Title: Book the Best De Soto LUXURY Hotels - Upscale Hotels in De Soto, WI | Expedia.ca [Hotels in De Soto](https://expedia.ca/De-Soto-Hotels.d6338410.Travel-Guide-Hotels)[Vacation Rentals in De Soto](https://expedia.ca/De-Soto-Vacation-Rentals.d6338410.Travel-Guide-VacationRentals)[De Soto Car Rentals](https://expedia.ca/Car-Rentals-In-De-Soto.d6338410.Car-Rental-Guide)[De Soto Vacation Packages](https://expedia.ca/De-Soto.d6338410.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in De Soto, WI ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on De Soto Luxury Hotels Tonight [Oct 3 - Oct 4](https://www.expedia.ca/Hotel-Search?regionId=6338410&startDate=2025-10-03&endDate=2025-10-04&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 4 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6338410&startDate=2025-10-04&endDate=2025-10-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6338410&startDate=2025-10-03&endDate=2025-10-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6338410&startDate=2025-10-10&endDate=2025-10-12&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top De Soto Luxury Hotels ## Top De Soto Hotel Reviews ![Old Towne Motel](//images.trvl-media.com/lodging/9000000/8270000/8269600/8269592/684f3044_y.jpg) ### Old Towne Motel 10/10 Excellent "It is wonderful to support a good small town motel, that is clean and comfortable, and quiet, and walk in patio doors from the parking lot. " [](https://expedia.ca/La-Crosse-Hotels-Old-Towne-Motel.h8269592.Hotel-Information) ## Frequently asked questions ### Are you looking for a luxury hotel for your stay in De Soto? > Use Expedia to arrange your flight to La Crosse, WI (LSE-La Crosse Municipal) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are an important consideration when you plan a trip, so we make it easy to get what you want to make your stay relaxing and comfortable. If you want a posh hotel with fine dining, a spa, or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that De Soto has to offer. De Soto has some interesting things to see and do including Mississippi River, so you might want to take in the local sights during your visit. ### When can I expect good weather in De Soto? > Planning for the weather is a good way to make your trip to De Soto relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 68°F, while the coldest months are January and February with an average of 24°F. The snowiest months in De Soto are January, April, March, and February, with each month seeing an average of 9 inches of snowfall. ### What's there to see and do in De Soto? > Take in the sights and attractions that De Soto offers with a visit to Mississippi River, Vernon Vineyards, and Yellow River State Forest. 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