Title: Book the Best Cross Key Waterways SPA Resorts from CA $249 - Spa Hotels in Cross Key Waterways, Key Largo | Expedia.ca [Flights to Key Largo](https://expedia.ca/Cheap-Flights-To-Key-Largo.d8369.Travel-Guide-Flights)[Things to do in Key Largo](https://expedia.ca/Things-To-Do-In-Key-Largo.d8369.Travel-Guide-Activities)[Cross Key Waterways Car Rentals](https://expedia.ca/Car-Rentals-In-Cross-Key-Waterways.d553248635976480816.Car-Rental-Guide)[Cross Key Waterways Vacations](https://expedia.ca/Cross-Key-Waterways.d553248635976480816.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/pool.jpeg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Cross Key Waterways, Key Largo from CA $249 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Cross Key Waterways Spa Hotels Tonight [Sep 27 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=553248635976480816&startDate=2025-09-27&endDate=2025-09-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 28 - Sep 29](https://www.expedia.ca/Hotel-Search?regionId=553248635976480816&startDate=2025-09-28&endDate=2025-09-29&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248635976480816&startDate=2025-10-03&endDate=2025-10-05&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635976480816&startDate=2025-10-10&endDate=2025-10-12&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Cross Key Waterways Spa Hotels ![Exterior](https://images.trvl-media.com/lodging/75000000/74510000/74501700/74501641/fcd75612.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/75000000/74510000/74501700/74501641/3c8fb00e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite | Living area](https://images.trvl-media.com/lodging/75000000/74510000/74501700/74501641/4ae3e8fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/75000000/74510000/74501700/74501641/396da292.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kona Kai Resort and Gallery - Adults Only Key Largo 9.8/10 Exceptional (259) "Had an amazing time everyone was very welcoming " CA $187 CA $249 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Key-Largo-Hotels-Kona-Kai-Resort-And-Gallery.h74501641.Hotel-Information) ![Body treatments, aromatherapy, hot stone massages, deep-tissue massages](https://images.trvl-media.com/lodging/1000000/10000/3500/3427/c2842ab0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Poolside bar](https://images.trvl-media.com/lodging/1000000/10000/3500/3427/b2a768a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/1000000/10000/3500/3427/f2f49899.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/10000/3500/3427/af093823.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Reefhouse Resort & Marina Key Largo 9.2/10 Wonderful (1308) "We had a great stay and will definitely stay here again and recommend to others. " CA $305 CA $399 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Key-Largo-Hotels-Reefhouse-Resort-Marina.h3427.Hotel-Information) ![Sauna, hot tub, steam room, body treatments, hot stone massages](https://images.trvl-media.com/lodging/12000000/11920000/11919100/11919055/0480bee7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, beach cabanas, sun loungers, beach umbrellas](https://images.trvl-media.com/lodging/12000000/11920000/11919100/11919055/d9cc2f68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/12000000/11920000/11919100/11919055/489feb58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House, 3 Bedrooms, Pool Access, Bay View (Balcony/Patio, Private Pool) | Beach](https://images.trvl-media.com/lodging/12000000/11920000/11919100/11919055/10dd6c61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Playa Largo Resort & Spa, Autograph Collection Key Largo 9.0/10 Wonderful (1001) "By far one of the best hotels in the keys. " CA $333 CA $451 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Key-Largo-Hotels-Playa-Largo-Resort-Spa.h11919055.Hotel-Information) ![In-room dining](https://images.trvl-media.com/lodging/109000000/108750000/108743400/108743380/c244835e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, individually furnished, blackout drapes](https://images.trvl-media.com/lodging/109000000/108750000/108743400/108743380/dc4f4949.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/109000000/108750000/108743400/108743380/a7f8b8c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![55-inch Smart TV with digital channels, books](https://images.trvl-media.com/lodging/109000000/108750000/108743400/108743380/96d842c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Premium Floating Bungalow by Stay Ombi Key Largo CA $1,114 CA $1,253 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Key-Largo-Hotels-Premium-Floating-Bungalow-By-Stay-Ombi.h108743380.