Title: Book the Best Central San Diego SPA Resorts - Spa Hotels in Central San Diego, CA | Expedia.ca [Central San Diego Travel Guide](https://expedia.ca/Central-San-Diego.dx6056570)[Hotels in Central San Diego](https://expedia.ca/Central-San-Diego-Hotels.d6056570.Travel-Guide-Hotels)[Vacation Rentals in Central San Diego](https://expedia.ca/Central-San-Diego-Vacation-Rentals.d6056570.Travel-Guide-VacationRentals)[Flights to Central San Diego](https://expedia.ca/Cheap-Flights-To-Central-San-Diego.d6056570.Travel-Guide-Flights)[Things to do in Central San Diego](https://expedia.ca/Things-To-Do-In-Central-San-Diego.d6056570.Travel-Guide-Activities)[Central San Diego Car Rentals](https://expedia.ca/Car-Rentals-In-Central-San-Diego.d6056570.Car-Rental-Guide)[Central San Diego Vacation Packages](https://expedia.ca/Central-San-Diego.d6056570.Destination-Travel-Guides) ![Balboa Park featuring aircraft and interior views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/21000/21283-Balboa-Park.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Central San Diego, CA ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Central San Diego Spa Hotels Tonight [Oct 20 - Oct 21](https://www.expedia.ca/Hotel-Search?regionId=6056570&startDate=2025-10-20&endDate=2025-10-21&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 21 - Oct 22](https://www.expedia.ca/Hotel-Search?regionId=6056570&startDate=2025-10-21&endDate=2025-10-22&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6056570&startDate=2025-10-24&endDate=2025-10-26&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6056570&startDate=2025-10-31&endDate=2025-11-02&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Central San Diego Spa Hotels ![Premier Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/fde0003f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/cc4883a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor banquet area](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/6257cb78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/76794add.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Handlery Hotel Mission Valley 8.2/10 Very good (2148) "The hotel is very clean, pool and spa are fantastic, the food at the hotel was excellent " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eugene CA $143 CA $164 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![Couples treatment rooms, body treatments, hot stone massages](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/cba9a8a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/21efa256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/0bbd67f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/7442075b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Legacy Resort Hotel & Spa Mission Valley 9.2/10 Wonderful (2917) "Love this hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dana CA $240 CA $276 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/900/858/c5325c92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Penthouse](https://images.trvl-media.com/lodging/1000000/10000/900/858/36c2b78d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Down comforters, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/10000/900/858/93b051f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/10000/900/858/543624c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Mission Bay Spa and Marina Mission Bay 8.4/10 Very good (1550) "Clean rooms great view amazing pool and we loved the breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ad CA $237 CA $347 total includes taxes & fees Nov 1 - Nov 2 [](https://www.expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/7cb5b7d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/f0d27d94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/98dcc319.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sundeck](https://images.trvl-media.com/lodging/1000000/40000/36200/36183/52554aaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Humphreys Half Moon Inn Point Loma 9.2/10 Wonderful (2581) "Lovely place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary CA $178 CA $232 total includes taxes & fees Nov 20 - Nov 21 [](https://www.expedia.ca/San-Diego-Hotels-Humphreys-Half-Moon-Inn.h36183.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/9700/9660/8496a8ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/9700/9660/5c2bbbc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Californian cuisine, pool views ](https://images.trvl-media.com/lodging/1000000/10000/9700/9660/8c14c190.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/9700/9660/9de092e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Island Palms Hotel & Marina Point Loma 8.8/10 Excellent (1562) "Staff were great and friendly, good food and drink, clean and good central location. " ![Australia](https://a.travel-assets.com/egds/marks/flags/au.svg) Mick CA $173 CA $199 total includes taxes & fees Nov 20 - Nov 21 [](https://www.expedia.ca/San-Diego-Hotels-Best-Western-Plus-Island-Palms-Hotel-Marina.h9660.Hotel-Information) ![Fitness studio](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/8d3908bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/8995625e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 restaurants, breakfast served](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/250333ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/91cdc1c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sycuan Casino Resort El Cajon 9.2/10 Wonderful (1582) "Great resort!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vicky CA $126 CA $156 total includes taxes & fees Nov 19 - Nov 20 [](https://www.expedia.ca/El-Cajon-Hotels-Sycuan-Casino-Resort.h33661441.Hotel-Information) ![Suite, 2 Bedrooms, Non Smoking | Private kitchen](https://images.trvl-media.com/lodging/1000000/10000/4700/4694/ed817c90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4700/4694/ca148444.