Title: Book the Best BUSINESS Hotels in Clayton in 2025 | Expedia.ca [Vacation Rentals in St. Louis](https://expedia.ca/St-Louis-Vacation-Rentals.d178309.Travel-Guide-VacationRentals)[Flights to St. Louis](https://expedia.ca/Cheap-Flights-To-St-Louis.d178309.Travel-Guide-Flights)[Things to do in St. Louis](https://expedia.ca/Things-To-Do-In-St-Louis.d178309.Travel-Guide-Activities)[Clayton Car Rentals](https://expedia.ca/Car-Rentals-In-Clayton.d6058846.Car-Rental-Guide)[Clayton Vacations](https://expedia.ca/Clayton.d6058846.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/55f30f08c9d896777e94f92aa4ffc891.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Clayton, MO from CA $161 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Clayton Business Hotels Tonight [Sep 27 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=6058846&startDate=2025-09-27&endDate=2025-09-28&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 28 - Sep 29](https://www.expedia.ca/Hotel-Search?regionId=6058846&startDate=2025-09-28&endDate=2025-09-29&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6058846&startDate=2025-10-03&endDate=2025-10-05&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6058846&startDate=2025-10-10&endDate=2025-10-12&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Clayton Business Hotels ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/18200/18144/b3c5d3cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18200/18144/a7d1479b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/20000/18200/18144/550bec82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/20000/18200/18144/13e26dd3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clayton Plaza Hotel & Extended Stay Clayton 8.8/10 Excellent (2981) "Great staff and hotel!" CA $138 CA $161 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/St-Louis-Hotels-Clayton-Plaza-Hotel-Extended-Stay.h18144.Hotel-Information) ![Outdoor pool, open 8:00 AM to 8:30 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/3100/3072/b428f8e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Room, 1 King Bed with Sofa bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/10000/3100/3072/6c844457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/3100/3072/73dd8f80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, 1 King Bed with Sofa bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/10000/3100/3072/88c34883.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Le Méridien St. Louis Clayton Clayton 8.8/10 Excellent (658) "The room was clean and service was excellent." CA $229 CA $270 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/St-Louis-Hotels-Le-Meridien-St-Louis-Clayton.h3072.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/1000000/20000/17600/17599/ff4ffddd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/20000/17600/17599/a029e58d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/17600/17599/8ba6c79d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/17600/17599/87996df8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Clayton/St. Louis-Galleria Area Clayton 9.0/10 Wonderful (882) "Will definitely stay again." CA $188 CA $221 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/St-Louis-Hotels-Hampton-Inn-Suites-ClaytonSt-Louis-Galleria-Area.h17599.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/1000000/10000/4600/4507/77f53ef5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, pillowtop beds](https://images.trvl-media.com/lodging/1000000/10000/4600/4507/8ea5b33c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, designer toiletries, hair dryer, bathrobes](https://images.trvl-media.com/lodging/1000000/10000/4600/4507/c731e83a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/4600/4507/2ca29666.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Seven Gables, St. Louis West, a Tribute Portfolio Hotel Clayton 8.4/10 Very good (573) "Staff was excellent and the court yard was a wonderful place to sit and have a glass of wine. The upscale bathroom is off the charts! " CA $170 CA $211 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/St-Louis-Hotels-Seven-Gables-Inn.h4507.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/9a597e77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/w4000h2663x0y0-dfd3faff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/8fec4778.