Title: Book the Best BUSINESS Hotels in Charleston in 2026 | Expedia.ca [Hotels in Charleston](https://expedia.ca/Charleston-Hotels.d7182.Travel-Guide-Hotels)[Vacation Rentals in Charleston](https://expedia.ca/Charleston-Vacation-Rentals.d7182.Travel-Guide-VacationRentals)[Charleston Car Rentals](https://expedia.ca/Car-Rentals-In-Charleston.d7182.Car-Rental-Guide)[Charleston Vacation Packages](https://expedia.ca/Charleston.d7182.Destination-Travel-Guides) ![Cypress Trees on the Horizon. A sting of cypress trees of various sizes extend across the horizon as the sunken sun paints the multicolored sky. ](https://images.trvl-media.com/place/7182/2c4b1a06-d3aa-4171-b8b6-0e4eaaa0e80e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/7182/2c4b1a06-d3aa-4171-b8b6-0e4eaaa0e80e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Charleston Business Hotels Tonight [Mar 28 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=7182&startDate=2026-03-28&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Mar 29 - Mar 30](https://www.expedia.ca/Hotel-Search?regionId=7182&startDate=2026-03-29&endDate=2026-03-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Apr 3 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=7182&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [Apr 10 - Apr 12](https://www.expedia.ca/Hotel-Search?regionId=7182&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Charleston business-friendly hotels ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/a42cb957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/7fdae22d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/08c2ace2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/15abbdc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverstone Hotel Charleston-Sikeston [](https://www.expedia.ca/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information) Charleston 6.8/10 (410 reviews) "Clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chris CA $80 CA $89 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/978331d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/f90ef358.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Sikeston, MO [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) Sikeston 9.4/10 Exceptional (1,002 reviews) "Very nice for overnight stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Scott CA $153 CA $176 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Desk, laptop workspace, blackout drapes, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/fe0d924e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/dba6fd48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible (Tub)](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/86c003aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Cape Girardeau West [](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) Cape Girardeau 9.0/10 Wonderful (1,002 reviews) "Very convient location. Next door to Outback and Target. Walmart is not far away. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rob CA $100 CA $113 total includes taxes & fees Apr 9 - Apr 10 [](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/8bb15ffe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/51a3fe78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/6cd5cd8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/266a85bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Cape Girardeau [](https://www.expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (167 reviews) "Nearby Mexican restaurant, clean room, pleasant staff, good breakfast choices " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Larry CA $129 CA $145 total includes taxes & fees Apr 12 - Apr 13 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/f27091ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Jackpot Suite | Living area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/e87009c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverview [](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (533 reviews) "Room was perfect" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Derrick CA $164 CA $186 total includes taxes & fees Apr 8 - Apr 9 [](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Individually decorated, individually furnished, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/bf40a512.