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Our top choices for Colleton Medical Center hotels

A hotel room with a bed, bedside lamps, a nightstand, a mirror, and a framed photo collage on the wall.
A modern living room with a sofa, armchair, and coffee table, a desk with a computer, and a staircase leading to an upper level.
A living room with a sofa, armchair, and a small round table with a lamp and decorative items.
A pool area with lounge chairs, a pool, and a building with a 'Sleep Inn' sign.

1. Sleep Inn Walterboro I-95

Sleep Inn Walterboro I-95
2 km from Colleton Medical Center
United States
France
CA $105
CA $118 total
includes taxes & fees
Nov 2 - Nov 3
Sleep Inn Walterboro I-95
A hotel room with a bed, bedside tables, a desk, a TV, a window, and a door.
A Southern Inn hotel with a brick facade, orange doors, and a prominent blue sign.
A bathroom with a granite countertop, a sink, a vanity with a mirror, and a microwave.
A hallway with a Christmas tree on a pedestal table, a door, a wall clock, and a calendar.

2. Southern Inn By OYO Walterboro I-95

Southern Inn By OYO Walterboro I-95
1.8 km from Colleton Medical Center
United States
jesus
CA $62
CA $70 total
includes taxes & fees
Oct 7 - Oct 8
Southern Inn By OYO Walterboro I-95
A reception area with a marble counter, a glass door entrance, and a wooden floor.
A dining area with a table and chairs, a microwave on a small table, and a kitchen area with cabinets and a countertop.
A reception area with a wooden wall, a sofa, a chair, and a potted plant.
A kitchen with a microwave, coffee maker, and fruit juice dispenser.

3. Travelodge by Wyndham Walterboro

Travelodge by Wyndham Walterboro
1.8 km from Colleton Medical Center
United States
Gabriella
CA $74
CA $83 total
includes taxes & fees
Oct 8 - Oct 9
Travelodge by Wyndham Walterboro
A hotel with a covered front porch, a two-story building, and a parking lot with motorcycles.
A poolside area with a lifeguard chair, a pool ladder, and two white chairs.
A hotel bathroom with a granite countertop, a sink, a mirror, and a towel rack.
A reception desk with a framed welcome sign, a computer, and a potted plant.

4. Super 8 by Wyndham Walterboro

Super 8 by Wyndham Walterboro
2.3 km from Colleton Medical Center
United States
David
CA $68
CA $76 total
includes taxes & fees
Oct 8 - Oct 9
Super 8 by Wyndham Walterboro
A spacious hotel lobby with a central bar area, multiple seating arrangements, and large windows providing natural light.
A swimming pool with lounge chairs, a fence, and a building with stone and brick exterior.
A modern hotel with a flat roof, a prominent entrance, and a parking lot.
A rack of dumbbells with weights labeled 5 and 10.

5. Hampton Inn & Suites Walterboro

Hampton Inn & Suites Walterboro
6.9 km from Colleton Medical Center
United States
Lauren
CA $225
CA $251 total
includes taxes & fees
Nov 3 - Nov 4
Hampton Inn & Suites Walterboro
A hotel room with two beds, a desk, a chair, and a large window with curtains.
A reception area with a wooden counter, a potted plant, and a tiled floor.
A hotel hallway with a blue carpet, white walls, and doors on both sides.
A modern dining area with yellow and teal chairs, wooden tables, and a large window offering a view of greenery.

6. Comfort Inn & Suites Walterboro I-95

Comfort Inn & Suites Walterboro I-95
6.6 km from Colleton Medical Center
United States
andrew
CA $134
CA $150 total
includes taxes & fees
Nov 1 - Nov 2
Comfort Inn & Suites Walterboro I-95
A room with a window view of a forest path, a white air conditioning unit, a grey upholstered bench, and a wall-mounted lamp.
A hotel room with a wooden dining table, blue sofa, and a small wooden coffee table. A hallway leads to the bathroom.
A room with a wooden desk, a green office chair, a grey sofa, and a window with a view of trees and a building.
A gym with exercise equipment, a wall-mounted TV, and a window with a view.

7. Holiday Inn Exp Walterboro by IHG

Holiday Inn Exp Walterboro by IHG
6.8 km from Colleton Medical Center
United States
Jennifer
CA $200
CA $223 total
includes taxes & fees
Nov 1 - Nov 2
Holiday Inn Exp Walterboro by IHG
A Microtel Inn Suites by Wyndham with a parking lot and a red car parked in front.
A swimming pool with a white fence, a lifeguard chair, and a sign indicating no diving.
Two cold drink vending machines and a snack shelf stocked with various brands.
A modern hotel lobby with wooden counters, a digital screen, a coffee machine, and a tiled floor.

8. Microtel Inn & Suites by Wyndham Walterboro

Microtel Inn & Suites by Wyndham Walterboro
6.9 km from Colleton Medical Center
United States
Sarah
CA $134
CA $151 total
includes taxes & fees
Nov 1 - Nov 2
Microtel Inn & Suites by Wyndham Walterboro
A hotel room with two beds, a chair, a desk, and a mirror.
A kitchen area with a coffee machine, a microwave, a toaster, and a refrigerator.
A vending machine with a Pepsi logo, a Scotsman branded air conditioning unit, and a staircase in the background.
A kitchen with a dining table, chairs, a ceiling fan, a TV, and a door leading outside.

