Title: Hotels by Best Western in De Soto | Expedia.ca [De Soto Travel Guide](https://expedia.ca/De-Soto.dx6085105)[Hotels in De Soto](https://expedia.ca/De-Soto-Hotels.d6085105.Travel-Guide-Hotels)[Vacation Rentals in De Soto](https://expedia.ca/De-Soto-Vacation-Rentals.d6085105.Travel-Guide-VacationRentals)[Flights to De Soto](https://expedia.ca/Cheap-Flights-To-De-Soto.d6085105.Travel-Guide-Flights)[De Soto Car Rentals](https://expedia.ca/Car-Rentals-In-De-Soto.d6085105.Car-Rental-Guide)[De Soto Vacation Packages](https://expedia.ca/De-Soto.d6085105.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/1f71f3ee006639c0d49d18546ddf62b5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Jessica King # Find Hotels by Best Western in De Soto ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 22 - Oct 23](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-10-22&endDate=2025-10-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 23 - Oct 24](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-10-23&endDate=2025-10-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top De Soto Best Western Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDe-Soto-Hotels-Best-Western.0-0-d6085105--bBestWestern.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDe-Soto-Hotels-Best-Western.0-0-d6085105--bBestWestern.Travel-Guide-Filter-Hotels) ## Top De Soto Hotel Reviews ![Drury Inn & Suites St. Louis Arnold](//images.trvl-media.com/lodging/4000000/3870000/3861200/3861101/a7778b87_y.jpg) ### Drury Inn & Suites St. Louis Arnold 10/10 Excellent "Was a wonderful trip" [](https://expedia.ca/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Arnold.h3861101.Hotel-Information) ![Pear Tree Inn St. Louis Arnold](//images.trvl-media.com/lodging/1000000/50000/40200/40112/d33a8d98_y.jpg) ### Pear Tree Inn St. Louis Arnold 10/10 Excellent "We would stay here agsin. Clean, quiet & helpful service." [](https://expedia.ca/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Arnold.h40112.Hotel-Information) ![Comfort Inn Festus - St Louis South](//images.trvl-media.com/lodging/1000000/50000/40200/40138/3ea7ebcc_y.jpg) ### Comfort Inn Festus - St Louis South 10/10 Excellent " Mika went above and beyond even getting us ice when we checked in. As I was checking out Gary fell out used.Mika got him up and inside. Got ice and bandages. We were soon on our way." [](https://expedia.ca/Farmington-Hotels-Comfort-Inn-Festus-St-Louis-South.h40138.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Festus - St. Louis South](//images.trvl-media.com/lodging/1000000/50000/42200/42120/1887aa70_y.jpg) ### La Quinta Inn & Suites by Wyndham Festus - St. Louis South 10/10 Excellent " Clean rooms,breakfast " [](https://expedia.ca/Farmington-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Festus-St-Louis-South.h42120.Hotel-Information) ![Baymont Inn and Suites by Wyndham Farmington, MO](//images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg) ### Baymont Inn and Suites by Wyndham Farmington, MO 10/10 Excellent "Everyone was very thoughtful and the room was excellent. Great place to stay !!!!!" [](https://expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information) ### Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy 10/10 Excellent "Great for a weekend getaway!" [](https://expedia.ca/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information) ![Super 8 by Wyndham Farmington](//images.trvl-media.com/lodging/1000000/860000/855800/855747/d234bb55_y.jpg) ### Super 8 by Wyndham Farmington 10/10 Excellent "Its ok for price" [](https://expedia.ca/Farmington-Hotels-Super-8-By-Wyndham-Farmington.h855747.Hotel-Information) ![WoodSpring Suites St. Louis Arnold](//images.trvl-media.com/lodging/3000000/2760000/2759000/2758955/6ce331bd_y.jpg) ### WoodSpring Suites St. Louis Arnold 10/10 Excellent "Great location and great price. " [](https://expedia.ca/St-Louis-Hotels-WoodSpring-Suites-St-Louis-Arnold.h2758955.Hotel-Information) ![Super 8 by Wyndham Potosi](//images.trvl-media.com/lodging/1000000/160000/158800/158717/2cf60fb9_y.jpg) ### Super 8 by Wyndham Potosi 10/10 Excellent "The desk clerk went above and beyond. All of the non-smoking rooms were sold out online but he made sure I had one! The check-in process was very easy and the staff was very friendly! Would highly recommend." 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