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-11&endDate=2025-10-12®ionId=553248635976480816&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Cross Key Waterways Hotel Reviews ![Chesapeake Beach Resort](//images.trvl-media.com/lodging/1000000/10000/4200/4170/689f4306_y.jpg) ### Chesapeake Beach Resort 10/10 Excellent "Everything was perfect and beautiful " [](https://expedia.ca/Islamorada-Hotels-Chesapeake-Beach-Resort.h4170.Hotel-Information) ![Holiday Inn Key Largo by IHG](//images.trvl-media.com/lodging/1000000/10000/7300/7230/160ba216_y.jpg) ### Holiday Inn Key Largo by IHG 10/10 Excellent "Absolutely loved this property. Has everything you need for a relaxing stay" [](https://expedia.ca/Key-Largo-Hotels-Holiday-Inn-Key-Largo.h7230.Hotel-Information) ![Playa Largo Resort & Spa, Autograph Collection](//images.trvl-media.com/lodging/12000000/11920000/11919100/11919055/489feb58_y.jpg) ### Playa Largo Resort & Spa, Autograph Collection 10/10 Excellent "By far one of the best hotels in the keys. " [](https://expedia.ca/Key-Largo-Hotels-Playa-Largo-Resort-Spa.h11919055.Hotel-Information) ![Ocean Pointe Suites at Key Largo](//images.trvl-media.com/lodging/1000000/10000/5600/5502/c6c81bd5_y.jpg) ### Ocean Pointe Suites at Key Largo 10/10 Excellent "Perfect for a family and adult kids " [](https://expedia.ca/Tavernier-Hotels-Ocean-Pointe-Suites-At-Key-Largo.h5502.Hotel-Information) ![Reefhouse Resort & Marina](//images.trvl-media.com/lodging/1000000/10000/3500/3427/af093823_y.jpg) ### Reefhouse Resort & Marina 10/10 Excellent "Staff has been so accommodating, the pool and the grounds are beautiful, rooms are very comfortable. Great place!" [](https://expedia.ca/Key-Largo-Hotels-Reefhouse-Resort-Marina.h3427.Hotel-Information) ![Baker's Cay Resort Key Largo, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/20000/14100/14042/bbdba544_y.jpg) ### Baker's Cay Resort Key Largo, Curio Collection by Hilton 10/10 Excellent "Bakers Cay was a wonderful place to stay and unwind. The service was outstanding and location perfect. Thank you" [](https://expedia.ca/Key-Largo-Hotels-Bakers-Cay-Resort-Key-Largo.h14042.Hotel-Information) ![Marina Del Mar Resort and Marina](//images.trvl-media.com/lodging/1000000/10000/5200/5114/d42f8885_y.jpg) ### Marina Del Mar Resort and Marina 10/10 Excellent "Loved " [](https://expedia.ca/Key-Largo-Hotels-Marina-Del-Mar-Resort-And-Marina.h5114.Hotel-Information) ## Frequently asked questions ### Looking for a spa hotel in Cross Key Waterways? > Book one of our fantastic spa hotels and pamper yourself from the moment you arrive. Hotels with spas are a great way to take a break from your routine and add a layer of luxury to your vacation. ### What's there to see and do in Cross Key Waterways? > Enjoy Cross Key Waterways with a stop at MarineLab Undersea Laboratory, Caribbean Club Bar, and John Pennekamp Coral Reef State Park. If you have some spare time during your trip, you might want to check out Jimmy Johnson's Big Chill and Harry Harris Park. ### What is a Cross Key Waterways spa hotel? > Spa hotels in Cross Key Waterways provide lodging and have a full on-site spa which offers services such as massages and body treatments. Some also offer in-room treatments. 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[Lgbt Friendly Hotels in Key Largo Village](https://www.expedia.ca/Key-Largo-Village-Key-Largo-Hotels-LGBT-Friendly-Hotel.0-n553248635976468738-0-tLGBTFriendlyHotel.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Key Largo Village](https://www.expedia.ca/Key-Largo-Village-Key-Largo-Hotels-Luxury-Hotel.0-n553248635976468738-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Key Largo Village](https://www.expedia.ca/Key-Largo-Village-Key-Largo-Hotels-Pet-Friendly-Hotel.0-n553248635976468738-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Scuba Diving Hotels in Key Largo Village](https://www.expedia.ca/Key-Largo-Village-Key-Largo-Hotels-Scuba-Diving-Vacations.0-n553248635976468738-0-tscubadivingvacations.Travel-Guide-Filter-Hotels) - [Spa Hotels in Key Largo Village](https://www.expedia.ca/Key-Largo-Village-Key-Largo-Hotels-Spa-Hotel.0-n553248635976468738-0-tSpaHotel.