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/a54897ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Ritz-Carlton, St. Louis Clayton 9.2/10 Wonderful (550) "Service is exceptional!!!" CA $807 CA $940 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-11&endDate=2025-10-12®ionId=6058846&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Clayton Hotel Reviews ![Drury Plaza Hotel St. Louis at the Arch](//images.trvl-media.com/lodging/1000000/550000/546300/546271/78b2a688_y.jpg) ### Drury Plaza Hotel St. Louis at the Arch 10/10 Excellent "great location for our trip goals" [](https://expedia.ca/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-At-The-Arch.h546271.Hotel-Information) ![Hyatt Regency St. Louis at The Arch](//images.trvl-media.com/lodging/1000000/20000/14900/14877/335a172e_y.jpg) ### Hyatt Regency St. Louis at The Arch 10/10 Excellent "Everyone & everything " [](https://expedia.ca/St-Louis-Hotels-Hyatt-Regency-St-Louis-At-The-Arch.h14877.Hotel-Information) ![Forest Park Hotel by MDR](//images.trvl-media.com/lodging/1000000/30000/22300/22298/21d70af8_y.jpg) ### Forest Park Hotel by MDR 10/10 Excellent "Love it " [](https://expedia.ca/St-Louis-Hotels-Holiday-Inn-St-Louis-Forest-Park.h22298.Hotel-Information) ![Magnolia Hotel St. Louis, a Tribute Portfolio Hotel](//images.trvl-media.com/lodging/9000000/8140000/8132000/8131949/4b87c2a3_y.jpg) ### Magnolia Hotel St. Louis, a Tribute Portfolio Hotel 10/10 Excellent "Beautiful hotel near the Busch stadium- And the Arch no pet fees Great bar and lobby" [](https://expedia.ca/St-Louis-Hotels-Magnolia-Hotel-St-Louis.h8131949.Hotel-Information) ![Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham](//images.trvl-media.com/lodging/1000000/50000/42200/42122/bfca870c_y.jpg) ### Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham 10/10 Excellent "Was very happy with our stay. Our suite was well worth the very reasonable price. King Bed was very comfortable. AC was a little noisy but no issues." [](https://expedia.ca/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information) ![Hollywood Casino & Hotel St. Louis](//images.trvl-media.com/lodging/1000000/90000/82600/82568/7188325f_y.jpg) ### Hollywood Casino & Hotel St. Louis 10/10 Excellent "Clean room staff very friendly " [](https://expedia.ca/St-Louis-Hotels-Hollywood-Casino-Hotel-St-Louis.h82568.Hotel-Information) ![Pear Tree Inn St. Louis Near Union Station](//images.trvl-media.com/lodging/1000000/30000/26600/26572/0bb9dbf3_y.jpg) ### Pear Tree Inn St. Louis Near Union Station 10/10 Excellent "clean, well maintained, friendly courteous staff, excellent breakfast" [](https://expedia.ca/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Near-Union-Station.h26572.Hotel-Information) ![Clayton Plaza Hotel & Extended Stay](//images.trvl-media.com/lodging/1000000/20000/18200/18144/b3c5d3cd_y.jpg) ### Clayton Plaza Hotel & Extended Stay 10/10 Excellent "We loved our stay at Clayton Plaza Hotel! Especially the Jacuzzi in our room! The staff was very friendly and awesome! " [](https://expedia.ca/St-Louis-Hotels-Clayton-Plaza-Hotel-Extended-Stay.h18144.Hotel-Information) ![Pear Tree Inn St. Louis Airport](//images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/fc156cf2_y.jpg) ### Pear Tree Inn St. Louis Airport 10/10 Excellent "Great staff" [](https://expedia.ca/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Airport.h1096579.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Clayton cost? > You can expect to pay between CA $161 and CA $940 per night for business-friendly hotels in Clayton. Top deals on stays that cater to corporate travellers are a few clicks away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### What are the best business-friendly hotels in Clayton? > Pick from multiple business-friendly hotels in Clayton that have a total average guest review rating of 8.8. [Drury Plaza Hotel St. Louis at the Arch](https://www.expedia.ca/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-At-The-Arch.h546271.Hotel-Information) is a favourite with many corporate travellers. This 3-stars property comes with amenities such as a terrace and a swimming pool. [Moonrise Hotel](https://www.expedia.ca/St-Louis-Hotels-Moonrise-Hotel.h2292856.Hotel-Information) is another sought-after option. It has a 4-stars rating and conveniences including a rooftop terrace and a