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms, Non Smoking | Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/4700/4694/94fbda6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4700/4694/01804477.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Diego Country Estates San Diego Country Estates 9.4/10 Exceptional (236) "Clean, spacious rooms." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa CA $111 CA $158 total includes taxes & fees Oct 21 - Oct 22 [](https://www.expedia.ca/Ramona-Hotels-San-Diego-Country-Estates.h4694.Hotel-Information) ![Couples treatment rooms, body treatments, aromatherapy](https://images.trvl-media.com/lodging/2000000/1450000/1445800/1445745/92ce23e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/2000000/1450000/1445800/1445745/841cf4f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1450000/1445800/1445745/3072d298.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1450000/1445800/1445745/75d17156.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Riviera Oaks Resort San Diego Country Estates 9.6/10 Exceptional (1014) "Clean, friendly staff, well maintained, nice looking property." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Timmy CA $102 CA $132 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Ramona-Hotels-Riviera-Oaks-Resort.h1445745.Hotel-Information) ![Body treatments, aromatherapy, body wraps, body scrubs, facials](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/b1fc21d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Californian cuisine, ocean views ](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/06f19e3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/9fc82331.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1880000/1871700/1871645/2df2def5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Bayfront Downtown San Diego 8.6/10 Excellent (1792) "Super clean room and the staff at the pool bar was exceptional. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stanley CA $254 CA $363 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Bayfront.h1871645.Hotel-Information) ![Couples treatment rooms, sauna, hot tub, steam room, body treatments](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/d9cbfe80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/c2d82864.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/423e7241.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/99024d06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Loews Coronado Bay Resort Silver Strand 8.8/10 Excellent (1053) "Beautiful quiet hotel." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lori CA $279 CA $374 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Coronado-Hotels-Loews-Coronado-Bay-Resort.h25840.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-03&endDate=2025-11-04®ionId=6056570&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Central San Diego Hotel Reviews ![Hilton San Diego Mission Valley](//images.trvl-media.com/lodging/1000000/20000/16100/16019/w3839h2160x1y0-98566ca3_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "Super easy check in process, staff was extremely hospitable. My room was comfortable as well. Great job Hilton" [](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](//images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Great for the price" [](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![DoubleTree by Hilton Hotel San Diego - Mission Valley](//images.trvl-media.com/lodging/1000000/10000/400/332/8e34f752_y.jpg) ### DoubleTree by Hilton Hotel San Diego - Mission Valley 10/10 Excellent "It was a quick over night stay. Did not use any additional amenities. Always enjoy the warm cookies!" [](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ![Handlery Hotel](//images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55_y.jpg) ### Handlery Hotel 10/10 Excellent "Clean room awesome staff and quiet space " [](https://expedia.ca/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ![Ramada Suites by Wyndham San Diego/Hotel Circle Area](//images.trvl-media.com/lodging/1000000/20000/11600/11553/43298e98_y.jpg) ### Ramada Suites by Wyndham San Diego/Hotel Circle Area 10/10 Excellent "Great place. Needs a renovation though…" [](https://expedia.ca/San-Diego-Hotels-Ramada-Suites-By-Wyndham-San-Diego.h11553.Hotel-Information) ![San Diego Marriott Mission Valley](//images.trvl-media.com/lodging/1000000/10000/8400/8332/21e561fb_y.jpg) ### San Diego Marriott Mission Valley 10/10 Excellent "Air conditioning Bed was very comfortable " [](https://expedia.ca/San-Diego-Hotels-San-Diego-Marriott-Mission-Valley.h8332.Hotel-Information) ![California Suites Hotel](//images.trvl-media.com/lodging/1000000/50000/40600/40531/4d1b251a_y.jpg) ### California Suites Hotel 10/10 Excellent "Love this spot!" [](https://expedia.ca/San-Diego-Hotels-California-Suites-Hotel.h40531.Hotel-Information) ![The Atwood Hotel San Diego - SeaWorld/Zoo](//images.trvl-media.com/lodging/14000000/13160000/13155700/13155645/61eaf52a_y.jpg) ### The Atwood Hotel San Diego - SeaWorld/Zoo 10/10 Excellent "This motel was clean. Safe with free parking. The staff was very friendly. The pool and hot tub were nice. I would stay here again!" [](https://expedia.ca/San-Diego-Hotels-The-Atwood.h13155645.Hotel-Information) ![Town and Country San Diego](//images.trvl-media.com/lodging/1000000/30000/21400/21394/bbee5f13_y.jpg) ### Town and Country San Diego 10/10 Excellent "Very family oriented we had some neighbors who were there to party however that’s not the hotel‘s fault. The hotel itself was magnificent. Very well. Kept grounds plenty to do, especially for children. I love the fire pits and the fact that you get to buy s’mores packages." 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