Title: Hotels by Red Lion in Central San Mateo from CA $143 | Expedia.ca [Central San Mateo Travel Guide](https://expedia.ca/San-Francisco-Central-San-Mateo.dx553248635976470619)[Vacation Rentals in San Francisco](https://expedia.ca/San-Francisco-Vacation-Rentals.d178305.Travel-Guide-VacationRentals)[Flights to San Francisco](https://expedia.ca/Cheap-Flights-To-San-Francisco.d178305.Travel-Guide-Flights)[Things to do in San Francisco](https://expedia.ca/Things-To-Do-In-San-Francisco.d178305.Travel-Guide-Activities)[Central San Mateo Car Rentals](https://expedia.ca/Car-Rentals-In-Central-San-Mateo.d553248635976470619.Car-Rental-Guide)[Central San Mateo Vacations](https://expedia.ca/Central-San-Mateo.d553248635976470619.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/ef18e451fe99b17b227295b762641efd.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Red Lion in Central San Mateo from CA $143 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 21 - Oct 22](https://www.expedia.ca/Hotel-Search?regionId=553248635976470619&startDate=2025-10-21&endDate=2025-10-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 22 - Oct 23](https://www.expedia.ca/Hotel-Search?regionId=553248635976470619&startDate=2025-10-22&endDate=2025-10-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976470619&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635976470619&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Central San Mateo Red Lion Hotels ![Property entrance](https://images.trvl-media.com/lodging/27000000/26600000/26597900/26597887/0100efb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/27000000/26600000/26597900/26597887/449f78dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/27000000/26600000/26597900/26597887/123beae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, in-room safe, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/27000000/26600000/26597900/26597887/e207d49f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Signature San Francisco Downtown San Francisco 7.8/10 Good (1011) "Always been great stay the rooms are nice and clean plus the staff very nice and helpful, I really recommend this place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mohamed CA $163 CA $192 total includes taxes & fees Oct 22 - Oct 23 [](https://www.expedia.ca/San-Francisco-Hotels-Signature-San-Francisco.h26597887.Hotel-Information) ![Luxury Room | Living area](https://images.trvl-media.com/lodging/22000000/21570000/21568300/21568246/5184c2fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/22000000/21570000/21568300/21568246/ba703a4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Room](https://images.trvl-media.com/lodging/22000000/21570000/21568300/21568246/3decfbb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/22000000/21570000/21568300/21568246/0a7748d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Signature Inn Oakland Piedmont Avenue 8.2/10 Very good (511) "I have stayed twice now. I love the location and the staff are helpful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Duane CA $125 CA $143 total includes taxes & fees Nov 10 - Nov 11 [](https://www.expedia.ca/Oakland-Hotels-Broadway-Motel.h21568246.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-04&endDate=2025-11-05®ionId=553248635976470619&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FCentral-San-Mateo-San-Francisco-Hotels-Red-Lion.0-n553248635976470619-0--bRedLion.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FCentral-San-Mateo-San-Francisco-Hotels-Red-Lion.0-n553248635976470619-0--bRedLion.Travel-Guide-Filter-Hotels) ## Top Central San Mateo Hotel Reviews ![Hyatt Regency San Francisco](//images.trvl-media.com/lodging/1000000/30000/23800/23774/1f7903cc_y.jpg) ### Hyatt Regency San Francisco 10/10 Excellent "The stay was nice. The room was clean. The only thing i would recommend is that the bar area open early on Sundays during nfl season. When you get off your flight you want to wind down and have a cocktail available. Also maybe putting water and coffee in the lobby complementary. Also open the club regency on Sunda for viewing and pictures. " [](https://expedia.ca/San-Francisco-Hotels-Hyatt-Regency-San-Francisco.h23774.Hotel-Information) ![Fairmont San Francisco](//images.trvl-media.com/lodging/1000000/20000/18200/18200/6f6889e4_y.jpg) ### Fairmont