terrace. ### How many business-friendly hotels are there in Clayton? > Clayton has 5 hotels that accommodate corporate travellers. Whether you're seeking a central location or conveniences such as conference rooms and dependable WiFi, you'll find everything you need on Expedia. ### What are the best cheap business-friendly hotels in Clayton? > Business-friendly hotels in Clayton start at only CA $161 per night, so your official work trip doesn't need to cost a fortune. [Best Western Plus St. Louis Airport Hotel](https://www.expedia.ca/St-Louis-Hotels-Best-Western-Plus-St-Louis-Airport-Hotel.h50618.Hotel-Information) is a cost-effective option that features plenty of amenities, like an electric car charging station and pillow top mattresses. [Hampton Inn & Suites St. Louis at Forest Park](https://www.expedia.ca/St-Louis-Hotels-Hampton-Inn-Suites-St-Louis-At-Forest-Park.h1427801.Hotel-Information) is another cheap stay that's favoured by corporate guests. Conveniences here include a swimming pool and pillow top mattresses. When it's time to do some sightseeing in Clayton, add a few fabulous free attractions to your business trip agenda. [Forest Park](https://www.expedia.ca/Forest-Park-St-Louis.d6005687.Vacation-Attraction) and [Anheuser-Busch Brewery](https://www.expedia.ca/Anheuser-Busch-Brewery-St-Louis.d502864.Vacation-Attraction) are visitor favourites. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### Are there any family-friendly hotels in Clayton that are also business friendly? > [Drury Plaza Hotel St. Louis at the Arch](https://www.expedia.ca/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-At-The-Arch.h546271.Hotel-Information) is a top pick for leisure and corporate guests alike. Complimentary breakfast and housekeeping services are just a couple of the amenities you'll find at this 3-stars Clayton escape. Alternatively, vacation with the fam and work on the go at [Best Western Plus St. Louis Airport Hotel](https://www.expedia.ca/St-Louis-Hotels-Best-Western-Plus-St-Louis-Airport-Hotel.h50618.Hotel-Information). Enjoy the use of conveniences like a nearby theme park and a nearby zoo at this top 2.5-stars property. When you've finished work, there are loads of family-friendly attractions to see around Clayton. [St. Louis Zoo](https://www.expedia.ca/St-Louis-Zoo-St-Louis.d502878.Vacation-Attraction) and [Forest Park](https://www.expedia.ca/Forest-Park-St-Louis.d6005687.Vacation-Attraction) promise fun for young and old. ### Are there any 5-star business-friendly hotels in Clayton? > Check out [Four Seasons Hotel St Louis](https://www.expedia.ca/St-Louis-Hotels-Four-Seasons-Hotel-St-Louis.h2851438.Hotel-Information). Around 13 kilometres from the downtown area of Clayton, this business-friendly getaway has a 5-star rating and handy perks including room service and proposal/romance packages. [The Ritz-Carlton, St. Louis](https://www.expedia.ca/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information) is another 5-star option that's ideal for business travellers. It's located about 0.97 kilometres from the city centre and comes with massage services and concierge services. ### Why book your business-friendly hotel in Clayton with Expedia? > Expedia is here to help you find an ideal business-friendly hotel for your upcoming work trip. From conference spaces and room service to gyms and spas, our accommodations have all you'll need to get the job done. ### How can I find cheap business-friendly hotels in Clayton? > When work takes you to Clayton, our "business friendly" filter will help you find the perfect hotel. From free WiFi and included breakfast to concierge services and conference spaces, they come with the amenities you need for a productive and comfortable stay. Another handy tip? Narrow your search by your preferred star rating and budget to view the most affordable properties. ### What is there to do in Clayton near my business-friendly hotel? > There are lots of awesome things to see and experience in Clayton. Drop by big attractions like [St. Louis Zoo](https://www.expedia.ca/St-Louis-Zoo-St-Louis.d502878.Vacation-Attraction), [Forest Park](https://www.expedia.ca/Forest-Park-St-Louis.d6005687.Vacation-Attraction) and [Fox Theatre](https://www.expedia.ca/Fox-Theater-Grand-Center.d502865.Vacation-Attraction). 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