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/d5d0cfa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/594efec2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) [](https://www.expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) Sikeston 8.4/10 Very good (755 reviews) "Very nice place, very nice stay! They were out of cream cheese for the bagels at breakfast though.:-)" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark CA $86 CA $98 total includes taxes & fees Apr 9 - Apr 10 [](https://www.expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/6f9bce18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/db8c9491.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c65fb6ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Cape Girardeau Conference Center [](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (1,003 reviews) "Great room, staff and breakfast! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kenneth CA $139 CA $157 total includes taxes & fees Apr 26 - Apr 27 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/5b2269be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/ffb58563.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Accessible (Sofa Sleeper, Tub, 2 Rooms)](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/0f190cb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Cape Girardeau [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (1,002 reviews) "The room was great and the staff was friendly as always. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) LuAnne CA $126 CA $143 total includes taxes & fees Apr 2 - Apr 3 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/e6e29f10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/b20a49e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/81fbb6f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/540ce58d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Cape Girardeau I 55 East [](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (799 reviews) "Great place to stay. Clean and close to restaurants! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Diane CA $147 CA $166 total includes taxes & fees Apr 4 - Apr 5 [](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/58cb82c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, down comforters, desk, iron/ironing board](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/4b95ba78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8 AM to 11 PM, sun loungers](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/65f9cbe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Sikeston Southwest by IHG [](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) Sikeston 8.6/10 Excellent (451 reviews) "Clean rooms, friendly staff and convenient location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark CA $129 CA $146 total includes taxes & fees Apr 12 - Apr 13 [](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-04-11&endDate=2026-04-12®ionId=7182&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Charleston Hotel Reviews ![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed_y.jpg) ### Drury Inn & Suites Cape Girardeau 10/10 Excellent "Clean room, friendly staff, great breakfast. " [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "We will definitely be back! We travel from Wisconsin to Texas at least 2 times a year to visit family and we like to break our trip up with an overnight stay. This Drury Inn in Siikeston, Missouri will be our home away from " [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95_y.jpg) ### Pear Tree Inn Cape Girardeau West 10/10 Excellent "My wife and I stay was absolutely lovely. " [](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg) ### Best Western Plus Sikeston I-55 10/10 Excellent "Room was clean, breakfast was good, staff was friendly " [](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Super 8 by Wyndham Charleston/Sikeston East MO](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6_y.jpg) ### Super 8 by Wyndham Charleston/Sikeston East MO 2/10 Terrible "Mold on ceiling, pillows were absolutely filthy, dust everywhere, dirt getting stuck to feet on floors, Breakfast was nutra grain bars, cereal, and apples, terrible selection no hot food whatsoever. I do not recommend " [](https://expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "The hot tub was not hot enough but that was not on my list, it was suggested here. My complaint was, for seniors, there should be handrail installed to hold on to for stepping up and into the hot tub and getting out, it's very precarious as it is now. My second suggestion was people are not