Title: Book the Best Depew SPA Resorts from CA $199 - Spa Hotels in Depew, NY | Expedia.ca [Hotels in Depew](https://expedia.ca/Depew-Hotels.d6338362.Travel-Guide-Hotels)[Vacation Rentals in Depew](https://expedia.ca/Depew-Vacation-Rentals.d6338362.Travel-Guide-VacationRentals)[Depew Car Rentals](https://expedia.ca/Car-Rentals-In-Depew.d6338362.Car-Rental-Guide)[Depew Vacation Packages](https://expedia.ca/Depew.d6338362.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Depew, NY from CA $199 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Depew Spa Hotels Tonight [Oct 27 - Oct 28](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-10-27&endDate=2025-10-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 28 - Oct 29](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-10-28&endDate=2025-10-29&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-10-31&endDate=2025-11-02&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-11-07&endDate=2025-11-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Depew Spa Hotels ![2 restaurants, dinner served](https://images.trvl-media.com/lodging/16000000/15040000/15031200/15031117/c468db44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Queen Beds](https://images.trvl-media.com/lodging/16000000/15040000/15031200/15031117/bde63631.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/16000000/15040000/15031200/15031117/7ae798f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15040000/15031200/15031117/14f70c6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Delavan Hotel & Spa Bowmansville 8.8/10 Excellent (1003) "Great place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tyler CA $175 CA $199 total includes taxes & fees Nov 10 - Nov 11 [](https://www.expedia.ca/Buffalo-Hotels-The-Delavan-Hotel-Spa.h15031117.Hotel-Information) ![Hot stone massages, deep-tissue massages, Swedish massages](https://images.trvl-media.com/lodging/18000000/17040000/17038300/17038248/dd3fc86a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/18000000/17040000/17038300/17038248/727bae68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/18000000/17040000/17038300/17038248/bde93c89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/18000000/17040000/17038300/17038248/1b8dbb7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Curtiss Hotel, an Ascend Collection Hotel Downtown Buffalo 9.4/10 Exceptional (1003) "Nice hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin CA $276 CA $322 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/Buffalo-Hotels-Curtiss-Hotel.h17038248.Hotel-Information) ![Couples treatment rooms, body treatments, hot stone massages](https://images.trvl-media.com/lodging/7000000/6300000/6290200/6290133/c1a06a49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/7000000/6300000/6290200/6290133/2a49ee3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking (Williams)](https://images.trvl-media.com/lodging/7000000/6300000/6290200/6290133/988dd78d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/7000000/6300000/6290200/6290133/729fa626.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Mosey Buffalo Williamsville, Tapestry Collection by Hilton Buffalo 9.4/10 Exceptional (1014) "Was clean and quiet. Enjoyed our visit " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tami CA $196 CA $223 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Buffalo-Hotels-The-Mosey-Buffalo-Williamsville.h6290133.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-11&endDate=2025-11-12®ionId=6338362&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Depew Hotel Reviews ![Sleep Inn & Suites Buffalo Airport](//images.trvl-media.com/lodging/1000000/90000/85100/85007/ae021a7d_y.jpg) ### Sleep Inn & Suites Buffalo Airport 10/10 Excellent "Everything was clean and convenient but staff was a little rude (especially the shuttle guy) and the common areas near the lobby looked pretty beat up. Everything in the room itself was perfectly clean and functional though, including one of the most comfortable beds I've ever seen in a hotel. The free breakfast was great too. Overall I'd definitely recommend this place." [](https://expedia.ca/Buffalo-Hotels-Sleep-Inn-Suites-Buffalo-Airport.h85007.Hotel-Information) ![Garden