Title: Book the Best BOUTIQUE Hotels in Cincinnati Central Business District in 2025 | Expedia.ca [Vacation Rentals in Cincinnati](https://expedia.ca/Cincinnati-Vacation-Rentals.d178249.Travel-Guide-VacationRentals)[Flights to Cincinnati](https://expedia.ca/Cheap-Flights-To-Cincinnati.d178249.Travel-Guide-Flights)[Things to do in Cincinnati](https://expedia.ca/Things-To-Do-In-Cincinnati.d178249.Travel-Guide-Activities)[Cincinnati Central Business District Car Rentals](https://expedia.ca/Car-Rentals-In-Cincinnati-Central-Business-District.d553248635976479977.Car-Rental-Guide)[Cincinnati Central Business District Vacations](https://expedia.ca/Cincinnati-Central-Business-District.d553248635976479977.Destination-Travel-Guides) ![Cincinnati featuring interior views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/25000/25600-Cincinnati.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Boutique Hotels in Cincinnati Central Business District, OH from CA $269 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Cincinnati Central Business District Boutique Hotels Tonight [Oct 22 - Oct 23](https://www.expedia.ca/Hotel-Search?regionId=553248635976479977&startDate=2025-10-22&endDate=2025-10-23&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 23 - Oct 24](https://www.expedia.ca/Hotel-Search?regionId=553248635976479977&startDate=2025-10-23&endDate=2025-10-24&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976479977&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635976479977&startDate=2025-10-31&endDate=2025-11-02&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Cincinnati Central Business District Boutique Hotels ![1 bedroom, Egyptian cotton sheets, premium bedding, in-room safe](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/e40ec4ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/5b64e900.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dinner and brunch served](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/17dd1cba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/25619903.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Cincinnati Downtown Cincinnati 8.8/10 Excellent (1019) "Love it great hotel" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) deborah CA $225 CA $269 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Cincinnati-Hotels-21c-Museum-Hotel-Cincinnati.h5287002.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-06&endDate=2025-11-07®ionId=553248635976479977&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top Cincinnati Central Business District Hotel Reviews ![21c Museum Hotel Cincinnati](//images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/e40ec4ea_y.jpg) ### 21c Museum Hotel Cincinnati 10/10 Excellent "Love it great hotel" [](https://expedia.ca/Cincinnati-Hotels-21c-Museum-Hotel-Cincinnati.h5287002.Hotel-Information) ![Renaissance Cincinnati Downtown Hotel](//images.trvl-media.com/lodging/8000000/7320000/7316500/7316480/8f1dcd04_y.jpg) ### Renaissance Cincinnati Downtown Hotel 10/10 Excellent "It was very nice and clean. I would definitely stay again. " [](https://expedia.ca/Cincinnati-Hotels-Renaissance-Cincinnati-Downtown-Hotel.h7316480.Hotel-Information) ![The Cincinnatian Hotel Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/20000/12500/12411/90dd12e1_y.jpg) ### The Cincinnatian Hotel Curio Collection by Hilton 10/10 Excellent "Great experience " [](https://expedia.ca/Cincinnati-Hotels-The-Cincinnatian-Hotel-Curio-Collection-By-Hilton.h12411.Hotel-Information) ## Frequently asked questions ### What's the best boutique hotel in Cincinnati Central Business District? > [21c Museum Hotel Cincinnati](https://www.expedia.ca/Cincinnati-Hotels-21c-Museum-Hotel-Cincinnati.h5287002.Hotel-Information) is a favorite hotel with Expedia travelers looking for a stylish stay, and features a full-service spa and massages. ### What's there to see and do in Cincinnati Central Business District? > Once you've decided where you'd like to stay, plan what to do for fun on your vacation. Activities and attractions to experience around Cincinnati Central Business District include Great American Ball Park, Ohio River Valley, and Taft Theatre. While you're here, you might also like to explore more of the area and take in additional sights like Fountain Square, Aronoff Center for the Arts, and Cincinnati Reds Hall of Fame and Museum. ### What's the best way to get to my boutique hotel in Cincinnati Central Business District? > You have a few options for transportation to and around Cincinnati Central Business District. The closest major airport is Cincinnati, OH (LUK-Cincinnati Municipal - Lunken Field), which is located 4.3 mi (7 km) away, but Cincinnati-Northern Kentucky Int'l Airport (CVG) may also be an option. 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