showering off, particularly kids when they get into the hot tub/pool and there were a huge amount of foam suds from people bodies. Something to remind people they should wash before entering? Maybe the answer could also be twioce a day cleaning of the hot tub?" [](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33_y.jpg) ### Days Inn and Suites by Wyndham Sikeston 2/10 Terrible "There were roaches crawling up the wall when we went in and the outside was horrible! Looked like a vacant building!! I want my money back" [](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Candlewood Suites Cape Girardeau by IHG](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg) ### Candlewood Suites Cape Girardeau by IHG 2/10 Terrible "Booked reservation online with Expedia and when I get to the candle wood suites they turn me away saying they don't have any rooms available. Very inconvenient " [](https://expedia.ca/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information) ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG 10/10 Excellent "Great Staff! " [](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Charleston cost? ### Why book your business-friendly hotel in Charleston with Expedia? ### How can I find cheap business-friendly hotels in Charleston? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Cheap Hotels in Advance ](https://www.expedia.ca/Advance-Hotels-Cheap-Hotels.0-0-d553248634983475122-tCheapHotels.Travel-Guide-Filter-Hotels) - [Apartments in Baker ](https://www.expedia.ca/Baker-Apartments.d553248634983252914-aaApartments.Travel-Guide-Accommodation) - [Apartments in Bell City ](https://www.expedia.ca/Bell-City-Apartments.d553248634983588961-aaApartments.Travel-Guide-Accommodation) - [Cheap Hotels in Benton ](https://www.expedia.ca/Benton-Hotels-Cheap-Hotels.0-0-d553248634983369680-tCheapHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Benton ](https://www.expedia.ca/Benton-Hotels-Luxury-Hotel.0-0-d553248634983369680-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Benton Hotels ](https://www.expedia.ca/Benton-Hotels.d553248634983369680.Travel-Guide-Hotels) - [Cheap Hotels in Bertrand ](https://www.expedia.ca/Bertrand-Hotels-Cheap-Hotels.0-0-d3000349285-tCheapHotels.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in Bertrand ](https://www.expedia.ca/Bertrand-Hotels-Hotel-With-Pool.0-0-d3000349285-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Bertrand Hotels ](https://www.expedia.ca/Bertrand-Hotels.d3000349285.Travel-Guide-Hotels) - [Motels in Bertrand ](https://www.expedia.ca/Bertrand-Motels.d3000349285-aaMotels.Travel-Guide-Accommodation) - [Blodgett Hotels ](https://www.expedia.ca/Blodgett-Hotels.d3000349291.Travel-Guide-Hotels) - [Apartments in Canalou ](https://www.expedia.ca/Canalou-Apartments.d3000349311-aaApartments.Travel-Guide-Accommodation) - [Canalou Hotels ](https://www.expedia.ca/Canalou-Hotels.d3000349311.Travel-Guide-Hotels) - [All Inclusive Resorts and in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-All-Inclusive-Hotel.0-0-d820-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Boutique-Hotel.0-0-d820-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Casino Hotels in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Casino-Hotel.0-0-d820-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Cheap-Hotels.0-0-d820-tCheapHotels.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Hotel-With-Pool.0-0-d820-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Hotels with Bar in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Hotels-With-Bar.0-0-d820-tHotelswithBar.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d820-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Hotels-With-Indoor-Pool.0-0-d820-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - [Oceanfront Hotels in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Oceanfront-Hotels.0-0-d820-tOceanfrontHotels.