San Francisco 10/10 Excellent "Nice views!" [](https://expedia.ca/San-Francisco-Hotels-Fairmont-San-Francisco.h18200.Hotel-Information) ![Holiday Inn Golden Gateway by IHG](//images.trvl-media.com/lodging/1000000/20000/10600/10538/9ba9bb1f_y.jpg) ### Holiday Inn Golden Gateway by IHG 10/10 Excellent "I enjoyed my stay — the hotel had a welcoming atmosphere and the amenities were nice. The room was spacious and the bed was comfortable. The only thing that stood out was that it wasn’t quite as clean as I expected (a bit of dust and a few missed spots). Other than that, it was a good experience, and I’d consider staying again." [](https://expedia.ca/San-Francisco-Hotels-Holiday-Inn-Golden-Gateway.h10538.Hotel-Information) ![Hyatt Regency San Francisco Downtown SOMA ](//images.trvl-media.com/lodging/1000000/10000/500/491/5e565895_y.jpg) ### Hyatt Regency San Francisco Downtown SOMA 10/10 Excellent " Beautiful clean rooms helpful staff central located to just about anything great view on thirty six floor i could see golden gate from my room room and the water stunning great bartendars as well parking sucked 95 for the weekend did not move my car from parking garage because rates are insane but its frisco id stay here again" [](https://expedia.ca/San-Francisco-Hotels-The-Park-Central-San-Francisco-Hyatt-Affiliated-Hotel.h491.Hotel-Information) ![Club Quarters Hotel in San Francisco](//images.trvl-media.com/lodging/1000000/920000/913000/912982/5ee1ba27_y.jpg) ### Club Quarters Hotel in San Francisco 10/10 Excellent "The water bottle refill station takes forever to fill up. Please see if 8th floor can have a faster water fill. Thank you. The front door wave wasn’t working, and the situation about the smoke smell in the room was handled right away, thank you, everything else was great. " [](https://expedia.ca/San-Francisco-Hotels-Club-Quarters-Hotel-In-San-Francisco.h912982.Hotel-Information) ![Handlery Union Square Hotel](//images.trvl-media.com/lodging/1000000/10000/6700/6666/b8dfc462_y.jpg) ### Handlery Union Square Hotel 10/10 Excellent "Love stay at this property when visiting San Francisco. Francisco is extremely close to all tourist attractions in Union Square clean customer service will return." [](https://expedia.ca/San-Francisco-Hotels-Handlery-Union-Square-Hotel.h6666.Hotel-Information) ![Best Western Plus Grosvenor Airport Hotel](//images.trvl-media.com/lodging/1000000/10000/7700/7635/062e9dfe_y.jpg) ### Best Western Plus Grosvenor Airport Hotel 10/10 Excellent "Yes" [](https://expedia.ca/San-Francisco-Hotels-Best-Western-Plus-Grosvenor-Airport-Hotel.h7635.Hotel-Information) ![Hyatt Centric Fisherman's Wharf San Francisco](//images.trvl-media.com/lodging/1000000/30000/22500/22500/1d699bf3_y.jpg) ### Hyatt Centric Fisherman's Wharf San Francisco 10/10 Excellent "Nice hotel, smart area, super clean room, great breakfast. " [](https://expedia.ca/San-Francisco-Hotels-Hyatt-Centric-Fishermans-Wharf-San-Francisco.h22500.Hotel-Information) ![Chancellor Hotel on Union Square](//images.trvl-media.com/lodging/1000000/30000/20600/20547/944f985c_y.jpg) ### Chancellor Hotel on Union Square 10/10 Excellent "Great" [](https://expedia.ca/San-Francisco-Hotels-Chancellor-Hotel-On-Union-Square.h20547.Hotel-Information) ## Find out more about Central San Mateo ## Central San Mateo Hotels Guide Expedia.ca offers a selection of 4811 hotels in Central San Mateo. You are sure to find cheap deals and discount rates among them with our Best Price Guarantee. No matter what type of hotel strikes your fancy, we will let you search for your preferred one to accommodate your travel needs. Expedia.ca will not only save you time, but also money when booking your stay at a hotel in Central San Mateo. Making reservations so you can stay within your budget is easy with us. Expedia.ca even provides you with a map so you may find hotels in the Central San Mateo neighborhood you prefer. Go ahead. Enter your travel dates to view the best offers on hotel rooms in Central San Mateo, San Francisco now! ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [4 Star Hotels in San Mateo](https://www.expedia.ca/4Star-San-Mateo-Hotels.s40-0-d6653.Travel-Guide-Filter-Hotels) - [5 Star Hotels in San Mateo](https://www.expedia.ca/5Star-San-Mateo-Hotels.s50-0-d6653.