9. Econo Lodge Walterboro I-95

Econo Lodge Walterboro I-95
5.9 km from Colleton Medical Center
United States
anita
CA $67
CA $75 total
includes taxes & fees
Nov 1 - Nov 2
Econo Lodge Walterboro I-95
A modern living room with a sofa, a round table, a TV mounted on a wooden wall, and a kitchen area in the background.
A hotel room with a bed, a mounted TV, a mirror, and a wooden panel wall.
A modern living room with large windows, a ceiling fan, and a mix of seating including a sofa, armchairs, and ottomans.
Room

10. Best Western Of Walterboro

Best Western Of Walterboro
6.3 km from Colleton Medical Center
United States
JUAN
CA $126
CA $141 total
includes taxes & fees
Oct 29 - Oct 30
Best Western Of Walterboro
A Quality Inn hotel with a prominent sign, a covered entrance, and a parking lot.
A pool area with lounge chairs and umbrellas, a building with balconies, and a clear sky.
A waffle maker with a digital display and a push button.
A reception desk with a 'Quality by Choice Hotels' sign, a Dell computer, and a stone-patterned wall.

11. Quality Inn Walterboro I-95

Quality Inn Walterboro I-95
6.8 km from Colleton Medical Center
United States
Marvin
CA $84
CA $94 total
includes taxes & fees
Nov 3 - Nov 4
Quality Inn Walterboro I-95
A hotel lobby with seating arrangements, a television, a kitchen area, and a large window with curtains.
A reception desk at Days Inn with a 'Hello Sunshine' sign, a clock, and a framed certificate on the wall.
A hotel room with a bed, a desk with a TV, a chair, a desk lamp, and a bedside table with a lamp.
A hotel room with two beds, a desk with a TV, a chair, a small table, and a mirror.

12. Days Inn by Wyndham Walterboro

Days Inn by Wyndham Walterboro
6.8 km from Colleton Medical Center
United States
christopher
CA $93
CA $105 total
includes taxes & fees
Oct 28 - Oct 29
Days Inn by Wyndham Walterboro
A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.
A small office space with a desk, chair, and a microwave.
A motel with a covered parking area, multiple rooms, and a central building with a blue roof.
A room with a floral sofa, a small table, a lamp, a framed picture on the wall, and a window with curtains.

13. Rodeway Inn Walterboro I-95

Rodeway Inn Walterboro I-95
6.4 km from Colleton Medical Center
United States
Patricia
CA $71
CA $79 total
includes taxes & fees
Nov 5 - Nov 6
Rodeway Inn Walterboro I-95
A reception desk with a Baymont Inn & Suites sign, a chandelier, and a fire extinguisher.
A kitchen with a refrigerator, microwave, coffee maker, and various appliances.
A Baymont Inn & Suites building with a prominent sign, a fountain, and statues in front.
A hotel room with two beds, a desk, a chair, a mirror, and a window.

14. Baymont by Wyndham Walterboro

Baymont by Wyndham Walterboro
6.2 km from Colleton Medical Center
United States
Marguerite
CA $63
CA $70 total
includes taxes & fees
Oct 7 - Oct 8
Baymont by Wyndham Walterboro
A wooden gazebo with a green roof, surrounded by a grassy area and a wooden fence.
A bathroom with a sink, mirror, and shower.
A hotel with a red and white facade, a parking lot, and a palm tree.
A hotel lobby with a reception desk, seating area, and a Red Roof Inn sign.

15. Red Roof Inn Walterboro

Red Roof Inn Walterboro
6.1 km from Colleton Medical Center
United States
wendy
CA $68
CA $77 total
includes taxes & fees
Nov 2 - Nov 3
Red Roof Inn Walterboro
A hotel room with two beds, a bedside table with a phone, and a wall-mounted light.
A hotel room with two beds, a desk, a television, and a window with curtains.
A room with a tiled floor, a white door, and a window with blinds. There are two round tables with chairs.
A building with a registration sign, a flat facade, and a clear blue sky.

16. Moonnight inn.

Moonnight inn.
6.6 km from Colleton Medical Center
United States
John
CA $65
CA $73 total
includes taxes & fees
Oct 18 - Oct 19
Moonnight inn.
View all properties

Compare popular hotels close to Colleton Medical Center

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A hotel room with a bed, bedside lamps, a nightstand, a mirror, and a framed photo collage on the wall.
Sleep Inn Walterboro I-95
7.6
Good
651 reviews
View
A hotel room with a bed, bedside tables, a desk, a TV, a window, and a door.
Southern Inn By OYO Walterboro I-95
6.6
109 reviews
View
A reception area with a marble counter, a glass door entrance, and a wooden floor.
Travelodge by Wyndham Walterboro
6.4
599 reviews
View
A hotel with a covered front porch, a two-story building, and a parking lot with motorcycles.
Super 8 by Wyndham Walterboro
6.2
221 reviews
View
A spacious hotel lobby with a central bar area, multiple seating arrangements, and large windows providing natural light.
Hampton Inn & Suites Walterboro
9.2
Wonderful
1,004 reviews
View