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Pet-Friendly-Hotel.0-0-d820-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Romantic-Hotel.0-0-d820-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Spa-Hotel.0-0-d820-tSpaHotel.Travel-Guide-Filter-Hotels) - [Cape Girardeau Hotels ](https://www.expedia.ca/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels) - [Inns in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Inns.d820-aaInns.Travel-Guide-Accommodation) - [Rv Parks in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-RV-Parks.d820-aaRVParks.Travel-Guide-Accommodation) - [Hotels near Cape Rock Park ](https://www.expedia.ca/Cape-Rock-Park-Hotels.0-l553248621532655781-0.Travel-Guide-Filter-Hotels) - [Catron Hotels ](https://www.expedia.ca/Catron-Hotels.d3000349317.Travel-Guide-Hotels) - [Rv Parks in Chaffee ](https://www.expedia.ca/Chaffee-RV-Parks.d553248634983269107-aaRVParks.Travel-Guide-Accommodation) - [Cabin Rentals in Commerce ](https://www.expedia.ca/Commerce-Cabins.d553248634983177483-aaCabins.Travel-Guide-Accommodation) - [Mississippi County Hotels ](https://www.expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Hotel-Destinations) - [Hotels near eDen Spa & Salon ](https://www.expedia.ca/EDen-Spa-Salon-Hotels.0-l553248621532655776-0.Travel-Guide-Filter-Hotels) - [East Prairie Hotels ](https://www.expedia.ca/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels) - [Howardville Hotels ](https://www.expedia.ca/Howardville-Hotels.d553248634983363505.Travel-Guide-Hotels) - [Hotels near Isle Casino Cape Girardeau ](https://www.expedia.ca/Isle-Casino-Cape-Girardeau-Hotels.0-l553248621532655780-0.Travel-Guide-Filter-Hotels) - [B&B in Kelso ](https://www.expedia.ca/Kelso-Bed-And-Breakfast.d553248634983171130-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cheap Hotels in Marston ](https://www.expedia.ca/Marston-Hotels-Cheap-Hotels.0-0-d55824-tCheapHotels.Travel-Guide-Filter-Hotels) - [Matthews Hotels ](https://www.expedia.ca/Matthews-Hotels.d553248634983428760.Travel-Guide-Hotels) - [Lodges in Matthews ](https://www.expedia.ca/Matthews-Lodges.d553248634983428760-aaLodges.Travel-Guide-Accommodation) - [Hotels with smoking rooms in Miner ](https://www.expedia.ca/Miner-Hotels-Hotels-With-Smoking-Rooms.0-0-d553248634983441802-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Miner ](https://www.expedia.ca/Miner-Hotels-Luxury-Hotel.0-0-d553248634983441802-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Miner Hotels ](https://www.expedia.ca/Miner-Hotels.d553248634983441802.Travel-Guide-Hotels) - [Lodges in Miner ](https://www.expedia.ca/Miner-Lodges.d553248634983441802-aaLodges.Travel-Guide-Accommodation) - [Apartments in Morehouse ](https://www.expedia.ca/Morehouse-Apartments.d553248634983462037-aaApartments.Travel-Guide-Accommodation) - [Morehouse Hotels ](https://www.expedia.ca/Morehouse-Hotels.d553248634983462037.Travel-Guide-Hotels) - [Cheap Hotels in New Madrid ](https://www.expedia.ca/New-Madrid-Hotels-Cheap-Hotels.0-0-d3000445315-tCheapHotels.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in New Madrid ](https://www.expedia.ca/New-Madrid-Hotels-Hotel-With-Pool.0-0-d3000445315-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Luxury Hotels in New Madrid ](https://www.expedia.ca/New-Madrid-Hotels-Luxury-Hotel.0-0-d3000445315-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [New Madrid Hotels ](https://www.expedia.ca/New-Madrid-Hotels.d3000445315.Travel-Guide-Hotels) - [B&B in Oran ](https://www.expedia.ca/Oran-Bed-And-Breakfast.d3000445386-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Hotels with a Pool in Oran ](https://www.expedia.ca/Oran-Hotels-Hotel-With-Pool.0-0-d3000445386-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Oran ](https://www.expedia.ca/Oran-Hotels-Luxury-Hotel.0-0-d3000445386-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Oran Hotels ](https://www.expedia.ca/Oran-Hotels.d3000445386.Travel-Guide-Hotels) - [Inns in Oran ](https://www.expedia.ca/Oran-Inns.d3000445386-aaInns.Travel-Guide-Accommodation) - [Cheap Hotels in Parma ](https://www.expedia.ca/Parma-Hotels-Cheap-Hotels.0-0-d553248634983328909-tCheapHotels.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Scott City ](https://www.expedia.ca/Scott-City-Hotels-Cheap-Hotels.0-0-d553248634983544376-tCheapHotels.Travel-Guide-Filter-Hotels) - [Scott City Hotels ](https://www.expedia.ca/Scott-City-Hotels.d553248634983544376.Travel-Guide-Hotels) - [Apartments in Sikeston ](https://www.expedia.ca/Sikeston-Apartments.d6058766-aaApartments.Travel-Guide-Accommodation) - [Cheap Hotels in Sikeston ](https://www.expedia.ca/Sikeston-Hotels-Cheap-Hotels.0-0-d6058766-tCheapHotels.Travel-Guide-Filter-Hotels) - [Hotels with Kitchenettes in Sikeston ](https://www.expedia.ca/Sikeston-Hotels-Hotels-With-Kitchenettes.0-0-d6058766-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Sikeston ](https://www.expedia.ca/Sikeston-Hotels-Pet-Friendly-Hotel.0-0-d6058766-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Sikeston Hotels ](https://www.expedia.ca/Sikeston-Hotels.d6058766.Travel-Guide-Hotels) - [Hotels near Southeast Missouri State University ](https://www.expedia.ca/Southeast-Missouri-State-University-Hotels.0-l553248621554122994-0.Travel-Guide-Filter-Hotels) - [Wilson City Hotels ](https://www.expedia.ca/Wilson-City-Hotels.d553248634983391595.Travel-Guide-Hotels) - [Flights to Cape Girardeau ](https://www.expedia.ca/Cheap-Flights-To-Cape-Girardeau.d820.Travel-Guide-Flights) - [Flights from East Prairie ](https://www.expedia.ca/lp/flights/3000349349/flights-from-east-prairie) - [Flights from Commerce ](https://www.expedia.ca/lp/flights/553248634983177483/flights-from-commerce) - [Flights from Chaffee ](https://www.expedia.ca/lp/flights/553248634983269107/flights-from-chaffee) - [Flights from Scott City ](https://www.expedia.ca/lp/flights/553248634983544376/flights-from-scott-city) - [Flights from Cape Girardeau ](https://www.expedia.ca/lp/flights/820/flights-from-cape-girardeau) - [Flights from Accra (ACC) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/acc/cgi/accra-to-cape-girardeau) - [Flights from Bloomington (BMI) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/bmi/cgi/bloomington-to-cape-girardeau) - [Flights from Buffalo (BUF) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/buf/cgi/buffalo-to-cape-girardeau) - [Flights from Colombo (CMB) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/cmb/cgi/colombo-to-cape-girardeau) - [Flights from Dhaka (DAC) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/dac/cgi/dhaka-to-cape-girardeau) - [Flights from Detroit (DTW) to Sikeston (SIK) ](https://www.expedia.ca/lp/flights/dtw/sik/detroit-to-sikeston) - [Flights from Grand Island (GRI) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/gri/cgi/grand-island-to-cape-girardeau) - [Flights from New York (JFK) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/jfk/cgi/new-york-to-cape-girardeau) - [Flights from Las Vegas (LAS) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/las/cgi/las-vegas-to-cape-girardeau) - [Flights from Ocala (OCF) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/ocf/cgi/ocala-to-cape-girardeau) - [Flights from Pierre (PIR) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/pir/cgi/pierre-to-cape-girardeau) - [Flights from St. Louis (STL) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/stl/cgi/st-louis-to-cape-girardeau) - [Flights from Edmonton (YEG) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yeg/cgi/edmonton-to-cape-girardeau) - [Flights from Toronto (YTO) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yto/cgi/toronto-to-cape-girardeau) - [Flights from Montreal (YUL) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yul/cgi/montreal-to-cape-girardeau) - [Flights from Vancouver (YVR) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yvr/cgi/vancouver-to-cape-girardeau) - [Flights from Winnipeg (YWG) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/ywg/cgi/winnipeg-to-cape-girardeau) - [Flights from Calgary (YYC) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yyc/cgi/calgary-to-cape-girardeau) - [Flights from Toronto (YYZ) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yyz/cgi/toronto-to-cape-girardeau) - [Visit Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau.dx820) - [Eden Spa & Salon ](https://www.expedia.ca/EDen-Spa-Salon-Cape-Girardeau.d553248621532655776.Vacation-Attraction) - [Southeast Missouri State University ](https://www.expedia.ca/Southeast-Missouri-State-University-Cape-Girardeau.d553248621554122994.Vacation-Attraction) - [Avis Rental Cars in Sikeston ](https://www.expedia.ca/Avis-Car-Rentals-In-Sikeston.d6058766-c41.Car-Rental-Guide-Suppliers) - [Rental cars Cape Girardeau Municipal airport ](https://www.expedia.ca/Car-Rentals-In-Cape-Girardeau-Municipal.d6026978.Car-Rental-Guide) - [Car rental Cape Girardeau ](https://www.expedia.ca/Car-Rentals-In-Cape-Girardeau.d820.Car-Rental-Guide) - [Car rental Sikeston ](https://www.expedia.ca/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide) - [Hertz Rental Cars in Sikeston ](https://www.expedia.ca/Hertz-Car-Rentals-In-Sikeston.d6058766-c40.Car-Rental-Guide-Suppliers) - [National Car Rental Rental Cars in Sikeston ](https://www.expedia.ca/National-Car-Rental-Car-Rentals-In-Sikeston.d6058766-c42.Car-Rental-Guide-Suppliers) - [Book Business Hotels in Charleston on Expedia.com ](https://www.expedia.com/Charleston-Hotels-Business-Hotel.0-0-d7182-tBusinessHotel.Travel-Guide-Filter-Hotels)