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Belmont](https://www.expedia.ca/Belmont-Hotels-Best-Western.0-0-d6845--bBestWestern.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Belmont](https://www.expedia.ca/Belmont-Hotels-Marriott-Hotels-Resorts.0-0-d6845--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Vagabond Inn Hotels in Beresford Park](https://www.expedia.ca/Beresford-Park-San-Francisco-Hotels-Vagabond-Inn.0-n553248635976471741-0--bVagabondInn.Travel-Guide-Filter-Hotels) - [Nikko Hotels in Burlingame](https://www.expedia.ca/Burlingame-Hotels-Nikko.0-0-d7146--bNikko.Travel-Guide-Filter-Hotels) - 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[Flights to San Mateo](https://www.expedia.ca/Cheap-Flights-To-San-Mateo.d6653.Travel-Guide-Flights) - [Flights from Amsterdam to San Mateo](https://www.expedia.ca/lp/flights/178229/6653/amsterdam-to-san-mateo) - [Flights from Chicago to San Mateo](https://www.expedia.ca/lp/flights/178248/6653/chicago-to-san-mateo) - [Flights from Dallas to San Mateo](https://www.expedia.ca/lp/flights/178253/6653/dallas-to-san-mateo) - [Flights from Las Vegas to San Mateo](https://www.expedia.ca/lp/flights/178276/6653/las-vegas-to-san-mateo) - [Flights from Los Angeles to San Mateo](https://www.expedia.ca/lp/flights/178280/6653/los-angeles-to-san-mateo) - [Flights from Manila to San Mateo](https://www.expedia.ca/lp/flights/178282/6653/manila-to-san-mateo) - [Flights from Mexico City to San Mateo](https://www.expedia.ca/lp/flights/178285/6653/mexico-city-to-san-mateo) - [Flights from Montreal to San Mateo](https://www.expedia.ca/lp/flights/178288/6653/montreal-to-san-mateo) - [Flights from Portland to San Mateo](https://www.expedia.ca/lp/flights/178299/6653/portland-to-san-mateo) - [Flights from Seattle to San Mateo](https://www.expedia.ca/lp/flights/178307/6653/seattle-to-san-mateo) - [Flights from Toronto to San Mateo](https://www.expedia.ca/lp/flights/178314/6653/toronto-to-san-mateo) - [Flights from Vancouver to San Mateo](https://www.expedia.ca/lp/flights/178315/6653/vancouver-to-san-mateo) - [Flights from Berlin to San Mateo](https://www.expedia.ca/lp/flights/179892/6653/berlin-to-san-mateo) - [Flights from Québec City to San Mateo](https://www.expedia.ca/lp/flights/180017/6653/quebec-city-to-san-mateo) - [Flights from San José to San Mateo](https://www.expedia.ca/lp/flights/603085/6653/san-jose-to-san-mateo) - [Flights from Vancouver (YVR) to San Francisco (SFO)](https://www.expedia.ca/lp/flights/yvr/sfo/vancouver-to-san-francisco) - [Flights from Calgary (YYC) to San Francisco (SFO)](https://www.expedia.ca/lp/flights/yyc/sfo/calgary-to-san-francisco) - [Flights from Toronto (YYZ) to San Francisco (SFO)](https://www.expedia.ca/lp/flights/yyz/sfo/toronto-to-san-francisco) - 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[Hertz Rental Cars in San Mateo](https://www.expedia.ca/Hertz-Car-Rentals-In-San-Mateo.d6653-c40.Car-Rental-Guide-Suppliers) - [Interrent EU Rental Cars in San Mateo](https://www.expedia.ca/Interrent-EU-Car-Rentals-In-San-Mateo.d6653-c1043.Car-Rental-Guide-Suppliers) - [Luxury Car Rentals in San Mateo](https://www.expedia.ca/Luxury-Car-Rentals-In-San-Mateo.d6653-tLuxury.Car-Rental-Guide-Class) - [Pickup Car Rentals in San Mateo](https://www.expedia.ca/Pickup-Car-Rentals-In-San-Mateo.d6653-tPickup.Car-Rental-Guide-Class) - [Right-Cars Rental Cars in San Mateo](https://www.expedia.ca/Right-Cars-Car-Rentals-In-San-Mateo.d6653-c1102.Car-Rental-Guide-Suppliers) - [Sixt Rental Cars in San Mateo](https://www.expedia.ca/Sixt-Car-Rentals-In-San-Mateo.d6653-c35.Car-Rental-Guide-Suppliers) - [U-Save Rental Cars in San Mateo](https://www.expedia.ca/U-Save-Car-Rentals-In-San-Mateo.d6653-c34.Car-Rental-Guide-Suppliers) - [Van Car Rentals in San Mateo](https://www.expedia.ca/Van-Car-Rentals-In-San-Mateo.d6653-tVan.Car-Rental-Guide-Class) - [San Mateo Vacation Rentals](https://www.expedia.ca/San-Mateo-Vacation-Rentals.d6653.Travel-Guide-VacationRentals) - [Things to do in San Mateo](https://www.expedia.ca/Things-To-Do-In-San-Mateo.d6653.Travel-Guide-Activities) - [Book Hotels in Central San Mateo on Expedia.com](https://www.expedia.com/Central-San-Mateo-San-Francisco-Hotels-Red-Lion.0-n553248635976470619-0--bRedLion.Travel-Guide-Filter-Hotels)