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Largo Gardens](https://www.expedia.ca/Largo-Gardens-Key-Largo-Hotels-Adults-Only-Resorts.0-n553248635976471939-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Largo Gardens](https://www.expedia.ca/Largo-Gardens-Key-Largo-Hotels-All-Inclusive-Hotel.0-n553248635976471939-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Largo Gardens](https://www.expedia.ca/Largo-Gardens-Key-Largo-Hotels-Beach-Hotel.0-n553248635976471939-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Largo Gardens](https://www.expedia.ca/Largo-Gardens-Key-Largo-Hotels-Boutique-Hotel.0-n553248635976471939-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in Largo Gardens](https://www.expedia.ca/Largo-Gardens-Key-Largo-Hotels-Hotel-With-Pool.0-n553248635976471939-0-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Hotels with Kitchenettes in Largo Gardens](https://www.expedia.ca/Largo-Gardens-Key-Largo-Hotels-Hotels-With-Kitchenettes.0-n553248635976471939-0-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Largo Gardens](https://www.expedia.ca/Largo-Gardens-Key-Largo-Hotels-Pet-Friendly-Hotel.0-n553248635976471939-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Largo Gardens](https://www.expedia.ca/Largo-Gardens-Key-Largo-Hotels-Spa-Hotel.0-n553248635976471939-0-tSpaHotel.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Largo Sound Village](https://www.expedia.ca/Largo-Sound-Village-Key-Largo-Hotels-All-Inclusive-Hotel.0-n553248635976481003-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Largo Sound Village](https://www.expedia.ca/Largo-Sound-Village-Key-Largo-Hotels-Pet-Friendly-Hotel.0-n553248635976481003-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Miami](https://www.expedia.ca/Miami-Hotels-Business-Hotel.0-0-d178286-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Hotels & Resorts for Couples in Miami](https://www.expedia.ca/Miami-Hotels-Couples-Resorts-Hotels.0-0-d178286-tCouplesResortsHotels.Travel-Guide-Filter-Hotels) - [Green Hotels in Miami](https://www.expedia.ca/Miami-Hotels-Green-Sustainable.0-0-d178286-tGreenSustainable.Travel-Guide-Filter-Hotels) - [Hotels with Wifi in Miami](https://www.expedia.ca/Miami-Hotels-Hotel-With-Wifi.0-0-d178286-tHotelwithwifi.Travel-Guide-Filter-Hotels) - [Hotels with Bar in Miami](https://www.expedia.ca/Miami-Hotels-Hotels-With-Bar.0-0-d178286-tHotelswithBar.Travel-Guide-Filter-Hotels) - [Hotels with Childcare in Miami](https://www.expedia.ca/Miami-Hotels-Hotels-With-Childcare.0-0-d178286-tHotelswithChildcare.Travel-Guide-Filter-Hotels) - [Hotels with smoking rooms in Miami](https://www.expedia.ca/Miami-Hotels-Hotels-With-Smoking-Rooms.0-0-d178286-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels) - [Lake Hotels in Miami](https://www.expedia.ca/Miami-Hotels-Lake-Hotels.0-0-d178286-tLakeHotels.Travel-Guide-Filter-Hotels) - [Mountain Hotels in Miami](https://www.expedia.ca/Miami-Hotels-Mountain-Hotels.0-0-d178286-tMountainHotels.Travel-Guide-Filter-Hotels) - [Scuba Diving Hotels in Miami](https://www.expedia.ca/Miami-Hotels-Scuba-Diving-Vacations.0-0-d178286-tscubadivingvacations.Travel-Guide-Filter-Hotels) - [Ski Hotels in Miami](https://www.expedia.ca/Miami-Hotels-Ski-Hotel.0-0-d178286-tSkiHotel.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Miami](https://www.expedia.ca/Miami-Hotels-Waterpark-Hotels.0-0-d178286-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Winery Hotels in Miami](https://www.expedia.ca/Miami-Hotels-Winery-Hotel.0-0-d178286-tWineryHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in North Key Largo](https://www.expedia.ca/North-Key-Largo-Hotels-Cheap-Hotels.0-0-d553248635976475358-tCheapHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in North Key Largo](https://www.expedia.ca/North-Key-Largo-Hotels-Luxury-Hotel.0-0-d553248635976475358-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Historic Hotels in South Beach](https://www.expedia.ca/South-Beach-Miami-Hotels-Historic-Hotel.0-n6138745-0-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Hotels with Early Check-in in South Beach](https://www.expedia.ca/South-Beach-Miami-Hotels-Hotel-With-Early-Check-In.0-n6138745-0-thotelwithearlycheckin.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Winston Waterways](https://www.expedia.ca/Winston-Waterways-Key-Largo-Hotels-Boutique-Hotel.0-n553248635976481538-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Hotels with Free Parking in Winston Waterways](https://www.expedia.ca/Winston-Waterways-Key-Largo-Hotels-Hotels-With-Free-Parking.0-n553248635976481538-0-tHotelswithFreeParking.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Winston Waterways](https://www.expedia.ca/Winston-Waterways-Key-Largo-Hotels-Pet-Friendly-Hotel.0-n553248635976481538-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Book Hotels in Cross Key Waterways on Expedia.com](https://www.expedia.com/Cross-Key-Waterways-Key-Largo-Hotels-Spa-Hotel.0-n553248635976480816-0-tSpaHotel.Travel-Guide-Filter-Hotels)