check prices for these dates Tonight [Mar 3 - Mar 4](https://www.expedia.ca/Hotel-Search?regionId=553248635975749483&startDate=2026-03-03&endDate=2026-03-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 4 - Mar 5](https://www.expedia.ca/Hotel-Search?regionId=553248635975749483&startDate=2026-03-04&endDate=2026-03-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 6 - Mar 8](https://www.expedia.ca/Hotel-Search?regionId=553248635975749483&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 13 - Mar 15](https://www.expedia.ca/Hotel-Search?regionId=553248635975749483&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. 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[Book now](https://expedia.ca/deals?rfrr=HTG_SPRING_PROMO_553248635975749483) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Antofagasta-De-La-Sierra-Department.d553248635975749483.Hotel-Destinations)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Antofagasta-De-La-Sierra-Department.d553248635975749483.Hotel-Destinations) ## Top Antofagasta de la Sierra Department Hotel Reviews ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Top cities in Antofagasta de la Sierra Department - [Antofagasta de la Sierra Hotels ](https://expedia.ca/Antofagasta-De-La-Sierra-Hotels.d6348231.Travel-Guide-Hotels) ### Explore more hotels - [Hosteria Pucara ](https://expedia.ca/Antofagasta-De-La-Sierra-Hotels-Hosteria-Pucara.h42527742.Hotel-Information) - [Hacienda de Molinos ](https://expedia.ca/Molinos-Hotels-Hacienda-De-Molinos.h9028723.Hotel-Information) [See a list of all hotels in Antofagasta de la Sierra Department](https://expedia.ca/All-Antofagasta-De-La-Sierra-Department-Hotels.d553248635975749483.Travel-Guide-City-All-Hotels) ### More ways to book - [Book Hotels in Antofagasta de la Sierra Department on Expedia.com.ar ](https://www.expedia.com.ar/Destinos-En-Departamento-Antofagasta-De-La-Sierra.d553248635975749483.Destinos-con-Hoteles) ### Expedia's Latest Trends Hotels - [Hotels in Downtown Dallas](https://expedia.ca/Downtown-Dallas-Dallas-Hotels.0-n800026-0.Travel-Guide-Filter-Hotels) - [Hotels in San Luis del Palmar Department](https://expedia.ca/Destinations-In-San-Luis-Del-Palmar-Department.d553248635975751164.Hotel-Destinations) - [The Whytehouse Villa](https://expedia.ca/Montego-Bay-Hotels-The-Whytehouse-Villa.h74779720.Hotel-Information) - [Best Hotels in La Puntilla](https://expedia.ca/La-Puntilla-Hotels.d6348238.Travel-Guide-Hotels) - 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