Beginning of main content

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Central San Diego Business Hotels

See all 220 Hotels in Central San Diego
Country Inn & Suites by Carlson-San Diego North

Country Inn & Suites by Carlson-San Diego North

5975 Lusk Blvd, San Diego
3.5 out of 5.0
4.3 out of 5 (1,994 reviews)
Nice quiet hotel away from fast track of DowntownVery quiet. Relaxing with comfort. Hot tub was fantastic. Beautifully decorated. Expansive breakfast buffet. Evening warm cookies.
  7 Jan 2018

C$116

C$116
Ramada San Diego North Hotel and Conference Center

Ramada San Diego North Hotel and Conference Center

5550 Kearny Mesa Rd, San Diego
3.5 out of 5.0
3.8 out of 5 (3,474 reviews)
Clean hotel, good price, and nice staff. Nice hotel with good parking. Staff very nice. Just wish fitness center was bigger. Would like additional treadmill machines.
  16 Jan 2018

C$83

C$83
HYATT house San Diego/Sorrento Mesa

HYATT house San Diego/Sorrento Mesa

10044 Pacific Mesa Blvd, San Diego
3.5 out of 5.0
4.5 out of 5 (1,230 reviews)
Great for family and businessThe courtyard of the Sorento Mesa Hyatt House is the perfect place to escape to at the end of the day. Quite, peaceful and very well appointed with pool, hot tub, gas fire place, bars, tables and high-end gas grills. Located outside of the San Diego center City it is still only 20 minutes from everything. ...
  31 Dec 2017

C$166

C$166
Four Points by Sheraton San Diego

Four Points by Sheraton San Diego

8110 Aero Dr, San Diego
3.0 out of 5.0
3.6 out of 5 (1,217 reviews)
Good choice everything was very good only that you could hear very easily what other rooms or what outside
  16 Jan 2018

C$103

C$103
Holiday Inn Express Hotel & Suites San Diego-Sorrento Valley

Holiday Inn Express Hotel & Suites San Diego-Sorrento Valley

5925 Lusk Blvd, San Diego
2.5 out of 5.0
4.4 out of 5 (575 reviews)
nice and quietgood hotel , nice staff and clean, quiet but far from center
  15 Jan 2018

C$134

C$134
Courtyard by Marriott San Diego Central

Courtyard by Marriott San Diego Central

8651 Spectrum Center Blvd, San Diego
3.5 out of 5.0
4.3 out of 5 (795 reviews)
Fantastic!!!!This hotel was GREAT!!! The rooms are VERY clean. I always leave hotels talking crap about something I didn't like BUT this hotel exceed my expectation. Quiet and cozy. Definitely going there again!! Thank you for making my stay more enjoyable :)
  30 Oct 2017

C$164

C$164
Courtyard by Marriott San Diego Sorrento Valley

Courtyard by Marriott San Diego Sorrento Valley

9650 Scranton Rd, San Diego
3.5 out of 5.0
4.2 out of 5 (596 reviews)
Convenient for a night stay. Comfortable placeIt is a nice quiet evening. Close to San Diego and shopping.
  15 Dec 2017

C$126

C$126
Hampton Inn San Diego-Kearny Mesa

Hampton Inn San Diego-Kearny Mesa

5434 Kearny Mesa Rd, San Diego
2.5 out of 5.0
4.5 out of 5 (566 reviews)
Check in check out fast I enjoyed stay there room clean, food could be better
  2 Jan 2018

C$160

C$160
Residence Inn San Diego Sorrento Mesa/Sorrento Valley

Residence Inn San Diego Sorrento Mesa/Sorrento Valley

5995 Pacific Mesa Ct, San Diego
3.5 out of 5.0
4.4 out of 5 (202 reviews)
Clean hotel Everything was great here, would stay here again in the future.
  19 Dec 2017

C$161

C$161
Best Western San Diego/Miramar Hotel

Best Western San Diego/Miramar Hotel

9310 Kearny Mesa Rd, San Diego
3.0 out of 5.0
3.8 out of 5 (925 reviews)
Great hotel at a great price!Front desk staff was very friendly and accomodating.
  28 Nov 2017

C$104

C$104
Map

Recently booked Central San Diego hotels

HYATT house San Diego/Sorrento Mesa
3.5 out of 5.0
Last booking: 2 minutes ago
Country Inn & Suites by Carlson-San Diego North
3.5 out of 5.0
Last booking: 36 minutes ago
Holiday Inn San Diego North Miramar
3.5 out of 5.0
Last booking: 43 minutes ago
Four Points by Sheraton San Diego
3.0 out of 5.0
Last booking: 54 minutes ago
Hilton Garden Inn San Diego Mission Valley Stadium
3.5 out of 5.0
Last booking: 1 hour ago
California Suites Hotel
2.5 out of 5.0
Last booking: 1 hour ago
Courtyard by Marriott San Diego Sorrento Valley
3.5 out of 5.0
Last booking: 1 hour ago
Pleasant Inn
3.0 out of 5.0
Last booking: 2 hours ago
Holiday Inn Express Hotel & Suites San Diego-Sorrento Valley
2.5 out of 5.0
Last booking: 2 hours ago

Pocket Guide: Business Hotels in Central San Diego

Search for hotels in Central San Diego on Expedia. You can easily find your hotels in Central San Diego using one of the methods below:

  • View our selection of featured hotels in Central San Diego
  • Use the map to find hotels in the Central San Diego neighborhood you prefer
  • Use the filters to see hotels in a specific area of Central San Diego, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Central San Diego
  • Enter your travel dates to view the best deals on hotels in Central San Diego - while they last