Top Colleton Medical Center Hotel Reviews

Microtel Inn & Suites by Wyndham Walterboro

Microtel Inn & Suites by Wyndham Walterboro

8/10 Good
"Right off I95 - easy off and on. Cracker Barrel restaurant right across street as well as a gas station. Room was clean, quiet and affordable for a quick night on way South."
DANIEL 1-night trip
Posted 1 hour ago
Microtel Inn & Suites by Wyndham Walterboro
Comfort Inn & Suites Walterboro I-95

Comfort Inn & Suites Walterboro I-95

8/10 Good
"No directional signage stood out at night when turning onto Street during a rainstorm and that was under construction and was a hairpin turn to the hotel. Be careful. Older hotel needing multiple upgrades, but staff is nice and friendly."
Luke 1-night trip
Posted 6 hours ago
Comfort Inn & Suites Walterboro I-95
Econo Lodge Walterboro I-95

Econo Lodge Walterboro I-95

10/10 Excellent
"Property is under a redo, office completely torn up. You’d never know by looking, but the room was fantastic! Room was updated, clean, new tv with lots of channels. I’ll be there again the next couple of nights."
Mike 1-night trip
Posted 16 hours ago
Econo Lodge Walterboro I-95
Quality Inn Walterboro I-95

Quality Inn Walterboro I-95

8/10 Good
"Ill start by saying the price was great. We were just looking for a quick rest on the way to Disney. Pros: great location. Great on a budget. Pillows and bed were SUPER comfy, sheets were clean and smelled nice. Staff were so nice. Room was quiet, plenty of parking. No carpet in the rooms which is absolute must for me. Cons: air conditioner was extremely weak. We turned it down to 67 and it was barely cool. Coffee pot had a pod that had obviously been left in there so long it was molded and disnetengrated to the machine. I almost threw up over that. There were spots on the floor next to the trash can, could have been from dirty mop water, could have been from a previous guest, who knows. Walls had dirty spots in places. Toilet is so close to the door that the door scrapes it as you open it, so its extremely tight. So the hotel was ok. It did smell clean when we got in the room, but you can tell they dont deep clean. So if these small things dont bother you, its perfect. I was satisfied for our one night stay, and would stay again."
Jennifer 1-night trip
Posted 2 days ago
Quality Inn Walterboro I-95
Sleep Inn Walterboro I-95

Sleep Inn Walterboro I-95

10/10 Excellent
"This Sleep In hotel in Waterloo was just what I needed and appreciate the good bed, nice shower, and hot breakfast. Room was clean and had a large TV. Price and value were perfect. I WOULD stay here again in my travels. AC worked nicely too. Waterloo location off freeway 95. easy on off location. Felt safe too. However, Please repair lock on downstairs lobby restroom."
SHARON 1-night trip
Posted 3 days ago
Sleep Inn Walterboro I-95
Moonnight inn.

Moonnight inn.

8/10 Good
"Convenient stop on I95. This is a former motel 6 without frills but our room was clean and very affordable and fine for a night on the road in a pet friendly hotel."
Thomas 1-night trip
Posted 4 days ago
Moonnight inn.
Red Roof Inn Walterboro

Red Roof Inn Walterboro

10/10 Excellent
"Clean room"
Carlos 1-night trip
Posted 12 days ago
Red Roof Inn Walterboro
Southern Inn By OYO Walterboro I-95

Southern Inn By OYO Walterboro I-95

10/10 Excellent
"Bee was great!! Good price = good hotel"
jesus 1-night trip
Posted 3 weeks ago
Southern Inn By OYO Walterboro I-95
Charming Retreat on 20 Acres w/ Private Lake!

Charming Retreat on 20 Acres w/ Private Lake!

10/10 Excellent
"We stayed for 2 weeks and the peacefulness of the location was what we needed in the evenings. Will save this location for future use."
Jennifer A. 11-night trip
Posted 3 months ago
Charming Retreat on 20 Acres w/ Private Lake!

Frequently asked questions

What's the area like around Colleton Medical Center?
Colleton Medical Center is located in Walterboro. This welcoming area is known for its array of dining options. You'll find 45 hotels and other accommodations within a few miles for a convenient home base.
What's the best place to stay near Colleton Medical Center?
Baymont by Wyndham Walterboro is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 3.9 mi (6.2 km) from Colleton Medical Center. Other good choices within a few miles include Microtel Inn & Suites by Wyndham Walterboro and Travelodge by Wyndham Walterboro.
How many hotels will I be able to find close to Colleton Medical Center?
Expedia has 45 hotels and other accommodations a few miles from Colleton Medical Center.
If I need to cancel the hotel reservation for my stay near Colleton Medical Center, will I receive a refund?
Yes, most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within 24 hours of booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to view the best deals available near Colleton Medical Center.