Title: Book the Best De Soto CASINO Hotels & Resorts in 2025 | Expedia.ca [Hotels in De Soto](https://expedia.ca/De-Soto-Hotels.d6085105.Travel-Guide-Hotels)[Vacation Rentals in De Soto](https://expedia.ca/De-Soto-Vacation-Rentals.d6085105.Travel-Guide-VacationRentals)[De Soto Car Rentals](https://expedia.ca/Car-Rentals-In-De-Soto.d6085105.Car-Rental-Guide)[De Soto Vacation Packages](https://expedia.ca/De-Soto.d6085105.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/1f71f3ee006639c0d49d18546ddf62b5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Jessica King # Find Casino Hotels in De Soto, MO from CA $130 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on De Soto Casino Hotels Tonight [Nov 4 - Nov 5](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-11-04&endDate=2025-11-05&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 5 - Nov 6](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-11-05&endDate=2025-11-06&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-11-07&endDate=2025-11-09&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-11-14&endDate=2025-11-16&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top De Soto Casino Hotels ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/5600/5523/219ce8d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5600/5523/01075f37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sports facility](https://images.trvl-media.com/lodging/1000000/10000/5600/5523/96723311.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/5600/5523/540bf915.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Festus Festus 6.8/10 (908) "They was doing construction on The floor I was on . The had 10 Mexican people in the hallway drinking and partying. They refuse to give me my money back. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Keilen CA $113 CA $130 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/Festus-Hotels-Baymont-By-Wyndham-Festus.h5523.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-18&endDate=2025-11-19®ionId=6085105&adults=2&amenities=CASINO&sort=RECOMMENDED&openPlayBack=true) ## Find out more about De Soto ### Discover top De Soto attractions While De Soto, Missouri, may not be renowned for its casinos, it offers a variety of attractions that cater to those who appreciate a lively atmosphere and some chance-based fun. Start your adventure at the nearby River City Casino in St. Louis, just a short drive away. This expansive venue boasts a wide range of slot machines and table games, alongside a selection of fine dining options to satisfy your culinary cravings after a day of play. For a more family-friendly option, consider a visit to the nearby Meramec River where you can indulge in fishing or kayaking, offering a refreshing break from the casino scene. Nature lovers can also explore the scenic trails at the nearby Huzzah Conservation Area, perfect for hiking and enjoying the beautiful landscapes of Missouri. After a day of excitement, unwind at one of De Soto's charming hotels, many of which provide modern amenities and attentive service designed to make you feel pampered. The area around Highway 67 not only offers convenient access to these attractions but also features some delightful eateries and local shops, ensuring that your stay is both comfortable and enriching. Enjoy the thrill of gaming and the warmth of Midwestern hospitality as you explore what De Soto and its surroundings have to offer! ## Top De Soto Hotel Reviews ## Frequently asked questions ### When should I take my casino trip to De Soto? > You might spend a lot of your vacation inside, but if you want to see more of the area, taking a look at local weather data can help you. The hottest months are usually July and August with an average temp of 75°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for De Soto is 46 inches. ### What is there to do in De Soto? > You can head to Redfield's Flea Market to shop for memorable gifts and souvenirs. You'll find attractions to visit in the area like Jorkerst Memorial Park. In addition, you might want to visit Sunrise Lake Beach and Washington State Park. ### What are my transportation options for my casino getaway to De Soto? > Here are some transportation options in De Soto: You can arrange a flight to the closest airport, which is St. Louis, MO (SUS-Spirit of St. Louis), 36.5 mi (58.8 km) from the city center. 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