Place Hotel](//images.trvl-media.com/lodging/2000000/1070000/1060800/1060721/40afc3e4_y.jpg) ### Garden Place Hotel 10/10 Excellent "Great location for the airport!" [](https://expedia.ca/Buffalo-Hotels-Garden-Place-Hotel.h1060721.Hotel-Information) ![Hyatt Regency Buffalo / Hotel and Conference Center](//images.trvl-media.com/lodging/1000000/30000/23200/23101/00561234_y.jpg) ### Hyatt Regency Buffalo / Hotel and Conference Center 10/10 Excellent "Went there for the hockey game. Trolley is just outside the door and free to go to the game. Good location. All you need" [](https://expedia.ca/Buffalo-Hotels-Hyatt-Regency-Buffalo-Hotel-And-Conference-Center.h23101.Hotel-Information) ![M Hotel Buffalo](//images.trvl-media.com/lodging/1000000/20000/11300/11231/2c4d5593_y.jpg) ### M Hotel Buffalo 10/10 Excellent "Close to shopping and a variety of other activities." [](https://expedia.ca/Buffalo-Hotels-Millennium-Buffalo.h11231.Hotel-Information) ![Buffalo Airport Hotel](//images.trvl-media.com/lodging/1000000/30000/26100/26001/90223c0d_y.jpg) ### Buffalo Airport Hotel 10/10 Excellent "The airport shuttle was very convenient especially because the rental didn’t have a vehicle for us upon arrival. " [](https://expedia.ca/Buffalo-Hotels-Buffalo-Airport-Hotel.h26001.Hotel-Information) ![DoubleTree by Hilton Hotel Buffalo - Amherst](//images.trvl-media.com/lodging/1000000/10000/3000/2914/e3e45ea5_y.jpg) ### DoubleTree by Hilton Hotel Buffalo - Amherst 10/10 Excellent "Clean " [](https://expedia.ca/Buffalo-Hotels-DoubleTree-By-Hilton-Hotel-Buffalo-Amherst.h2914.Hotel-Information) ## Frequently asked questions ### Looking for a spa hotel in Depew? > Treat yourself to some pampering and book a hotel with a spa. Check out the waterfalls in Depew - worth a picture or two! Hotels with spas are a great way to break out of your daily routine and add a layer of luxury to your holiday. ### What's there to see and do in Depew? > Enjoy Depew and visit Walden Galleria Mall, Samuel's Grande Manor, and Glen Falls. If you have some spare time during your trip, you might want to check out Broadway Market and Buffalo Museum of Science. ### What is a Depew spa hotel? > Spa hotels in Depew feature full on-site spas and offer services like facials and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. 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Airport (EWR) to Buffalo (BUF)](https://www.expedia.ca/lp/flights/ewr/buf/newark-liberty-intl-airport-to-buffalo) - [Flights from New York (JFK) to Buffalo (BUF)](https://www.expedia.ca/lp/flights/jfk/buf/new-york-to-buffalo) - [Flights from Orlando (MCO) to Buffalo (BUF)](https://www.expedia.ca/lp/flights/mco/buf/orlando-to-buffalo) - [Flights from Chicago (ORD) to Buffalo (BUF)](https://www.expedia.ca/lp/flights/ord/buf/chicago-to-buffalo) - [Flights from Philadelphia (PHL) to Buffalo (BUF)](https://www.expedia.ca/lp/flights/phl/buf/philadelphia-to-buffalo) - [Flights from Ottawa (YOW) to Buffalo (BUF)](https://www.expedia.ca/lp/flights/yow/buf/ottawa-to-buffalo) - [Flights from Montreal (YUL) to Buffalo (BUF)](https://www.expedia.ca/lp/flights/yul/buf/montreal-to-buffalo) - [Flights from Vancouver (YVR) to Buffalo (BUF)](https://www.expedia.ca/lp/flights/yvr/buf/vancouver-to-buffalo) - [Flights from Calgary (YYC) to Buffalo (BUF)](https://www.expedia.ca/lp/flights/yyc/buf/calgary-to-buffalo) - [Flights from Toronto (YYZ) to Buffalo (BUF)](https://www.expedia.ca/lp/flights/yyz/buf/toronto-to-buffalo) - [Diamond Hawk Golf Course](https://www.expedia.ca/Diamond-Hawk-Golf-Course-Buffalo.d6276883.Vacation-Attraction) - [Holiday Twin Rinks](https://www.expedia.ca/Holiday-Twin-Rinks-Buffalo.d6207411.Vacation-Attraction) - [Walden Galleria Mall](https://www.expedia.ca/Walden-Galleria-Mall-Buffalo.d6129205.Vacation-Attraction) - [Rental cars Buffalo Niagara Intl. airport](https://www.expedia.ca/Car-Rentals-In-Buffalo-Niagara-Intl.d4609346.Car-Rental-Guide) - [Things to do in Buffalo](https://www.expedia.ca/Things-To-Do-In-Buffalo.d602674.Travel-Guide-Activities) - [Book Spa Hotels in Depew on Expedia.com](https://www.expedia.com/Depew-Hotels-Spa-Hotel.0-0-d6338362-tSpaHotel.Travel-Guide-Filter-Hotels)